SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CU1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 8 HIS C 104
HIS C  79
HIS C 113
HIS C 160
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.1A)
ZN  C 201 (-3.2A)
CU1  C 200 (-3.2A)
 1.06A 1azmA-2aqtC:
undetectable		 1azmA-2aqtC:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 8 HIS C 104
HIS C  79
HIS C 113
HIS C 160
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.1A)
ZN  C 201 (-3.2A)
CU1  C 200 (-3.2A)
 0.93A 1bzmA-2aqtC:
undetectable		 1bzmA-2aqtC:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 11 PRO A 414
HIS A  81
HIS A 126
HIS A  83
ASP A 458
 None
CU1  A1004 (-3.3A)
CU1  A1003 (-3.2A)
CU1  A1003 ( 3.0A)
None
 1.45A 1c3sA-1zpuA:
undetectable		 1c3sA-1zpuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		5 / 12 HIS A  78
GLU A  47
ASP A  81
GLY A  60
HIS A  46
 ZN  A 203 (-3.1A)
SO4  A 209 (-3.4A)
ZN  A 203 (-2.2A)
None
CU1  A 201 ( 3.1A)
 1.28A 1d4fC-3f7lA:
undetectable		 1d4fC-3f7lA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 6ek9 -
(-) 		4 / 6 GLN A  36
CYH A 117
VAL A 116
CYH A  41
 None
CU1  A 207 ( 2.2A)
None
CU1  A 205 (-2.1A)
 1.38A 1ekjG-6ek9A:
undetectable
1ekjH-6ek9A:
undetectable		 1ekjG-6ek9A:
undetectable
1ekjH-6ek9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 485
HIS A 483
HIS A 418
HIS A  81
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 (-3.2A)
 1.31A 1fweC-1zpuA:
undetectable		 1fweC-1zpuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		4 / 5 PHE A 196
GLY A  69
SER A 193
THR A 192
 CU1  A 300 (-4.8A)
None
None
EDO  A1206 ( 3.0A)
 1.31A 1icvA-2yoyA:
undetectable
1icvB-2yoyA:
undetectable		 1icvA-2yoyA:
22.62
1icvB-2yoyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 12 HIS C  81
ALA C 101
GLY C 103
GLU C  87
PRO C  88
 CU1  C 200 (-3.3A)
None
None
None
None
 1.31A 1mj2A-2aqtC:
undetectable
1mj2B-2aqtC:
undetectable		 1mj2A-2aqtC:
20.00
1mj2B-2aqtC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.32A 1mj2B-4ouaB:
undetectable		 1mj2B-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.33A 1mj2B-4ouaA:
undetectable		 1mj2B-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.33A 1mj2D-4ouaB:
undetectable		 1mj2D-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.35A 1mj2D-4ouaA:
undetectable		 1mj2D-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 12 HIS C  81
ALA C 101
GLY C 103
GLU C  87
PRO C  88
 CU1  C 200 (-3.3A)
None
None
None
None
 1.28A 1mj2C-2aqtC:
undetectable
1mj2D-2aqtC:
undetectable		 1mj2C-2aqtC:
20.00
1mj2D-2aqtC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.31A 1mjoB-4ouaB:
undetectable		 1mjoB-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.32A 1mjoB-4ouaA:
undetectable		 1mjoB-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.37A 1mjoA-4ouaB:
undetectable		 1mjoA-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.37A 1mjoA-4ouaA:
undetectable		 1mjoA-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 12 HIS C  81
ALA C 101
GLY C 103
GLU C  87
PRO C  88
 CU1  C 200 (-3.3A)
None
None
None
None
 1.29A 1mjoC-2aqtC:
undetectable
1mjoD-2aqtC:
undetectable		 1mjoC-2aqtC:
20.00
1mjoD-2aqtC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
ALA B 270
PHE B 272
GLY B  58
 CU1  B 601 (-3.1A)
None
None
NA  B 603 (-4.5A)
 1.31A 1mjoD-4ouaB:
undetectable		 1mjoD-4ouaB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
ALA A 270
PHE A 272
GLY A  58
 CU1  A 401 (-3.2A)
None
None
NA  A 403 (-4.4A)
 1.33A 1mjoD-4ouaA:
undetectable		 1mjoD-4ouaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 11 GLU C  87
PRO C  88
HIS C  81
ALA C 101
GLY C 103
 None
None
CU1  C 200 (-3.3A)
None
None
 1.27A 1mjqA-2aqtC:
undetectable
1mjqB-2aqtC:
undetectable		 1mjqA-2aqtC:
20.00
1mjqB-2aqtC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 HIS A 334
PHE A 281
GLY A 283
ALA A 332
HIS A 333
 CU1  A   5 (-3.1A)
None
None
None
HEA  A   2 ( 3.3A)
 1.11A 1mjqC-3omnA:
undetectable
1mjqD-3omnA:
undetectable		 1mjqC-3omnA:
10.67
1mjqD-3omnA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 11 GLU C  87
PRO C  88
HIS C  81
ALA C 101
GLY C 103
 None
None
CU1  C 200 (-3.3A)
None
None
 1.31A 1mjqI-2aqtC:
undetectable
1mjqJ-2aqtC:
undetectable		 1mjqI-2aqtC:
20.00
1mjqJ-2aqtC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 12 HIS A 334
PHE A 281
GLY A 283
ALA A 332
HIS A 333
 CU1  A   5 (-3.1A)
None
None
None
HEA  A   2 ( 3.3A)
 1.10A 1mjqI-3omnA:
undetectable
1mjqJ-3omnA:
undetectable		 1mjqI-3omnA:
10.67
1mjqJ-3omnA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.56A 1oe1A-1b3iA:
3.8		 1oe1A-1b3iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.22A 1oe1A-1f56A:
2.3		 1oe1A-1f56A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.40A 1oe1A-2ft7A:
3.6		 1oe1A-2ft7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.41A 1oe1A-2n0mA:
undetectable		 1oe1A-2n0mA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.46A 1oe1A-3cvdA:
undetectable		 1oe1A-3cvdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.39A 1oe1A-4dpcX:
undetectable		 1oe1A-4dpcX:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		5 / 5 HIS A  39
CYH A  82
PRO A  84
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
None
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.79A 1oe2A-1b3iA:
5.8		 1oe2A-1b3iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 5 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.22A 1oe2A-1f56A:
4.3		 1oe2A-1f56A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		5 / 5 HIS A  46
CYH A 112
PRO A 114
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 ( 4.5A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.82A 1oe2A-2ft7A:
7.2		 1oe2A-2ft7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.41A 1oe2A-2n0mA:
8.5		 1oe2A-2n0mA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		5 / 5 HIS A  39
CYH A  89
PRO A  91
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
None
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.81A 1oe2A-3cvdA:
6.0		 1oe2A-3cvdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		5 / 5 HIS X  37
CYH X  84
PRO X  86
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 ( 4.9A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.74A 1oe2A-4dpcX:
6.6		 1oe2A-4dpcX:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.58A 1oe3A-1b3iA:
3.3		 1oe3A-1b3iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.26A 1oe3A-1f56A:
2.3		 1oe3A-1f56A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.42A 1oe3A-2ft7A:
3.6		 1oe3A-2ft7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.45A 1oe3A-2n0mA:
5.3		 1oe3A-2n0mA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.47A 1oe3A-3cvdA:
2.8		 1oe3A-3cvdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.43A 1oe3A-4dpcX:
undetectable		 1oe3A-4dpcX:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 10 HIS A 282
VAL A 258
LEU A 205
LEU A 138
THR A 134
 CU1  A 402 (-3.0A)
None
None
None
None
 1.19A 1rj6B-4ouaA:
undetectable		 1rj6B-4ouaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.49A 1rjoA-2aqtC:
undetectable		 1rjoA-2aqtC:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.52A 1rjoA-3f7lA:
undetectable		 1rjoA-3f7lA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.66A 1rjoA-3omnA:
undetectable		 1rjoA-3omnA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.49A 1rjoA-4l05A:
undetectable		 1rjoA-4l05A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.61A 1rjoA-4ouaB:
undetectable		 1rjoA-4ouaB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.69A 1rjoA-4ouaA:
undetectable		 1rjoA-4ouaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.52A 1rjoA-5kbmA:
undetectable		 1rjoA-5kbmA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.51A 1rkyA-2aqtC:
undetectable		 1rkyA-2aqtC:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.52A 1rkyA-3f7lA:
undetectable		 1rkyA-3f7lA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.67A 1rkyA-3omnA:
undetectable		 1rkyA-3omnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.50A 1rkyA-4l05A:
undetectable		 1rkyA-4l05A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.65A 1rkyA-4ouaB:
undetectable		 1rkyA-4ouaB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.52A 1rkyA-5kbmA:
undetectable		 1rkyA-5kbmA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
GLU A 248
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
None
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 1.33A 1uttA-4ouaA:
undetectable		 1uttA-4ouaA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 1v54A-2aqtC:
undetectable		 1v54A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 1v54A-3f7lA:
undetectable		 1v54A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 1v54A-3omnA:
57.8		 1v54A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 1v54A-4l05A:
undetectable		 1v54A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 1v54A-5kbmA:
undetectable		 1v54A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 1v54N-2aqtC:
undetectable		 1v54N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 1v54N-3f7lA:
undetectable		 1v54N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 1v54N-3omnA:
57.8		 1v54N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 1v54N-4l05A:
undetectable		 1v54N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 1v54N-5kbmA:
undetectable		 1v54N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 1v55A-2aqtC:
undetectable		 1v55A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 1v55A-3f7lA:
undetectable		 1v55A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 1v55A-3omnA:
57.6		 1v55A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 1v55A-4l05A:
undetectable		 1v55A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 1v55A-5kbmA:
undetectable		 1v55A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.69A 1v55N-2aqtC:
undetectable		 1v55N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.69A 1v55N-3f7lA:
undetectable		 1v55N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 1v55N-3omnA:
57.5		 1v55N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.63A 1v55N-4l05A:
undetectable		 1v55N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.72A 1v55N-5kbmA:
undetectable		 1v55N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		5 / 12 HIS A  78
GLU A  47
ASP A  81
GLY A  60
HIS A  46
 ZN  A 203 (-3.1A)
SO4  A 209 (-3.4A)
ZN  A 203 (-2.2A)
None
CU1  A 201 ( 3.1A)
 1.26A 1v8bC-3f7lA:
undetectable		 1v8bC-3f7lA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.48A 1w2zA-2aqtC:
undetectable		 1w2zA-2aqtC:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.53A 1w2zA-3f7lA:
undetectable		 1w2zA-3f7lA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.72A 1w2zA-3omnA:
undetectable		 1w2zA-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.50A 1w2zA-4l05A:
undetectable		 1w2zA-4l05A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.63A 1w2zA-4ouaB:
undetectable		 1w2zA-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 1w2zA-4ouaA:
undetectable		 1w2zA-4ouaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.53A 1w2zA-5kbmA:
undetectable		 1w2zA-5kbmA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.43A 1w2zB-2aqtC:
undetectable		 1w2zB-2aqtC:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.47A 1w2zB-3f7lA:
undetectable		 1w2zB-3f7lA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.71A 1w2zB-3omnA:
undetectable		 1w2zB-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.47A 1w2zB-4l05A:
undetectable		 1w2zB-4l05A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 1w2zB-4ouaB:
undetectable		 1w2zB-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.47A 1w2zB-5kbmA:
undetectable		 1w2zB-5kbmA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.45A 1w2zC-2aqtC:
undetectable		 1w2zC-2aqtC:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.49A 1w2zC-3f7lA:
undetectable		 1w2zC-3f7lA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.70A 1w2zC-3omnA:
undetectable		 1w2zC-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.48A 1w2zC-4l05A:
undetectable		 1w2zC-4l05A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.63A 1w2zC-4ouaB:
undetectable		 1w2zC-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.72A 1w2zC-4ouaA:
undetectable		 1w2zC-4ouaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.49A 1w2zC-5kbmA:
undetectable		 1w2zC-5kbmA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.44A 1w2zD-2aqtC:
undetectable		 1w2zD-2aqtC:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.48A 1w2zD-3f7lA:
undetectable		 1w2zD-3f7lA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.69A 1w2zD-3omnA:
undetectable		 1w2zD-3omnA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.48A 1w2zD-4l05A:
undetectable		 1w2zD-4l05A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 1w2zD-4ouaB:
undetectable		 1w2zD-4ouaB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.48A 1w2zD-5kbmA:
undetectable		 1w2zD-5kbmA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 2dyrA-2aqtC:
undetectable		 2dyrA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 2dyrA-3f7lA:
