SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1PE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 8 GLY A 134
GLU A 219
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.69A 1ax9A-4be9A:
43.6		 1ax9A-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 8 GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.87A 1ax9A-4be9A:
43.6		 1ax9A-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.03A 1axwA-4xscA:
36.4		 1axwA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.69A 1axwA-4xscA:
36.4		 1axwA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.79A 1axwB-4xscA:
36.5		 1axwB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.93A 1axwB-4xscA:
36.5		 1axwB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.83A 1b02A-4xscA:
31.4		 1b02A-4xscA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.95A 1b02A-4xscA:
31.4		 1b02A-4xscA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 ALA A 245
LEU A 126
LEU A 278
THR A 123
LEU A  47
 None
None
1PE  A2712 ( 4.5A)
None
None
 1.11A 1bzfA-1q0zA:
undetectable		 1bzfA-1q0zA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.31A 1dx6A-4be9A:
42.2		 1dx6A-4be9A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 1zcn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		4 / 8 PHE A 151
THR A 152
ILE A 156
HIS A  59
 None
1PE  A 400 ( 4.6A)
None
1PE  A 400 ( 4.4A)
 0.83A 1ei6D-1zcnA:
undetectable		 1ei6D-1zcnA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3dao PUTATIVE PHOSPHATE
([Eubacterium]
rectale) 		5 / 12 CYH A 162
ASP A 103
TRP A 183
ILE A 121
PRO A 120
 None
None
1PE  A 265 ( 4.0A)
None
None
 1.44A 1g60B-3daoA:
4.2		 1g60B-3daoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 ILE A 582
LYS A 314
ALA A 317
VAL A 531
 None
1PE  A 602 (-2.8A)
None
None
 0.99A 1hk1A-3owaA:
1.0		 1hk1A-3owaA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.63A 1hvyA-4xscA:
40.7		 1hvyA-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
GLU A  75
ILE A  96
TRP A  97
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.75A 1hvyA-4xscA:
40.7		 1hvyA-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.57A 1hvyB-4xscA:
40.8		 1hvyB-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.68A 1hvyB-4xscA:
40.8		 1hvyB-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
GLU A  75
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.49A 1hvyC-4xscA:
40.7		 1hvyC-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
GLU A  75
ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.71A 1hvyC-4xscA:
40.7		 1hvyC-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.60A 1hvyC-4xscA:
40.7		 1hvyC-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.53A 1hvyD-4xscA:
40.7		 1hvyD-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.74A 1hvyD-4xscA:
40.7		 1hvyD-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
PHE A 213
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
1PE  A1002 (-3.8A)
 0.74A 1hvyD-4xscA:
40.7		 1hvyD-4xscA:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		4 / 4 GLY A 308
ASP A 329
GLY A 350
THR A 374
 1PE  A1262 ( 3.9A)
None
None
None
 1.05A 1hxbB-2fafA:
undetectable		 1hxbB-2fafA:
10.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 9 PHE A  68
GLU A  75
ILE A  96
TRP A  97
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.54A 1i00A-4xscA:
40.6		 1i00A-4xscA:
64.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 9 PHE A  68
TRP A  97
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.7A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.78A 1i00A-4xscA:
40.6		 1i00A-4xscA:
64.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.43A 1i00B-4xscA:
24.2		 1i00B-4xscA:
64.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.67A 1i00B-4xscA:
24.2		 1i00B-4xscA:
64.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		5 / 11 SER A 258
GLY A 253
TYR A 185
GLY A 256
HIS A 420
 None
None
None
1PE  A1262 (-3.3A)
None
 1.14A 1iolA-2fafA:
undetectable		 1iolA-2fafA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3ucx SHORT CHAIN
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ARG A 224
ALA A 218
SER A 220
TYR A 213
 None
None
None
1PE  A 262 ( 3.9A)
 1.11A 1j36A-3ucxA:
0.0		 1j36A-3ucxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3ucx SHORT CHAIN
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ARG A 224
ALA A 218
SER A 220
TYR A 213
 None
None
None
1PE  A 262 ( 3.9A)
 1.11A 1j36B-3ucxA:
0.5		 1j36B-3ucxA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A  24
VAL A  96
VAL A 131
TRP A  20
LEU A  67
 None
None
I3C  A1141 (-4.3A)
1PE  A1140 (-3.3A)
None
 1.43A 1jkhA-5forA:
undetectable
1jkhB-5forA:
undetectable		 1jkhA-5forA:
11.98
1jkhB-5forA:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.91A 1ju6A-4xscA:
40.0		 1ju6A-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.53A 1ju6A-4xscA:
40.0		 1ju6A-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ILE A  96
TRP A  97
GLY A 210
PHE A 213
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
 1.10A 1ju6A-4xscA:
40.0		 1ju6A-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 9 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.55A 1ju6B-4xscA:
40.0		 1ju6B-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.89A 1ju6C-4xscA:
40.0		 1ju6C-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.54A 1ju6C-4xscA:
40.0		 1ju6C-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.54A 1ju6D-4xscA:
40.0		 1ju6D-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ILE A  96
TRP A  97
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.89A 1ju6D-4xscA:
40.0		 1ju6D-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujA-4xscA:
39.0		 1jujA-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.49A 1jujA-4xscA:
39.0		 1jujA-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujB-4xscA:
39.0		 1jujB-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.50A 1jujB-4xscA:
39.0		 1jujB-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujC-4xscA:
39.0		 1jujC-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.49A 1jujC-4xscA:
39.0		 1jujC-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujD-4xscA:
39.0		 1jujD-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.49A 1jujD-4xscA:
39.0		 1jujD-4xscA:
65.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 1k2rA-3hzpA:
undetectable
1k2rB-3hzpA:
undetectable		 1k2rA-3hzpA:
14.05
1k2rB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.41A 1k2rA-3hzpA:
undetectable
1k2rB-3hzpA:
undetectable		 1k2rA-3hzpA:
14.05
1k2rB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.39A 1k2sA-3hzpA:
undetectable
1k2sB-3hzpA:
undetectable		 1k2sA-3hzpA:
14.05
1k2sB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 1k2tA-3hzpA:
undetectable
1k2tB-3hzpA:
undetectable		 1k2tA-3hzpA:
14.05
1k2tB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 1k2tA-3hzpA:
undetectable
1k2tB-3hzpA:
undetectable		 1k2tA-3hzpA:
14.05
1k2tB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 1k2uA-3hzpA:
undetectable
1k2uB-3hzpA:
undetectable		 1k2uA-3hzpA:
14.05
1k2uB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4aj9 CATALASE-3
(Neurospora
crassa) 		5 / 12 GLU A 317
ARG A 252
ILE A 315
TYR A 323
ALA A 322
 1PE  A1719 (-3.6A)
1PE  A1719 ( 4.6A)
None
None
None
 1.00A 1kijB-4aj9A:
undetectable		 1kijB-4aj9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 675
TYR A 804
LEU A 644
 1PE  A1863 ( 4.3A)
1PE  A1858 (-3.5A)
None
 1.10A 1kxhA-2xzlA:
undetectable		 1kxhA-2xzlA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 1lzxA-3hzpA:
undetectable
1lzxB-3hzpA:
undetectable		 1lzxA-3hzpA:
14.05
1lzxB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 1lzxA-3hzpA:
undetectable
1lzxB-3hzpA:
undetectable		 1lzxA-3hzpA:
14.05
1lzxB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.35A 1lzzA-3hzpA:
undetectable
1lzzB-3hzpA:
undetectable		 1lzzA-3hzpA:
14.05
1lzzB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 1lzzA-3hzpA:
undetectable
1lzzB-3hzpA:
undetectable		 1lzzA-3hzpA:
14.05
1lzzB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 1m00A-3hzpA:
undetectable
1m00B-3hzpA:
undetectable		 1m00A-3hzpA:
14.05
1m00B-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.47A 1m00A-3hzpA:
undetectable
1m00B-3hzpA:
undetectable		 1m00A-3hzpA:
14.05
1m00B-3hzpA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
TYR A 144
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.42A 1maaC-4be9A:
40.4		 1maaC-4be9A:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 8 GLY A 134
GLU A 219
SER A 220
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
 0.39A 1maaD-4be9A:
37.0		 1maaD-4be9A:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 8 GLY A 135
GLU A 219
SER A 220
HIS A 465
 1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
 0.75A 1maaD-4be9A:
37.0		 1maaD-4be9A:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		3 / 3 PHE A 217
TYR A 227
PRO A 225
 None
1PE  A 503 (-4.1A)
None
 1.06A 1mcnA-4pv4A:
undetectable
1mcnB-4pv4A:
undetectable
1mcnP-4pv4A:
undetectable		 1mcnA-4pv4A:
18.96
1mcnB-4pv4A:
18.96
1mcnP-4pv4A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 SER A 122
ILE A 179
GLU A 117
GLY A 101
 1PE  A 401 (-3.2A)
None
None
None
 0.97A 1meiA-4q6uA:
undetectable		 1meiA-4q6uA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 1mmvA-3hzpA:
undetectable
1mmvB-3hzpA:
undetectable		 1mmvA-3hzpA:
14.05
1mmvB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 1mmwA-3hzpA:
undetectable
1mmwB-3hzpA:
undetectable		 1mmwA-3hzpA:
14.05
1mmwB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 1mmwA-3hzpA:
undetectable
1mmwB-3hzpA:
undetectable		 1mmwA-3hzpA:
14.05
1mmwB-3hzpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.88A 1muiB-4ktpA:
undetectable		 1muiB-4ktpA:
9.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 11 GLY A 135
SER A 220
VAL A 256
LEU A 315
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 ( 4.4A)
1PE  A1553 (-4.3A)
None
 0.94A 1mx1A-4be9A:
41.2		 1mx1A-4be9A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 6eub ANGIOPOIETIN-RELATED
PROTEIN 4
(Homo
sapiens) 		5 / 12 VAL A 275
LEU A 287
LEU A 390
LEU A 277
HIS A 356
 None
None
None
None
1PE  A 501 ( 4.3A)
 1.00A 1mx1C-6eubA:
undetectable		 1mx1C-6eubA:
7.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
PHE A 427
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.7A)
None
 0.51A 1mx1D-4be9A:
41.3		 1mx1D-4be9A:
31.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 134
GLY A 135
SER A 220
LEU A 315
PHE A 427
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.3A)
1PE  A1553 (-4.7A)
None
 0.67A 1mx1F-4be9A:
40.8		 1mx1F-4be9A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 6eub ANGIOPOIETIN-RELATED
PROTEIN 4
(Homo
sapiens) 		5 / 12 VAL A 275
LEU A 287
LEU A 390
LEU A 277
HIS A 356
 None
None
None
None
1PE  A 501 ( 4.3A)
 0.95A 1mx1F-6eubA:
undetectable		 1mx1F-6eubA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4e13 DIKETOREDUCTASE
(Acinetobacter
baylyi) 		5 / 12 PHE A 258
TYR A 261
LEU A 262
ALA A 244
TYR A 281
 None
None
None
1PE  A 306 ( 4.6A)
GOL  A 304 (-4.0A)
 1.31A 1mx8A-4e13A:
undetectable		 1mx8A-4e13A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 427
LEU A 620
LEU A 627
GLY A 628
 1PE  A1864 (-4.2A)
None
None
None
 0.84A 1n13D-2xzlA:
undetectable
1n13E-2xzlA:
undetectable		 1n13D-2xzlA:
9.58
1n13E-2xzlA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
ALA A 420
GLY A 260
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.24A 1nbiC-4pv4A:
undetectable		 1nbiC-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
GLY A 260
SER A 189
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.29A 1nbiC-4pv4A:
undetectable		 1nbiC-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
ALA A 420
GLY A 260
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.25A 1nbiD-4pv4A:
undetectable		 1nbiD-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4pv4 PROLINE
AMINOPEPTIDASE P II
(Yersinia
pestis) 		5 / 12 THR A 380
GLY A 260
SER A 189
HIS A 193
TYR A 227
 MG  A 502 (-3.5A)
None
None
None
1PE  A 503 (-4.1A)
 1.27A 1nbiD-4pv4A:
undetectable		 1nbiD-4pv4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ILE A 147
GLY A 148
GLY A 150
VAL A 172
PRO A 203
 None
NAD  A 400 ( 3.9A)
NAD  A 400 ( 3.3A)
1PE  A 404 (-4.0A)
NAD  A 400 (-3.7A)
 0.99A 1nv8A-3kb6A:
6.5		 1nv8A-3kb6A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ILE A 147
GLY A 148
GLY A 150
VAL A 172
PRO A 203
 None
NAD  A 400 ( 3.9A)
NAD  A 400 ( 3.3A)
1PE  A 404 (-4.0A)
NAD  A 400 (-3.7A)
 0.96A 1nv8B-3kb6A:
6.2		 1nv8B-3kb6A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 1om4A-3hzpA:
undetectable
1om4B-3hzpA:
undetectable		 1om4A-3hzpA:
14.18
1om4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 1om4A-3hzpA:
undetectable
1om4B-3hzpA:
undetectable		 1om4A-3hzpA:
14.18
1om4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 1p6hA-3hzpA:
undetectable
1p6hB-3hzpA:
undetectable		 1p6hA-3hzpA:
13.98
1p6hB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 1p6iA-3hzpA:
undetectable
1p6iB-3hzpA:
undetectable		 1p6iA-3hzpA:
13.98
1p6iB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6I_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.33A 1p6iA-3hzpA:
undetectable
1p6iB-3hzpA:
undetectable		 1p6iA-3hzpA:
13.98
1p6iB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.35A 1p6jA-3hzpA:
undetectable
1p6jB-3hzpA:
undetectable		 1p6jA-3hzpA:
13.98
1p6jB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.33A 1p6jA-3hzpA:
undetectable
1p6jB-3hzpA:
undetectable		 1p6jA-3hzpA:
13.98
1p6jB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 132
GLN A 139
PHE A 130
TRP A  84
 1PE  A 402 (-3.7A)
None
1PE  A 402 (-3.5A)
None
 1.34A 1p6kA-5w95A:
undetectable		 1p6kA-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 290
GLY A 177
GLY A  82
ILE A 270
THR A 244
 1PE  A 401 (-4.4A)
None
None
1PE  A 401 (-4.3A)
None
 1.06A 1p91B-5w95A:
undetectable		 1p91B-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ5_A_ACTA2145_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		4 / 5 ARG A 255
TYR A 256
TYR A 284
TYR A 285
 None
1PE  A 502 ( 4.7A)
None
None
 0.90A 1pj5A-5ofqA:
0.0		 1pj5A-5ofqA:
18.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.43A 1qtiA-4be9A:
43.6		 1qtiA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.81A 1qtiA-4be9A:
43.6		 1qtiA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.78A 1qtiA-4be9A:
43.6		 1qtiA-4be9A:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5n6v AMYLOSUCRASE
(Neisseria
polysaccharea) 		3 / 3 GLU A 271
TRP A 194
LYS A 113
 None
1PE  A 709 ( 4.4A)
None
 1.33A 1qu2A-5n6vA:
undetectable		 1qu2A-5n6vA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 265
THR A 403
GLY A 374
LEU A 322
LEU A 324
 None
None
None
1PE  A 501 (-4.7A)
None
 0.99A 1rjdB-4dn7A:
undetectable		 1rjdB-4dn7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 265
THR A 403
GLY A 374
LEU A 322
LEU A 324
 None
None
None
1PE  A 501 (-4.7A)
None
 1.00A 1rjdC-4dn7A:
undetectable		 1rjdC-4dn7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 132
GLN A 139
PHE A 130
TRP A  84
 1PE  A 402 (-3.7A)
None
1PE  A 402 (-3.5A)
None
 1.32A 1rs6A-5w95A:
undetectable		 1rs6A-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 8 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 1rs6A-3hzpA:
undetectable
1rs6B-3hzpA:
undetectable		 1rs6A-3hzpA:
13.98
