SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'HIS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254
(Thermotoga
maritima) 		4 / 4 HIS A 186
LEU A  83
LEU A 121
LEU A  93
 HIS  A 186 ( 1.0A)
LEU  A  83 ( 0.6A)
LEU  A 121 ( 0.6A)
LEU  A  93 ( 0.6A)
 1.18A 1a4lD-3kbbA:
undetectable		 1a4lD-3kbbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  27
HIS A   7
LEU A   6
LEU A 191
ALA A  20
 ALA  A  27 ( 0.0A)
HIS  A   7 ( 1.0A)
LEU  A   6 ( 0.6A)
LEU  A 191 ( 0.6A)
ALA  A  20 ( 0.0A)
 1.09A 1bzfA-5hfiA:
undetectable		 1bzfA-5hfiA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		3 / 3 TRP A 385
VAL A 287
TRP A 456
 HIS  A 502 (-3.9A)
None
None
 1.16A 1c4dA-4oflA:
undetectable
1c4dB-4oflA:
undetectable		 1c4dA-4oflA:
2.88
1c4dB-4oflA:
2.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1c9sA-4b27A:
13.2
1c9sK-4b27A:
13.3		 1c9sA-4b27A:
76.32
1c9sK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1c9sA-4b27A:
13.2
1c9sB-4b27A:
13.4		 1c9sA-4b27A:
76.32
1c9sB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.14A 1c9sB-4b27A:
13.4
1c9sC-4b27A:
13.3		 1c9sB-4b27A:
76.32
1c9sC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 1c9sC-4b27A:
13.3
1c9sD-4b27A:
13.3		 1c9sC-4b27A:
76.32
1c9sD-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 1c9sD-4b27A:
13.3
1c9sE-4b27A:
13.4		 1c9sD-4b27A:
76.32
1c9sE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1c9sE-4b27A:
13.4
1c9sF-4b27A:
13.4		 1c9sE-4b27A:
76.32
1c9sF-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1c9sF-4b27A:
13.4
1c9sG-4b27A:
13.3		 1c9sF-4b27A:
76.32
1c9sG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 1c9sG-4b27A:
13.3
1c9sH-4b27A:
13.3		 1c9sG-4b27A:
76.32
1c9sH-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1c9sH-4b27A:
13.3
1c9sI-4b27A:
13.4		 1c9sH-4b27A:
76.32
1c9sI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1c9sI-4b27A:
13.4
1c9sJ-4b27A:
13.5		 1c9sI-4b27A:
76.32
1c9sJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 1c9sJ-4b27A:
13.5
1c9sK-4b27A:
13.3		 1c9sJ-4b27A:
76.32
1c9sK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 1c9sJ-6gefA:
undetectable
1c9sK-6gefA:
undetectable		 1c9sJ-6gefA:
undetectable
1c9sK-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 1c9sL-4b27A:
13.1
1c9sM-4b27A:
13.1		 1c9sL-4b27A:
76.32
1c9sM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 1c9sM-4b27A:
13.1
1c9sN-4b27A:
13.1		 1c9sM-4b27A:
76.32
1c9sN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 1c9sN-4b27A:
13.1
1c9sO-4b27A:
13.0		 1c9sN-4b27A:
76.32
1c9sO-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.24A 1c9sO-4b27A:
13.0
1c9sP-4b27A:
13.2		 1c9sO-4b27A:
76.32
1c9sP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 1c9sP-4b27A:
13.2
1c9sQ-4b27A:
13.2		 1c9sP-4b27A:
76.32
1c9sQ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 1c9sQ-4b27A:
13.2
1c9sR-4b27A:
13.1		 1c9sQ-4b27A:
76.32
1c9sR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.27A 1c9sR-4b27A:
13.1
1c9sS-4b27A:
13.1		 1c9sR-4b27A:
76.32
1c9sS-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.29A 1c9sS-4b27A:
13.1
1c9sT-4b27A:
13.1		 1c9sS-4b27A:
76.32
1c9sT-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 7 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.27A 1c9sT-4b27A:
13.1
1c9sU-4b27A:
13.2		 1c9sT-4b27A:
76.32
1c9sU-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1c9sU-4b27A:
13.2
1c9sV-4b27A:
13.1		 1c9sU-4b27A:
76.32
1c9sV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.30A 1c9sL-4b27A:
13.1
1c9sV-4b27A:
13.1		 1c9sL-4b27A:
76.32
1c9sV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ASP A 177
ASP A 175
TYR A 336
THR A 132
 HIS  A1001 (-3.2A)
HIS  A1001 (-3.9A)
None
HIS  A1001 (-3.6A)