undetectable		 2dyrA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 2dyrA-3omnA:
57.9		 2dyrA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 2dyrA-4l05A:
undetectable		 2dyrA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 2dyrA-5kbmA:
undetectable		 2dyrA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 2dyrN-2aqtC:
undetectable		 2dyrN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 2dyrN-3f7lA:
undetectable		 2dyrN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 2dyrN-3omnA:
57.8		 2dyrN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 2dyrN-4l05A:
undetectable		 2dyrN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 2dyrN-5kbmA:
undetectable		 2dyrN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.62A 2dysA-2aqtC:
undetectable		 2dysA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.63A 2dysA-3f7lA:
undetectable		 2dysA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.22A 2dysA-3omnA:
57.9		 2dysA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.53A 2dysA-4l05A:
undetectable		 2dysA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.65A 2dysA-5kbmA:
undetectable		 2dysA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.62A 2dysN-2aqtC:
undetectable		 2dysN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.62A 2dysN-3f7lA:
undetectable		 2dysN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.24A 2dysN-3omnA:
57.8		 2dysN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.50A 2dysN-4l05A:
undetectable		 2dysN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.65A 2dysN-5kbmA:
undetectable		 2dysN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 2eijA-2aqtC:
undetectable		 2eijA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 2eijA-3f7lA:
undetectable		 2eijA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.09A 2eijA-3omnA:
57.6		 2eijA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 2eijA-4l05A:
undetectable		 2eijA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 2eijA-5kbmA:
undetectable		 2eijA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 2eijN-2aqtC:
undetectable		 2eijN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 2eijN-3f7lA:
undetectable		 2eijN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 2eijN-3omnA:
57.5		 2eijN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.61A 2eijN-4l05A:
undetectable		 2eijN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 2eijN-5kbmA:
undetectable		 2eijN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 2eikA-2aqtC:
undetectable		 2eikA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.64A 2eikA-3f7lA:
undetectable		 2eikA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.00A 2eikA-3omnA:
57.6		 2eikA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.57A 2eikA-4l05A:
undetectable		 2eikA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 2eikA-5kbmA:
undetectable		 2eikA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.69A 2eikN-2aqtC:
undetectable		 2eikN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.69A 2eikN-3f7lA:
undetectable		 2eikN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 2eikN-3omnA:
57.6		 2eikN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 2eikN-4l05A:
undetectable		 2eikN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.72A 2eikN-5kbmA:
undetectable		 2eikN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.63A 2eilA-2aqtC:
undetectable		 2eilA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.64A 2eilA-3f7lA:
undetectable		 2eilA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 2eilA-3omnA:
57.8		 2eilA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.55A 2eilA-4l05A:
undetectable		 2eilA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.66A 2eilA-5kbmA:
undetectable		 2eilA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 2eilN-2aqtC:
undetectable		 2eilN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 2eilN-3f7lA:
undetectable		 2eilN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 2eilN-3omnA:
57.9		 2eilN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 2eilN-4l05A:
undetectable		 2eilN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 2eilN-5kbmA:
undetectable		 2eilN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.70A 2eimA-2aqtC:
undetectable		 2eimA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.72A 2eimA-3f7lA:
undetectable		 2eimA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 2eimA-3omnA:
57.4		 2eimA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.65A 2eimA-4l05A:
undetectable		 2eimA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.74A 2eimA-5kbmA:
undetectable		 2eimA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 2eimN-2aqtC:
undetectable		 2eimN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 2eimN-3f7lA:
undetectable		 2eimN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 2eimN-3omnA:
57.3		 2eimN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 2eimN-4l05A:
undetectable		 2eimN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 2eimN-5kbmA:
undetectable		 2eimN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.58A 2einA-2aqtC:
undetectable		 2einA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.57A 2einA-3f7lA:
undetectable		 2einA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.22A 2einA-3omnA:
57.6		 2einA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.46A 2einA-4l05A:
undetectable		 2einA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.59A 2einA-5kbmA:
undetectable		 2einA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 2einN-2aqtC:
undetectable		 2einN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 2einN-3f7lA:
undetectable		 2einN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.34A 2einN-3omnA:
57.6		 2einN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.57A 2einN-4l05A:
undetectable		 2einN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 2einN-5kbmA:
undetectable		 2einN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.73A 2fqdA-1b3iA:
3.1		 2fqdA-1b3iA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.55A 2fqdA-1f56A:
1.7		 2fqdA-1f56A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.42A 2fqdA-2ft7A:
2.6		 2fqdA-2ft7A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.57A 2fqdA-2n0mA:
3.5		 2fqdA-2n0mA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.33A 2fqdA-3cvdA:
undetectable		 2fqdA-3cvdA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.39A 2fqdA-4dpcX:
undetectable		 2fqdA-4dpcX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.70A 2fqeA-1b3iA:
2.9		 2fqeA-1b3iA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.51A 2fqeA-1f56A:
1.8		 2fqeA-1f56A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.40A 2fqeA-2ft7A:
2.6		 2fqeA-2ft7A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.57A 2fqeA-2n0mA:
3.5		 2fqeA-2n0mA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.37A 2fqeA-3cvdA:
undetectable		 2fqeA-3cvdA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.35A 2fqeA-4dpcX:
undetectable		 2fqeA-4dpcX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.30A 2fqeA-1zpuA:
30.2		 2fqeA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.83A 2fqeA-1zpuA:
30.2		 2fqeA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.69A 2fqfA-1b3iA:
3.1		 2fqfA-1b3iA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.51A 2fqfA-1f56A:
1.7		 2fqfA-1f56A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.39A 2fqfA-2ft7A:
undetectable		 2fqfA-2ft7A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.57A 2fqfA-2n0mA:
3.5		 2fqfA-2n0mA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.39A 2fqfA-3cvdA:
undetectable		 2fqfA-3cvdA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.35A 2fqfA-4dpcX:
undetectable		 2fqfA-4dpcX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.23A 2fqfA-1zpuA:
30.2		 2fqfA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.79A 2fqfA-1zpuA:
30.2		 2fqfA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.68A 2fqgA-1b3iA:
2.9		 2fqgA-1b3iA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.53A 2fqgA-1f56A:
0.3		 2fqgA-1f56A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.41A 2fqgA-2ft7A:
undetectable		 2fqgA-2ft7A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.59A 2fqgA-2n0mA:
3.4		 2fqgA-2n0mA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.38A 2fqgA-3cvdA:
undetectable		 2fqgA-3cvdA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.34A 2fqgA-4dpcX:
undetectable		 2fqgA-4dpcX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.18A 2fqgA-1zpuA:
30.1		 2fqgA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.78A 2fqgA-1zpuA:
30.1		 2fqgA-1zpuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1598_0
(NITROUS OXIDE
REDUCTASE)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		4 / 4 HIS B 217
CYH B 252
CYH B 256
MET B 263
 CU1  B 288 (-3.2A)
CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 288 (-2.3A)
 0.47A 2iwkA-3om3B:
9.4		 2iwkA-3om3B:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		3 / 3 CYH B 252
CYH B 256
HIS B 260
 CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 287 (-3.0A)
 0.25A 2iwkA-3om3B:
9.4		 2iwkA-3om3B:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1598_0
(NITROUS OXIDE
REDUCTASE)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		4 / 4 HIS B 217
CYH B 252
CYH B 256
MET B 263
 CU1  B 288 (-3.2A)
CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 288 (-2.3A)
 0.47A 2iwkB-3om3B:
9.5		 2iwkB-3om3B:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		3 / 3 CYH B 252
CYH B 256
HIS B 260
 CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 287 (-3.0A)
 0.24A 2iwkB-3om3B:
9.5		 2iwkB-3om3B:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 9 ASP B 253
HIS B  91
HIS B  57
HIS B  82
LEU B 247
 None
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.16A 2jihA-4ouaB:
undetectable		 2jihA-4ouaB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.42A 2oqeA-2aqtC:
undetectable		 2oqeA-2aqtC:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.45A 2oqeA-3f7lA:
undetectable		 2oqeA-3f7lA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.66A 2oqeA-3omnA:
undetectable		 2oqeA-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.42A 2oqeA-4l05A:
undetectable		 2oqeA-4l05A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeA-4ouaB:
undetectable		 2oqeA-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 2oqeA-4ouaA:
undetectable		 2oqeA-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.46A 2oqeA-5kbmA:
undetectable		 2oqeA-5kbmA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.41A 2oqeB-2aqtC:
undetectable		 2oqeB-2aqtC:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.44A 2oqeB-3f7lA:
undetectable		 2oqeB-3f7lA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.65A 2oqeB-3omnA:
undetectable		 2oqeB-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.41A 2oqeB-4l05A:
undetectable		 2oqeB-4l05A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeB-4ouaB:
undetectable		 2oqeB-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 2oqeB-4ouaA:
undetectable		 2oqeB-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.45A 2oqeB-5kbmA:
undetectable		 2oqeB-5kbmA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.43A 2oqeC-2aqtC:
undetectable		 2oqeC-2aqtC:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.45A 2oqeC-3f7lA:
undetectable		 2oqeC-3f7lA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.66A 2oqeC-3omnA:
undetectable		 2oqeC-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.42A 2oqeC-4l05A:
undetectable		 2oqeC-4l05A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeC-4ouaB:
undetectable		 2oqeC-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.72A 2oqeC-4ouaA:
undetectable		 2oqeC-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.46A 2oqeC-5kbmA:
undetectable		 2oqeC-5kbmA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.43A 2oqeD-2aqtC:
undetectable		 2oqeD-2aqtC:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.45A 2oqeD-3f7lA:
undetectable		 2oqeD-3f7lA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.63A 2oqeD-3omnA:
undetectable		 2oqeD-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.42A 2oqeD-4l05A:
undetectable		 2oqeD-4l05A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.65A 2oqeD-4ouaB:
undetectable		 2oqeD-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.71A 2oqeD-4ouaA:
undetectable		 2oqeD-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.47A 2oqeD-5kbmA:
undetectable		 2oqeD-5kbmA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.42A 2oqeF-2aqtC:
undetectable		 2oqeF-2aqtC:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.44A 2oqeF-3f7lA:
undetectable		 2oqeF-3f7lA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.65A 2oqeF-3omnA:
undetectable		 2oqeF-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.42A 2oqeF-4l05A:
undetectable		 2oqeF-4l05A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeF-4ouaB:
undetectable		 2oqeF-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.72A 2oqeF-4ouaA:
undetectable		 2oqeF-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.45A 2oqeF-5kbmA:
undetectable		 2oqeF-5kbmA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 HIS A 118
MET A 122
MET A  47
 CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
None
 1.42A 2vj1A-2n0mA:
undetectable		 2vj1A-2n0mA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.53A 2w0qA-2aqtC:
undetectable		 2w0qA-2aqtC:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.55A 2w0qA-3f7lA:
undetectable		 2w0qA-3f7lA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.67A 2w0qA-3omnA:
undetectable		 2w0qA-3omnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.53A 2w0qA-4l05A:
undetectable		 2w0qA-4l05A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.59A 2w0qA-4ouaB:
undetectable		 2w0qA-4ouaB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.67A 2w0qA-4ouaA:
undetectable		 2w0qA-4ouaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.57A 2w0qA-5kbmA:
undetectable		 2w0qA-5kbmA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.46A 2w0qB-2aqtC:
undetectable		 2w0qB-2aqtC:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.50A 2w0qB-3f7lA:
undetectable		 2w0qB-3f7lA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.68A 2w0qB-3omnA:
undetectable		 2w0qB-3omnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.49A 2w0qB-4l05A:
undetectable		 2w0qB-4l05A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.62A 2w0qB-4ouaB:
undetectable		 2w0qB-4ouaB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.70A 2w0qB-4ouaA:
undetectable		 2w0qB-4ouaA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.51A 2w0qB-5kbmA:
undetectable		 2w0qB-5kbmA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A 128
HIS A 126
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1003 (-3.2A)
CU1  A1002 ( 3.3A)
 0.91A 2wkoA-1zpuA:
undetectable		 2wkoA-1zpuA:
14.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 4 HIS C  79
HIS C  81
HIS C 104
HIS C 160
 CU1  C 200 (-3.1A)
CU1  C 200 (-3.3A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.2A)
 0.18A 2wkoA-2aqtC:
19.4		 2wkoA-2aqtC:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		4 / 4 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.3A)
ZN  A 156 ( 3.2A)
CU1  A 155 (-3.0A)
 0.72A 2wkoA-2k4wA:
14.9		 2wkoA-2k4wA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		4 / 4 HIS A  44
HIS A  46
HIS A  61
HIS A 118
 CU  A 202 ( 2.9A)
CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.17A 2wkoA-3f7lA:
30.5		 2wkoA-3f7lA:
61.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		4 / 4 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 201 ( 3.1A)
CU1  A 201 ( 3.2A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.27A 2wkoA-4l05A:
19.9		 2wkoA-4l05A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		4 / 4 HIS A  75
HIS A  77
HIS A  93
HIS A 153
 CU1  A 201 (-3.0A)
CU1  A 201 (-3.1A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.2A)
 0.18A 2wkoA-5kbmA:
16.2		 2wkoA-5kbmA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A 128
HIS A 126
VAL A  96
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1003 (-3.2A)
None
CU1  A1002 ( 3.3A)
 0.99A 2wkoF-1zpuA:
undetectable		 2wkoF-1zpuA:
14.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 5 HIS C  79
HIS C  81
HIS C 104
HIS C 160
 CU1  C 200 (-3.1A)
CU1  C 200 (-3.3A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.2A)
 0.18A 2wkoF-2aqtC:
19.4		 2wkoF-2aqtC:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		4 / 5 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.3A)
ZN  A 156 ( 3.2A)
CU1  A 155 (-3.0A)
 0.69A 2wkoF-2k4wA:
14.7		 2wkoF-2k4wA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		5 / 5 HIS A  44
HIS A  46
HIS A  61
VAL A 116
HIS A 118
 CU  A 202 ( 2.9A)
CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 4.4A)
CU1  A 201 ( 3.2A)
 0.17A 2wkoF-3f7lA:
30.4		 2wkoF-3f7lA:
61.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		4 / 5 HIS A  48
HIS A  50
HIS A  73
HIS A 128
 CU1  A 201 ( 3.1A)
CU1  A 201 ( 3.2A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.27A 2wkoF-4l05A:
19.9		 2wkoF-4l05A:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
VAL B 286
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.94A 2wkoF-4ouaB:
undetectable		 2wkoF-4ouaB:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		5 / 5 HIS A  75
HIS A  77
HIS A  93
VAL A 151
HIS A 153
 CU1  A 201 (-3.0A)
CU1  A 201 (-3.1A)
CU1  A 201 (-4.2A)
CU1  A 201 ( 4.4A)
CU1  A 201 (-3.2A)
 0.22A 2wkoF-5kbmA:
16.4		 2wkoF-5kbmA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 419
HIS A 418
ILE A 470
HIS A  83
 None
CU1  A1002 ( 3.3A)
None
CU1  A1003 ( 3.0A)
 0.93A 2x0pA-1zpuA:
undetectable		 2x0pA-1zpuA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.58A 2xxgA-1b3iA:
5.9		 2xxgA-1b3iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.26A 2xxgA-1f56A:
4.2		 2xxgA-1f56A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.38A 2xxgA-2ft7A:
6.2		 2xxgA-2ft7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.40A 2xxgA-2n0mA:
8.4		 2xxgA-2n0mA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.42A 2xxgA-3cvdA:
6.0		 2xxgA-3cvdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.40A 2xxgA-4dpcX:
5.8		 2xxgA-4dpcX:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		5 / 5 HIS A  39
CYH A  82
PRO A  84
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
None
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.82A 2xxgC-1b3iA:
5.7		 2xxgC-1b3iA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 5 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.25A 2xxgC-1f56A:
4.3		 2xxgC-1f56A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		5 / 5 HIS A  46
CYH A 112
PRO A 114
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 ( 4.5A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.86A 2xxgC-2ft7A:
7.2		 2xxgC-2ft7A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 5 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.42A 2xxgC-2n0mA:
8.4		 2xxgC-2n0mA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		5 / 5 HIS A  39
CYH A  89
PRO A  91
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
None
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.86A 2xxgC-3cvdA:
6.1		 2xxgC-3cvdA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		5 / 5 HIS X  37
CYH X  84
PRO X  86
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 ( 4.9A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.79A 2xxgC-4dpcX:
6.9		 2xxgC-4dpcX:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 2y69A-2aqtC:
undetectable		 2y69A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 2y69A-3f7lA:
undetectable		 2y69A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 2y69A-3omnA:
58.0		 2y69A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.61A 2y69A-4l05A:
undetectable		 2y69A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 2y69A-5kbmA:
undetectable		 2y69A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.71A 2y69N-2aqtC:
undetectable		 2y69N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.72A 2y69N-3f7lA:
undetectable		 2y69N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 2y69N-3omnA:
57.9		 2y69N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.64A 2y69N-4l05A:
undetectable		 2y69N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.75A 2y69N-5kbmA:
undetectable		 2y69N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 12 HIS C 122
ASP C 125
LEU C 173
GLY C 103
HIS C  81
 ZN  C 201 (-3.1A)
ZN  C 201 (-2.2A)
None
None
CU1  C 200 (-3.3A)
 1.16A 2zj0C-2aqtC:
undetectable		 2zj0C-2aqtC:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		5 / 12 HIS A  90
ASP A  93
LEU A 141
GLY A  72
HIS A  50
 ZN  A 203 (-3.1A)
ZN  A 203 (-2.2A)
None
None
CU1  A 201 ( 3.2A)
 1.17A 2zj0C-4l05A:
undetectable		 2zj0C-4l05A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 2zxwA-2aqtC:
undetectable		 2zxwA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 2zxwA-3f7lA:
undetectable		 2zxwA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.25A 2zxwA-3omnA:
57.7		 2zxwA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 2zxwA-4l05A:
undetectable		 2zxwA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 2zxwA-5kbmA:
undetectable		 2zxwA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 2zxwN-2aqtC:
undetectable		 2zxwN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 2zxwN-3f7lA:
undetectable		 2zxwN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.22A 2zxwN-3omnA:
57.7		 2zxwN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 2zxwN-4l05A:
undetectable		 2zxwN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 2zxwN-5kbmA:
undetectable		 2zxwN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 3abkA-2aqtC:
undetectable		 3abkA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3abkA-3f7lA:
undetectable		 3abkA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 3abkA-3omnA:
57.5		 3abkA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.61A 3abkA-4l05A:
undetectable		 3abkA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 3abkA-5kbmA:
undetectable		 3abkA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 3abkN-2aqtC:
undetectable		 3abkN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3abkN-3f7lA:
undetectable		 3abkN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 3abkN-3omnA:
57.5		 3abkN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.61A 3abkN-4l05A:
undetectable		 3abkN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 3abkN-5kbmA:
undetectable		 3abkN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.63A 3ablA-2aqtC:
undetectable		 3ablA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.63A 3ablA-3f7lA:
undetectable		 3ablA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.24A 3ablA-3omnA:
57.7		 3ablA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.55A 3ablA-4l05A:
undetectable		 3ablA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.65A 3ablA-5kbmA:
undetectable		 3ablA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.63A 3ablN-2aqtC:
undetectable		 3ablN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.63A 3ablN-3f7lA:
undetectable		 3ablN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.29A 3ablN-3omnA:
57.7		 3ablN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.54A 3ablN-4l05A:
undetectable		 3ablN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.66A 3ablN-5kbmA:
undetectable		 3ablN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 3abmA-2aqtC:
undetectable		 3abmA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3abmA-3f7lA:
undetectable		 3abmA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.18A 3abmA-3omnA:
57.8		 3abmA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 3abmA-4l05A:
undetectable		 3abmA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 3abmA-5kbmA:
undetectable		 3abmA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 3abmN-2aqtC:
undetectable		 3abmN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3abmN-3f7lA:
undetectable		 3abmN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3abmN-3omnA:
57.8		 3abmN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 3abmN-4l05A:
undetectable		 3abmN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 3abmN-5kbmA:
undetectable		 3abmN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 5c92 KELCH
DOMAIN-CONTAINING
PROTEIN
(Colletotrichum
graminicola) 		4 / 6 TYR A 334
MET A 173
PHE A 174
PHE A 138
 CU1  A 503 (-4.3A)
None
None
None
 1.15A 3af3A-5c92A:
undetectable		 3af3A-5c92A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.70A 3ag1A-2aqtC:
undetectable		 3ag1A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.71A 3ag1A-3f7lA:
undetectable		 3ag1A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 3ag1A-3omnA:
57.2		 3ag1A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.66A 3ag1A-4l05A:
undetectable		 3ag1A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.74A 3ag1A-5kbmA:
undetectable		 3ag1A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.72A 3ag1N-2aqtC:
undetectable		 3ag1N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.74A 3ag1N-3f7lA:
undetectable		 3ag1N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 3ag1N-3omnA:
57.1		 3ag1N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.68A 3ag1N-4l05A:
undetectable		 3ag1N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 3ag2A-2aqtC:
undetectable		 3ag2A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 3ag2A-3f7lA:
undetectable		 3ag2A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3ag2A-3omnA:
57.6		 3ag2A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 3ag2A-4l05A:
undetectable		 3ag2A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 3ag2A-5kbmA:
undetectable		 3ag2A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 3ag2N-2aqtC:
undetectable		 3ag2N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 3ag2N-3f7lA:
undetectable		 3ag2N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 3ag2N-3omnA:
57.7		 3ag2N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 3ag2N-4l05A:
undetectable		 3ag2N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 3ag2N-5kbmA:
undetectable		 3ag2N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 3ag3A-2aqtC:
undetectable		 3ag3A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 3ag3A-3f7lA:
undetectable		 3ag3A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3ag3A-3omnA:
57.5		 3ag3A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 3ag3A-4l05A:
undetectable		 3ag3A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 3ag3A-5kbmA:
undetectable		 3ag3A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 3ag3N-2aqtC:
undetectable		 3ag3N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3ag3N-3f7lA:
undetectable		 3ag3N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 3ag3N-3omnA:
57.5		 3ag3N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 3ag3N-4l05A:
undetectable		 3ag3N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 3ag3N-5kbmA:
undetectable		 3ag3N-5kbmA:
14.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 3ag4A-3omnA:
57.4		 3ag4A-3omnA:
51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.05A 3ag4N-3omnA:
57.4		 3ag4N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 3asnA-2aqtC:
undetectable		 3asnA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 3asnA-3f7lA:
undetectable		 3asnA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.00A 3asnA-3omnA:
58.0		 3asnA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 3asnA-4l05A:
undetectable		 3asnA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 3asnA-5kbmA:
undetectable		 3asnA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 3asnN-2aqtC:
undetectable		 3asnN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3asnN-3f7lA:
undetectable		 3asnN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 3asnN-3omnA:
57.9		 3asnN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 3asnN-4l05A:
undetectable		 3asnN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 3asnN-5kbmA:
undetectable		 3asnN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 3asoA-2aqtC:
undetectable		 3asoA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 3asoA-3f7lA:
undetectable		 3asoA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.00A 3asoA-3omnA:
57.9		 3asoA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.61A 3asoA-4l05A:
undetectable		 3asoA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 3asoA-5kbmA:
undetectable		 3asoA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 3asoN-2aqtC:
undetectable		 3asoN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.64A 3asoN-3f7lA:
undetectable		 3asoN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 3asoN-3omnA:
57.9		 3asoN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 3asoN-4l05A:
undetectable		 3asoN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 3asoN-5kbmA:
undetectable		 3asoN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5c92 KELCH
DOMAIN-CONTAINING
PROTEIN
(Colletotrichum
graminicola) 		4 / 5 VAL A  19
VAL A  30
GLN A  65
PHE A  72
 None
None
None
CU1  A 503 (-4.4A)
 1.10A 3bjwH-5c92A:
undetectable		 3bjwH-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5c92 KELCH
DOMAIN-CONTAINING
PROTEIN
(Colletotrichum
graminicola) 		4 / 6 VAL A  19
VAL A  30
GLN A  65
PHE A  72
 None
None
None
CU1  A 503 (-4.4A)
 1.16A 3bjwF-5c92A:
undetectable		 3bjwF-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5c92 KELCH
DOMAIN-CONTAINING
PROTEIN
(Colletotrichum
graminicola) 		4 / 5 VAL A  19
VAL A  30
GLN A  65
PHE A  72
 None
None
None
CU1  A 503 (-4.4A)
 1.07A 3bjwB-5c92A:
undetectable		 3bjwB-5c92A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 10 GLY A  72
ALA A  51
HIS A  73
HIS A  48
HIS A 128
 None
None
ZN  A 156 ( 3.2A)
CU1  A 155 (-3.1A)
CU1  A 155 (-3.0A)
 1.46A 3boyA-2k4wA:
0.0
3boyC-2k4wA:
0.0		 3boyA-2k4wA:
18.24
3boyC-2k4wA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 10 HIS A  48
HIS A 128
GLY A  72
ALA A  51
HIS A  73
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.0A)
None
None
ZN  A 156 ( 3.2A)
 1.47A 3boyA-2k4wA:
0.0
3boyB-2k4wA:
0.0		 3boyA-2k4wA:
18.24
3boyB-2k4wA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 10 HIS A  48
HIS A 128
GLY A  72
ALA A  51
HIS A  73
 CU1  A 155 (-3.1A)
CU1  A 155 (-3.0A)
None
None
ZN  A 156 ( 3.2A)
 1.47A 3boyB-2k4wA:
0.0
3boyC-2k4wA:
0.0		 3boyB-2k4wA:
18.24
3boyC-2k4wA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.70A 3bvdA-2aqtC:
undetectable		 3bvdA-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 3bvdA-3f7lA:
undetectable		 3bvdA-3f7lA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.52A 3bvdA-3omnA:
36.6		 3bvdA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 3bvdA-4l05A:
undetectable		 3bvdA-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 251
HIS A 283
HIS A 282
 CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
 0.77A 3bvdA-4ouaA:
undetectable		 3bvdA-4ouaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 3bvdA-5kbmA:
undetectable		 3bvdA-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 6ek9 -
(-) 		4 / 4 LEU A 131
ASP A  82
VAL A  89
THR A  71
 None
None
None
CU1  A 214 (-3.6A)
 1.13A 3cyxB-6ek9A:
undetectable		 3cyxB-6ek9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		6 / 11 ALA A 115
GLY A 112
ILE A 121
ASN A 120
VAL A 151
ARG A 159
 None
None
None
None
CU1  A 201 ( 4.4A)
None
 1.47A 3dcmX-5kbmA:
undetectable		 3dcmX-5kbmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.72A 3dtuA-2aqtC:
undetectable		 3dtuA-2aqtC:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.73A 3dtuA-3f7lA:
undetectable		 3dtuA-3f7lA:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.12A 3dtuA-3omnA:
65.9		 3dtuA-3omnA:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.68A 3dtuA-4l05A:
undetectable		 3dtuA-4l05A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.75A 3dtuA-5kbmA:
undetectable		 3dtuA-5kbmA:
12.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_B_CUB1004_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		4 / 4 HIS B 217
CYH B 252
CYH B 256
MET B 263
 CU1  B 288 (-3.2A)
CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 288 (-2.3A)
 0.08A 3dtuB-3om3B:
35.5		 3dtuB-3om3B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		3 / 3 CYH B 252
CYH B 256
HIS B 260
 CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 287 (-3.0A)
 0.09A 3dtuB-3om3B:
35.5		 3dtuB-3om3B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.73A 3dtuC-2aqtC:
undetectable		 3dtuC-2aqtC:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.73A 3dtuC-3f7lA:
undetectable		 3dtuC-3f7lA:
13.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 3dtuC-3omnA:
66.2		 3dtuC-3omnA:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.68A 3dtuC-4l05A:
undetectable		 3dtuC-4l05A:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		3 / 3 CYH B 252
CYH B 256
HIS B 260
 CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 287 (-3.0A)
 0.08A 3dtuD-3om3B:
36.2		 3dtuD-3om3B:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DTU_D_CUD4_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 3om3 CYTOCHROME C OXIDASE
SUBUNIT 2
(Rhodobacter
sphaeroides) 		4 / 4 HIS B 217
CYH B 252
CYH B 256
MET B 263
 CU1  B 288 (-3.2A)
CU1  B 288 ( 2.2A)
CU1  B 287 ( 2.3A)
CU1  B 288 (-2.3A)
 0.10A 3dtuD-3om3B:
36.2		 3dtuD-3om3B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5fej COPM
(Synechocystis
sp.
PCC
6803) 		5 / 12 MET A  63
LEU A 128
ALA A 130
HIS A 148
MET A 145
 None
None
None
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 1.19A 3erdA-5fejA:
undetectable		 3erdA-5fejA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		3 / 3 GLY A  67
PRO A 114
LEU A  86
 None
CU1  A 200 ( 4.5A)
None
 0.45A 3hcpB-2ft7A:
undetectable		 3hcpB-2ft7A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.44A 3hiiA-2aqtC:
undetectable		 3hiiA-2aqtC:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.45A 3hiiA-3f7lA:
undetectable		 3hiiA-3f7lA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.61A 3hiiA-3omnA:
undetectable		 3hiiA-3omnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.38A 3hiiA-4l05A:
undetectable		 3hiiA-4l05A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.67A 3hiiA-4ouaB:
undetectable		 3hiiA-4ouaB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.73A 3hiiA-4ouaA:
undetectable		 3hiiA-4ouaA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.46A 3hiiA-5kbmA:
2.3		 3hiiA-5kbmA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.45A 3hiiB-2aqtC:
undetectable		 3hiiB-2aqtC:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.46A 3hiiB-3f7lA:
undetectable		 3hiiB-3f7lA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.60A 3hiiB-3omnA:
undetectable		 3hiiB-3omnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.40A 3hiiB-4l05A:
undetectable		 3hiiB-4l05A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.67A 3hiiB-4ouaB:
undetectable		 3hiiB-4ouaB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.47A 3hiiB-5kbmA:
2.1		 3hiiB-5kbmA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 9 THR B 268
HIS B 255
HIS B 251
HIS B 282
ILE B 278
 None
CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
None
None
 1.34A 3hy7A-4ouaB:
undetectable		 3hy7A-4ouaB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 9 THR A 268
HIS A 255
HIS A 251
HIS A 282
ILE A 278
 None
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.0A)
None
 1.33A 3hy7A-4ouaA:
undetectable		 3hy7A-4ouaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 9 THR B 268
HIS B 255
HIS B 251
HIS B 282
ILE B 278
 None
CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
None
None
 1.31A 3hy7B-4ouaB:
undetectable		 3hy7B-4ouaB:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		5 / 6 HIS A 334
VAL A 245
LEU A 292
ILE A 355
LEU A 241
 CU1  A   5 (-3.1A)
None
None
None
None
 1.49A 3kk6A-3omnA:
undetectable		 3kk6A-3omnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  83
HIS A 126
HIS A  81
 CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.3A)
 0.86A 3mihA-1zpuA:
undetectable		 3mihA-1zpuA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C 160
HIS C  81
MET C 158
 CU1  C 200 (-3.2A)
CU1  C 200 (-3.3A)
None
 1.00A 3mihA-2aqtC:
undetectable		 3mihA-2aqtC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		3 / 3 HIS A 128
HIS A  50
MET A 126
 CU1  A 155 (-3.0A)
CU1  A 155 (-3.3A)
CU1  A 155 ( 4.2A)
 1.01A 3mihA-2k4wA:
undetectable		 3mihA-2k4wA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		3 / 3 HIS A 118
HIS A  49
MET A  47
 CU1  A 201 (-3.1A)
CU1  A 201 (-3.2A)
None
 1.01A 3mihA-2n0mA:
undetectable		 3mihA-2n0mA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A 128
HIS A  50
MET A 126
 CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.2A)
None
 0.97A 3mihA-4l05A:
undetectable		 3mihA-4l05A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5fej COPM
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A  56
HIS A  57
MET A  53
 CU1  A 201 (-2.9A)
CU1  A 201 (-2.9A)
CU1  A 201 (-3.0A)
 0.90A 3mihA-5fejA:
undetectable		 3mihA-5fejA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5fej COPM
(Synechocystis
sp.
PCC
6803) 		3 / 3 HIS A 148
HIS A 149
MET A 145
 CU1  A 202 (-2.8A)
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 0.85A 3mihA-5fejA:
undetectable		 3mihA-5fejA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS B  57
HIS B  91
HIS B  82
ASP B 252
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.13A 3nvcA-4ouaB:
undetectable		 3nvcA-4ouaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS B  91
HIS B  57
HIS B 283
ASP B 252
 CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
None
 0.95A 3nvcA-4ouaB:
undetectable		 3nvcA-4ouaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS A  57
HIS A  91
HIS A  82
ASP A 252
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
None
 1.14A 3nvcA-4ouaA:
undetectable		 3nvcA-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS A  91
HIS A  57
HIS A 283
ASP A 252
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
None
 1.01A 3nvcA-4ouaA:
undetectable		 3nvcA-4ouaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 5 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.61A 3qpkA-1ws7A:
2.5		 3qpkA-1ws7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 413
CYH A 484
ILE A 486
HIS A 489
LEU A 494
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
None
 0.41A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 128
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.11A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.32A 3qpkA-4ouaB:
undetectable		 3qpkA-4ouaB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.31A 3qpkA-4ouaA:
undetectable		 3qpkA-4ouaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA603_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.23A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.27A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.83A 3qpkA-1zpuA:
40.6		 3qpkA-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.60A 3qpkB-1ws7A:
4.8		 3qpkB-1ws7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.29A 3qpkB-1zpuA:
40.6		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 128