1rs6B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.42A 1rs7A-3hzpA:
undetectable
1rs7B-3hzpA:
undetectable		 1rs7A-3hzpA:
13.98
1rs7B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 1rs7A-3hzpA:
undetectable
1rs7B-3hzpA:
undetectable		 1rs7A-3hzpA:
13.98
1rs7B-3hzpA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 8 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.48A 1rtsA-4xscA:
40.9		 1rtsA-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.51A 1rtsB-4xscA:
40.7		 1rtsB-4xscA:
65.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.77A 1sduB-4ktpA:
undetectable		 1sduB-4ktpA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.93A 1sguB-4ktpA:
undetectable		 1sguB-4ktpA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 1.02A 1t85A-3bx8A:
undetectable		 1t85A-3bx8A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.99A 1t87A-3bx8A:
undetectable		 1t87A-3bx8A:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.12A 1tlsA-4xscA:
36.3		 1tlsA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.81A 1tlsA-4xscA:
36.3		 1tlsA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.08A 1tlsB-4xscA:
36.5		 1tlsB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.72A 1tlsB-4xscA:
36.5		 1tlsB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
 1.05A 1tlsB-4xscA:
36.5		 1tlsB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.07A 1tsnA-4xscA:
36.4		 1tsnA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 1tsnA-4xscA:
36.4		 1tsnA-4xscA:
40.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4e13 DIKETOREDUCTASE
(Acinetobacter
baylyi) 		4 / 4 SER A 248
ILE A 247
VAL A 239
THR A 276
 1PE  A 306 (-3.1A)
1PE  A 306 ( 3.9A)
1PE  A 306 (-4.6A)
None
 1.19A 1u70A-4e13A:
undetectable		 1u70A-4e13A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5oqp CONDENSIN COMPLEX
SUBUNIT 3
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  53
ILE A  13
VAL A  17
ALA A  18
PHE A  21
 1PE  A1001 ( 3.8A)
None
None
None
None
 0.88A 1uduB-5oqpA:
undetectable		 1uduB-5oqpA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 1v54A-4q6uA:
undetectable
1v54C-4q6uA:
undetectable		 1v54A-4q6uA:
21.76
1v54C-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 1v54N-4q6uA:
undetectable
1v54P-4q6uA:
undetectable		 1v54N-4q6uA:
21.76
1v54P-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.50A 1v55A-4q6uA:
undetectable
1v55C-4q6uA:
undetectable		 1v55A-4q6uA:
21.76
1v55C-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4rus FISH-EGG LECTIN
(Cyprinus
carpio) 		3 / 3 GLN A 118
ILE A  98
TYR A  99
 None
None
1PE  A 305 ( 4.0A)
 0.73A 1vifA-4rusA:
undetectable		 1vifA-4rusA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2y6i COLLAGENASE
(Hathewaya
histolytica) 		3 / 3 ASP A 340
TYR A 344
GLU A 381
 1PE  A1799 (-3.8A)
1PE  A1799 ( 4.1A)
None
 0.77A 1vm1A-2y6iA:
undetectable		 1vm1A-2y6iA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 ILE A 147
GLY A 148
GLY A 150
SER A 154
VAL A 172
PRO A 203
 None
NAD  A 400 ( 3.9A)
NAD  A 400 ( 3.3A)
None
1PE  A 404 (-4.0A)
NAD  A 400 (-3.7A)
 1.42A 1vq1B-3kb6A:
6.4		 1vq1B-3kb6A:
24.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.35A 1w6rA-4be9A:
42.2		 1w6rA-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.86A 1w6rA-4be9A:
42.2		 1w6rA-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 11 GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.36A 1w76A-4be9A:
43.7		 1w76A-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 10 GLY A 133
GLY A 134
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.33A 1w76B-4be9A:
43.7		 1w76B-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 10 GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.04A 1w76B-4be9A:
43.7		 1w76B-4be9A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 10 GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.80A 1w76B-4be9A:
43.7		 1w76B-4be9A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5cbm M17 FAMILY
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 5 ALA A 410
TYR A 411
ALA A 318
GLN A 296
 None
1PE  A 705 (-4.5A)
None
None
 1.10A 1xl6A-5cbmA:
undetectable
1xl6B-5cbmA:
undetectable		 1xl6A-5cbmA:
18.72
1xl6B-5cbmA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.03A 1ya4A-4be9A:
41.2		 1ya4A-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
SER A 311
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.00A 1ya4A-4be9A:
41.2		 1ya4A-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
LEU A 355
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
PEG  A1555 (-4.6A)
None
 0.66A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
SER A 309
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 1.01A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 135
SER A 220
SER A 311
LEU A 355
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
PEG  A1555 (-4.6A)
None
 0.81A 1ya4B-4be9A:
37.0		 1ya4B-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 133
LEU A 138
LEU A 355
LEU A 315
HIS A 465
 None
None
PEG  A1555 (-4.6A)
1PE  A1553 (-4.3A)
None
 1.02A 1ya4C-4be9A:
41.1		 1ya4C-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 134
GLY A 135
SER A 220
LEU A 355
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
PEG  A1555 (-4.6A)
None
 0.66A 1ya4C-4be9A:
41.1		 1ya4C-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 GLY A 135
SER A 220
SER A 311
LEU A 355
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
PEG  A1555 (-4.6A)
None
 0.93A 1ya4C-4be9A:
41.1		 1ya4C-4be9A:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 6 GLY A 133
SER A 220
LEU A 138
HIS A 465
 None
1PE  A1553 (-2.9A)
None
None
 0.85A 1yajF-4be9A:
40.3		 1yajF-4be9A:
32.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5ce5 TRIACYLGLYCEROL
LIPASE
(Geobacillus
thermocatenulatu
s) 		4 / 4 GLY A  16
SER A 114
ILE A 320
HIS A 359
 P15  A 403 ( 4.2A)
P15  A 403 (-2.3A)
1PE  A 404 (-4.6A)
P15  A 403 (-4.2A)
 1.17A 1yajJ-5ce5A:
7.9		 1yajJ-5ce5A:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ILE A  32
ASN A 101
ILE A 102
ASP A 103
 1PE  A 504 ( 4.7A)
None
None
None
 0.27A 1yc2E-1s7gA:
32.9		 1yc2E-1s7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		6 / 7 ALA A  24
SER A  27
ILE A  32
ASN A 101
ILE A 102
ASP A 103
 NAD  A 703 (-3.8A)
None
1PE  A 504 ( 4.7A)
None
None
None
 0.29A 1yc5A-1s7gA:
27.6		 1yc5A-1s7gA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.95A 1yrcA-3bx8A:
undetectable		 1yrcA-3bx8A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.96A 1yrdA-3bx8A:
undetectable		 1yrdA-3bx8A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 1zzqA-3hzpA:
undetectable
1zzqB-3hzpA:
undetectable		 1zzqA-3hzpA:
14.96
1zzqB-3hzpA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 132
GLN A 139
PHE A 130
TRP A  84
 1PE  A 402 (-3.7A)
None
1PE  A 402 (-3.5A)
None
 1.35A 1zzqA-5w95A:
undetectable		 1zzqA-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.50A 1zzqA-3hzpA:
undetectable
1zzqB-3hzpA:
undetectable		 1zzqA-3hzpA:
14.96
1zzqB-3hzpA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		4 / 8 THR A 434
VAL A 596
GLY A 597
ILE A 632
 ADP  A1854 (-4.3A)
None
None
1PE  A1866 ( 4.0A)
 0.73A 2a1mB-2xzlA:
undetectable		 2a1mB-2xzlA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4kvl FATTY ACID
ALPHA-OXIDASE
(Oryza
sativa) 		4 / 4 ILE A 500
ASP A 528
LEU A 533
ARG A 493
 1PE  A 707 (-4.8A)
None
None
None
 1.29A 2a7qA-4kvlA:
undetectable		 2a7qA-4kvlA:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 9 GLY A 133
GLY A 134
SER A 220
ALA A 221
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-2.9A)
1PE  A1553 (-3.5A)
None
 0.87A 2aceA-4be9A:
42.4		 2aceA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 9 GLY A 134
GLY A 135
SER A 220
ALA A 221
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-3.5A)
None
None
 0.92A 2aceA-4be9A:
42.4		 2aceA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 7 GLY A 134
GLU A 219
SER A 220
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
None
1PE  A1553 (-2.9A)
None
None
 0.72A 2ackA-4be9A:
42.7		 2ackA-4be9A:
32.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 7 GLY A 135
SER A 220
PHE A 356
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.84A 2ackA-4be9A:
42.7		 2ackA-4be9A:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 301
GLN A 269
TYR A 187
TRP A 153
 UNL  A 401 ( 4.2A)
UNL  A 401 ( 3.7A)
None
1PE  A 406 (-3.1A)
 1.22A 2aowA-4h41A:
2.1		 2aowA-4h41A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 301
GLN A 269
TYR A 187
TRP A 153
 UNL  A 401 ( 4.2A)
UNL  A 401 ( 3.7A)
None
1PE  A 406 (-3.1A)
 1.16A 2aoxA-4h41A:
undetectable		 2aoxA-4h41A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 301
GLN A 269
TYR A 187
TRP A 153
 UNL  A 401 ( 4.2A)
UNL  A 401 ( 3.7A)
None
1PE  A 406 (-3.1A)
 1.15A 2aoxB-4h41A:
0.0		 2aoxB-4h41A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2avvA-4ktpA:
undetectable		 2avvA-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 491
GLY A 556
ARG A 554
THR A 478
TYR A 331
 1PE  A 962 ( 4.5A)
None
None
None
1PE  A 962 (-4.7A)
 0.86A 2axnA-3m62A:
undetectable		 2axnA-3m62A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.83A 2b7zA-4ktpA:
undetectable		 2b7zA-4ktpA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4l8p BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hiranonis) 		5 / 12 LEU A  26
ILE A 139
LEU A  42
LEU A  34
PHE A  31
 None
1PE  A 204 ( 4.6A)
None
None
None
 1.03A 2bdmA-4l8pA:
undetectable		 2bdmA-4l8pA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		5 / 12 GLY A  86
ASP A  10
SER A  11
ASP A  89
ALA A  88
 None
None
1PE  A 301 ( 4.3A)
None
1PE  A 301 (-4.2A)
 1.10A 2br4C-4hyqA:
2.1		 2br4C-4hyqA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		3 / 3 ALA A 164
THR A 101
PHE A 158
 1PE  A1346 ( 4.7A)
1PE  A1346 ( 4.7A)
None
 0.76A 2c6nB-5aovA:
undetectable		 2c6nB-5aovA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 11 THR A 246
MET A 245
THR A 231
ALA A 228
VAL A 179
 None
1PE  A 401 ( 4.3A)
None
1PE  A 401 ( 4.0A)
None
 1.39A 2cojA-5w95A:
undetectable
2cojB-5w95A:
undetectable		 2cojA-5w95A:
12.23
2cojB-5w95A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		4 / 6 ALA A 170
TYR A 150
TYR A 112
ILE A 172
 None
None
1PE  A   5 (-3.6A)
None
 1.16A 2dcfA-3lewA:
undetectable		 2dcfA-3lewA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 2dyrA-4q6uA:
undetectable
2dyrC-4q6uA:
undetectable		 2dyrA-4q6uA:
21.76
2dyrC-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 2dyrN-4q6uA:
undetectable
2dyrP-4q6uA:
undetectable		 2dyrN-4q6uA:
21.76
2dyrP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 2eijN-4q6uA:
undetectable
2eijP-4q6uA:
undetectable		 2eijN-4q6uA:
21.76
2eijP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 2eikN-4q6uA:
undetectable
2eikP-4q6uA:
undetectable		 2eikN-4q6uA:
21.76
2eikP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.47A 2eilN-4q6uA:
undetectable
2eilP-4q6uA:
undetectable		 2eilN-4q6uA:
21.76
2eilP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.32A 2eimJ-5aovA:
undetectable		 2eimJ-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.46A 2eimN-4q6uA:
undetectable
2eimP-4q6uA:
undetectable		 2eimN-4q6uA:
21.76
2eimP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.32A 2eimW-5aovA:
undetectable		 2eimW-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 2einA-4q6uA:
undetectable
2einC-4q6uA:
undetectable		 2einA-4q6uA:
21.76
2einC-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 6 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.98A 2feuA-3bx8A:
undetectable		 2feuA-3bx8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.97A 2feuB-3bx8A:
undetectable		 2feuB-3bx8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 8 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.50A 2g6hA-3hzpA:
undetectable
2g6hB-3hzpA:
undetectable		 2g6hA-3hzpA:
14.25
2g6hB-3hzpA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 2g6kA-3hzpA:
undetectable
2g6kB-3hzpA:
undetectable		 2g6kA-3hzpA:
14.25
2g6kB-3hzpA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.50A 2g6mA-3hzpA:
undetectable
2g6mB-3hzpA:
undetectable		 2g6mA-3hzpA:
14.25
2g6mB-3hzpA:
14.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 5 ALA A  24
ILE A  32
ASN A 101
ILE A 102
ASP A 103
 NAD  A 703 (-3.8A)
1PE  A 504 ( 4.7A)
None
None
None
 0.34A 2h4jA-1s7gA:
27.1		 2h4jA-1s7gA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 8 GLY A 134
GLY A 135
ALA A 221
PHE A 356
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-3.5A)
None
None
 1.02A 2ha4A-4be9A:
40.3		 2ha4A-4be9A:
30.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 7 GLY A 134
GLY A 135
ALA A 221
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-3.5A)
None
 0.25A 2ha4B-4be9A:
41.5		 2ha4B-4be9A:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.79A 2hs1A-4ktpA:
undetectable		 2hs1A-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.90A 2hs1B-4ktpA:
undetectable		 2hs1B-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 2hx4A-3hzpA:
undetectable
2hx4B-3hzpA:
undetectable		 2hx4A-3hzpA:
14.18
2hx4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 421
ASP A 472
ASP A 416
 1PE  A 604 (-3.2A)
None
None
 0.72A 2igtA-4z7eA:
undetectable		 2igtA-4z7eA:
26.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.94A 2kceA-4xscA:
36.5		 2kceA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.30A 2kceA-4xscA:
36.5		 2kceA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 LEU A 180
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.81A 2kceB-4xscA:
36.5		 2kceB-4xscA:
40.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.82A 2pymB-4ktpA:
undetectable		 2pymB-4ktpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2pynB-4ktpA:
undetectable		 2pynB-4ktpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2q63B-4ktpA:
undetectable		 2q63B-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4l8p BILE ACID
7A-DEHYDRATASE, BAIE
([Clostridium]
hiranonis) 		3 / 3 ASN A 107
LEU A 108
HIS A  83
 None
None
1PE  A 204 ( 4.6A)
 0.84A 2q6fB-4l8pA:
undetectable		 2q6fB-4l8pA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE
([Candida]
glabrata) 		5 / 12 LEU A 309
LEU A 313
MET A 218
LEU A 269
THR A 265
 None
None
None
1PE  A 604 ( 4.3A)
1PE  A 604 (-3.5A)
 1.25A 2q7kA-5jlcA:
2.6		 2q7kA-5jlcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.81A 2qakB-4ktpA:
undetectable		 2qakB-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 8 PHE A  27
THR A  54
THR A 136
VAL A 108
 None
1PE  A 179 ( 4.7A)
None
None
 0.97A 2qbmA-3bx8A:
undetectable		 2qbmA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		5 / 8 PHE A  83
TYR A  56
THR A  54
VAL A 121
THR A 136
 None
None
1PE  A 179 ( 4.7A)
None
None
 1.05A 2qbmA-3bx8A:
undetectable		 2qbmA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		4 / 6 ARG A 142
GLU A 141
GLN A  88
PRO A  83
 GOL  A 302 ( 4.3A)
None
1PE  A 303 (-3.9A)
None
 1.48A 2qqtA-5u56A:
undetectable		 2qqtA-5u56A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.77A 2r5pD-4ktpA:
undetectable		 2r5pD-4ktpA:
10.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		6 / 8 ARG A 105
LYS A 262
LYS A 263
HIS A 283
ASP A 330
ARG A 424
 1PE  A1262 (-3.7A)
1PE  A1262 (-4.3A)
MN  A1701 ( 1.9A)
MN  A1701 (-3.2A)
MN  A1701 (-2.3A)
1PE  A1262 (-3.0A)
 0.67A 2rk8A-2fafA:
53.8		 2rk8A-2fafA:
63.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		6 / 7 ARG A 105
LYS A 262
LYS A 263
HIS A 283
ASP A 330