 1.10A 1ceaA-4phcA:
undetectable
1ceaB-4phcA:
undetectable		 1ceaA-4phcA:
10.14
1ceaB-4phcA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		4 / 8 ASP A 109
ASP A  29
TYR A 176
TYR A 295
 HIS  A 505 (-2.3A)
HIS  A 505 ( 4.5A)
6KY  A 504 (-4.0A)
6KY  A 504 (-3.4A)
 1.43A 1ceaA-5jh8A:
undetectable
1ceaB-5jh8A:
undetectable		 1ceaA-5jh8A:
12.70
1ceaB-5jh8A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.99A 1d4fC-5d7aA:
undetectable		 1d4fC-5d7aA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 1woj 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 11 HIS A 310
VAL A 280
LEU A 264
THR A 233
THR A 234
 HIS  A 310 (-1.0A)
VAL  A 280 ( 0.6A)
LEU  A 264 ( 0.6A)
THR  A 233 (-0.9A)
THR  A 234 ( 0.9A)
 1.32A 1dmyA-1wojA:
undetectable		 1dmyA-1wojA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 300
GLY A  56
GLY A  57
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.01A 1dx6A-4mwtA:
8.6		 1dx6A-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 9 TYR A   5
ASP A 109
MET A 174
TYR A 176
ASP A 177
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.3A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
 0.78A 1e9lA-5jh8A:
32.5		 1e9lA-5jh8A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 HIS A  58
HIS A 183
HIS A 239
ASP A 315
 HIS  A  58 (-1.0A)
HIS  A 183 (-1.0A)
HIS  A 239 (-1.0A)
ASP  A 315 (-0.6A)
 0.43A 1e9yB-4kqnA:
23.2		 1e9yB-4kqnA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 5 HIS A  35
GLU A  99
ALA A 102
SER A 109
 HIS  A  35 ( 1.0A)
GLU  A  99 ( 0.5A)
ALA  A 102 ( 0.0A)
SER  A 109 ( 0.0A)
 1.11A 1errA-4mwtA:
undetectable
1errB-4mwtA:
undetectable		 1errA-4mwtA:
20.65
1errB-4mwtA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
GLY B 198
ASP B 200
GLN B 201
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 0.59A 1ffyA-4oudB:
5.1		 1ffyA-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		4 / 8 TYR A 219
ILE A 151
HIS A 141
LEU A 137
 TYR  A 219 ( 1.3A)
ILE  A 151 ( 0.7A)
HIS  A 141 ( 1.0A)
LEU  A 137 ( 0.6A)
 0.88A 1fslA-1wlyA:
undetectable		 1fslA-1wlyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 6 HIS A  58
HIS A  60
HIS A 183
HIS A 239
ASP A 315
 HIS  A  58 (-1.0A)
HIS  A  60 (-1.0A)
HIS  A 183 (-1.0A)
HIS  A 239 (-1.0A)
ASP  A 315 (-0.6A)
 0.56A 1fweC-4kqnA:
24.2		 1fweC-4kqnA:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 1gtfA-4b27A:
13.3
1gtfK-4b27A:
13.3		 1gtfA-4b27A:
76.32
1gtfK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.16A 1gtfA-4b27A:
13.3
1gtfB-4b27A:
13.5		 1gtfA-4b27A:
76.32
1gtfB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 1gtfB-4b27A:
13.5
1gtfC-4b27A:
13.2		 1gtfB-4b27A:
76.32
1gtfC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1gtfC-4b27A:
13.2
1gtfD-4b27A:
13.3		 1gtfC-4b27A:
76.32
1gtfD-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 1gtfC-6gefA:
undetectable
1gtfD-6gefA:
undetectable		 1gtfC-6gefA:
undetectable
1gtfD-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 1gtfD-4b27A:
13.3
1gtfE-4b27A:
13.4		 1gtfD-4b27A:
76.32
1gtfE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1gtfE-4b27A:
13.4
1gtfF-4b27A:
13.3		 1gtfE-4b27A:
76.32
1gtfF-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 1gtfF-4b27A:
13.3
1gtfG-4b27A:
13.2		 1gtfF-4b27A:
76.32
1gtfG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 1gtfG-4b27A:
13.2
1gtfH-4b27A:
13.4		 1gtfG-4b27A:
76.32
1gtfH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.25A 1gtfG-6gefA:
undetectable
1gtfH-6gefA:
undetectable		 1gtfG-6gefA:
undetectable
1gtfH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 1gtfH-4b27A:
13.4
1gtfI-4b27A:
13.3		 1gtfH-4b27A:
76.32
1gtfI-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 1gtfH-6gefA:
undetectable