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.15A 3qpkB-1zpuA:
40.6		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.30A 3qpkB-4ouaB:
undetectable		 3qpkB-4ouaB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.29A 3qpkB-4ouaA:
undetectable		 3qpkB-4ouaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB603_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 3qpkB-1zpuA:
40.5		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.24A 3qpkB-1zpuA:
40.6		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.81A 3qpkB-1zpuA:
40.6		 3qpkB-1zpuA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.71A 3s33A-2aqtC:
undetectable		 3s33A-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3s33A-3f7lA:
undetectable		 3s33A-3f7lA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.43A 3s33A-3omnA:
36.5		 3s33A-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.57A 3s33A-4l05A:
undetectable		 3s33A-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 3s33A-5kbmA:
undetectable		 3s33A-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.72A 3s38A-2aqtC:
undetectable		 3s38A-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 3s38A-3f7lA:
undetectable		 3s38A-3f7lA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.54A 3s38A-3omnA:
36.4		 3s38A-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 3s38A-4l05A:
undetectable		 3s38A-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 3s38A-5kbmA:
undetectable		 3s38A-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.69A 3s39A-2aqtC:
undetectable		 3s39A-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 3s39A-3f7lA:
undetectable		 3s39A-3f7lA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.42A 3s39A-3omnA:
36.7		 3s39A-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.54A 3s39A-4l05A:
undetectable		 3s39A-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 3s39A-5kbmA:
undetectable		 3s39A-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.76A 3s3aA-2aqtC:
undetectable		 3s3aA-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.73A 3s3aA-3f7lA:
undetectable		 3s3aA-3f7lA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.46A 3s3aA-3omnA:
36.1		 3s3aA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 3s3aA-4l05A:
undetectable		 3s3aA-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.75A 3s3aA-5kbmA:
undetectable		 3s3aA-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.74A 3s3bA-2aqtC:
undetectable		 3s3bA-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.70A 3s3bA-3f7lA:
undetectable		 3s3bA-3f7lA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.42A 3s3bA-3omnA:
36.6		 3s3bA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 3s3bA-4l05A:
undetectable		 3s3bA-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.73A 3s3bA-5kbmA:
undetectable		 3s3bA-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.71A 3s3cA-2aqtC:
undetectable		 3s3cA-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3s3cA-3f7lA:
undetectable		 3s3cA-3f7lA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.50A 3s3cA-3omnA:
36.7		 3s3cA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.56A 3s3cA-4l05A:
undetectable		 3s3cA-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 3s3cA-5kbmA:
undetectable		 3s3cA-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 3s3dA-2aqtC:
undetectable		 3s3dA-2aqtC:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.61A 3s3dA-3f7lA:
undetectable		 3s3dA-3f7lA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.42A 3s3dA-3omnA:
36.6		 3s3dA-3omnA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.51A 3s3dA-4l05A:
undetectable		 3s3dA-4l05A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.63A 3s3dA-5kbmA:
undetectable		 3s3dA-5kbmA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 8 HIS C 104
HIS C  79
HIS C 113
HIS C 160
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.1A)
ZN  C 201 (-3.2A)
CU1  C 200 (-3.2A)
 1.04A 3w6hA-2aqtC:
undetectable		 3w6hA-2aqtC:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 3wg7A-2aqtC:
undetectable		 3wg7A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 3wg7A-3f7lA:
undetectable		 3wg7A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 3wg7A-3omnA:
57.6		 3wg7A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.56A 3wg7A-4l05A:
undetectable		 3wg7A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 3wg7A-5kbmA:
undetectable		 3wg7A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 3wg7N-2aqtC:
undetectable		 3wg7N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 3wg7N-3f7lA:
undetectable		 3wg7N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 3wg7N-3omnA:
57.6		 3wg7N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 3wg7N-4l05A:
undetectable		 3wg7N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 3wg7N-5kbmA:
undetectable		 3wg7N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 3x2qA-2aqtC:
undetectable		 3x2qA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 3x2qA-3f7lA:
undetectable		 3x2qA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 3x2qA-3omnA:
57.8		 3x2qA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 3x2qA-4l05A:
undetectable		 3x2qA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 3x2qA-5kbmA:
undetectable		 3x2qA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.71A 3x2qN-2aqtC:
undetectable		 3x2qN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.71A 3x2qN-3f7lA:
undetectable		 3x2qN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.03A 3x2qN-3omnA:
57.9		 3x2qN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.64A 3x2qN-4l05A:
undetectable		 3x2qN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.73A 3x2qN-5kbmA:
undetectable		 3x2qN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		4 / 5 HIS A 109
HIS A  93
GLU A 110
HIS A  75
 None
CU1  A 201 (-4.2A)
None
CU1  A 201 (-3.0A)
 1.34A 4a7bB-5kbmA:
undetectable		 4a7bB-5kbmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 5 HIS C  81
SER C 156
SER C  85
VAL C 184
 CU1  C 200 (-3.3A)
None
None
None
 1.13A 4a99D-2aqtC:
undetectable		 4a99D-2aqtC:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 HIS A  50
GLY A  72
HIS A  48
HIS A  82
GLY A 145
 CU1  A 155 (-3.3A)
None
CU1  A 155 (-3.1A)
ZN  A 156 (-3.3A)
None
 1.17A 4bz6C-2k4wA:
undetectable		 4bz6C-2k4wA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG B  92
HIS B  91
LEU B 247
ASP B 287
 None
CU1  B 601 (-3.2A)
None
None
 1.13A 4cevA-4ouaB:
undetectable
4cevB-4ouaB:
undetectable		 4cevA-4ouaB:
18.89
4cevB-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG A  92
HIS A  91
LEU A 247
ASP A 287
 None
CU1  A 401 (-3.3A)
None
None
 1.16A 4cevA-4ouaA:
undetectable
4cevB-4ouaA:
undetectable		 4cevA-4ouaA:
21.31
4cevB-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ASP B 287
ARG B  92
HIS B  91
LEU B 247
 None
None
CU1  B 601 (-3.2A)
None
 1.11A 4cevA-4ouaB:
undetectable
4cevC-4ouaB:
undetectable		 4cevA-4ouaB:
18.89
4cevC-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ASP A 287
ARG A  92
HIS A  91
LEU A 247
 None
None
CU1  A 401 (-3.3A)
None
 1.14A 4cevA-4ouaA:
undetectable
4cevC-4ouaA:
undetectable		 4cevA-4ouaA:
21.31
4cevC-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG B  92
HIS B  91
LEU B 247
ASP B 287
 None
CU1  B 601 (-3.2A)
None
None
 1.11A 4cevD-4ouaB:
undetectable
4cevE-4ouaB:
undetectable		 4cevD-4ouaB:
18.89
4cevE-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG A  92
HIS A  91
LEU A 247
ASP A 287
 None
CU1  A 401 (-3.3A)
None
None
 1.15A 4cevD-4ouaA:
undetectable
4cevE-4ouaA:
undetectable		 4cevD-4ouaA:
21.31
4cevE-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG B  92
HIS B  91
LEU B 247
ASP B 287
 None
CU1  B 601 (-3.2A)
None
None
 1.12A 4cevE-4ouaB:
undetectable
4cevF-4ouaB:
undetectable		 4cevE-4ouaB:
18.89
4cevF-4ouaB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 ARG A  92
HIS A  91
LEU A 247
ASP A 287
 None
CU1  A 401 (-3.3A)
None
None
 1.15A 4cevE-4ouaA:
undetectable
4cevF-4ouaA:
undetectable		 4cevE-4ouaA:
21.31
4cevF-4ouaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 1b3i PROTEIN
(PLASTOCYANIN)
(Prochlorothrix
hollandica) 		4 / 4 HIS A  39
CYH A  82
HIS A  85
MET A  90
 CU1  A 110 ( 2.9A)
CU1  A 110 ( 2.3A)
CU1  A 110 ( 3.0A)
CU1  A 110 ( 2.9A)
 0.65A 4ef3A-1b3iA:
3.0		 4ef3A-1b3iA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 1f56 PLANTACYANIN
(Spinacia
oleracea) 		4 / 4 HIS A  34
CYH A  74
HIS A  79
MET A  84
 CU1  A  92 (-3.1A)
CU1  A  92 (-2.1A)
CU1  A  92 ( 3.1A)
CU1  A  92 (-2.7A)
 0.52A 4ef3A-1f56A:
0.6		 4ef3A-1f56A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 2ft7 AZURIN
(Pseudomonas
aeruginosa) 		4 / 4 HIS A  46
CYH A 112
HIS A 115
MET A 117
 CU1  A 200 (-3.0A)
CU1  A 200 (-2.0A)
CU1  A 200 (-3.3A)
CU1  A 200 (-2.5A)
 0.38A 4ef3A-2ft7A:
2.7		 4ef3A-2ft7A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 2n0m LIPID MODIFIED
AZURIN PROTEIN
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  49
CYH A 113
HIS A 118
MET A 122
 CU1  A 201 (-3.2A)
CU1  A 201 (-2.1A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.1A)
 0.56A 4ef3A-2n0mA:
3.6		 4ef3A-2n0mA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 3cvd PLASTOCYANIN
(Phormidium
laminosum) 		4 / 4 HIS A  39
CYH A  89
HIS A  92
MET A  97
 CU1  A 106 (-3.1A)
CU1  A 106 (-2.2A)
CU1  A 106 (-3.9A)
CU1  A 106 (-2.4A)
 0.35A 4ef3A-3cvdA:
undetectable		 4ef3A-3cvdA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 4dpc PLASTOCYANIN A,
CHLOROPLASTIC
(Populus
nigra) 		4 / 4 HIS X  37
CYH X  84
HIS X  87
MET X  92
 CU1  X 100 (-3.0A)
CU1  X 100 (-2.1A)
CU1  X 100 (-3.1A)
CU1  X 100 (-2.7A)
 0.32A 4ef3A-4dpcX:
undetectable		 4ef3A-4dpcX:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  83
HIS A 126
HIS A 416
HIS A 485
 CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
 0.30A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 418
HIS A 483
HIS A  81
HIS A 128
 CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
 0.68A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.33A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 416
HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.64A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.24A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.80A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A 416
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 1.40A 4ef3A-1zpuA:
30.1		 4ef3A-1zpuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 5msz THERMOBIA DOMESTICA
DOMESTICA AA15
(Thermobia
domestica) 		4 / 5 HIS A   1
ALA A  89
HIS A  91
TYR A 184
 CU1  A 303 (-3.0A)
CU1  A 303 ( 4.0A)
CU1  A 303 (-3.2A)
CU1  A 303 (-4.9A)
 0.65A 4gboA-5mszA:
14.1		 4gboA-5mszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5msz THERMOBIA DOMESTICA
DOMESTICA AA15
(Thermobia
domestica) 		4 / 5 HIS A   1
ALA A  89
HIS A  91
TYR A 184
 CU1  A 303 (-3.0A)
CU1  A 303 ( 4.0A)
CU1  A 303 (-3.2A)
CU1  A 303 (-4.9A)
 0.83A 4gboB-5mszA:
13.9		 4gboB-5mszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 8 HIS A 251
HIS A 283
HIS A 255
PHE A 239
 CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
CU1  A 402 (-3.1A)
None
 0.88A 4n16A-4ouaA:
undetectable		 4n16A-4ouaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5fje COPPER STORAGE
PROTEIN 1
(Methylosinus
trichosporium) 		5 / 10 CYH A 110
LEU A  58
CYH A 117
ALA A  61
LEU A  19
 CU1  A1127 ( 2.1A)
CU1  A1127 ( 4.2A)
CU1  A1123 ( 2.1A)
None
CU1  A1123 (-4.9A)
 1.19A 4p65A-5fjeA:
undetectable
4p65B-5fjeA:
undetectable
4p65F-5fjeA:
undetectable
4p65H-5fjeA:
undetectable		 4p65A-5fjeA:
8.33
4p65B-5fjeA:
14.63
4p65F-5fjeA:
14.63
4p65H-5fjeA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.46A 4p6sA-4ouaB:
21.0		 4p6sA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.21A 4p6sA-4ouaB:
21.0		 4p6sA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.46A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.22A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.49A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.44A 4p6sA-4ouaA:
20.5		 4p6sA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
 0.38A 4p6sB-4ouaB:
21.0		 4p6sB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B  82
HIS B  57
HIS B 255
HIS B 251
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
 0.99A 4p6sB-4ouaB:
21.0		 4p6sB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
 0.98A 4p6sB-4ouaB:
21.0		 4p6sB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
 0.37A 4p6sB-4ouaA:
20.6		 4p6sB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS A  82
HIS A  57
HIS A 255
HIS A 251
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
 0.97A 4p6sB-4ouaA:
20.6		 4p6sB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.96A 4p6sB-4ouaA:
20.6		 4p6sB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5fej COPM
(Synechocystis
sp.
PCC
6803) 		5 / 12 MET A  63
LEU A 128
ALA A 130
HIS A 148
MET A 145
 None
None
None
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 1.13A 4zn7A-5fejA:
undetectable		 4zn7A-5fejA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5fej COPM
(Synechocystis
sp.