ARG A 424
 1PE  A1262 (-3.7A)
1PE  A1262 (-4.3A)
MN  A1701 ( 1.9A)
MN  A1701 (-3.2A)
MN  A1701 (-2.3A)
1PE  A1262 (-3.0A)
 0.63A 2rk8B-2fafA:
55.1		 2rk8B-2fafA:
63.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.28A 2tsrA-4xscA:
40.8		 2tsrA-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
GLU A  75
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.39A 2tsrC-4xscA:
40.5		 2tsrC-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.60A 2tsrC-4xscA:
40.5		 2tsrC-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 10 PHE A  68
GLU A  75
ILE A  96
TRP A  97
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.77A 2tsrC-4xscA:
40.5		 2tsrC-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.56A 2tsrD-4xscA:
24.4		 2tsrD-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 9 PHE A  68
ILE A  96
TRP A  97
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.85A 2tsrD-4xscA:
24.4		 2tsrD-4xscA:
65.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.87A 2wa2B-5xg9B:
undetectable		 2wa2B-5xg9B:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 6eub ANGIOPOIETIN-RELATED
PROTEIN 4
(Homo
sapiens) 		3 / 3 SER A 357
HIS A 333
ASP A 330
 1PE  A 501 ( 4.0A)
None
None
 0.60A 2wa2B-6eubA:
undetectable		 2wa2B-6eubA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 GLY A 327
GLY A 351
GLN A 352
THR A 353
 1PE  A 994 (-3.6A)
1PE  A 994 (-4.4A)
None
GOL  A1005 ( 2.7A)
 0.57A 2wd9B-3etcA:
49.6		 2wd9B-3etcA:
37.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2xzl ATP-DEPENDENT
HELICASE NAM7
(Saccharomyces
cerevisiae) 		5 / 10 THR A 439
ILE A 632
LEU A 427
GLY A 597
GLY A 430
 None
1PE  A1866 ( 4.0A)
1PE  A1864 (-4.2A)
None
None
 1.10A 2wd9C-2xzlA:
undetectable		 2wd9C-2xzlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 142
GLY A 227
ALA A 228
LEU A 232
 1PE  A 401 (-4.6A)
None
1PE  A 401 ( 4.0A)
1PE  A 401 ( 4.9A)
 0.88A 2wekB-5w95A:
3.4		 2wekB-5w95A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 VAL A 310
SER A 419
THR A 616
VAL A 648
ALA A 426
 None
U  D   5 ( 3.5A)
U  D   6 ( 2.8A)
1PE  A1003 ( 4.0A)
1PE  A1003 (-3.6A)
 1.25A 2x2iA-2xzoA:
undetectable		 2x2iA-2xzoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens) 		5 / 12 VAL A 310
SER A 419
THR A 616
VAL A 648
ALA A 426
 None
U  D   5 ( 3.5A)
U  D   6 ( 2.8A)
1PE  A1003 ( 4.0A)
1PE  A1003 (-3.6A)
 1.27A 2x2iC-2xzoA:
undetectable		 2x2iC-2xzoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4aj9 CATALASE-3
(Neurospora
crassa) 		3 / 3 ARG A 554
GLU A 337
SER A 232
 None
1PE  A1721 ( 4.1A)
None
 0.90A 2xctD-4aj9A:
undetectable		 2xctD-4aj9A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.47A 2y69A-4q6uA:
undetectable
2y69C-4q6uA:
undetectable		 2y69A-4q6uA:
21.76
2y69C-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		3 / 3 TYR A 112
GLU A 497
ASN A 503
 1PE  A   5 (-3.6A)
1PE  A   5 (-2.6A)
None
 0.80A 2y7hC-3lewA:
undetectable		 2y7hC-3lewA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		5 / 12 LEU A  58
ILE A  63
MET A  20
PHE A  47
PHE A  34
 None
None
1PE  A 131 ( 3.8A)
None
1PE  A 131 (-4.5A)
 1.04A 2ygpA-3hzpA:
undetectable		 2ygpA-3hzpA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		4 / 7 ALA A 170
TYR A 150
TYR A 112
ILE A 172
 None
None
1PE  A   5 (-3.6A)
None
 1.16A 2zm7A-3lewA:
undetectable		 2zm7A-3lewA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 6 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 1.02A 2zuhA-3bx8A:
undetectable		 2zuhA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 6 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 1.00A 2zuiA-3bx8A:
undetectable		 2zuiA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.96A 2zwtA-3bx8A:
undetectable		 2zwtA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.96A 2zwuA-3bx8A:
undetectable		 2zwuA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 2zxwA-4q6uA:
undetectable
2zxwC-4q6uA:
undetectable		 2zxwA-4q6uA:
21.76
2zxwC-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 2zxwN-4q6uA:
undetectable
2zxwP-4q6uA:
undetectable		 2zxwN-4q6uA:
21.76
2zxwP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 TYR A 331
PHE A 215
GLY A 333
ASN A 297
PHE A 342
 None
MCN  A 801 (-3.5A)
None
1PE  A 803 (-4.5A)
None
 1.40A 2zznB-4zohA:
undetectable		 2zznB-4zohA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC
(Bordetella
pertussis) 		5 / 12 SER A 157
ASP A 171
GLN A 174
ALA A 175
ILE A 179
 None
1PE  A 607 (-3.4A)
P6G  A 609 (-3.7A)
None
None
 1.19A 3a35B-4ql0A:
undetectable		 3a35B-4ql0A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 3abkA-4q6uA:
undetectable
3abkC-4q6uA:
undetectable		 3abkA-4q6uA:
21.76
3abkC-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 3abmN-4q6uA:
undetectable
3abmP-4q6uA:
undetectable		 3abmN-4q6uA:
21.76
3abmP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4rzl RESTRICTION
ENDONUCLEASE LPNPI
(Legionella
pneumophila) 		5 / 12 LEU A 107
LEU A  60
PHE A 125
LEU A 203
TYR A 207
 None
None
None
None
1PE  A 301 (-3.6A)
 1.50A 3adsA-4rzlA:
undetectable		 3adsA-4rzlA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.37A 3ag1J-5aovA:
undetectable		 3ag1J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 210
MET A 245
THR A 244
LEU A 243
 None
1PE  A 401 ( 4.3A)
None
None
 1.43A 3ag1J-5w95A:
undetectable		 3ag1J-5w95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.33A 3ag2J-5aovA:
undetectable		 3ag2J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.50A 3ag2N-4q6uA:
undetectable
3ag2P-4q6uA:
undetectable		 3ag2N-4q6uA:
21.76
3ag2P-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 3ag3N-4q6uA:
undetectable
3ag3P-4q6uA:
undetectable		 3ag3N-4q6uA:
21.76
3ag3P-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.34A 3ag4J-5aovA:
undetectable		 3ag4J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1y11 HYPOTHETICAL PROTEIN
RV1264/MT1302
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 171
THR A  56
LEU A  53
TRP A  34
 1PE  A 409 ( 4.7A)
1PE  A 409 ( 4.7A)
1PE  A 409 ( 4.1A)
None
 1.22A 3arrA-1y11A:
undetectable		 3arrA-1y11A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 3asnA-4q6uA:
undetectable
3asnC-4q6uA:
undetectable		 3asnA-4q6uA:
21.76
3asnC-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.50A 3b3mA-3hzpA:
undetectable
3b3mB-3hzpA:
undetectable		 3b3mA-3hzpA:
14.18
3b3mB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 3b3mA-3hzpA:
undetectable
3b3mB-3hzpA:
undetectable		 3b3mA-3hzpA:
14.18
3b3mB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3b3nA-3hzpA:
undetectable
3b3nB-3hzpA:
undetectable		 3b3nA-3hzpA:
14.18
3b3nB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 3b3nA-3hzpA:
undetectable
3b3nB-3hzpA:
undetectable		 3b3nA-3hzpA:
14.18
3b3nB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 3b3oA-3hzpA:
undetectable
3b3oB-3hzpA:
undetectable		 3b3oA-3hzpA:
14.18
3b3oB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.32A 3b3oA-3hzpA:
undetectable
3b3oB-3hzpA:
undetectable		 3b3oA-3hzpA:
14.18
3b3oB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3b3pA-3hzpA:
undetectable
3b3pB-3hzpA:
undetectable		 3b3pA-3hzpA:
14.18
3b3pB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 8 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 3b3pA-3hzpA:
undetectable
3b3pB-3hzpA:
undetectable		 3b3pA-3hzpA:
14.18
3b3pB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3dao PUTATIVE PHOSPHATE
([Eubacterium]
rectale) 		4 / 6 THR A 151
VAL A 152
GLU A 159
CYH A 162
 1PE  A 265 ( 4.1A)
None
None
None
 0.98A 3b6rB-3daoA:
undetectable		 3b6rB-3daoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		4 / 8 LEU A 103
ILE A 162
HIS A 160
TYR A 195
 None
None
None
1PE  A 500 (-4.7A)
 0.95A 3b9lA-4dn7A:
2.9		 3b9lA-4dn7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 5 VAL A 204
GLN A 195
PHE A 188
ARG A  78
 None
1PE  A 402 (-4.0A)
None
None
 1.43A 3bjwE-4p7yA:
undetectable		 3bjwE-4p7yA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.87A 3d1zA-4ktpA:
undetectable		 3d1zA-4ktpA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3e2s PROLINE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 PRO A 477
ILE A 480
PRO A 482
TYR A 481
 1PE  A2003 ( 4.9A)
None
None
None
 1.23A 3d9lA-3e2sA:
0.7
3d9lY-3e2sA:
undetectable		 3d9lA-3e2sA:
14.00
3d9lY-3e2sA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.36A 3dqtA-2g8yA:
undetectable
3dqtB-2g8yA:
1.2		 3dqtA-2g8yA:
23.36
3dqtB-2g8yA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5dqn CYTOCHROME P450
CYP125
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A 251
THR A 255
CYH A 360
 1PE  A 505 ( 3.4A)
HEM  A 501 (-3.8A)
HEM  A 501 (-2.3A)
 0.50A 3e4eA-5dqnA:
28.5		 3e4eA-5dqnA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5dqn CYTOCHROME P450
CYP125
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A 251
THR A 255
CYH A 360
 1PE  A 505 ( 3.4A)
HEM  A 501 (-3.8A)
HEM  A 501 (-2.3A)
 0.46A 3e4eB-5dqnA:
28.4		 3e4eB-5dqnA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 8 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 3e7gC-3hzpA:
undetectable
3e7gD-3hzpA:
undetectable		 3e7gC-3hzpA:
17.05
3e7gD-3hzpA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN
(Azotobacter
vinelandii) 		3 / 3 VAL B 434
LYS B 438
HIS B 457
 None
1PE  B5017 (-4.9A)
None
 0.95A 3elzA-2afhB:
undetectable		 3elzA-2afhB:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 3f7q INTEGRIN BETA-4
(Homo
sapiens) 		3 / 3 GLU A1254
VAL A1273
CYH A1256
 1PE  A 703 (-3.1A)
None
None
 0.99A 3fbxA-3f7qA:
undetectable		 3fbxA-3f7qA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.42A 3fc5A-3hzpA:
undetectable
3fc5B-3hzpA:
undetectable		 3fc5A-3hzpA:
14.18
3fc5B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 3fc5A-3hzpA:
undetectable
3fc5B-3hzpA:
undetectable		 3fc5A-3hzpA:
14.18
3fc5B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		5 / 10 GLY A 101
GLY A 102
THR A 103
ASN A  59
ILE A  97
 None
None
None
1PE  A  12 (-3.9A)
None
 1.21A 3fw1A-3lewA:
undetectable		 3fw1A-3lewA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 1.00A 3fwfA-3bx8A:
undetectable		 3fwfA-3bx8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 1.00A 3fwfB-3bx8A:
undetectable		 3fwfB-3bx8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.96A 3fwiA-3bx8A:
undetectable		 3fwiA-3bx8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.98A 3fwjA-3bx8A:
undetectable		 3fwjA-3bx8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5u56 MACROPHAGE GROWTH
LOCUS A
(Francisella
tularensis) 		4 / 6 ARG A 142
GLU A 141
GLN A  88
PRO A  83
 GOL  A 302 ( 4.3A)
None
1PE  A 303 (-3.9A)
None
 1.45A 3gclA-5u56A:
undetectable		 3gclA-5u56A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4e13 DIKETOREDUCTASE
(Acinetobacter
baylyi) 		4 / 7 PHE A 258
PHE A 236
SER A 248
TYR A 245
 None
None
1PE  A 306 (-3.1A)
None
 1.50A 3hggA-4e13A:
1.7		 3hggA-4e13A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3hsnA-3hzpA:
undetectable
3hsnB-3hzpA:
undetectable		 3hsnA-3hzpA:
14.18
3hsnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 3hsnA-3hzpA:
undetectable
3hsnB-3hzpA:
undetectable		 3hsnA-3hzpA:
14.18
3hsnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.47A 3hsoA-3hzpA:
undetectable
3hsoB-3hzpA:
undetectable		 3hsoA-3hzpA:
14.18
3hsoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.44A 3hspA-3hzpA:
undetectable
3hspB-3hzpA:
undetectable		 3hspA-3hzpA:
14.18
3hspB-3hzpA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5dqn CYTOCHROME P450
CYP125
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ILE A  80
GLN A  95
VAL A  98
MET A 183
VAL A 246
VAL A 250
 None
1PE  A 505 (-3.6A)
1PE  A 505 ( 4.6A)
None
None
1PE  A 505 (-4.4A)
 0.86A 3iw1A-5dqnA:
64.2		 3iw1A-5dqnA:
72.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5dqn CYTOCHROME P450
CYP125
(Mycolicibacteriu
m
smegmatis) 		8 / 12 ILE A  80
VAL A  98
MET A 183
PRO A 196
SER A 200
ILE A 204
VAL A 246
VAL A 250
 None
1PE  A 505 ( 4.6A)
None
None
1PE  A 505 ( 4.4A)
None
None
1PE  A 505 (-4.4A)
 0.73A 3iw1A-5dqnA:
64.2		 3iw1A-5dqnA:
72.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 ILE A 303
ALA A 326
ALA A 323
ALA A 250
VAL A 249
 None
1PE  A 994 ( 3.7A)
None
None
EPE  A 996 (-3.6A)
 1.05A 3jb3A-3etcA:
undetectable		 3jb3A-3etcA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.41A 3jt3A-3hzpA:
undetectable
3jt3B-3hzpA:
undetectable		 3jt3A-3hzpA:
14.18
3jt3B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3jt4A-3hzpA:
undetectable
3jt4B-3hzpA:
undetectable		 3jt4A-3hzpA:
14.18
3jt4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.34A 3jt4A-3hzpA:
undetectable
3jt4B-3hzpA:
undetectable		 3jt4A-3hzpA:
14.18
3jt4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3jt5A-3hzpA:
undetectable
3jt5B-3hzpA:
undetectable		 3jt5A-3hzpA:
14.18
3jt5B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 3jt5A-3hzpA:
undetectable
3jt5B-3hzpA:
undetectable		 3jt5A-3hzpA:
14.18
3jt5B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 3jt6A-3hzpA:
undetectable
3jt6B-3hzpA:
undetectable		 3jt6A-3hzpA:
14.18
3jt6B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 3jt6A-3hzpA:
undetectable
3jt6B-3hzpA:
undetectable		 3jt6A-3hzpA:
14.18
3jt6B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.43A 3jt7A-3hzpA:
undetectable
3jt7B-3hzpA:
undetectable		 3jt7A-3hzpA:
14.18
3jt7B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 3jt7A-3hzpA:
undetectable
3jt7B-3hzpA:
undetectable		 3jt7A-3hzpA:
14.18
3jt7B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3jt8A-3hzpA:
undetectable
3jt8B-3hzpA:
undetectable		 3jt8A-3hzpA:
14.18
3jt8B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 3jt8A-3hzpA:
undetectable
3jt8B-3hzpA:
undetectable		 3jt8A-3hzpA:
14.18
3jt8B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3jt9A-3hzpA:
undetectable
3jt9B-3hzpA:
undetectable		 3jt9A-3hzpA:
14.18
3jt9B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 3jt9A-3hzpA:
undetectable
3jt9B-3hzpA:
undetectable		 3jt9A-3hzpA:
14.18
3jt9B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3jtaA-3hzpA:
undetectable
3jtaB-3hzpA:
undetectable		 3jtaA-3hzpA:
14.18
3jtaB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.46A 3jtaA-3hzpA:
undetectable
3jtaB-3hzpA:
undetectable		 3jtaA-3hzpA:
14.18
3jtaB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 9 TYR A 250
PHE A 237
ALA A 279
THR A  97
ILE A 150
 None
1PE  A 403 ( 3.9A)
None
None
None
 1.43A 3jusB-5cdhA:
undetectable		 3jusB-5cdhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 3jwsA-3hzpA:
undetectable
3jwsB-3hzpA:
undetectable		 3jwsA-3hzpA:
14.42
3jwsB-3hzpA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3jwtA-3hzpA:
undetectable
3jwtB-3hzpA:
undetectable		 3jwtA-3hzpA:
14.42
3jwtB-3hzpA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 3jwtA-3hzpA:
undetectable
3jwtB-3hzpA:
undetectable		 3jwtA-3hzpA:
14.42
3jwtB-3hzpA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 3jx0A-3hzpA:
undetectable
3jx0B-3hzpA:
undetectable		 3jx0A-3hzpA:
14.89
3jx0B-3hzpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 3jx0A-3hzpA:
undetectable
3jx0B-3hzpA:
undetectable		 3jx0A-3hzpA:
14.89
3jx0B-3hzpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3jx1A-3hzpA:
undetectable
3jx1B-3hzpA:
undetectable		 3jx1A-3hzpA:
14.89
3jx1B-3hzpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_2
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 1zcn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		4 / 6 ASN A  17