1gtfI-6gefA:
undetectable		 1gtfH-6gefA:
undetectable
1gtfI-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 1gtfI-4b27A:
13.3
1gtfJ-4b27A:
13.5		 1gtfI-4b27A:
76.32
1gtfJ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 1gtfI-6gefA:
undetectable
1gtfJ-6gefA:
undetectable		 1gtfI-6gefA:
undetectable
1gtfJ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 1gtfJ-4b27A:
13.5
1gtfK-4b27A:
13.3		 1gtfJ-4b27A:
76.32
1gtfK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 7 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.19A 1gtfL-4b27A:
13.1
1gtfM-4b27A:
13.1		 1gtfL-4b27A:
76.32
1gtfM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.31A 1gtfM-4b27A:
13.1
1gtfN-4b27A:
13.1		 1gtfM-4b27A:
76.32
1gtfN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.33A 1gtfN-4b27A:
13.1
1gtfO-4b27A:
13.1		 1gtfN-4b27A:
76.32
1gtfO-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 1gtfO-4b27A:
13.1
1gtfP-4b27A:
13.0		 1gtfO-4b27A:
76.32
1gtfP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 1gtfP-4b27A:
13.0
1gtfQ-4b27A:
13.1		 1gtfP-4b27A:
76.32
1gtfQ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 1gtfQ-4b27A:
13.1
1gtfR-4b27A:
13.1		 1gtfQ-4b27A:
76.32
1gtfR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.24A 1gtfR-4b27A:
13.1
1gtfS-4b27A:
13.1		 1gtfR-4b27A:
76.32
1gtfS-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 1gtfS-4b27A:
13.1
1gtfT-4b27A:
13.1		 1gtfS-4b27A:
76.32
1gtfT-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.30A 1gtfT-4b27A:
13.1
1gtfU-4b27A:
13.1		 1gtfT-4b27A:
76.32
1gtfU-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 1gtfT-6gefA:
undetectable
1gtfU-6gefA:
undetectable		 1gtfT-6gefA:
undetectable
1gtfU-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 1gtfU-4b27A:
13.1
1gtfV-4b27A:
13.1		 1gtfU-4b27A:
76.32
1gtfV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 1gtfU-6gefA:
undetectable
1gtfV-6gefA:
undetectable		 1gtfU-6gefA:
undetectable
1gtfV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 1gtfL-4b27A:
13.1
1gtfV-4b27A:
13.1		 1gtfL-4b27A:
76.32
1gtfV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.31A 1gtfL-6gefA:
undetectable
1gtfV-6gefA:
undetectable		 1gtfL-6gefA:
undetectable
1gtfV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
 1.12A 1gtnB-4b27A:
13.2
1gtnC-4b27A:
13.2		 1gtnB-4b27A:
76.32
1gtnC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 1gtnB-4b27A:
13.2
1gtnC-4b27A:
13.2		 1gtnB-4b27A:
76.32
1gtnC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.17A 1gtnE-4b27A:
13.3
1gtnF-4b27A:
13.2		 1gtnE-4b27A:
76.32
1gtnF-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 7 GLY A  23
HIS A  34
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.16A 1gtnF-4b27A:
13.2
1gtnG-4b27A:
13.2		 1gtnF-4b27A:
76.32
1gtnG-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 7 THR A 251
GLY A 290
HIS A 292
THR A 280
 THR  A 251 ( 0.8A)
GLY  A 290 ( 0.0A)
HIS  A 292 ( 1.0A)
THR  A 280 ( 0.8A)
 0.88A 1gtnF-4dlkA:
undetectable
1gtnG-4dlkA:
undetectable		 1gtnF-4dlkA:
13.35
1gtnG-4dlkA:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 1gtnG-4b27A:
13.2
1gtnH-4b27A:
13.3		 1gtnG-4b27A:
76.32
1gtnH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.22A 1gtnG-6gefA:
undetectable
1gtnH-6gefA:
undetectable		 1gtnG-6gefA:
undetectable
1gtnH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1gtnH-4b27A:
13.3
1gtnI-4b27A:
13.3		 1gtnH-4b27A:
76.32
1gtnI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 7 GLY A  23
HIS A  34
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1gtnJ-4b27A:
13.4
1gtnK-4b27A:
13.3		 1gtnJ-4b27A:
76.32
1gtnK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 7 THR A 251
GLY A 290
HIS A 292
THR A 280