PCC
6803) 		5 / 11 MET A  63
LEU A 128
ALA A 130
HIS A 148
MET A 145
 None
None
None
CU1  A 202 (-2.8A)
CU1  A 202 (-3.3A)
 1.13A 4zn7B-5fejA:
undetectable		 4zn7B-5fejA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		5 / 12 HIS A  78
GLU A  47
ASP A  81
GLY A  60
HIS A  46
 ZN  A 203 (-3.1A)
SO4  A 209 (-3.4A)
ZN  A 203 (-2.2A)
None
CU1  A 201 ( 3.1A)
 1.27A 5axdA-3f7lA:
undetectable		 5axdA-3f7lA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		5 / 12 HIS A  78
GLU A  47
ASP A  81
GLY A  60
HIS A  46
 ZN  A 203 (-3.1A)
SO4  A 209 (-3.4A)
ZN  A 203 (-2.2A)
None
CU1  A 201 ( 3.1A)
 1.26A 5axdC-3f7lA:
undetectable		 5axdC-3f7lA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 5b1aA-2aqtC:
undetectable		 5b1aA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 5b1aA-3f7lA:
undetectable		 5b1aA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5b1aA-3omnA:
57.9		 5b1aA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.57A 5b1aA-4l05A:
undetectable		 5b1aA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 5b1aA-5kbmA:
undetectable		 5b1aA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 5b1aN-2aqtC:
undetectable		 5b1aN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 5b1aN-3f7lA:
undetectable		 5b1aN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.24A 5b1aN-3omnA:
57.9		 5b1aN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.59A 5b1aN-4l05A:
undetectable		 5b1aN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 5b1aN-5kbmA:
undetectable		 5b1aN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 5b1bA-2aqtC:
undetectable		 5b1bA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 5b1bA-3f7lA:
undetectable		 5b1bA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 5b1bA-3omnA:
57.6		 5b1bA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 5b1bA-4l05A:
undetectable		 5b1bA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 5b1bA-5kbmA:
undetectable		 5b1bA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 5b1bN-2aqtC:
undetectable		 5b1bN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 5b1bN-3f7lA:
undetectable		 5b1bN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.18A 5b1bN-3omnA:
57.5		 5b1bN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 5b1bN-4l05A:
undetectable		 5b1bN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 5b1bN-5kbmA:
undetectable		 5b1bN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 5b3sA-2aqtC:
undetectable		 5b3sA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 5b3sA-3f7lA:
undetectable		 5b3sA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 5b3sA-3omnA:
57.9		 5b3sA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 5b3sA-4l05A:
undetectable		 5b3sA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 5b3sA-5kbmA:
undetectable		 5b3sA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 5b3sN-2aqtC:
undetectable		 5b3sN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 5b3sN-3f7lA:
undetectable		 5b3sN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5b3sN-3omnA:
57.9		 5b3sN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.61A 5b3sN-4l05A:
undetectable		 5b3sN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 5b3sN-5kbmA:
undetectable		 5b3sN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 PRO A 140
HIS A  50
GLY A  72
HIS A  48
LEU A 141
 None
CU1  A 155 (-3.3A)
None
CU1  A 155 (-3.1A)
None
 1.35A 5eeiA-2k4wA:
undetectable		 5eeiA-2k4wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2k4w SUPEROXIDE DISMUTASE
[CU-ZN]
(Salmonella
enterica) 		5 / 12 PRO A 140
HIS A  50
GLY A  72
HIS A  48
LEU A 141
 None
CU1  A 155 (-3.3A)
None
CU1  A 155 (-3.1A)
None
 1.34A 5eeiB-2k4wA:
undetectable		 5eeiB-2k4wA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5fje COPPER STORAGE
PROTEIN 1
(Methylosinus
trichosporium) 		5 / 12 VAL A  29
ASP A  32
ASP A  21
HIS A  25
ALA A 109
 None
None
None
None
CU1  A1127 ( 4.2A)
 1.39A 5hnzB-5fjeA:
undetectable		 5hnzB-5fjeA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.46A 5i3aA-4ouaB:
21.2		 5i3aA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  91
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.45A 5i3aA-4ouaB:
21.2		 5i3aA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 7 HIS B 255
HIS B 283
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.1A)
None
 0.87A 5i3aA-4ouaB:
21.2		 5i3aA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.45A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.20A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.43A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.48A 5i3aA-4ouaA:
20.8		 5i3aA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.41A 5i3aB-4ouaB:
21.1		 5i3aB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.21A 5i3aB-4ouaB:
21.1		 5i3aB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  91
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.49A 5i3aB-4ouaB:
21.1		 5i3aB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.39A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.21A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.47A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.46A 5i3aB-4ouaA:
20.8		 5i3aB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B  57
HIS B  82
HIS B 251
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
 0.48A 5i3bA-4ouaB:
21.2		 5i3bA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  82
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
 1.20A 5i3bA-4ouaB:
21.2		 5i3bA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS B 255
HIS B 251
HIS B  91
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.45A 5i3bA-4ouaB:
21.2		 5i3bA-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A  57
HIS A  82
HIS A 251
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
None
 0.47A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.20A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 251
HIS A  91
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.43A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 7 HIS A 255
HIS A 283
HIS A  82
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
None
 1.48A 5i3bA-4ouaA:
20.9		 5i3bA-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B  57
HIS B  82
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
CU1  B 602 (-3.1A)
None
 0.39A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B  57
HIS B  91
HIS B 255
ALA B 273
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-3.1A)
None
 1.33A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 255
HIS B 251
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.1A)
None
 1.03A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 255
HIS B 283
HIS B  57
ALA B 273
 CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.1A)
None
 0.90A 5i3bB-4ouaB:
21.3		 5i3bB-4ouaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A  57
HIS A  82
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.1A)
None
 0.41A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A  57
HIS A  91
HIS A 255
ALA A 273
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
CU1  A 402 (-3.1A)
None
 1.28A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 255
HIS A 251
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
None
 1.02A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 255
HIS A 283
HIS A  57
ALA A 273
 CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.2A)
None
 0.81A 5i3bB-4ouaA:
20.9		 5i3bB-4ouaA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 5iy5A-2aqtC:
undetectable		 5iy5A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5iy5A-3f7lA:
undetectable		 5iy5A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 5iy5A-3omnA:
57.7		 5iy5A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 5iy5A-4l05A:
undetectable		 5iy5A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 5iy5A-5kbmA:
undetectable		 5iy5A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 5iy5N-2aqtC:
undetectable		 5iy5N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5iy5N-3f7lA:
undetectable		 5iy5N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5iy5N-3omnA:
57.7		 5iy5N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 5iy5N-4l05A:
undetectable		 5iy5N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 5iy5N-5kbmA:
undetectable		 5iy5N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5msz THERMOBIA DOMESTICA
DOMESTICA AA15
(Thermobia
domestica) 		5 / 12 GLY A  49
TYR A 184
ASN A 186
PHE A  97
LEU A 156
 None
CU1  A 303 (-4.9A)
None
None
None
 1.46A 5kklB-5mszA:
undetectable		 5kklB-5mszA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.27A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 416
HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.68A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.31A 5mejA-4ouaA:
undetectable		 5mejA-4ouaA:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		6 / 6 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 416
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
 0.20A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 6 HIS A  81
HIS A 128
HIS A 416
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
 0.79A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 128
HIS A 483
HIS A 418
HIS A 485
HIS A 416
 CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
 1.39A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 416
HIS A 418
HIS A 483
HIS A  81
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
 0.65A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.22A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.48A 5mejA-1ws7A:
3.1		 5mejA-1ws7A:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEJ_A_CUA504_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mejA-1zpuA:
44.2		 5mejA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.25A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 416
HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.67A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.30A 5mewA-4ouaA:
undetectable		 5mewA-4ouaA:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		6 / 6 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 416
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 6 HIS A  81
HIS A 128
HIS A 416
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
 0.79A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 128
HIS A 483
HIS A 418
HIS A 485
HIS A 416
 CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
 1.39A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 416
HIS A 418
HIS A 483
HIS A  81
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
 0.65A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.22A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.48A 5mewA-1ws7A:
3.1		 5mewA-1ws7A:
12.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MEW_A_CUA504_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.12A 5mewA-1zpuA:
44.2		 5mewA-1zpuA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.23A 5mhuA-1zpuA:
44.1		 5mhuA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 416
HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.68A 5mhuA-1zpuA:
44.1		 5mhuA-1zpuA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.32A 5mhuA-4ouaA:
undetectable		 5mhuA-4ouaA:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		6 / 6 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 416
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mhuA-1zpuA:
44.2		 5mhuA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 128
HIS A 483
HIS A 418
HIS A 485
HIS A 416
 CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
 1.39A 5mhuA-1zpuA:
44.2		 5mhuA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 416
HIS A 418
HIS A 483
HIS A  81
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
 0.65A 5mhuA-1zpuA:
44.2		 5mhuA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.21A 5mhuA-1zpuA:
44.1		 5mhuA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mhuA-1zpuA:
44.1		 5mhuA-1zpuA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mhuA-1ws7A:
3.3		 5mhuA-1ws7A:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHU_A_CUA504_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.12A 5mhuA-1zpuA:
44.1		 5mhuA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.22A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA501_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A 416
HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.68A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 255
HIS A 251
HIS A  57
HIS A 283
HIS A  91
 CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.2A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
 1.32A 5mhvA-4ouaA:
undetectable		 5mhvA-4ouaA:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		6 / 6 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 416
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1004 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 128
HIS A 483
HIS A 418
HIS A 485
HIS A 416
 CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
 1.38A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA502_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 6 HIS A 416
HIS A 418
HIS A 483
HIS A  81
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1004 (-3.3A)
CU1  A1002 (-3.3A)
 0.65A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.21A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA503_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mhvA-1ws7A:
3.2		 5mhvA-1ws7A:
12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHV_A_CUA504_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mhvA-1zpuA:
44.2		 5mhvA-1zpuA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.21A 5mhwA-1zpuA:
44.1		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.72A 5mhwA-1zpuA:
44.1		 5mhwA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.83A 5mhwA-4ouaB:
undetectable		 5mhwA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.81A 5mhwA-4ouaA:
undetectable		 5mhwA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mhwA-1zpuA:
44.2		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mhwA-1zpuA:
44.2		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5mhwA-1zpuA:
44.2		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mhwA-1zpuA:
44.1		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mhwA-1zpuA:
44.1		 5mhwA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mhwA-1ws7A:
3.1		 5mhwA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHW_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.12A 5mhwA-1zpuA:
44.2		 5mhwA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.20A 5mhxA-1zpuA:
44.2		 5mhxA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5mhxA-1zpuA:
44.2		 5mhxA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mhxA-4ouaB:
undetectable		 5mhxA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mhxA-4ouaA:
undetectable		 5mhxA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.18A 5mhxA-1zpuA:
44.1		 5mhxA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mhxA-1zpuA:
44.1		 5mhxA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.86A 5mhxA-1zpuA:
44.1		 5mhxA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mhxA-1zpuA:
44.2		 5mhxA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mhxA-1zpuA:
44.2		 5mhxA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mhxA-1ws7A:
3.2		 5mhxA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHX_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mhxA-1zpuA:
44.1		 5mhxA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.19A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mhyA-4ouaB:
undetectable		 5mhyA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mhyA-4ouaA:
undetectable		 5mhyA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mhyA-1ws7A:
3.1		 5mhyA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHY_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mhyA-1zpuA:
44.2		 5mhyA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.19A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.72A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mhzA-4ouaB:
undetectable		 5mhzA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mhzA-4ouaA:
undetectable		 5mhzA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mhzA-1ws7A:
3.2		 5mhzA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MHZ_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.12A 5mhzA-1zpuA:
44.2		 5mhzA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.19A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mi1A-4ouaB:
undetectable		 5mi1A-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mi1A-4ouaA:
undetectable		 5mi1A-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.71A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mi1A-1ws7A:
3.2		 5mi1A-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI1_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mi1A-1zpuA:
44.2		 5mi1A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.19A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mi2A-4ouaB:
undetectable		 5mi2A-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mi2A-4ouaA:
undetectable		 5mi2A-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.86A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mi2A-1ws7A:
3.1		 5mi2A-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MI2_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mi2A-1zpuA:
44.2		 5mi2A-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.18A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.72A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5miaA-4ouaB:
undetectable		 5miaA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5miaA-4ouaA:
undetectable		 5miaA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.19A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5miaA-1ws7A:
3.2		 5miaA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIA_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5miaA-1zpuA:
44.1		 5miaA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.18A 5mibA-1zpuA:
44.1		 5mibA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5mibA-1zpuA:
44.1		 5mibA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mibA-4ouaB:
undetectable		 5mibA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mibA-4ouaA:
undetectable		 5mibA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mibA-1zpuA:
44.1		 5mibA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mibA-1zpuA:
44.1		 5mibA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5mibA-1zpuA:
44.1		 5mibA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mibA-1zpuA:
44.1		 5mibA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mibA-1zpuA:
44.1		 5mibA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.50A 5mibA-1ws7A:
3.1		 5mibA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIB_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mibA-1zpuA:
44.2		 5mibA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.18A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5micA-4ouaB:
undetectable		 5micA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5micA-4ouaA:
undetectable		 5micA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.19A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5micA-1ws7A:
3.1		 5micA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIC_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5micA-1zpuA:
44.1		 5micA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.17A 5midA-1zpuA:
44.1		 5midA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5midA-1zpuA:
44.1		 5midA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5midA-4ouaB:
undetectable		 5midA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5midA-4ouaA:
undetectable		 5midA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5midA-1zpuA:
44.2		 5midA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5midA-1zpuA:
44.2		 5midA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5midA-1zpuA:
44.2		 5midA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5midA-1zpuA:
44.1		 5midA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5midA-1zpuA:
44.1		 5midA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.50A 5midA-1ws7A:
3.4		 5midA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MID_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5midA-1zpuA:
44.2		 5midA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 128
HIS A 416
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.18A 5mieA-1zpuA:
44.1		 5mieA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 485
HIS A  81
HIS A  83
HIS A 126
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 (-3.2A)
 0.73A 5mieA-1zpuA:
44.1		 5mieA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  82
HIS B 283
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 602 (-3.0A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.82A 5mieA-4ouaB:
undetectable		 5mieA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  82
HIS A 283
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 402 (-2.9A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.80A 5mieA-4ouaA:
undetectable		 5mieA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5mieA-1zpuA:
44.2		 5mieA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.70A 5mieA-1zpuA:
44.2		 5mieA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5mieA-1zpuA:
44.2		 5mieA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5mieA-1zpuA:
44.2		 5mieA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5mieA-1zpuA:
44.2		 5mieA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.49A 5mieA-1ws7A:
3.0		 5mieA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIE_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5mieA-1zpuA:
44.2		 5mieA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA601_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 128
HIS A 418
HIS A 483
 CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
 0.18A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B  82
HIS B  91
HIS B  57
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 601 (-3.1A)
 0.30A 5migA-4ouaB:
undetectable		 5migA-4ouaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A  82
HIS A  91
HIS A  57
 CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.2A)
 0.30A 5migA-4ouaA:
undetectable		 5migA-4ouaA:
23.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		5 / 5 HIS A  81
HIS A  83
TRP A 124
HIS A 126
HIS A 485
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1003 ( 4.5A)
CU1  A1003 (-3.2A)
CU1  A1003 (-3.4A)
 0.19A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 416
HIS A 418
HIS A 483
HIS A 128
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1002 (-3.3A)
CU1  A1002 (-3.3A)
 0.71A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA602_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 485
HIS A 416
HIS A 483
HIS A 418
 CU1  A1003 (-3.4A)
CU1  A1004 (-3.2A)
CU1  A1002 (-3.3A)
CU1  A1002 ( 3.3A)
 0.87A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A  81
HIS A  83
HIS A 416
HIS A 418
 CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
 0.20A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA603_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 416
HIS A 418
HIS A  81
HIS A  83
 CU1  A1004 (-3.2A)
CU1  A1002 ( 3.3A)
CU1  A1004 (-3.3A)
CU1  A1003 ( 3.0A)
 0.76A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)		 1ws7 MAVICYANIN
(Cucurbita
pepo) 		4 / 4 HIS A  45
CYH A  86
ILE A  88
HIS A  91
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.2A)
CU1  A1001 ( 4.5A)
CU1  A1001 (-3.1A)
 0.50A 5migA-1ws7A:
3.2		 5migA-1ws7A:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MIG_A_CUA604_0
(LACCASE 2)		 1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 413
CYH A 484
ILE A 486
HIS A 489
 CU1  A1001 (-3.1A)
CU1  A1001 (-2.1A)
CU1  A1001 (-3.9A)
CU1  A1001 (-3.1A)
 0.13A 5migA-1zpuA:
44.1		 5migA-1zpuA:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS B  91
ASP B 252
HIS B 236
HIS B 251
 CU1  B 601 (-3.2A)
None
None
CU1  B 602 (-3.2A)
 1.06A 5nelB-4ouaB:
undetectable
5nelC-4ouaB:
undetectable		 5nelB-4ouaB:
19.49
5nelC-4ouaB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 6 HIS A  91
ASP A 252
HIS A 236
HIS A 251
 CU1  A 401 (-3.3A)
None
None
CU1  A 402 (-3.0A)
 1.06A 5nelB-4ouaA:
undetectable
5nelC-4ouaA:
undetectable		 5nelB-4ouaA:
20.89
5nelC-4ouaA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 5msz THERMOBIA DOMESTICA
DOMESTICA AA15
(Thermobia
domestica) 		4 / 5 HIS A   1
ALA A  89
HIS A  91
TYR A 184
 CU1  A 303 (-3.0A)
CU1  A 303 ( 4.0A)
CU1  A 303 (-3.2A)
CU1  A 303 (-4.9A)
 0.65A 5uizA-5mszA:
14.1		 5uizA-5mszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		5 / 12 HIS A  78
GLU A  47
ASP A  81
GLY A  60
HIS A  46
 ZN  A 203 (-3.1A)
SO4  A 209 (-3.4A)
ZN  A 203 (-2.2A)
None
CU1  A 201 ( 3.1A)
 1.30A 5utuH-3f7lA:
undetectable		 5utuH-3f7lA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.71A 5w97a-2aqtC:
undetectable		 5w97a-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.71A 5w97a-3f7lA:
undetectable		 5w97a-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.14A 5w97a-3omnA:
57.4		 5w97a-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.67A 5w97a-4l05A:
undetectable		 5w97a-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 5waua-2aqtC:
undetectable		 5waua-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5waua-3f7lA:
undetectable		 5waua-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 5waua-3omnA:
57.7		 5waua-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.64A 5waua-4l05A:
undetectable		 5waua-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 5waua-5kbmA:
undetectable		 5waua-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 5x19A-2aqtC:
undetectable		 5x19A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5x19A-3f7lA:
undetectable		 5x19A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5x19A-3omnA:
57.3		 5x19A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.63A 5x19A-4l05A:
undetectable		 5x19A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 5x19A-5kbmA:
undetectable		 5x19A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.69A 5x19N-2aqtC:
undetectable		 5x19N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5x19N-3f7lA:
undetectable		 5x19N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5x19N-3omnA:
57.2		 5x19N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.64A 5x19N-4l05A:
undetectable		 5x19N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 5x19N-5kbmA:
undetectable		 5x19N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.69A 5x1bA-2aqtC:
undetectable		 5x1bA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.69A 5x1bA-3f7lA:
undetectable		 5x1bA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 5x1bA-3omnA:
56.6		 5x1bA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.64A 5x1bA-4l05A:
undetectable		 5x1bA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 5x1bA-5kbmA:
undetectable		 5x1bA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 5x1bN-2aqtC:
undetectable		 5x1bN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5x1bN-3f7lA:
undetectable		 5x1bN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 5x1bN-3omnA:
56.4		 5x1bN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.64A 5x1bN-4l05A:
undetectable		 5x1bN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 5x1bN-5kbmA:
undetectable		 5x1bN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.71A 5x1fA-2aqtC:
undetectable		 5x1fA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.72A 5x1fA-3f7lA:
undetectable		 5x1fA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.16A 5x1fA-3omnA:
57.3		 5x1fA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.67A 5x1fA-4l05A:
undetectable		 5x1fA-4l05A:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 5x1fN-3omnA:
57.3		 5x1fN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.65A 5x1fN-4l05A:
undetectable		 5x1fN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 5xdqA-2aqtC:
undetectable		 5xdqA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 5xdqA-3f7lA:
undetectable		 5xdqA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 5xdqA-3omnA:
57.9		 5xdqA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 5xdqA-4l05A:
undetectable		 5xdqA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 5xdqA-5kbmA:
undetectable		 5xdqA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 5xdqN-2aqtC:
undetectable		 5xdqN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5xdqN-3f7lA:
undetectable		 5xdqN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5xdqN-3omnA:
57.9		 5xdqN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 5xdqN-4l05A:
undetectable		 5xdqN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.71A 5xdqN-5kbmA:
undetectable		 5xdqN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 5xdxA-2aqtC:
undetectable		 5xdxA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5xdxA-3f7lA:
undetectable		 5xdxA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.08A 5xdxA-3omnA:
57.5		 5xdxA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.62A 5xdxA-4l05A:
undetectable		 5xdxA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 5xdxA-5kbmA:
undetectable		 5xdxA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.69A 5xdxN-2aqtC:
undetectable		 5xdxN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.69A 5xdxN-3f7lA:
undetectable		 5xdxN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.07A 5xdxN-3omnA:
57.5		 5xdxN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.63A 5xdxN-4l05A:
undetectable		 5xdxN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.72A 5xdxN-5kbmA:
undetectable		 5xdxN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 5z84A-2aqtC:
undetectable		 5z84A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.64A 5z84A-3f7lA:
undetectable		 5z84A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 5z84A-3omnA:
58.0		 5z84A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.55A 5z84A-4l05A:
undetectable		 5z84A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 5z84A-5kbmA:
undetectable		 5z84A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 5z84N-2aqtC:
undetectable		 5z84N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 5z84N-3f7lA:
undetectable		 5z84N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.26A 5z84N-3omnA:
58.0		 5z84N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 5z84N-4l05A:
undetectable		 5z84N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 5z84N-5kbmA:
undetectable		 5z84N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 5z85A-2aqtC:
undetectable		 5z85A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 5z85A-3f7lA:
undetectable		 5z85A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.26A 5z85A-3omnA:
58.0		 5z85A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 5z85A-4l05A:
undetectable		 5z85A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.69A 5z85A-5kbmA:
undetectable		 5z85A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.66A 5z85N-2aqtC:
undetectable		 5z85N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 5z85N-3f7lA:
undetectable		 5z85N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.26A 5z85N-3omnA:
58.0		 5z85N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.56A 5z85N-4l05A:
undetectable		 5z85N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 5z85N-5kbmA:
undetectable		 5z85N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 5z86A-2aqtC:
undetectable		 5z86A-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.66A 5z86A-3f7lA:
undetectable		 5z86A-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.11A 5z86A-3omnA:
58.0		 5z86A-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.56A 5z86A-4l05A:
undetectable		 5z86A-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 5z86A-5kbmA:
undetectable		 5z86A-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.70A 5z86N-2aqtC:
undetectable		 5z86N-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.70A 5z86N-3f7lA:
undetectable		 5z86N-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.25A 5z86N-3omnA:
58.0		 5z86N-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.60A 5z86N-4l05A:
undetectable		 5z86N-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.73A 5z86N-5kbmA:
undetectable		 5z86N-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 5zcoA-2aqtC:
undetectable		 5zcoA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 5zcoA-3f7lA:
undetectable		 5zcoA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 5zcoA-3omnA:
57.9		 5zcoA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 5zcoA-4l05A:
undetectable		 5zcoA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.68A 5zcoA-5kbmA:
undetectable		 5zcoA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 5zcoN-2aqtC:
undetectable		 5zcoN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 5zcoN-3f7lA:
undetectable		 5zcoN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 5zcoN-3omnA:
58.0		 5zcoN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.56A 5zcoN-4l05A:
undetectable		 5zcoN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 5zcoN-5kbmA:
undetectable		 5zcoN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 5zcpA-2aqtC:
undetectable		 5zcpA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.64A 5zcpA-3f7lA:
undetectable		 5zcpA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.17A 5zcpA-3omnA:
58.0		 5zcpA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.55A 5zcpA-4l05A:
undetectable		 5zcpA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 5zcpA-5kbmA:
undetectable		 5zcpA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 5zcpN-2aqtC:
undetectable		 5zcpN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.67A 5zcpN-3f7lA:
undetectable		 5zcpN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.27A 5zcpN-3omnA:
58.0		 5zcpN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.57A 5zcpN-4l05A:
undetectable		 5zcpN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 5zcpN-5kbmA:
undetectable		 5zcpN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.63A 5zcqA-2aqtC:
undetectable		 5zcqA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.63A 5zcqA-3f7lA:
undetectable		 5zcqA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 5zcqA-3omnA:
58.0		 5zcqA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.54A 5zcqA-4l05A:
undetectable		 5zcqA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.66A 5zcqA-5kbmA:
undetectable		 5zcqA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.65A 5zcqN-2aqtC:
undetectable		 5zcqN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 5zcqN-3f7lA:
undetectable		 5zcqN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.20A 5zcqN-3omnA:
58.0		 5zcqN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.55A 5zcqN-4l05A:
undetectable		 5zcqN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 5zcqN-5kbmA:
undetectable		 5zcqN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B  57
CYH B  80
HIS B  82
HIS B  91
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
 0.15A 5zrdA-4ouaB:
33.2		 5zrdA-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A  57
CYH A  80
HIS A  82
HIS A  91
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
 0.16A 5zrdA-4ouaA:
32.1		 5zrdA-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS B 251
HIS B 255
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
 0.27A 5zrdA-4ouaB:
33.2		 5zrdA-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 251
HIS A 255
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
 0.33A 5zrdA-4ouaA:
32.1		 5zrdA-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 5 HIS C  79
HIS C 160
HIS C  81
HIS C 104
 CU1  C 200 (-3.1A)
CU1  C 200 (-3.2A)
CU1  C 200 (-3.3A)
ZN  C 201 ( 3.1A)
 1.07A 5zrdB-2aqtC:
undetectable		 5zrdB-2aqtC:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		4 / 5 HIS A  44
HIS A 118
HIS A  46
HIS A  61
 CU  A 202 ( 2.9A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
 1.08A 5zrdB-3f7lA:
undetectable		 5zrdB-3f7lA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B  57
HIS B  82
PHE B  87
HIS B  91
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.1A)
None
CU1  B 601 (-3.2A)
 1.05A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B 251
HIS B 255
PHE B 279
HIS B 282
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-4.5A)
None
CU1  B 602 (-3.0A)
 0.22A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A  57
HIS A  82
PHE A  87
HIS A  91
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.3A)
None
CU1  A 401 (-3.3A)
 1.03A 5zrdB-4ouaA:
34.0		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A 251
HIS A 255
PHE A 279
HIS A 282
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-4.8A)
CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
 0.27A 5zrdB-4ouaA:
34.0		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		4 / 5 HIS A  75
HIS A 153
HIS A  77
HIS A  93
 CU1  A 201 (-3.0A)
CU1  A 201 (-3.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-4.2A)
 1.09A 5zrdB-5kbmA:
undetectable		 5zrdB-5kbmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B  57
CYH B  80
HIS B  82
HIS B  91
PHE B 279
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-4.5A)
 0.39A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
HIS B 283
PHE B  87
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
None
 1.04A 5zrdB-4ouaB:
34.4		 5zrdB-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A  57
CYH A  80
HIS A  82
HIS A  91
PHE A 279
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 402 (-4.8A)
 0.36A 5zrdB-4ouaA:
33.9		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 251
HIS A 255
HIS A 283
PHE A  87
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
None
 0.99A 5zrdB-4ouaA:
33.9		 5zrdB-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 4 HIS C  79
HIS C 160
HIS C  81
HIS C 104
 CU1  C 200 (-3.1A)
CU1  C 200 (-3.2A)
CU1  C 200 (-3.3A)
ZN  C 201 ( 3.1A)
 1.09A 5zrdC-2aqtC:
undetectable		 5zrdC-2aqtC:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		4 / 4 HIS A  44
HIS A 118
HIS A  46
HIS A  61
 CU  A 202 ( 2.9A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
 1.11A 5zrdC-3f7lA:
undetectable		 5zrdC-3f7lA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		4 / 4 HIS A  48
HIS A 128
HIS A  50
HIS A  73
 CU1  A 201 ( 3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.2A)
ZN  A 203 (-3.1A)
 1.18A 5zrdC-4l05A:
undetectable		 5zrdC-4l05A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B 251
HIS B 255
HIS B 282
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.20A 5zrdC-4ouaB:
28.9		 5zrdC-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A 251
HIS A 255
HIS A 282
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
 0.29A 5zrdC-4ouaA:
28.0		 5zrdC-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		4 / 4 HIS A  75
HIS A 153
HIS A  77
HIS A  93
 CU1  A 201 (-3.0A)
CU1  A 201 (-3.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-4.2A)
 1.11A 5zrdC-5kbmA:
undetectable		 5zrdC-5kbmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B  57
CYH B  80
HIS B  82
HIS B  91
PHE B 279
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-4.5A)
 0.40A 5zrdC-4ouaB:
28.9		 5zrdC-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
HIS B 283
PHE B  87
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
None
 1.07A 5zrdC-4ouaB:
28.9		 5zrdC-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A  57
CYH A  80
HIS A  82
HIS A  91
PHE A 279
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 402 (-4.8A)
 0.36A 5zrdC-4ouaA:
28.1		 5zrdC-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 251
HIS A 255
HIS A 283
PHE A  87
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
None
 1.03A 5zrdC-4ouaA:
28.1		 5zrdC-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS B  57
CYH B  80
HIS B  82
HIS B  91
PHE B 279
 CU1  B 601 (-3.1A)
CU1  B 601 (-3.5A)
CU1  B 601 (-3.1A)
CU1  B 601 (-3.2A)
CU1  B 602 (-4.5A)
 0.41A 5zrdD-4ouaB:
6.5		 5zrdD-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS B 251
HIS B 255
HIS B 283
PHE B  87
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
CU1  B 602 (-3.0A)
None
 1.04A 5zrdD-4ouaB:
6.5		 5zrdD-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		5 / 5 HIS A  57
CYH A  80
HIS A  82
HIS A  91
PHE A 279
 CU1  A 401 (-3.2A)
CU1  A 401 (-3.7A)
CU1  A 401 (-3.3A)
CU1  A 401 (-3.3A)
CU1  A 402 (-4.8A)
 0.38A 5zrdD-4ouaA:
5.4		 5zrdD-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 5 HIS A 251
HIS A 255
HIS A 283
PHE A  87
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-2.9A)
None
 1.00A 5zrdD-4ouaA:
5.4		 5zrdD-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		4 / 4 HIS C  79
HIS C 160
HIS C  81
HIS C 104
 CU1  C 200 (-3.1A)
CU1  C 200 (-3.2A)
CU1  C 200 (-3.3A)
ZN  C 201 ( 3.1A)
 1.09A 5zrdD-2aqtC:
undetectable		 5zrdD-2aqtC:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		4 / 4 HIS A  44
HIS A 118
HIS A  46
HIS A  61
 CU  A 202 ( 2.9A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
 1.10A 5zrdD-3f7lA:
undetectable		 5zrdD-3f7lA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		4 / 4 HIS A  48
HIS A 128
HIS A  50
HIS A  73
 CU1  A 201 ( 3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.2A)
ZN  A 203 (-3.1A)
 1.18A 5zrdD-4l05A:
undetectable		 5zrdD-4l05A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4oua LATENT FORM OF PPO4
TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS B 251
HIS B 255
HIS B 282
HIS B 283
 CU1  B 602 (-3.2A)
CU1  B 602 (-3.1A)
None
CU1  B 602 (-3.0A)
 0.19A 5zrdD-4ouaB:
6.5		 5zrdD-4ouaB:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		4 / 4 HIS A 251
HIS A 255
HIS A 282
HIS A 283
 CU1  A 402 (-3.0A)
CU1  A 402 (-3.1A)
CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
 0.26A 5zrdD-4ouaA:
5.4		 5zrdD-4ouaA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		4 / 4 HIS A  75
HIS A 153
HIS A  77
HIS A  93
 CU1  A 201 (-3.0A)
CU1  A 201 (-3.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-4.2A)
 1.11A 5zrdD-5kbmA:
undetectable		 5zrdD-5kbmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 12 HIS C 122
ASP C 125
LEU C 173
GLY C 103
HIS C  81
 ZN  C 201 (-3.1A)
ZN  C 201 (-2.2A)
None
None
CU1  C 200 (-3.3A)
 1.36A 6f3mA-2aqtC:
undetectable		 6f3mA-2aqtC:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		5 / 12 HIS A  90
ASP A  93
LEU A 141
GLY A  72
HIS A  50
 ZN  A 203 (-3.1A)
ZN  A 203 (-2.2A)
None
None
CU1  A 201 ( 3.2A)
 1.37A 6f3mA-4l05A:
undetectable		 6f3mA-4l05A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_1
(-)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 12 HIS C 122
ASP C 125
LEU C 173
GLY C 103
HIS C  81
 ZN  C 201 (-3.1A)
ZN  C 201 (-2.2A)
None
None
CU1  C 200 (-3.3A)
 1.30A 6f3nA-2aqtC:
undetectable		 6f3nA-2aqtC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_1
(-)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		5 / 12 HIS A  90
ASP A  93
LEU A 141
GLY A  72
HIS A  50
 ZN  A 203 (-3.1A)
ZN  A 203 (-2.2A)
None
None
CU1  A 201 ( 3.2A)
 1.32A 6f3nA-4l05A:
undetectable		 6f3nA-4l05A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_1
(-)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		5 / 12 HIS C 122
ASP C 125
LEU C 173
GLY C 103
HIS C  81
 ZN  C 201 (-3.1A)
ZN  C 201 (-2.2A)
None
None
CU1  C 200 (-3.3A)
 1.29A 6f3nD-2aqtC:
undetectable		 6f3nD-2aqtC:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_1
(-)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		5 / 12 HIS A  90
ASP A  93
LEU A 141
GLY A  72
HIS A  50
 ZN  A 203 (-3.1A)
ZN  A 203 (-2.2A)
None
None
CU1  A 201 ( 3.2A)
 1.31A 6f3nD-4l05A:
undetectable		 6f3nD-4l05A:
17.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.62A 6giqa-3omnA:
48.7		 6giqa-3omnA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE
(Agaricus
bisporus) 		3 / 3 HIS A 251
HIS A 283
HIS A 282
 CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
 0.76A 6giqa-4ouaA:
undetectable		 6giqa-4ouaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.73A 6hu9a-2aqtC:
undetectable		 6hu9a-2aqtC:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.72A 6hu9a-3f7lA:
undetectable		 6hu9a-3f7lA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 6hu9a-3omnA:
55.7		 6hu9a-3omnA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.66A 6hu9a-4l05A:
undetectable		 6hu9a-4l05A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.72A 6hu9m-2aqtC:
undetectable		 6hu9m-2aqtC:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.70A 6hu9m-3f7lA:
undetectable		 6hu9m-3f7lA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.32A 6hu9m-3omnA:
55.6		 6hu9m-3omnA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.63A 6hu9m-4l05A:
undetectable		 6hu9m-4l05A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.73A 6hu9m-5kbmA:
undetectable		 6hu9m-5kbmA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5msz THERMOBIA DOMESTICA
DOMESTICA AA15
(Thermobia
domestica) 		4 / 8 ASP A  35
HIS A   1
ARG A 165
GLU A 182
 None
CU1  A 303 (-3.0A)
None
CU1  A 303 ( 4.4A)
 1.15A 6mn4D-5mszA:
undetectable		 6mn4D-5mszA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.64A 6nknA-2aqtC:
undetectable		 6nknA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.65A 6nknA-3f7lA:
undetectable		 6nknA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 6nknA-3omnA:
57.0		 6nknA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.58A 6nknA-4l05A:
undetectable		 6nknA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.67A 6nknA-5kbmA:
undetectable		 6nknA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.63A 6nknN-2aqtC:
undetectable		 6nknN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.63A 6nknN-3f7lA:
undetectable		 6nknN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.23A 6nknN-3omnA:
57.0		 6nknN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.56A 6nknN-4l05A:
undetectable		 6nknN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.66A 6nknN-5kbmA:
undetectable		 6nknN-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.67A 6nmfA-2aqtC:
undetectable		 6nmfA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 6nmfA-3f7lA:
undetectable		 6nmfA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.15A 6nmfA-3omnA:
56.9		 6nmfA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.64A 6nmfA-4l05A:
undetectable		 6nmfA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.70A 6nmfA-5kbmA:
undetectable		 6nmfA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.72A 6nmfN-2aqtC:
undetectable		 6nmfN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.72A 6nmfN-3f7lA:
undetectable		 6nmfN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.13A 6nmfN-3omnA:
56.6		 6nmfN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.68A 6nmfN-4l05A:
undetectable		 6nmfN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.72A 6nmpA-2aqtC:
undetectable		 6nmpA-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.72A 6nmpA-3f7lA:
undetectable		 6nmpA-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.19A 6nmpA-3omnA:
57.1		 6nmpA-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.65A 6nmpA-4l05A:
undetectable		 6nmpA-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.75A 6nmpA-5kbmA:
undetectable		 6nmpA-5kbmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2aqt SUPEROXIDE DISMUTASE
[CU-ZN]
(Neisseria
meningitidis) 		3 / 3 HIS C  79
HIS C 104
HIS C  81
 CU1  C 200 (-3.1A)
ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
 0.68A 6nmpN-2aqtC:
undetectable		 6nmpN-2aqtC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE
(Alvinella
pompejana) 		3 / 3 HIS A  44
HIS A  61
HIS A  46
 CU  A 202 ( 2.9A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
 0.68A 6nmpN-3f7lA:
undetectable		 6nmpN-3f7lA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I
(Rhodobacter
sphaeroides) 		3 / 3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.21A 6nmpN-3omnA:
56.8		 6nmpN-3omnA:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4l05 SUPEROXIDE DISMUTASE
[CU-ZN]
(Brucella
abortus) 		3 / 3 HIS A  48
HIS A  73
HIS A  50
 CU1  A 201 ( 3.1A)
ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
 0.61A 6nmpN-4l05A:
undetectable		 6nmpN-4l05A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5
(Candida
albicans) 		3 / 3 HIS A  75
HIS A  93
HIS A  77
 CU1  A 201 (-3.0A)
CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
 0.72A 6nmpN-5kbmA:
undetectable		 6nmpN-5kbmA:
14.69