TYR A  24
TRP A  11
TRP A  34
 None
None
None
1PE  A 300 (-3.6A)
 1.49A 3jzjA-1zcnA:
0.0		 3jzjA-1zcnA:
16.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.82A 3k2hA-4xscA:
9.1		 3k2hA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.94A 3k2hA-4xscA:
9.1		 3k2hA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
 0.87A 3k2hA-4xscA:
9.1		 3k2hA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.84A 3k2hB-4xscA:
8.6		 3k2hB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.95A 3k2hB-4xscA:
8.6		 3k2hB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
 0.95A 3k2hB-4xscA:
8.6		 3k2hB-4xscA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		6 / 12 GLY A 312
GLY A 253
GLY A 255
SER A 223
ALA A 282
ASN A 281
 None
None
None
1PE  A 500 ( 4.6A)
None
None
 1.43A 3kkzB-4dn7A:
undetectable		 3kkzB-4dn7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.99A 3l63A-3bx8A:
undetectable		 3l63A-3bx8A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 278
PHE A 267
TYR A 272
VAL A 283
 None
None
1PE  A1355 (-4.4A)
None
 1.28A 3lb3A-5aovA:
undetectable		 3lb3A-5aovA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 278
PHE A 267
TYR A 272
VAL A 283
 None
None
1PE  A1355 (-4.4A)
None
 1.16A 3lb3B-5aovA:
undetectable		 3lb3B-5aovA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE
(Gallus
gallus) 		3 / 3 SER A 258
GLY A 255
SER A 189
 None
1PE  A1262 ( 3.8A)
None
 0.66A 3loqA-2fafA:
undetectable		 3loqA-2fafA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 0.99A 3mteA-3ltmA:
undetectable		 3mteA-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 1.03A 3mteB-3ltmA:
undetectable		 3mteB-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.36A 3n2rA-3hzpA:
undetectable
3n2rB-3hzpA:
undetectable		 3n2rA-3hzpA:
14.18
3n2rB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 3n2rA-3hzpA:
undetectable
3n2rB-3hzpA:
undetectable		 3n2rA-3hzpA:
14.18
3n2rB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 SER A  59
VAL A  57
TRP A  60
PHE A  89
 None
None
1PE  A1021 (-4.1A)
None
 1.40A 3n5tA-2g8yA:
undetectable
3n5tB-2g8yA:
1.6		 3n5tA-2g8yA:
23.86
3n5tB-2g8yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3n5vA-3hzpA:
undetectable
3n5vB-3hzpA:
undetectable		 3n5vA-3hzpA:
14.18
3n5vB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 3n5vA-3hzpA:
undetectable
3n5vB-3hzpA:
undetectable		 3n5vA-3hzpA:
14.18
3n5vB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3n5yA-3hzpA:
undetectable
3n5yB-3hzpA:
undetectable		 3n5yA-3hzpA:
14.18
3n5yB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 3n5yA-3hzpA:
undetectable
3n5yB-3hzpA:
undetectable		 3n5yA-3hzpA:
14.18
3n5yB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 3n5zA-3hzpA:
undetectable
3n5zB-3hzpA:
undetectable		 3n5zA-3hzpA:
14.18
3n5zB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 3n5zA-3hzpA:
undetectable
3n5zB-3hzpA:
undetectable		 3n5zA-3hzpA:
14.18
3n5zB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N67_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 6 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 3n67A-3hzpA:
0.0
3n67B-3hzpA:
0.0		 3n67A-3hzpA:
14.54
3n67B-3hzpA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N69_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 6 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.50A 3n69A-3hzpA:
0.0
3n69B-3hzpA:
0.0		 3n69A-3hzpA:
14.54
3n69B-3hzpA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 6 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 3n6aA-3hzpA:
0.0
3n6aB-3hzpA:
0.0		 3n6aA-3hzpA:
14.54
3n6aB-3hzpA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 6 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 3n6aA-3hzpA:
0.0
3n6aB-3hzpA:
0.0		 3n6aA-3hzpA:
14.54
3n6aB-3hzpA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 ARG A 449
VAL A 544
LEU A 395
GLY A 531
LEU A 443
 1PE  A   2 (-2.8A)
None
None
None
None
 0.98A 3n8zB-3fo5A:
undetectable		 3n8zB-3fo5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 287
PHE A 130
PHE A 278
VAL A 235
ALA A 228
 None
1PE  A 402 (-3.5A)
None
None
1PE  A 401 ( 4.0A)
 1.27A 3nhxA-5w95A:
undetectable		 3nhxA-5w95A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.50A 3nlkA-3hzpA:
undetectable
3nlkB-3hzpA:
undetectable		 3nlkA-3hzpA:
14.42
3nlkB-3hzpA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 3nlmA-3hzpA:
undetectable
3nlmB-3hzpA:
undetectable		 3nlmA-3hzpA:
14.18
3nlmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 3nlmA-3hzpA:
undetectable
3nlmB-3hzpA:
undetectable		 3nlmA-3hzpA:
14.18
3nlmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 3nlvA-3hzpA:
undetectable
3nlvB-3hzpA:
undetectable		 3nlvA-3hzpA:
14.18
3nlvB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 3nlwA-3hzpA:
undetectable
3nlwB-3hzpA:
undetectable		 3nlwA-3hzpA:
14.18
3nlwB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3nlxA-3hzpA:
undetectable
3nlxB-3hzpA:
undetectable		 3nlxA-3hzpA:
14.18
3nlxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3nlzA-3hzpA:
undetectable
3nlzB-3hzpA:
undetectable		 3nlzA-3hzpA:
14.18
3nlzB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 3nlzA-3hzpA:
undetectable
3nlzB-3hzpA:
undetectable		 3nlzA-3hzpA:
14.18
3nlzB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 3nm0A-3hzpA:
undetectable
3nm0B-3hzpA:
undetectable		 3nm0A-3hzpA:
14.18
3nm0B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 3nm0A-3hzpA:
undetectable
3nm0B-3hzpA:
undetectable		 3nm0A-3hzpA:
14.18
3nm0B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3nnyA-3hzpA:
undetectable
3nnyB-3hzpA:
undetectable		 3nnyA-3hzpA:
14.18
3nnyB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 3nnyA-3hzpA:
undetectable
3nnyB-3hzpA:
undetectable		 3nnyA-3hzpA:
14.18
3nnyB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 3nnzA-3hzpA:
undetectable
3nnzB-3hzpA:
undetectable		 3nnzA-3hzpA:
14.18
3nnzB-3hzpA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ALA A  71
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.04A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.64A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.10A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.68A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ALA A  71
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.06A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.64A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.11A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.70A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC
([Bacillus]
selenitireducens) 		5 / 12 ARG A 371
GLY A 376
ALA A 377
ILE A 420
ILE A 414
 1PE  A 802 (-3.8A)
None
None
None
None
 0.93A 3nu3A-4ktpA:
undetectable		 3nu3A-4ktpA:
9.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 7 GLY A 134
GLY A 135
SER A 220
PHE A 427
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
1PE  A1553 (-4.7A)
None
 0.52A 3o9mA-4be9A:
42.6		 3o9mA-4be9A:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 6 GLY A 134
GLY A 135
SER A 220
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
 0.47A 3o9mB-4be9A:
42.6		 3o9mB-4be9A:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2bi3 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
alcalophilus) 		3 / 3 LYS A 357
ARG A 304
LYS A 291
 None
None
1PE  A1366 ( 2.4A)
 1.39A 3okxA-2bi3A:
undetectable		 3okxA-2bi3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 GLN A 223
THR A 222
LEU A 194
 1PE  A 908 (-3.8A)
None
None
 0.61A 3ondA-4s38A:
undetectable		 3ondA-4s38A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 GLN A 223
THR A 222
LEU A 194
 1PE  A 908 (-3.8A)
None
None
 0.60A 3ondB-4s38A:
undetectable		 3ondB-4s38A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 0.99A 3p2kD-3ltmA:
undetectable		 3p2kD-3ltmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5dqn CYTOCHROME P450
CYP125
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 296
LEU A 398
VAL A 250
GLY A 252
ALA A 251
 None
None
1PE  A 505 (-4.4A)
HEM  A 501 (-3.4A)
1PE  A 505 ( 3.4A)
 1.14A 3pghB-5dqnA:
undetectable		 3pghB-5dqnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 TYR A 159
ILE A 114
SER A 149
SER A 146
 1PE  A 307 (-3.6A)
None
None
EDO  A 303 (-2.7A)
 1.23A 3pmzD-4j2hA:
undetectable		 3pmzD-4j2hA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3pneA-3hzpA:
undetectable
3pneB-3hzpA:
undetectable		 3pneA-3hzpA:
14.18
3pneB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 3pneA-3hzpA:
undetectable
3pneB-3hzpA:
undetectable		 3pneA-3hzpA:
14.18
3pneB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 3pnfA-3hzpA:
undetectable
3pnfB-3hzpA:
undetectable		 3pnfA-3hzpA:
14.18
3pnfB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 3pnfA-3hzpA:
undetectable
3pnfB-3hzpA:
undetectable		 3pnfA-3hzpA:
14.18
3pnfB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3pngA-3hzpA:
undetectable
3pngB-3hzpA:
undetectable		 3pngA-3hzpA:
14.18
3pngB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.50A 3pngA-3hzpA:
undetectable
3pngB-3hzpA:
undetectable		 3pngA-3hzpA:
14.18
3pngB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 3q99A-3hzpA:
undetectable
3q99B-3hzpA:
undetectable		 3q99A-3hzpA:
14.18
3q99B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 3q99A-3hzpA:
undetectable
3q99B-3hzpA:
undetectable		 3q99A-3hzpA:
14.18
3q99B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 3q9aA-3hzpA:
undetectable
3q9aB-3hzpA:
undetectable		 3q9aA-3hzpA:
14.18
3q9aB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q9A_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.33A 3q9aA-3hzpA:
undetectable
3q9aB-3hzpA:
undetectable		 3q9aA-3hzpA:
14.18
3q9aB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN
(Agrobacterium
fabrum) 		3 / 3 GLU A 103
PHE A 108
GLN A  99
 None
None
1PE  A 303 (-3.3A)
 0.74A 3r55A-5itoA:
undetectable		 3r55A-5itoA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 3rqjA-3hzpA:
undetectable
3rqjB-3hzpA:
undetectable		 3rqjA-3hzpA:
14.18
3rqjB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.47A 3rqkA-3hzpA:
undetectable
3rqkB-3hzpA:
undetectable		 3rqkA-3hzpA:
14.18
3rqkB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 3rqlA-3hzpA:
undetectable
3rqlB-3hzpA:
undetectable		 3rqlA-3hzpA:
14.18
3rqlB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3rqmA-3hzpA:
undetectable
3rqmB-3hzpA:
undetectable		 3rqmA-3hzpA:
14.18
3rqmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.46A 3rqmA-3hzpA:
undetectable
3rqmB-3hzpA:
undetectable		 3rqmA-3hzpA:
14.18
3rqmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 3rqnA-3hzpA:
undetectable
3rqnB-3hzpA:
undetectable		 3rqnA-3hzpA:
14.18
3rqnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 3rqnA-3hzpA:
undetectable
3rqnB-3hzpA:
undetectable		 3rqnA-3hzpA:
14.18
3rqnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		4 / 8 ASN A 223
GLU A 203
TYR A 246
LEU A 227
 1PE  A   7 (-3.0A)
1PE  A  13 ( 4.9A)
None
1PE  A   7 ( 4.9A)
 1.05A 3rqwC-3lewA:
2.0
3rqwD-3lewA:
2.0		 3rqwC-3lewA:
19.53
3rqwD-3lewA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		4 / 8 ASN A 223
GLU A 203
TYR A 246
LEU A 227
 1PE  A   7 (-3.0A)
1PE  A  13 ( 4.9A)
None
1PE  A   7 ( 4.9A)
 1.06A 3rqwI-3lewA:
undetectable
3rqwJ-3lewA:
undetectable		 3rqwI-3lewA:
19.53
3rqwJ-3lewA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		4 / 8 GLU A 203
TYR A 246
LEU A 227
ASN A 223
 1PE  A  13 ( 4.9A)
None
1PE  A   7 ( 4.9A)
1PE  A   7 (-3.0A)
 1.06A 3rqwF-3lewA:
1.6
3rqwJ-3lewA:
undetectable		 3rqwF-3lewA:
19.53
3rqwJ-3lewA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3svpA-3hzpA:
undetectable
3svpB-3hzpA:
undetectable		 3svpA-3hzpA:
14.18
3svpB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A 253
GLY A 255
SER A 223
ALA A 282
ASN A 281
 None
None
1PE  A 500 ( 4.6A)
None
None
 1.45A 3t7sC-4dn7A:
undetectable		 3t7sC-4dn7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 125
SER A  83
THR A 127
ASP A  23
 None
1PE  A 163 ( 4.6A)
1PE  A 163 ( 4.2A)
None
 1.40A 3tm4A-2qlpA:
undetectable		 3tm4A-2qlpA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2qlp DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 125
SER A  83
THR A 127
ASP A  23
 None
1PE  A 163 ( 4.6A)
1PE  A 163 ( 4.2A)
None
 1.37A 3tm4B-2qlpA:
undetectable		 3tm4B-2qlpA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 3tylA-3hzpA:
undetectable
3tylB-3hzpA:
undetectable		 3tylA-3hzpA:
14.18
3tylB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 3tylA-3hzpA:
undetectable
3tylB-3hzpA:
undetectable		 3tylA-3hzpA:
14.18
3tylB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.40A 3tymA-3hzpA:
undetectable
3tymB-3hzpA:
undetectable		 3tymA-3hzpA:
14.18
3tymB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 3tymA-3hzpA:
undetectable
3tymB-3hzpA:
undetectable		 3tymA-3hzpA:
14.18
3tymB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.39A 3tynA-3hzpA:
undetectable
3tynB-3hzpA:
undetectable		 3tynA-3hzpA:
14.18
3tynB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 3tynA-3hzpA:
undetectable
3tynB-3hzpA:
undetectable		 3tynA-3hzpA:
14.18
3tynB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.34A 3tyoA-3hzpA:
undetectable
3tyoB-3hzpA:
undetectable		 3tyoA-3hzpA:
14.18
3tyoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.34A 3tyoA-3hzpA:
undetectable
3tyoB-3hzpA:
undetectable		 3tyoA-3hzpA:
14.18
3tyoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 146
ILE A  22
TYR A 159
GLY A 190
 EDO  A 303 (-2.7A)
None
1PE  A 307 (-3.6A)
EDO  A 303 (-3.9A)
 0.96A 3uboB-4j2hA:
6.7		 3uboB-4j2hA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 3ufoA-3hzpA:
undetectable
3ufoB-3hzpA:
undetectable		 3ufoA-3hzpA:
14.18
3ufoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 3ufoA-3hzpA:
undetectable
3ufoB-3hzpA:
undetectable		 3ufoA-3hzpA:
14.18
3ufoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3ufpA-3hzpA:
undetectable
3ufpB-3hzpA:
undetectable		 3ufpA-3hzpA:
14.18
3ufpB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 3ufpA-3hzpA:
undetectable
3ufpB-3hzpA:
undetectable		 3ufpA-3hzpA:
14.18
3ufpB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.41A 3ufqA-3hzpA:
undetectable
3ufqB-3hzpA:
undetectable		 3ufqA-3hzpA:
14.18
3ufqB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.46A 3ufrA-3hzpA:
undetectable
3ufrB-3hzpA:
undetectable		 3ufrA-3hzpA:
14.18
3ufrB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 3ufsA-3hzpA:
undetectable
3ufsB-3hzpA:
undetectable		 3ufsA-3hzpA:
14.18
3ufsB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 3ufsA-3hzpA:
undetectable
3ufsB-3hzpA:
undetectable		 3ufsA-3hzpA:
14.18
3ufsB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 3uftA-3hzpA:
undetectable
3uftB-3hzpA:
undetectable		 3uftA-3hzpA:
14.18
3uftB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 3uftA-3hzpA:
undetectable
3uftB-3hzpA:
undetectable		 3uftA-3hzpA:
14.18
3uftB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 3ufuA-3hzpA:
undetectable
3ufuB-3hzpA:
undetectable		 3ufuA-3hzpA:
14.18
3ufuB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.45A 3ufuA-3hzpA:
undetectable
3ufuB-3hzpA:
undetectable		 3ufuA-3hzpA:
14.18
3ufuB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 3ufvA-3hzpA:
undetectable
3ufvB-3hzpA:
undetectable		 3ufvA-3hzpA:
14.18
3ufvB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 3ufvA-3hzpA:
undetectable
3ufvB-3hzpA:
undetectable		 3ufvA-3hzpA:
14.18
3ufvB-3hzpA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.26A 3uwlB-4xscA:
36.6		 3uwlB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 ILE A  96
LEU A 180
HIS A 184
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-4.7A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.23A 3uwlB-4xscA:
36.6		 3uwlB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.78A 3uwlB-4xscA:
36.6		 3uwlB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.76A 3uwlD-4xscA:
34.5		 3uwlD-4xscA:
41.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		4 / 8 VAL A 544
TYR A 546
LEU A 415
TYR A 570
 None
1PE  A   2 (-4.0A)
None
None
 1.11A 3v81A-3fo5A:
undetectable		 3v81A-3fo5A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.94A 3wrhA-3bx8A:
undetectable		 3wrhA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.98A 3wrjA-3bx8A:
undetectable		 3wrjA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.97A 3wrlA-3bx8A:
undetectable		 3wrlA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 1.01A 3wrlE-3bx8A:
undetectable		 3wrlE-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.97A 3wrmA-3bx8A:
undetectable		 3wrmA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.99A 3wrmF-3bx8A:
undetectable		 3wrmF-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 6 GLU A 171
LYS A 175
TRP A 235
GLU A 178
 None
1PE  A 402 (-3.0A)
1PE  A 402 (-4.0A)
1PE  A 402 (-3.7A)
 1.17A 4a7tA-5cdhA:
undetectable		 4a7tA-5cdhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 6 GLU A 171
LYS A 175
TRP A 235
GLU A 178
 None
1PE  A 402 (-3.0A)
1PE  A 402 (-4.0A)
1PE  A 402 (-3.7A)
 1.20A 4a7tF-5cdhA:
undetectable		 4a7tF-5cdhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 6 GLU A 171
LYS A 175
TRP A 235
GLU A 178
 None
1PE  A 402 (-3.0A)
1PE  A 402 (-4.0A)
1PE  A 402 (-3.7A)
 1.16A 4a7uA-5cdhA:
undetectable		 4a7uA-5cdhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE
(Corynebacterium
glutamicum) 		4 / 6 GLU A  56
PHE A  61
VAL A 104
PHE A 149
 1PE  A 301 ( 4.5A)
None
None
1PE  A 301 ( 4.8A)
 1.21A 4a97E-5wq3A:
undetectable		 4a97E-5wq3A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT2_A_ASDA1490_1
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3owa ACYL-COA
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 10 GLU A 367
ALA A 318
VAL A 274
PHE A 532
SER A 498
 None
None
None
1PE  A 602 (-4.4A)
None
 1.37A 4at2A-3owaA:
0.0		 4at2A-3owaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4c39A-3hzpA:
undetectable
4c39B-3hzpA:
undetectable		 4c39A-3hzpA:
14.18
4c39B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.44A 4c39A-3hzpA:
undetectable
4c39B-3hzpA:
undetectable		 4c39A-3hzpA:
14.18
4c39B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4camA-3hzpA:
undetectable
4camB-3hzpA:
undetectable		 4camA-3hzpA:
14.18
4camB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 4camA-3hzpA:
undetectable
4camB-3hzpA:
undetectable		 4camA-3hzpA:
14.18
4camB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.39A 4canA-3hzpA:
undetectable
4canB-3hzpA:
undetectable		 4canA-3hzpA:
14.18
4canB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 4canA-3hzpA:
undetectable
4canB-3hzpA:
undetectable		 4canA-3hzpA:
14.18
4canB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 4caoA-3hzpA:
undetectable
4caoB-3hzpA:
undetectable		 4caoA-3hzpA:
14.18
4caoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 4caoA-3hzpA:
undetectable
4caoB-3hzpA:
undetectable		 4caoA-3hzpA:
14.18
4caoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 4capA-3hzpA:
undetectable
4capB-3hzpA:
undetectable		 4capA-3hzpA:
14.18
4capB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4caqA-3hzpA:
undetectable
4caqB-3hzpA:
undetectable		 4caqA-3hzpA:
14.18
4caqB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 4caqA-3hzpA:
undetectable
4caqB-3hzpA:
undetectable		 4caqA-3hzpA:
14.18
4caqB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.40A 4cdtA-3hzpA:
undetectable
4cdtB-3hzpA:
undetectable		 4cdtA-3hzpA:
14.18
4cdtB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 4cdtA-3hzpA:
undetectable
4cdtB-3hzpA:
undetectable		 4cdtA-3hzpA:
14.18
4cdtB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.89A 4ctjC-5xg9B:
undetectable		 4ctjC-5xg9B:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4ctpA-3hzpA:
undetectable
4ctpB-3hzpA:
undetectable		 4ctpA-3hzpA:
14.18
4ctpB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.42A 4ctpA-3hzpA:
undetectable
4ctpB-3hzpA:
undetectable		 4ctpA-3hzpA:
14.18
4ctpB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 4ctqA-3hzpA:
undetectable
4ctqB-3hzpA:
undetectable		 4ctqA-3hzpA:
14.18
4ctqB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.41A 4ctrA-3hzpA:
undetectable
4ctrB-3hzpA:
undetectable		 4ctrA-3hzpA:
14.18
4ctrB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 4cttA-3hzpA:
undetectable
4cttB-3hzpA:
undetectable		 4cttA-3hzpA:
14.18
4cttB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 4cttA-3hzpA:
undetectable
4cttB-3hzpA:
undetectable		 4cttA-3hzpA:
14.18
4cttB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4ctuA-3hzpA:
undetectable
4ctuB-3hzpA:
undetectable		 4ctuA-3hzpA:
14.18
4ctuB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 4ctvA-3hzpA:
undetectable
4ctvB-3hzpA:
undetectable		 4ctvA-3hzpA:
14.18
4ctvB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 4ctvA-3hzpA:
undetectable
4ctvB-3hzpA:
undetectable		 4ctvA-3hzpA:
14.18
4ctvB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_A_H4BA1718_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.50A 4ctwA-3hzpA:
undetectable
4ctwB-3hzpA:
undetectable		 4ctwA-3hzpA:
14.18
4ctwB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 4ctwA-3hzpA:
undetectable
4ctwB-3hzpA:
undetectable		 4ctwA-3hzpA:
14.18
4ctwB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4ctxA-3hzpA:
undetectable
4ctxB-3hzpA:
undetectable		 4ctxA-3hzpA:
14.18
4ctxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4ctxA-3hzpA:
undetectable
4ctxB-3hzpA:
undetectable		 4ctxA-3hzpA:
14.18
4ctxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3wic GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 4 VAL A  89
VAL A  74
ASN A  80
ILE A 137
 None
None
None
1PE  A1005 (-4.7A)
 1.13A 4cutA-3wicA:
undetectable		 4cutA-3wicA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 4cx5A-3hzpA:
undetectable
4cx5B-3hzpA:
undetectable		 4cx5A-3hzpA:
14.18
4cx5B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.46A 4cx5A-3hzpA:
undetectable
4cx5B-3hzpA:
undetectable		 4cx5A-3hzpA:
14.18
4cx5B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.46A 4cx6A-3hzpA:
undetectable
4cx6B-3hzpA:
undetectable		 4cx6A-3hzpA:
14.18
4cx6B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.42A 4d1nA-3hzpA:
undetectable
4d1nB-3hzpA:
undetectable		 4d1nA-3hzpA:
13.88
4d1nB-3hzpA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 4d1nC-3hzpA:
undetectable
4d1nD-3hzpA:
undetectable		 4d1nC-3hzpA:
13.88
4d1nD-3hzpA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4d2yA-3hzpA:
undetectable
4d2yB-3hzpA:
undetectable		 4d2yA-3hzpA:
14.18
4d2yB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 4d2yA-3hzpA:
undetectable
4d2yB-3hzpA:
undetectable		 4d2yA-3hzpA:
14.18
4d2yB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 4d2zA-3hzpA:
undetectable
4d2zB-3hzpA:
undetectable		 4d2zA-3hzpA:
14.18
4d2zB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 4d2zA-3hzpA:
undetectable
4d2zB-3hzpA:
undetectable		 4d2zA-3hzpA:
14.18
4d2zB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 4d30A-3hzpA:
undetectable
4d30B-3hzpA:
undetectable		 4d30A-3hzpA:
14.18
4d30B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 4d30A-3hzpA:
undetectable
4d30B-3hzpA:
undetectable		 4d30A-3hzpA:
14.18
4d30B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.33A 4d31A-3hzpA:
undetectable
4d31B-3hzpA:
undetectable		 4d31A-3hzpA:
14.18
4d31B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 4d31A-3hzpA:
undetectable
4d31B-3hzpA:
undetectable		 4d31A-3hzpA:
14.18
4d31B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 4d3bA-3hzpA:
undetectable
4d3bB-3hzpA:
undetectable		 4d3bA-3hzpA:
14.18
4d3bB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4d7oA-3hzpA:
undetectable
4d7oB-3hzpA:
undetectable		 4d7oA-3hzpA:
14.18
4d7oB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.47A 4d7oA-3hzpA:
undetectable
4d7oB-3hzpA:
undetectable		 4d7oA-3hzpA:
14.18
4d7oB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 PHE A 172
PHE A 109
LEU A 112
ALA A 211
ARG A 167
 None
None
None
None
1PE  A1346 (-4.3A)
 1.32A 4dx7A-5aovA:
0.0		 4dx7A-5aovA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 266
ASN A  73
MET A 219
VAL A 244
 None
None
1PE  A1349 (-4.2A)
None
 1.04A 4e1gB-5aovA:
undetectable		 4e1gB-5aovA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.65A 4eb4A-4xscA:
40.1		 4eb4A-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A  68
ILE A  96
TRP A  97
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 0.70A 4eb4A-4xscA:
40.1		 4eb4A-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.68A 4eb4B-4xscA:
40.1		 4eb4B-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A  68
ILE A  96
TRP A  97
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 0.72A 4eb4B-4xscA:
40.1		 4eb4B-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 9 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.63A 4eb4C-4xscA:
40.6		 4eb4C-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 10 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.62A 4eb4D-4xscA:
40.5		 4eb4D-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
TRP A  97
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.74A 4eb4D-4xscA:
40.5		 4eb4D-4xscA:
65.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 ILE A 224
GLU A 331
ILE A 333
LEU A 326
THR A 426
 None
None
None
None
1PE  A1553 (-3.7A)
 1.07A 4ej1B-4be9A:
undetectable		 4ej1B-4be9A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4euxA-3hzpA:
undetectable
4euxB-3hzpA:
undetectable		 4euxA-3hzpA:
14.18
4euxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4euxA-3hzpA:
undetectable
4euxB-3hzpA:
undetectable		 4euxA-3hzpA:
14.18
4euxB-3hzpA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.25A 4ey6A-4be9A:
41.0		 4ey6A-4be9A:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		6 / 12 GLY A 133
GLY A 134
GLY A 135
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
None
 0.94A 4ey6A-4be9A:
41.0		 4ey6A-4be9A:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.28A 4ey6B-4be9A:
37.3		 4ey6B-4be9A:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		7 / 12 GLY A 133
GLY A 134
GLY A 135
GLU A 219
SER A 220
PHE A 356
HIS A 465
 None
PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
1PE  A1553 (-2.9A)
None
None
 0.91A 4ey6B-4be9A:
37.3		 4ey6B-4be9A:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3wic GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 8 SER A 304
GLU A 166
GLY A 105
ARG A 106
 None
1PE  A1004 ( 3.8A)
None
1PE  A1004 (-4.1A)
 0.94A 4fgzA-3wicA:
6.2
4fgzB-3wicA:
6.3		 4fgzA-3wicA:
22.49
4fgzB-3wicA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.03A 4fogA-4xscA:
36.3		 4fogA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 4fogA-4xscA:
36.3		 4fogA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 ILE A  96
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.12A 4fogC-4xscA:
36.4		 4fogC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.78A 4fogC-4xscA:
36.4		 4fogC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.12A 4fogD-4xscA:
36.4		 4fogD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.73A 4fogD-4xscA:
36.4		 4fogD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.71A 4fogD-4xscA:
36.4		 4fogD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.75A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.83A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.14A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.77A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.20A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.72A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.77A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.20A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.80A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  75
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.82A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 GLU A  75
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.85A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.22A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.23A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.62A 4foxD-4xscA:
36.3		 4foxD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.99A 4foxD-4xscA:
36.3		 4foxD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.64A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.73A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.08A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.22A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  75
ILE A  96
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.85A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.89A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.21A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.22A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.79A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.17A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.20A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 GLU A  75
ILE A  96
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.72A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 GLU A  75
ILE A  96
TRP A  97
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.83A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.18A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.68A 4fqsA-4xscA:
36.3		 4fqsA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
 0.71A 4fqsA-4xscA:
36.3		 4fqsA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.69A 4fqsB-4xscA:
36.3		 4fqsB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
 0.70A 4fqsB-4xscA:
36.3		 4fqsB-4xscA:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 4fvwA-3hzpA:
undetectable
4fvwB-3hzpA:
undetectable		 4fvwA-3hzpA:
14.18
4fvwB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 4fvwA-3hzpA:
undetectable
4fvwB-3hzpA:
undetectable		 4fvwA-3hzpA:
14.18
4fvwB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.50A 4fvxA-3hzpA:
undetectable
4fvxB-3hzpA:
undetectable		 4fvxA-3hzpA:
14.18
4fvxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 4fvxA-3hzpA:
undetectable
4fvxB-3hzpA:
undetectable		 4fvxA-3hzpA:
14.18
4fvxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.35A 4fvyA-3hzpA:
undetectable
4fvyB-3hzpA:
undetectable		 4fvyA-3hzpA:
14.18
4fvyB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 4fvyA-3hzpA:
undetectable
4fvyB-3hzpA:
undetectable		 4fvyA-3hzpA:
14.18
4fvyB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4fvzA-3hzpA:
undetectable
4fvzB-3hzpA:
undetectable		 4fvzA-3hzpA:
14.18
4fvzB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.42A 4fvzA-3hzpA:
undetectable
4fvzB-3hzpA:
undetectable		 4fvzA-3hzpA:
14.18
4fvzB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 4fw0A-3hzpA:
undetectable
4fw0B-3hzpA:
undetectable		 4fw0A-3hzpA:
14.18