 THR  A 251 ( 0.8A)
GLY  A 290 ( 0.0A)
HIS  A 292 ( 1.0A)
THR  A 280 ( 0.8A)
 0.95A 1gtnJ-4dlkA:
undetectable
1gtnK-4dlkA:
undetectable		 1gtnJ-4dlkA:
13.35
1gtnK-4dlkA:
13.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 VAL A  21
GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
ILE A  55
 VAL  A  21 ( 0.6A)
GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.29A 1gtnL-4b27A:
13.0
1gtnM-4b27A:
12.9		 1gtnL-4b27A:
76.32
1gtnM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.38A 1gtnM-4b27A:
12.9
1gtnN-4b27A:
13.1		 1gtnM-4b27A:
76.32
1gtnN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 11 HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 1gtnM-4b27A:
12.9
1gtnN-4b27A:
13.1		 1gtnM-4b27A:
76.32
1gtnN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.37A 1gtnN-4b27A:
13.1
1gtnO-4b27A:
13.0		 1gtnN-4b27A:
76.32
1gtnO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 1gtnN-6gefA:
undetectable
1gtnO-6gefA:
undetectable		 1gtnN-6gefA:
undetectable
1gtnO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.37A 1gtnO-4b27A:
13.0
1gtnP-4b27A:
13.0		 1gtnO-4b27A:
76.32
1gtnP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.11A 1gtnO-4b27A:
13.0
1gtnP-4b27A:
13.0		 1gtnO-4b27A:
76.32
1gtnP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
 0.23A 1gtnQ-4b27A:
13.0
1gtnR-4b27A:
13.1		 1gtnQ-4b27A:
76.32
1gtnR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.11A 1gtnQ-4b27A:
13.0
1gtnR-4b27A:
13.1		 1gtnQ-4b27A:
76.32
1gtnR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 1gtnR-4b27A:
13.1
1gtnS-4b27A:
13.0		 1gtnR-4b27A:
76.32
1gtnS-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 1gtnS-4b27A:
13.0
1gtnT-4b27A:
13.1		 1gtnS-4b27A:
76.32
1gtnT-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.37A 1gtnT-4b27A:
13.1
1gtnU-4b27A:
13.0		 1gtnT-4b27A:
76.32
1gtnU-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 1gtnU-4b27A:
13.0
1gtnV-4b27A:
13.0		 1gtnU-4b27A:
76.32
1gtnV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 10 HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.09A 1gtnU-4b27A:
13.0
1gtnV-4b27A:
13.0		 1gtnU-4b27A:
76.32
1gtnV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 12 ALA A  46
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.14A 1gtnL-4b27A:
13.0
1gtnV-4b27A:
13.0		 1gtnL-4b27A:
76.32
1gtnV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 12 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.36A 1gtnL-4b27A:
13.0
1gtnV-4b27A:
13.0		 1gtnL-4b27A:
76.32
1gtnV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 6 HIS A 274
ILE A 194
LYS A 240
ALA A 243
 HIS  A 274 (-1.0A)
ILE  A 194 ( 0.7A)
LYS  A 240 ( 0.0A)
ALA  A 243 ( 0.0A)
 0.98A 1hk1A-4dlkA:
undetectable		 1hk1A-4dlkA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 10 GLU A  83
THR A  85
GLU A 131
TYR A 263
TYR A 264
GLY A 286
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.6A)
None
 1.03A 1httA-1httA:
53.2		 1httA-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		10 / 10 GLU A  83
THR A  85
TYR A 107
ARG A 113
GLN A 127
GLU A 131
ARG A 259
TYR A 263
TYR A 264
GLY A 285
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
None
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
 0.00A 1httA-1httA:
53.2		 1httA-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		10 / 10 GLU A  90
THR A  92
TYR A 114
ARG A 120
GLN A 134
GLU A 138
ARG A 265
TYR A 269
TYR A 270
GLY A 291
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
 0.53A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		7 / 10 GLU A  90
THR A  92
TYR A 114
GLU A 138
TYR A 269
TYR A 270
GLY A 292
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
None
 1.00A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 10 GLU A 138
THR A  92
TYR A 269
GLU A  90
TYR A 114
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.5A)
None
HIS  A 501 (-3.6A)
None
 1.43A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 10 TYR A 114
ARG A 120
GLN A 134
GLU A 138
TYR A 270
 None
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-4.5A)
 1.10A 1httA-4e51A:
41.4		 1httA-4e51A:
51.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		7 / 10 THR A 132
ARG A 157
GLN A 173
ARG A 326
TYR A 330
TYR A 331
GLY A 360
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
 0.56A 1httA-4phcA:
33.5		 1httA-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 10 GLU A 126
THR A 128
GLN A 170
TYR A 318
TYR A 319
GLY A 339
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
 0.59A 1httA-4yrpA:
33.6		 1httA-4yrpA:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		6 / 10 GLU A  85
THR A  87
GLU A 133
TYR A 265
TYR A 266
GLY A 288
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
HIS  A 502 (-4.7A)
None
 1.01A 1httA-5e3iA:
43.6		 1httA-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		9 / 10 GLU A  85
THR A  87
TYR A 109
ARG A 115
GLN A 129
GLU A 133
TYR A 265
TYR A 266
GLY A 287
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
None
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
None
HIS  A 502 (-4.7A)
HIS  A 502 ( 3.8A)
 0.27A 1httA-5e3iA:
43.6		 1httA-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
ARG A 259
LEU A 261
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 0.36A 1httB-1httA:
49.5		 1httB-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLU A 131
THR A  85
GLU A  83
TYR A 288
TYR A 263
 HIS  A 450 ( 3.0A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.8A)
None
None
 1.22A 1httB-1httA:
49.5		 1httB-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 12 THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.13A 1httB-1httA:
49.5		 1httB-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
ARG A 265
LEU A 267
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 0.57A 1httB-4e51A:
40.3		 1httB-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A  90
THR A  92
GLN A 134
TYR A 269
GLY A 291
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.1A)
 1.19A 1httB-4e51A:
40.3		 1httB-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.17A 1httB-4e51A:
40.3		 1httB-4e51A:
51.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		10 / 12 THR A 132
ARG A 157
GLN A 173
ARG A 326
LEU A 328
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.53A 1httB-4phcA:
33.3		 1httB-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.24A 1httB-4phcA:
33.3		 1httB-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 126
GLN A 170
ARG A 314
GLY A 339
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.3A)
HIS  A 501 (-3.5A)
 1.11A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		9 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.65A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		7 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 (-3.5A)
 1.40A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 THR A 128
LEU A 316
TYR A 318
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
None
HIS  A 501 (-3.5A)
 1.24A 1httB-4yrpA:
32.9		 1httB-4yrpA:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		6 / 12 GLU A  85
ARG A 115
GLN A 129
ARG A 261
LEU A 263
GLY A 287
 HIS  A 502 (-3.8A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
ATP  A 501 (-2.8A)
None
HIS  A 502 ( 3.8A)
 0.87A 1httB-5e3iA:
42.0		 1httB-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		11 / 12 GLU A  85
THR A  87
ARG A 115
GLN A 129
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 287
TYR A 290
GLY A 309