4fw0B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4fw0A-3hzpA:
undetectable
4fw0B-3hzpA:
undetectable		 4fw0A-3hzpA:
14.18
4fw0B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2ci8 CYTOPLASMIC PROTEIN
NCK1
(Homo
sapiens) 		4 / 8 ASP A 316
ASN A 315
GLU A 336
ASP A 309
 None
None
None
1PE  A 482 (-3.7A)
 1.19A 4gkhB-2ci8A:
undetectable		 4gkhB-2ci8A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 4gqeA-3hzpA:
undetectable
4gqeB-3hzpA:
undetectable		 4gqeA-3hzpA:
14.18
4gqeB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4gqeA-3hzpA:
undetectable
4gqeB-3hzpA:
undetectable		 4gqeA-3hzpA:
14.18
4gqeB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 3zuc CELLULOSOMAL
SCAFFOLDIN
(Acetivibrio
cellulolyticus) 		4 / 4 LYS A  42
ALA A  90
SER A  92
THR A  70
 1PE  A1157 (-2.7A)
None
None
None
 1.31A 4i89B-3zucA:
undetectable		 4i89B-3zucA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.41A 4imtA-3hzpA:
undetectable
4imtB-3hzpA:
undetectable		 4imtA-3hzpA:
14.18
4imtB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.45A 4imwA-3hzpA:
undetectable
4imwB-3hzpA:
undetectable		 4imwA-3hzpA:
14.18
4imwB-3hzpA:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.42A 4iqqB-4xscA:
38.6		 4iqqB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.37A 4iqqC-4xscA:
38.8		 4iqqC-4xscA:
56.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 249
GLU A 256
GLY A 261
ASN A 282
GLU A 268
 None
None
1PE  A1343 ( 3.7A)
None
EDO  A1351 (-4.8A)
 1.46A 4jlgB-5aovA:
undetectable		 4jlgB-5aovA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4jsfA-3hzpA:
undetectable
4jsfB-3hzpA:
undetectable		 4jsfA-3hzpA:
14.18
4jsfB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.46A 4jsfA-3hzpA:
undetectable
4jsfB-3hzpA:
undetectable		 4jsfA-3hzpA:
14.18
4jsfB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 4jsgA-3hzpA:
undetectable
4jsgB-3hzpA:
undetectable		 4jsgA-3hzpA:
14.18
4jsgB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.42A 4jsgA-3hzpA:
undetectable
4jsgB-3hzpA:
undetectable		 4jsgA-3hzpA:
14.18
4jsgB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 4jsiA-3hzpA:
undetectable
4jsiB-3hzpA:
undetectable		 4jsiA-3hzpA:
14.18
4jsiB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 4jsiA-3hzpA:
undetectable
4jsiB-3hzpA:
undetectable		 4jsiA-3hzpA:
14.18
4jsiB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 4k5dA-3hzpA:
undetectable
4k5dB-3hzpA:
undetectable		 4k5dA-3hzpA:
14.18
4k5dB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 4k5eA-3hzpA:
undetectable
4k5eB-3hzpA:
undetectable		 4k5eA-3hzpA:
14.18
4k5eB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 4k5fA-3hzpA:
undetectable
4k5fB-3hzpA:
undetectable		 4k5fA-3hzpA:
14.18
4k5fB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4k5fA-3hzpA:
undetectable
4k5fB-3hzpA:
undetectable		 4k5fA-3hzpA:
14.18
4k5fB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.41A 4k5gA-3hzpA:
undetectable
4k5gB-3hzpA:
undetectable		 4k5gA-3hzpA:
14.18
4k5gB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 4k5gA-3hzpA:
undetectable
4k5gB-3hzpA:
undetectable		 4k5gA-3hzpA:
14.18
4k5gB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.42A 4k5jA-2g8yA:
undetectable
4k5jB-2g8yA:
undetectable		 4k5jA-2g8yA:
23.91
4k5jB-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.86A 4k8cA-1q0zA:
4.2		 4k8cA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.87A 4kahA-1q0zA:
4.2		 4kahA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.84A 4kanA-1q0zA:
4.1		 4kanA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.85A 4kanB-1q0zA:
3.8		 4kanB-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.87A 4kbeA-1q0zA:
4.1		 4kbeA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCH_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 4kchA-3hzpA:
undetectable
4kchB-3hzpA:
undetectable		 4kchA-3hzpA:
14.18
4kchB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 4kciA-3hzpA:
undetectable
4kciB-3hzpA:
undetectable		 4kciA-3hzpA:
14.18
4kciB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 4kcjA-3hzpA:
undetectable
4kcjB-3hzpA:
undetectable		 4kcjA-3hzpA:
14.18
4kcjB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.43A 4kckA-3hzpA:
undetectable
4kckB-3hzpA:
undetectable		 4kckA-3hzpA:
14.18
4kckB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4kckA-3hzpA:
undetectable
4kckB-3hzpA:
undetectable		 4kckA-3hzpA:
14.18
4kckB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 4kclA-3hzpA:
undetectable
4kclB-3hzpA:
undetectable		 4kclA-3hzpA:
14.18
4kclB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.43A 4kcmA-3hzpA:
undetectable
4kcmB-3hzpA:
undetectable		 4kcmA-3hzpA:
14.18
4kcmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4kcmA-3hzpA:
undetectable
4kcmB-3hzpA:
undetectable		 4kcmA-3hzpA:
14.18
4kcmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5jor FAB14.22 HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  42
ILE B  40
GLN B  41
SER B  44
 1PE  B 309 ( 3.9A)
None
1PE  B 310 ( 3.5A)
None
 1.07A 4kcnA-5jorB:
undetectable		 4kcnA-5jorB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4kcnA-3hzpA:
undetectable
4kcnB-3hzpA:
undetectable		 4kcnA-3hzpA:
14.18
4kcnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.34A 4kcoA-3hzpA:
undetectable
4kcoB-3hzpA:
undetectable		 4kcoA-3hzpA:
14.18
4kcoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4kcoA-3hzpA:
undetectable
4kcoB-3hzpA:
undetectable		 4kcoA-3hzpA:
14.18
4kcoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 0.98A 4l4gA-3bx8A:
undetectable		 4l4gA-3bx8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.86A 4lbgA-1q0zA:
3.9		 4lbgA-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		3 / 3 SER A 187
TYR A 198
PRO A 249
 None
1PE  A2712 (-4.2A)
None
 0.85A 4lbgB-1q0zA:
3.8		 4lbgB-1q0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.40A 4luxA-3hzpA:
undetectable
4luxB-3hzpA:
undetectable		 4luxA-3hzpA:
14.18
4luxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 4luxA-3hzpA:
undetectable
4luxB-3hzpA:
undetectable		 4luxA-3hzpA:
14.18
4luxB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLN A 223
THR A 222
LEU A 194
LEU A 190
 1PE  A 908 (-3.8A)
None
None
1PE  A 908 (-4.3A)
 1.03A 4lvcB-4s38A:
undetectable		 4lvcB-4s38A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.41A 4nosA-3hzpA:
undetectable
4nosB-3hzpA:
undetectable		 4nosA-3hzpA:
17.05
4nosB-3hzpA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4rus FISH-EGG LECTIN
(Cyprinus
carpio) 		4 / 6 LEU A  55
LEU A  78
PHE A 159
MET A 145
 None
1PE  A 305 (-4.4A)
None
None
 1.10A 4o1zA-4rusA:
undetectable		 4o1zA-4rusA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 ALA A 199
GLY A 234
ILE A 213
ASN A 212
MET A 196
 1PE  A 402 ( 4.4A)
None
None
CA  A 401 ( 4.4A)
None
 1.24A 4obwA-4wr2A:
undetectable		 4obwA-4wr2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 ALA A 199
GLY A 234
ILE A 213
ASN A 212
MET A 196
 1PE  A 402 ( 4.4A)
None
None
CA  A 401 ( 4.4A)
None
 1.26A 4obwD-4wr2A:
undetectable		 4obwD-4wr2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE
(Escherichia
coli) 		4 / 7 LEU A 222
LEU A 210
ILE A 195
ILE A 196
 None
1PE  A 601 ( 4.4A)
None
None
 0.62A 4ojbA-1xviA:
undetectable		 4ojbA-1xviA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 11 SER A 187
GLY A 490
LEU A 496
TRP A 482
ILE A 489
 None
None
None
1PE  A 803 ( 4.0A)
None
 1.37A 4pghC-4zohA:
undetectable		 4pghC-4zohA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 11 GLY A 134
GLY A 135
GLY A 218
ILE A 224
PHE A 427
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
None
None
1PE  A1553 (-4.7A)
 1.15A 4qoiA-4be9A:
undetectable
4qoiB-4be9A:
2.2		 4qoiA-4be9A:
16.76
4qoiB-4be9A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLU A  98
ILE A 153
THR A 148
TYR A 201
 1PE  A 307 (-3.8A)
1PE  A 307 ( 4.2A)
EDO  A 303 ( 4.2A)
None
 1.45A 4qwpA-4j2hA:
undetectable		 4qwpA-4j2hA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		4 / 7 ILE A  32
ASN A 101
ILE A 102
ASP A 103
 1PE  A 504 ( 4.7A)
None
None
None
 0.31A 4rmjA-1s7gA:
23.9		 4rmjA-1s7gA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TNS_A_REAA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1)		 1zcn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		8 / 9 HIS A  59
LYS A  63
ARG A  68
MET A 130
GLN A 131
PHE A 134
SER A 154
HIS A 157
 1PE  A 400 ( 4.4A)
PO4  A 321 (-2.6A)
PO4  A 321 (-3.8A)
1PE  A 400 (-3.8A)
1PE  A 400 (-4.5A)
1PE  A 400 (-3.7A)
PO4  A 321 (-2.7A)
1PE  A 400 ( 4.7A)
 0.28A 4tnsA-1zcnA:
24.7		 4tnsA-1zcnA:
77.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 TYR A 546
THR A 527
THR A 551
ALA A 550
TRP A 404
 1PE  A   2 (-4.0A)
1PE  A   2 ( 3.8A)
1PE  A   2 (-4.5A)
GOL  A 595 (-4.3A)
None
 1.24A 4u15B-3fo5A:
undetectable		 4u15B-3fo5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4uchA-3hzpA:
undetectable
4uchB-3hzpA:
undetectable		 4uchA-3hzpA:
14.18
4uchB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 8 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.35A 4uchA-3hzpA:
undetectable
4uchB-3hzpA:
undetectable		 4uchA-3hzpA:
14.18
4uchB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		5 / 12 GLY A  86
GLY A  84
GLY A 124
LEU A  92
ALA A  87
 None
1PE  A 205 ( 4.3A)
1PE  A 205 ( 4.7A)
None
None
 1.01A 4uciB-5uc0A:
undetectable		 4uciB-5uc0A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.46A 4ugzA-3hzpA:
undetectable
4ugzB-3hzpA:
undetectable		 4ugzA-3hzpA:
14.18
4ugzB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 4uh0A-3hzpA:
undetectable
4uh0B-3hzpA:
undetectable		 4uh0A-3hzpA:
14.18
4uh0B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 4uh1A-3hzpA:
undetectable
4uh1B-3hzpA:
undetectable		 4uh1A-3hzpA:
14.18
4uh1B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.42A 4uh2A-3hzpA:
undetectable
4uh2B-3hzpA:
undetectable		 4uh2A-3hzpA:
14.18
4uh2B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.41A 4uh3A-3hzpA:
undetectable
4uh3B-3hzpA:
undetectable		 4uh3A-3hzpA:
14.18
4uh3B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.41A 4uh4A-3hzpA:
undetectable
4uh4B-3hzpA:
undetectable		 4uh4A-3hzpA:
14.18
4uh4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 4uh4A-3hzpA:
undetectable
4uh4B-3hzpA:
undetectable		 4uh4A-3hzpA:
14.18
4uh4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.40A 4uh5A-3hzpA:
undetectable
4uh5B-3hzpA:
undetectable		 4uh5A-3hzpA:
13.98
4uh5B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.45A 4uh5A-3hzpA:
undetectable
4uh5B-3hzpA:
undetectable		 4uh5A-3hzpA:
13.98
4uh5B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4uh6A-3hzpA:
undetectable
4uh6B-3hzpA:
undetectable		 4uh6A-3hzpA:
13.98
4uh6B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4upmA-3hzpA:
undetectable
4upmB-3hzpA:
undetectable		 4upmA-3hzpA:
14.18
4upmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 4upmA-3hzpA:
undetectable
4upmB-3hzpA:
undetectable		 4upmA-3hzpA:
14.18
4upmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4upnA-3hzpA:
undetectable
4upnB-3hzpA:
undetectable		 4upnA-3hzpA:
14.18
4upnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 4upnA-3hzpA:
undetectable
4upnB-3hzpA:
undetectable		 4upnA-3hzpA:
14.18
4upnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 4upoA-3hzpA:
undetectable
4upoB-3hzpA:
undetectable		 4upoA-3hzpA:
14.18
4upoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.47A 4v3uA-3hzpA:
undetectable
4v3uB-3hzpA:
undetectable		 4v3uA-3hzpA:
13.88
4v3uB-3hzpA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 4v3vA-3hzpA:
undetectable
4v3vB-3hzpA:
undetectable		 4v3vA-3hzpA:
14.18
4v3vB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 4v3xA-3hzpA:
undetectable
4v3xB-3hzpA:
undetectable		 4v3xA-3hzpA:
14.18
4v3xB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3X_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 4v3xA-3hzpA:
undetectable
4v3xB-3hzpA:
undetectable		 4v3xA-3hzpA:
14.18
4v3xB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 4v3yA-3hzpA:
undetectable
4v3yB-3hzpA:
undetectable		 4v3yA-3hzpA:
14.18
4v3yB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 5 GLY A 124
TYR A  94
GLU A  82
ASP A 119
 1PE  A 205 ( 4.7A)
1PE  A 205 (-4.0A)
None
None
 1.31A 4xueA-5uc0A:
undetectable		 4xueA-5uc0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3kb6 D-LACTATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 LEU A  67
ILE A  78
VAL A  48
VAL A  32
LEU A  58
 None
None
None
None
1PE  A 700 (-4.4A)
 1.07A 4y0qA-3kb6A:
undetectable		 4y0qA-3kb6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4aj9 CATALASE-3
(Neurospora
crassa) 		4 / 6 PHE A 338
GLY A 324
TYR A 323
ALA A 322
 1PE  A1721 ( 4.5A)
None
None
None
 1.09A 4yshB-4aj9A:
undetectable		 4yshB-4aj9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 9 ARG A 447
LEU A 508
ILE A 506
SER A 493
ALA A 470
 None
1PE  A   2 (-4.7A)
None
None
None
 1.45A 4z69A-3fo5A:
undetectable		 4z69A-3fo5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 10 ARG A 447
LEU A 508
ILE A 506
SER A 493
ALA A 470
 None
1PE  A   2 (-4.7A)
None
None
None
 1.42A 4z69I-3fo5A:
undetectable		 4z69I-3fo5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 7 THR A 231
LEU A 232
THR A 286
LEU A 290
 None
1PE  A 401 ( 4.9A)
None
1PE  A 401 (-4.4A)
 0.95A 4z91F-5w95A:
undetectable
4z91G-5w95A:
undetectable
4z91H-5w95A:
undetectable
4z91I-5w95A:
undetectable
4z91J-5w95A:
undetectable		 4z91F-5w95A:
12.30
4z91G-5w95A:
12.30
4z91H-5w95A:
12.30
4z91I-5w95A:
12.30
4z91J-5w95A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZUD_A_OLMA1201_1
(CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR)		 3m62 UBIQUITIN
CONJUGATION FACTOR
E4
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 490
SER A 477
LEU A 480
ARG A 554
ILE A 334
 1PE  A 962 ( 4.4A)
None
None
None
None
 1.47A 4zudA-3m62A:
2.7		 4zudA-3m62A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lew SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN
(Bacteroides
vulgatus) 		5 / 12 GLY A 101
GLY A 102
THR A 103
ASN A  59
ILE A  97
 None
None
None
1PE  A  12 (-3.9A)
None
 1.24A 4zvmA-3lewA:
undetectable
4zvmB-3lewA:
undetectable		 4zvmA-3lewA:
20.05
4zvmB-3lewA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 ILE A 149
ARG A 148
ILE A 280
GLU A 277
 None
None
None
1PE  A 410 (-4.1A)
 1.36A 4zzcA-2xrmA:
undetectable
4zzcB-2xrmA:
undetectable		 4zzcA-2xrmA:
20.36
4zzcB-2xrmA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2xrm INTRACELLULAR
SUBTILISIN PROTEASE
(Bacillus
clausii) 		4 / 6 ILE A 149
ARG A 148
ILE A 280
GLU A 277
 None
None
None
1PE  A 410 (-4.1A)
 1.32A 4zzcB-2xrmA:
undetectable
4zzcC-2xrmA:
undetectable		 4zzcB-2xrmA:
20.36
4zzcC-2xrmA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 4hyq PHOSPHOLIPASE A1
(Streptomyces
albidoflavus) 		4 / 7 SER A  13
TYR A  35
TYR A  12
PRO A 219
 None
None
1PE  A 301 (-4.8A)
None
 0.76A 5aclA-4hyqA:
undetectable		 5aclA-4hyqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 5ad4A-3hzpA:
undetectable
5ad4B-3hzpA:
undetectable		 5ad4A-3hzpA:
14.18
5ad4B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 5adaA-3hzpA:
undetectable
5adaB-3hzpA:
undetectable		 5adaA-3hzpA:
14.18
5adaB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 5adcA-3hzpA:
undetectable
5adcB-3hzpA:
undetectable		 5adcA-3hzpA:
14.18
5adcB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.41A 5adfA-3hzpA:
undetectable
5adfB-3hzpA:
undetectable		 5adfA-3hzpA:
13.98
5adfB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 5adgA-3hzpA:
undetectable
5adgB-3hzpA:
undetectable		 5adgA-3hzpA:
13.98
5adgB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.42A 5adlA-2g8yA:
1.0
5adlB-2g8yA:
1.9		 5adlA-2g8yA:
23.91
5adlB-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 5agkA-3hzpA:
undetectable
5agkB-3hzpA:
undetectable		 5agkA-3hzpA:
14.18
5agkB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 5aglA-3hzpA:
undetectable
5aglB-3hzpA:
undetectable		 5aglA-3hzpA:
14.18
5aglB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 5aglA-3hzpA:
undetectable
5aglB-3hzpA:
undetectable		 5aglA-3hzpA:
14.18
5aglB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 5agmA-3hzpA:
undetectable
5agmB-3hzpA:
undetectable		 5agmA-3hzpA:
14.18
5agmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 5agmA-3hzpA:
undetectable
5agmB-3hzpA:
undetectable		 5agmA-3hzpA:
14.18
5agmB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 5agnA-3hzpA:
undetectable
5agnB-3hzpA:
undetectable		 5agnA-3hzpA:
14.18
5agnB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.43A 5agoA-3hzpA:
undetectable
5agoB-3hzpA:
undetectable		 5agoA-3hzpA:
14.18
5agoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 5agoA-3hzpA:
undetectable
5agoB-3hzpA:
undetectable		 5agoA-3hzpA:
14.18
5agoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 5agpA-3hzpA:
undetectable
5agpB-3hzpA:
undetectable		 5agpA-3hzpA:
14.18
5agpB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 4 VAL A 287
ILE A 321
ASN A 304
VAL A  29
 None
None
1PE  A 405 (-3.6A)
None
 1.33A 5ajqA-5cdhA:
undetectable		 5ajqA-5cdhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		4 / 8 SER A 225
GLY A 222
ILE A 313
GLY A 134
 None
None
1PE  A1553 (-4.7A)
PGE  A1554 ( 4.7A)
 0.86A 5alcL-4be9A:
undetectable		 5alcL-4be9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.47A 5b1aN-4q6uA:
undetectable
5b1aP-4q6uA:
undetectable		 5b1aN-4q6uA:
21.76
5b1aP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 5b1bN-4q6uA:
undetectable
5b1bP-4q6uA:
undetectable		 5b1bN-4q6uA:
21.76
5b1bP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 5b3sN-4q6uA:
undetectable
5b3sP-4q6uA:
undetectable		 5b3sN-4q6uA:
21.76
5b3sP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A 672
TRP A 482
ASN A 297
 MCN  A 801 ( 3.2A)
1PE  A 803 ( 4.0A)
1PE  A 803 (-4.5A)
 0.98A 5dv4A-4zohA:
undetectable		 5dv4A-4zohA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ofq CYTOCHROME P450
(Bacillus
megaterium) 		3 / 3 ASP A 260
LEU A 369
ARG A 268
 1PE  A 502 ( 3.9A)
None
None
 0.77A 5e8qA-5ofqA:
undetectable		 5e8qA-5ofqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 156
ALA A 154
LEU A 153
LEU A 140
TRP A 105
 None
None
None
None
1PE  A 401 (-3.6A)
 1.16A 5eb5A-4q6uA:
undetectable		 5eb5A-4q6uA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.87A 5ec8C-5xg9B:
undetectable		 5ec8C-5xg9B:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EDL_A_VIBA201_1
(PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 TYR A 456
ILE A 490
SER A 530
TYR A 546
ARG A 449
 None
None
1PE  A   2 ( 4.3A)
1PE  A   2 (-4.0A)
1PE  A   2 (-2.8A)
 1.09A 5edlA-3fo5A:
undetectable		 5edlA-3fo5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EDL_A_VIBA201_1
(PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE)		 3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens) 		5 / 12 TYR A 456
VAL A 489
ILE A 490
TYR A 546
ARG A 449
 None
None
None
1PE  A   2 (-4.0A)
1PE  A   2 (-2.8A)
 1.24A 5edlA-3fo5A:
undetectable		 5edlA-3fo5A:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.65A 5fctA-4xscA:
40.5		 5fctA-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.85A 5fctA-4xscA:
40.5		 5fctA-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ILE A  96
TRP A  97
LEU A 180
GLY A 210
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
 0.85A 5fctA-4xscA:
40.5		 5fctA-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 VAL A  67
PHE A  68
ILE A  96
CYH A 183
LEU A 209
TYR A 246
 None
None
1PE  A1002 (-4.6A)
BVP  A1001 (-3.4A)
None
BVP  A1001 (-4.5A)
 0.75A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 VAL A  67
PHE A  68
ILE A  96
LEU A 180
LEU A 209
TYR A 246
 None
None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-4.5A)
 0.80A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 VAL A  67
PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
 None
None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
 0.81A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.44A 5fj3A-2g8yA:
undetectable
5fj3B-2g8yA:
1.3		 5fj3A-2g8yA:
23.91
5fj3B-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 GLU A 328
PHE A 350
GLY A 349
THR A 433
 None
1PE  A 994 ( 4.2A)
None
None
 0.86A 5flcB-3etcA:
undetectable		 5flcB-3etcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3etc AMP-BINDING PROTEIN
(Methanosarcina
acetivorans) 		4 / 8 GLU A 328
PHE A 350
GLY A 349
THR A 433
 None
1PE  A 994 ( 4.2A)
None
None
 0.87A 5flcF-3etcA:
undetectable		 5flcF-3etcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		4 / 7 ILE A 194
THR A 228
ILE A 229
SER A 232
 None
None
None
1PE  A 402 (-3.4A)
 0.76A 5fukA-5cdhA:
undetectable
5fukB-5cdhA:
undetectable		 5fukA-5cdhA:
21.35
5fukB-5cdhA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 5fvqA-3hzpA:
undetectable
5fvqB-3hzpA:
undetectable		 5fvqA-3hzpA:
14.18
5fvqB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 5fvsA-3hzpA:
undetectable
5fvsB-3hzpA:
undetectable		 5fvsA-3hzpA:
14.18
5fvsB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 5fvsA-3hzpA:
undetectable
5fvsB-3hzpA:
undetectable		 5fvsA-3hzpA:
14.18
5fvsB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 5fvtA-3hzpA:
undetectable
5fvtB-3hzpA:
undetectable		 5fvtA-3hzpA:
14.18
5fvtB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 5fvtA-3hzpA:
undetectable
5fvtB-3hzpA:
undetectable		 5fvtA-3hzpA:
14.18
5fvtB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.34A 5fvvA-3hzpA:
undetectable
5fvvB-3hzpA:
undetectable		 5fvvA-3hzpA:
13.98
5fvvB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.42A 5fvvA-3hzpA:
undetectable
5fvvB-3hzpA:
undetectable		 5fvvA-3hzpA:
13.98
5fvvB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 5fvwA-3hzpA:
undetectable
5fvwB-3hzpA:
undetectable		 5fvwA-3hzpA:
13.98
5fvwB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 5fvwA-3hzpA:
undetectable
5fvwB-3hzpA:
undetectable		 5fvwA-3hzpA:
13.98
5fvwB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 5fvxA-3hzpA:
undetectable
5fvxB-3hzpA:
undetectable		 5fvxA-3hzpA:
13.98
5fvxB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 5fw0A-3hzpA:
undetectable
5fw0B-3hzpA:
undetectable		 5fw0A-3hzpA:
14.18
5fw0B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.38A 5g0nA-3hzpA:
undetectable
5g0nB-3hzpA:
undetectable		 5g0nA-3hzpA:
14.89
5g0nB-3hzpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 5g0nA-3hzpA:
undetectable
5g0nB-3hzpA:
undetectable		 5g0nA-3hzpA:
14.89
5g0nB-3hzpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 5g0oA-3hzpA:
undetectable
5g0oB-3hzpA:
undetectable		 5g0oA-3hzpA:
14.89
5g0oB-3hzpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 5g0oA-3hzpA:
undetectable
5g0oB-3hzpA:
undetectable		 5g0oA-3hzpA:
14.89
5g0oB-3hzpA:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.40A 5h3aA-4xscA:
39.9		 5h3aA-4xscA:
57.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.44A 5h3aB-4xscA:
39.9		 5h3aB-4xscA:
57.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5t77 PUTATIVE LIPID II
FLIPPASE MURJ
(Thermosipho
africanus) 		4 / 5 GLY A 345
PRO A 413
THR A 349
THR A 298
 None
1PE  A 512 ( 4.3A)
None
None
 1.10A 5h5fA-5t77A:
undetectable		 5h5fA-5t77A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 333
GLY A 216
SER A 330
GLY A 669
SER A 484
 None
MO  A 802 ( 3.9A)
1PE  A 803 ( 4.8A)
MCN  A 801 (-3.2A)
MCN  A 801 (-4.1A)
 1.24A 5hikA-4zohA:
undetectable		 5hikA-4zohA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_1
(METTL3)		 4h41 PUTATIVE
ALPHA-L-FUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 4 ASP A  66
HIS A  70
ASN A 299
GLN A 269
 None
1PE  A 406 ( 2.7A)
UNL  A 401 ( 3.6A)
UNL  A 401 ( 3.7A)
 1.48A 5il1A-4h41A:
0.0		 5il1A-4h41A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 5iy5A-4q6uA:
undetectable
5iy5C-4q6uA:
undetectable		 5iy5A-4q6uA:
21.76
5iy5C-4q6uA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
 0.60A 5j7wC-4xscA:
36.5		 5j7wC-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.79A 5j7wD-4xscA:
36.5		 5j7wD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.88A 5j7wD-4xscA:
36.5		 5j7wD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ini HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 8 GLN A  84
ASN A 136
ALA A 142
GLN A 143
SER A 144
HIS A 151
 1PE  A 202 ( 4.2A)
AMP  A 201 (-3.8A)
1PE  A 202 ( 4.0A)
None
AMP  A 201 ( 2.6A)
AMP  A 201 (-4.1A)
 0.25A 5km8A-4iniA:
21.1
5km8B-4iniA:
20.1		 5km8A-4iniA:
91.55
5km8B-4iniA:
91.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 12 THR A 426
GLY A 253
ILE A 549
ASP A 228
LEU A 318
 1PE  A1553 (-3.7A)
None
1PE  A1553 ( 3.7A)
None
None
 0.93A 5l0zA-4be9A:
undetectable		 5l0zA-4be9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_B_6ZPB902_1
(GLUTAMATE RECEPTOR 2)		 5cdh MAJOR ACID
PHOSPHATASE
(Legionella
pneumophila) 		5 / 9 ASP A 281
PRO A 299
TYR A 323
LEU A 295
SER A 251
 1PE  A 403 ( 2.6A)
None
None
None
None
 1.48A 5l1fB-5cdhA:
2.6		 5l1fB-5cdhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4e13 DIKETOREDUCTASE
(Acinetobacter
baylyi) 		3 / 3 SER A 248
SER A 251
PHE A 236
 1PE  A 306 (-3.1A)
1PE  A 306 ( 4.9A)
None
 0.90A 5mugA-4e13A:
undetectable		 5mugA-4e13A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.91A 5n0sA-1s7gA:
undetectable		 5n0sA-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.92A 5n0sB-1s7gA:
0.6		 5n0sB-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.95A 5n0tA-1s7gA:
3.2		 5n0tA-1s7gA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.95A 5n0wB-1s7gA:
3.5		 5n0wB-1s7gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1s7g NAD-DEPENDENT
DEACETYLASE 2
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 189
PHE A  21
VAL A  20
ILE A  32
ALA A  28
 None
None
None
1PE  A 504 ( 4.7A)
NAD  A 703 ( 3.7A)
 0.95A 5n4iA-1s7gA:
3.6		 5n4iA-1s7gA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.86A 5njvD-5xg9B:
undetectable		 5njvD-5xg9B:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.31A 5nooA-4xscA:
39.4		 5nooA-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.37A 5nooB-4xscA:
39.2		 5nooB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 6 ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.69A 5nooC-4xscA:
38.9		 5nooC-4xscA:
56.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 181
SER A 183
VAL A 206
TRP A 482
ALA A 188
 None
None
None
1PE  A 803 ( 4.0A)
None
 1.35A 5tzoA-4zohA:
undetectable		 5tzoA-4zohA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 181
SER A 183
VAL A 206
TRP A 482
ALA A 188
 None
None
None
1PE  A 803 ( 4.0A)
None
 1.31A 5tzoC-4zohA:
undetectable		 5tzoC-4zohA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 6 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.36A 5unrA-3hzpA:
0.0
5unrB-3hzpA:
0.0		 5unrA-3hzpA:
14.18
5unrB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 5unrA-3hzpA:
undetectable
5unrB-3hzpA:
undetectable		 5unrA-3hzpA:
14.18
5unrB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.41A 5untA-3hzpA:
undetectable
5untB-3hzpA:
undetectable		 5untA-3hzpA:
14.18
5untB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 5unwA-3hzpA:
undetectable
5unwB-3hzpA:
undetectable		 5unwA-3hzpA:
14.18
5unwB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 5unyA-3hzpA:
undetectable
5unyB-3hzpA:
undetectable		 5unyA-3hzpA:
14.18
5unyB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 5unyA-3hzpA:
undetectable
5unyB-3hzpA:
undetectable		 5unyA-3hzpA:
14.18
5unyB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.44A 5unzA-3hzpA:
undetectable
5unzB-3hzpA:
undetectable		 5unzA-3hzpA:
14.18
5unzB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.48A 5uo0A-3hzpA:
undetectable
5uo0B-3hzpA:
undetectable		 5uo0A-3hzpA:
14.18
5uo0B-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.42A 5uo1A-3hzpA:
undetectable
5uo1B-3hzpA:
undetectable		 5uo1A-3hzpA:
13.98
5uo1B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 5uo4A-3hzpA:
undetectable
5uo4B-3hzpA:
undetectable		 5uo4A-3hzpA:
13.98
5uo4B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 5uo5A-3hzpA:
undetectable
5uo5B-3hzpA:
undetectable		 5uo5A-3hzpA:
13.98
5uo5B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1q0z ACLACINOMYCIN
METHYLESTERASE
(Streptomyces
purpurascens) 		5 / 12 LEU A 101
PHE A 193
ALA A 251
ILE A 185
GLY A 188
 1PE  A2712 (-4.8A)
None
AKA  A 600 ( 3.8A)
None
None
 0.88A 5veuB-1q0zA:
undetectable		 5veuB-1q0zA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.47A 5vuiA-3hzpA:
undetectable
5vuiB-3hzpA:
undetectable		 5vuiA-3hzpA:
14.18
5vuiB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.44A 5vujA-3hzpA:
undetectable
5vujB-3hzpA:
undetectable		 5vujA-3hzpA:
14.18
5vujB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.42A 5vukA-3hzpA:
undetectable
5vukB-3hzpA:
undetectable		 5vukA-3hzpA:
14.18
5vukB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.44A 5vukA-3hzpA:
undetectable
5vukB-3hzpA:
undetectable		 5vukA-3hzpA:
14.18
5vukB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.48A 5vumA-3hzpA:
undetectable
5vumB-3hzpA:
undetectable		 5vumA-3hzpA:
14.18
5vumB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 5vumA-3hzpA:
undetectable
5vumB-3hzpA:
undetectable		 5vumA-3hzpA:
14.18
5vumB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 5vunA-3hzpA:
undetectable
5vunB-3hzpA:
undetectable		 5vunA-3hzpA:
14.18
5vunB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 5vunA-3hzpA:
undetectable
5vunB-3hzpA:
undetectable		 5vunA-3hzpA:
14.18
5vunB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.36A 5vuoA-3hzpA:
undetectable
5vuoB-3hzpA:
undetectable		 5vuoA-3hzpA:
14.18
5vuoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 5vuoA-3hzpA:
undetectable
5vuoB-3hzpA:
undetectable		 5vuoA-3hzpA:
14.18
5vuoB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 5vupA-3hzpA:
undetectable
5vupB-3hzpA:
undetectable		 5vupA-3hzpA:
14.18
5vupB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.49A 5vupA-3hzpA:
undetectable
5vupB-3hzpA:
undetectable		 5vupA-3hzpA:
14.18
5vupB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 5vuqA-3hzpA:
undetectable
5vuqB-3hzpA:
undetectable		 5vuqA-3hzpA:
14.18
5vuqB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 5vuqA-3hzpA:
undetectable
5vuqB-3hzpA:
undetectable		 5vuqA-3hzpA:
14.18
5vuqB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 6 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 5vurA-3hzpA:
0.0
5vurB-3hzpA:
0.0		 5vurA-3hzpA:
14.18
5vurB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 5vurA-3hzpA:
undetectable
5vurB-3hzpA:
undetectable		 5vurA-3hzpA:
14.18
5vurB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 5vusA-3hzpA:
undetectable
5vusB-3hzpA:
undetectable		 5vusA-3hzpA:
14.18
5vusB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.40A 5vusA-3hzpA:
undetectable
5vusB-3hzpA:
undetectable		 5vusA-3hzpA:
14.18