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
HIS  A 502 (-3.5A)
 0.34A 1httB-5e3iA:
42.0		 1httB-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		5 / 12 GLU A  85
THR A  87
GLN A 129
TYR A 265
GLY A 287
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 ( 3.1A)
None
HIS  A 502 ( 3.8A)
 1.19A 1httB-5e3iA:
42.0		 1httB-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		8 / 12 GLU A  85
THR A  87
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 288
GLY A 309
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
None
HIS  A 502 (-3.5A)
 1.09A 1httB-5e3iA:
42.0		 1httB-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
GLN A 127
GLU A 131
ARG A 259
LEU A 261
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.30A 1httC-1httA:
51.7		 1httC-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 12 GLU A  83
THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.11A 1httC-1httA:
51.7		 1httC-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
GLN A 134
GLU A 138
ARG A 265
LEU A 267
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.54A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.14A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A  90
TYR A 270
GLY A 310
TYR A 269
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
None
HIS  A 501 ( 3.8A)
 1.21A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A 138
GLU A  90
TYR A 294
TYR A 269
ALA A  94
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
None
None
 0.99A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 THR A  92
GLN A 134
TYR A 269
GLY A 291
ALA A 312
 HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.1A)
HIS  A 501 ( 3.8A)
 1.21A 1httC-4e51A:
41.5		 1httC-4e51A:
51.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		9 / 12 THR A 132
GLN A 173
ARG A 326
LEU A 328
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.46A 1httC-4phcA:
33.6		 1httC-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.20A 1httC-4phcA:
33.6		 1httC-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-3.5A)
 1.13A 1httC-4yrpA:
33.6		 1httC-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		9 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.60A 1httC-4yrpA:
33.6		 1httC-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 THR A 128
LEU A 316
TYR A 318
TYR A 319
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
None
HIS  A 501 (-3.5A)
 1.28A 1httC-4yrpA:
33.6		 1httC-4yrpA:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		5 / 12 GLN A 129
ARG A 261
LEU A 263
GLY A 287
ALA A 311
 HIS  A 502 ( 3.1A)
ATP  A 501 (-2.8A)
None
HIS  A 502 ( 3.8A)
HIS  A 502 (-3.8A)
 0.88A 1httC-5e3iA:
43.7		 1httC-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		5 / 12 GLU A  85
GLN A 129
TYR A 265
TYR A 290
GLY A 288
 HIS  A 502 (-3.8A)
HIS  A 502 ( 3.1A)
None
HIS  A 502 (-4.5A)
None
 1.27A 1httC-5e3iA:
43.7		 1httC-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		11 / 12 GLU A  85
THR A  87
GLN A 129
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 287
TYR A 290
GLY A 309
ALA A 311
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
HIS  A 502 (-3.5A)
HIS  A 502 (-3.8A)
 0.26A 1httC-5e3iA:
43.7		 1httC-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		6 / 12 GLU A  85
THR A  87
GLN A 129
TYR A 265
GLY A 287
ALA A 311
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 ( 3.1A)
None
HIS  A 502 ( 3.8A)
HIS  A 502 (-3.8A)
 1.33A 1httC-5e3iA:
43.7		 1httC-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		8 / 12 GLU A  85
THR A  87
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 288
GLY A 309
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
None
HIS  A 502 (-3.5A)
 1.06A 1httC-5e3iA:
43.7		 1httC-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
ARG A 259
LEU A 261
TYR A 263
TYR A 264
GLY A 285
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.30A 1httD-1httA:
49.6		 1httD-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 12 GLU A  83
THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.04A 1httD-1httA:
49.6		 1httD-1httA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
ARG A 265
LEU A 267
TYR A 269
TYR A 270
GLY A 291
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.54A 1httD-4e51A:
40.4		 1httD-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		6 / 12 GLU A  90
THR A  92
GLN A 134
TYR A 269
GLY A 291
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-3.4A)
None
HIS  A 501 ( 4.1A)
HIS  A 501 ( 3.8A)
 1.33A 1httD-4e51A:
40.4		 1httD-4e51A:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.08A 1httD-4e51A:
40.4		 1httD-4e51A:
51.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		9 / 12 THR A 132
ARG A 157
GLN A 173
ARG A 326
LEU A 328
TYR A 330
TYR A 331
GLY A 360
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.7A)
 0.58A 1httD-4phcA:
33.4		 1httD-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.15A 1httD-4phcA:
33.4		 1httD-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 GLU A 126
GLN A 170
ARG A 314
LEU A 316
GLY A 339
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-4.6A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-3.5A)
 1.10A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 126
GLN A 170
LEU A 316
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-3.5A)
 1.01A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		8 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-3.5A)
 0.67A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 THR A 128
LEU A 316
TYR A 318
TYR A 319
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
None
HIS  A 501 (-3.5A)
 1.25A 1httD-4yrpA:
33.0		 1httD-4yrpA:
27.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		8 / 12 GLU A  85
ARG A 115
GLN A 129
ARG A 261
LEU A 263
TYR A 265
GLY A 287
ALA A 311
 HIS  A 502 (-3.8A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
ATP  A 501 (-2.8A)
None
None
HIS  A 502 ( 3.8A)
HIS  A 502 (-3.8A)
 0.70A 1httD-5e3iA:
42.0		 1httD-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		5 / 12 GLU A  85
ARG A 115
GLN A 129
TYR A 265
GLY A 288
 HIS  A 502 (-3.8A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
None
None
 1.31A 1httD-5e3iA:
42.0		 1httD-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		11 / 12 GLU A  85
THR A  87
ARG A 115
GLN A 129
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 287
GLY A 309
ALA A 311
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
HIS  A 502 ( 3.8A)
HIS  A 502 (-3.5A)
HIS  A 502 (-3.8A)
 0.32A 1httD-5e3iA:
42.0		 1httD-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		6 / 12 GLU A  85
THR A  87
GLN A 129
TYR A 265
GLY A 287
ALA A 311
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 ( 3.1A)
None
HIS  A 502 ( 3.8A)
HIS  A 502 (-3.8A)
 1.38A 1httD-5e3iA:
42.0		 1httD-5e3iA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		8 / 12 GLU A  85
THR A  87
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 288
GLY A 309
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
None
HIS  A 502 (-3.5A)
 1.00A 1httD-5e3iA:
42.0		 1httD-5e3iA:
55.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 HIS B  66
LEU B  29
ALA B  26
LEU B  25
 HIS  B  66 ( 1.0A)
LEU  B  29 ( 0.6A)
ALA  B  26 ( 0.0A)
LEU  B  25 ( 0.6A)
 0.75A 1hwiD-4oudB:
undetectable		 1hwiD-4oudB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		4 / 6 HIS A  99
ASP A  95
ASP A  65
PRO A  97
 HIS  A  99 (-1.0A)
ASP  A  95 ( 0.6A)
ASP  A  65 ( 0.6A)
PRO  A  97 ( 1.0A)