5vusB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 5vutA-3hzpA:
undetectable
5vutB-3hzpA:
undetectable		 5vutA-3hzpA:
14.18
5vutB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.36A 5vutA-3hzpA:
undetectable
5vutB-3hzpA:
undetectable		 5vutA-3hzpA:
14.18
5vutB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.43A 5vuuA-3hzpA:
undetectable
5vuuB-3hzpA:
undetectable		 5vuuA-3hzpA:
14.18
5vuuB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 5vuuA-3hzpA:
undetectable
5vuuB-3hzpA:
undetectable		 5vuuA-3hzpA:
14.18
5vuuB-3hzpA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.43A 5vuvA-3hzpA:
undetectable
5vuvB-3hzpA:
undetectable		 5vuvA-3hzpA:
13.98
5vuvB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.38A 5vuwA-3hzpA:
undetectable
5vuwB-3hzpA:
undetectable		 5vuwA-3hzpA:
13.98
5vuwB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 5vuwA-3hzpA:
undetectable
5vuwB-3hzpA:
undetectable		 5vuwA-3hzpA:
13.98
5vuwB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 5vuxA-3hzpA:
undetectable
5vuxB-3hzpA:
undetectable		 5vuxA-3hzpA:
13.98
5vuxB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.39A 5vuzA-3hzpA:
undetectable
5vuzB-3hzpA:
undetectable		 5vuzA-3hzpA:
13.98
5vuzB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 5vuzA-3hzpA:
undetectable
5vuzB-3hzpA:
undetectable		 5vuzA-3hzpA:
13.98
5vuzB-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.38A 5vv2A-3hzpA:
undetectable
5vv2B-3hzpA:
undetectable		 5vv2A-3hzpA:
13.98
5vv2B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 5vv2A-3hzpA:
undetectable
5vv2B-3hzpA:
undetectable		 5vv2A-3hzpA:
13.98
5vv2B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 6 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.41A 5vv4A-3hzpA:
0.0
5vv4B-3hzpA:
0.0		 5vv4A-3hzpA:
13.98
5vv4B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.49A 5vv5A-3hzpA:
undetectable
5vv5B-3hzpA:
undetectable		 5vv5A-3hzpA:
13.98
5vv5B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.43A 5vv5A-3hzpA:
undetectable
5vv5B-3hzpA:
undetectable		 5vv5A-3hzpA:
13.98
5vv5B-3hzpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 PHE A  89
SER A  59
VAL A  57
TRP A  60
 None
None
None
1PE  A1021 (-4.1A)
 1.38A 5vv7A-2g8yA:
1.3
5vv7B-2g8yA:
1.3		 5vv7A-2g8yA:
23.91
5vv7B-2g8yA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.36A 5w97J-5aovA:
undetectable		 5w97J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.31A 5wauJ-5aovA:
undetectable		 5wauJ-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		4 / 7 PHE A  83
TYR A  56
THR A  54
VAL A 121
 None
None
1PE  A 179 ( 4.7A)
None
 1.03A 5wk9A-3bx8A:
undetectable		 5wk9A-3bx8A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.97A 5wz1G-5xg9B:
undetectable		 5wz1G-5xg9B:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 5xg9 UNCONVENTIONAL
MYOSIN IB
(Entamoeba
histolytica) 		5 / 12 GLY B  35
GLY B  39
TRP B  37
GLU B  18
ILE B  27
 1PE  B 101 (-4.1A)
None
None
PEU  B 102 (-4.4A)
None
 0.95A 5wz1H-5xg9B:
undetectable		 5wz1H-5xg9B:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.33A 5x19J-5aovA:
undetectable		 5x19J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.47A 5x19N-4q6uA:
undetectable
5x19P-4q6uA:
undetectable		 5x19N-4q6uA:
21.76
5x19P-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 5x1bN-4q6uA:
undetectable
5x1bP-4q6uA:
undetectable		 5x1bN-4q6uA:
21.76
5x1bP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.30A 5x1bW-5aovA:
undetectable		 5x1bW-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.31A 5x1fW-5aovA:
undetectable		 5x1fW-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5w95 CONSERVED MEMBRANE
PROTEIN OF
UNCHARACTERISED
FUNCTION
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 210
MET A 245
THR A 244
LEU A 243
 None
1PE  A 401 ( 4.3A)
None
None
 1.36A 5x1fW-5w95A:
undetectable		 5x1fW-5w95A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.62A 5x5qB-4xscA:
40.6		 5x5qB-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.78A 5x5qB-4xscA:
40.6		 5x5qB-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.47A 5x5qC-4xscA:
41.0		 5x5qC-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 8 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.47A 5x5qD-4xscA:
41.0		 5x5qD-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 8 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.49A 5x5qF-4xscA:
41.5		 5x5qF-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.50A 5x66A-4xscA:
40.9
5x66B-4xscA:
9.9		 5x66A-4xscA:
69.66
5x66B-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.39A 5x66C-4xscA:
40.9		 5x66C-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.47A 5x66D-4xscA:
41.2		 5x66D-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.48A 5x66F-4xscA:
41.2		 5x66F-4xscA:
69.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 LYS A 379
LEU A 383
ARG A 380
 1PE  A2007 (-2.7A)
None
None
 0.82A 5yw0A-5kf7A:
undetectable		 5yw0A-5kf7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 MET A  75
ASP A 114
ARG A 109
 None
1PE  A 401 (-3.2A)
None
 0.91A 5z6jA-4q6uA:
undetectable		 5z6jA-4q6uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 MET A  75
ASP A 114
ARG A 109
 None
1PE  A 401 (-3.2A)
None
 0.84A 5z6kA-4q6uA:
undetectable		 5z6kA-4q6uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.35A 5z86J-5aovA:
undetectable		 5z86J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.48A 5zcqN-4q6uA:
undetectable
5zcqP-4q6uA:
undetectable		 5zcqN-4q6uA:
21.76
5zcqP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3bx8 ENGINEERED HUMAN
LIPOCALIN 2
(Homo
sapiens) 		5 / 12 VAL A 120
VAL A  33
GLY A  35
PHE A 123
VAL A 108
 None
None
None
1PE  A 179 (-3.8A)
None
 1.20A 6a94B-3bx8A:
undetectable		 6a94B-3bx8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 6aurA-3hzpA:
undetectable
6aurB-3hzpA:
undetectable		 6aurA-3hzpA:
17.69
6aurB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.44A 6ausA-3hzpA:
undetectable
6ausB-3hzpA:
undetectable		 6ausA-3hzpA:
17.69
6ausB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.37A 6ausA-3hzpA:
undetectable
6ausB-3hzpA:
undetectable		 6ausA-3hzpA:
17.69
6ausB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.45A 6autA-3hzpA:
undetectable
6autB-3hzpA:
undetectable		 6autA-3hzpA:
17.69
6autB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.47A 6autA-3hzpA:
undetectable
6autB-3hzpA:
undetectable		 6autA-3hzpA:
17.69
6autB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.33A 6auvA-3hzpA:
undetectable
6auvB-3hzpA:
undetectable		 6auvA-3hzpA:
17.69
6auvB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.39A 6auvA-3hzpA:
undetectable
6auvB-3hzpA:
undetectable		 6auvA-3hzpA:
17.69
6auvB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.35A 6auwA-3hzpA:
undetectable
6auwB-3hzpA:
undetectable		 6auwA-3hzpA:
17.69
6auwB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 6auwA-3hzpA:
undetectable
6auwB-3hzpA:
undetectable		 6auwA-3hzpA:
17.69
6auwB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.38A 6auxA-3hzpA:
undetectable
6auxB-3hzpA:
undetectable		 6auxA-3hzpA:
17.69
6auxB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.38A 6auxA-3hzpA:
undetectable
6auxB-3hzpA:
undetectable		 6auxA-3hzpA:
17.69
6auxB-3hzpA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.41A 6auyA-3hzpA:
undetectable
6auyB-3hzpA:
undetectable		 6auyA-3hzpA:
21.43
6auyB-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.42A 6auzA-3hzpA:
undetectable
6auzB-3hzpA:
undetectable		 6auzA-3hzpA:
21.43
6auzB-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.37A 6av0A-3hzpA:
undetectable
6av0B-3hzpA:
undetectable		 6av0A-3hzpA:
21.43
6av0B-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.41A 6av1A-3hzpA:
undetectable
6av1B-3hzpA:
undetectable		 6av1A-3hzpA:
21.43
6av1B-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.36A 6av2A-3hzpA:
undetectable
6av2B-3hzpA:
undetectable		 6av2A-3hzpA:
21.43
6av2B-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.35A 6av3A-3hzpA:
undetectable
6av3B-3hzpA:
undetectable		 6av3A-3hzpA:
21.43
6av3B-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.35A 6av4A-3hzpA:
undetectable
6av4B-3hzpA:
undetectable		 6av4A-3hzpA:
21.43
6av4B-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.42A 6av5A-3hzpA:
undetectable
6av5B-3hzpA:
undetectable		 6av5A-3hzpA:
21.43
6av5B-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2g8y MALATE/L-LACTATE
DEHYDROGENASES
(Escherichia
coli) 		4 / 7 SER A  59
VAL A  57
TRP A  60
PHE A  89
 None
None
1PE  A1021 (-4.1A)
None
 1.41A 6av7A-2g8yA:
undetectable
6av7B-2g8yA:
0.0		 6av7A-2g8yA:
14.57
6av7B-2g8yA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.43A 6cicA-3hzpA:
undetectable
6cicB-3hzpA:
undetectable		 6cicA-3hzpA:
21.43
6cicB-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.42A 6cicA-3hzpA:
undetectable
6cicB-3hzpA:
undetectable		 6cicA-3hzpA:
21.43
6cicB-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 MET A  20
ARG A 118
TRP A  51
PHE A  34
 1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
1PE  A 131 (-4.5A)
 1.46A 6cidA-3hzpA:
undetectable
6cidB-3hzpA:
undetectable		 6cidA-3hzpA:
21.43
6cidB-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3hzp NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION
(Prochlorococcus
marinus) 		4 / 7 PHE A  34
MET A  20
ARG A 118
TRP A  51
 1PE  A 131 (-4.5A)
1PE  A 131 ( 3.8A)
1PE  A 131 (-3.7A)
None
 1.47A 6cidA-3hzpA:
undetectable
6cidB-3hzpA:
undetectable		 6cidA-3hzpA:
21.43
6cidB-3hzpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4aj9 CATALASE-3
(Neurospora
crassa) 		5 / 10 GLY A 648
VAL A 634
VAL A 627
ALA A 673
LEU A 574
 1PE  A1723 ( 4.1A)
None
None
None
None
 1.16A 6czmA-4aj9A:
undetectable
6czmC-4aj9A:
undetectable		 6czmA-4aj9A:
20.93
6czmC-4aj9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4uop LIPOTEICHOIC ACID
PRIMASE
(Listeria
monocytogenes) 		4 / 7 ILE A 534
LEU A 535
VAL A 449
LEU A 492
 None
1PE  A1611 ( 4.7A)
None
None
 0.74A 6g9bA-4uopA:
undetectable
6g9bB-4uopA:
undetectable		 6g9bA-4uopA:
12.54
6g9bB-4uopA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 6eub ANGIOPOIETIN-RELATED
PROTEIN 4
(Homo
sapiens) 		4 / 5 THR A 393
THR A 382
HIS A 356
GLY A 377
 None
None
1PE  A 501 ( 4.3A)
None
 1.21A 6gbnC-6eubA:
undetectable		 6gbnC-6eubA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 9 THR A 426
GLY A 423
GLY A 353
VAL A 358
GLU A 219
 1PE  A1553 (-3.7A)
None
None
None
None
 1.45A 6gnfA-4be9A:
2.9		 6gnfA-4be9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN
(Agrobacterium
fabrum) 		5 / 11 TYR A  39
ASP A 187
THR A 188
THR A 168
GLY A 167
 6DB  A 304 (-3.9A)
None
None
6DB  A 304 ( 4.1A)
1PE  A 303 (-3.9A)
 1.32A 6mb5A-5itoA:
undetectable		 6mb5A-5itoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN
(Agrobacterium
fabrum) 		5 / 10 TYR A  39
ASP A 187
THR A 188
THR A 168
GLY A 167
 6DB  A 304 (-3.9A)
None
None
6DB  A 304 ( 4.1A)
1PE  A 303 (-3.9A)
 1.34A 6mb9C-5itoA:
undetectable		 6mb9C-5itoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 5ito NOPALINE-BINDING
PERIPLASMIC PROTEIN
(Agrobacterium
fabrum) 		5 / 10 TYR A  39
ASP A 187
THR A 188
THR A 168
GLY A 167
 6DB  A 304 (-3.9A)
None
None
6DB  A 304 ( 4.1A)
1PE  A 303 (-3.9A)
 1.35A 6mb9D-5itoA:
undetectable		 6mb9D-5itoA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.47A 6nknA-4q6uA:
undetectable
6nknC-4q6uA:
undetectable		 6nknA-4q6uA:
21.76
6nknC-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.38A 6nknJ-5aovA:
undetectable		 6nknJ-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.49A 6nmfN-4q6uA:
undetectable
6nmfP-4q6uA:
undetectable		 6nmfN-4q6uA:
21.76
6nmfP-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4q6u UNCHARACTERIZED
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ASP A 114
THR A 113
TYR A 132
HIS A 198
 1PE  A 401 (-3.2A)
None
None
None
 1.45A 6nmpA-4q6uA:
undetectable
6nmpC-4q6uA:
undetectable		 6nmpA-4q6uA:
21.76
6nmpC-4q6uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 11 GLY A 135
SER A 220
SER A 312
PHE A 427
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
1PE  A1553 (-4.7A)
None
 0.98A 6qgbA-4be9A:
1.8		 6qgbA-4be9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 10 GLY A 135
SER A 220
SER A 312
PHE A 427
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
1PE  A1553 (-4.7A)
None
 0.98A 6qgbB-4be9A:
10.2		 6qgbB-4be9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_C_BEZC701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 9 GLY A 135
SER A 220
SER A 312
PHE A 427
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
1PE  A1553 (-4.7A)
None
 0.99A 6qgbC-4be9A:
3.7		 6qgbC-4be9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 10 GLY A 135
SER A 220
SER A 312
PHE A 427
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
1PE  A1553 (-4.7A)
None
 0.99A 6qgbD-4be9A:
3.2		 6qgbD-4be9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 11 GLY A 135
SER A 220
SER A 312
PHE A 427
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
1PE  A1553 (-4.7A)
None
 0.97A 6qgbE-4be9A:
10.8		 6qgbE-4be9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4be9 STEROL ESTERASE
(Ophiostoma
piceae) 		5 / 10 GLY A 135
SER A 220
SER A 312
PHE A 427
HIS A 465
 1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
1PE  A1553 (-4.7A)
None
 0.96A 6qgbF-4be9A:
8.4		 6qgbF-4be9A:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.29A 6qxsB-4xscA:
34.5		 6qxsB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.82A 6qxsB-4xscA:
34.5		 6qxsB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.66A 6qxsB-4xscA:
34.5		 6qxsB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.55A 6qxsD-4xscA:
34.5		 6qxsD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
 0.55A 6qyaB-4xscA:
34.1		 6qyaB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.51A 6qyaD-4xscA:
34.1		 6qyaD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.59A 6qyaD-4xscA:
34.1		 6qyaD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.14A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 1.31A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
TRP A  97
LEU A 180
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.88A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.95A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.94A 6r2eB-4xscA:
40.0		 6r2eB-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 10 PHE A  68
ILE A  96
TRP A  97
LEU A 180
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.88A 6r2eC-4xscA:
39.9		 6r2eC-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 10 PHE A  68
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.99A 6r2eC-4xscA:
39.9		 6r2eC-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.87A 6r2eD-4xscA:
40.2		 6r2eD-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 1.32A 6r2eE-4xscA:
39.7		 6r2eE-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
TRP A  97
TYR A 123
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.92A 6r2eE-4xscA:
39.7		 6r2eE-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.89A 6r2eF-4xscA:
39.9		 6r2eF-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 1.32A 6r2eG-4xscA:
39.7		 6r2eG-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.94A 6r2eG-4xscA:
39.7		 6r2eG-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
TRP A  97
TYR A 123
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.95A 6r2eH-4xscA:
39.9		 6r2eH-4xscA:
65.94