 1.49A 1ilqA-4yzrA:
undetectable
1ilqC-4yzrA:
undetectable		 1ilqA-4yzrA:
13.02
1ilqC-4yzrA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 TYR A 288
ILE A 140
GLU A 131
LEU A  98
 None
None
HIS  A 450 ( 3.0A)
None
 1.01A 1j96B-1httA:
0.6		 1j96B-1httA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 11 GLY B  39
HIS B  48
HIS B  51
GLY B 198
ASP B 200
GLN B 201
ILE B 228
 GLY  B  39 ( 0.0A)
HIS  B  48 ( 1.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
ILE  B 228 ( 0.7A)
 0.67A 1jzsA-4oudB:
1.1		 1jzsA-4oudB:
19.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		6 / 9 LEU A 174
SER A 176
HIS A 302
ASP A 401
TYR A 402
HIS A 408
 HIS  A 501 (-4.3A)
HIS  A 501 (-3.4A)
NAD  A 502 (-3.9A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-4.4A)
HIS  A 501 ( 3.4A)
 0.35A 1karA-5vldA:
46.3
1karB-5vldA:
45.7		 1karA-5vldA:
48.13
1karB-5vldA:
48.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		6 / 9 LEU A 174
SER A 176
HIS A 302
ASP A 401
TYR A 402
HIS A 408
 HIS  A 501 (-4.3A)
HIS  A 501 (-3.4A)
NAD  A 502 (-3.9A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-4.4A)
HIS  A 501 ( 3.4A)
 0.37A 1karA-5vldA:
46.3
1karB-5vldA:
45.7		 1karA-5vldA:
48.13
1karB-5vldA:
48.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 300
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.23A 1maaA-4mwtA:
11.4		 1maaA-4mwtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		4 / 8 GLY A  57
GLU A 149
SER A 150
HIS A 429
 GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 0.79A 1maaD-4mwtA:
11.4		 1maaD-4mwtA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2r4h MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A  18
ILE A  48
GLY A  49
GLY A  21
 None
HIS  A  91 (-4.0A)
None
None
 0.72A 1me7A-2r4hA:
undetectable		 1me7A-2r4hA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 1wha KIAA0147 PROTEIN
(Homo
sapiens) 		4 / 4 HIS A  76
ALA A  25
PHE A  41
GLY A  27
 HIS  A  76 ( 1.0A)
ALA  A  25 ( 0.0A)
PHE  A  41 ( 1.3A)
GLY  A  27 ( 0.0A)
 1.21A 1mj2B-1whaA:
undetectable		 1mj2B-1whaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 1wha KIAA0147 PROTEIN
(Homo
sapiens) 		4 / 4 HIS A  76
ALA A  25
PHE A  41
GLY A  27
 HIS  A  76 ( 1.0A)
ALA  A  25 ( 0.0A)
PHE  A  41 ( 1.3A)
GLY  A  27 ( 0.0A)
 1.20A 1mj2D-1whaA:
undetectable		 1mj2D-1whaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1wha KIAA0147 PROTEIN
(Homo
sapiens) 		4 / 4 HIS A  76
ALA A  25
PHE A  41
GLY A  27
 HIS  A  76 ( 1.0A)
ALA  A  25 ( 0.0A)
PHE  A  41 ( 1.3A)
GLY  A  27 ( 0.0A)
 1.20A 1mjoB-1whaA:
undetectable		 1mjoB-1whaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 1wha KIAA0147 PROTEIN
(Homo
sapiens) 		4 / 4 HIS A  76
ALA A  25
PHE A  41
GLY A  27
 HIS  A  76 ( 1.0A)
ALA  A  25 ( 0.0A)
PHE  A  41 ( 1.3A)
GLY  A  27 ( 0.0A)
 1.24A 1mjoA-1whaA:
undetectable		 1mjoA-1whaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 1wha KIAA0147 PROTEIN
(Homo
sapiens) 		4 / 4 HIS A  76
ALA A  25
PHE A  41
GLY A  27
 HIS  A  76 ( 1.0A)
ALA  A  25 ( 0.0A)
PHE  A  41 ( 1.3A)
GLY  A  27 ( 0.0A)
 1.19A 1mjoD-1whaA:
undetectable		 1mjoD-1whaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2f06 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A  83
VAL A  86
LEU A  90
 HIS  A 152 (-3.7A)
None
None
 0.53A 1mz9B-2f06A:
undetectable		 1mz9B-2f06A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.22A 1nx9A-1rrvA:
3.4		 1nx9A-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.24A 1nx9B-1rrvA:
3.3		 1nx9B-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.23A 1nx9C-1rrvA:
3.4		 1nx9C-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		4 / 8 GLU A 293
GLN A 297
HIS A 241
SER A 273
 GLU  A 293 (-0.6A)
GLN  A 297 ( 0.6A)
HIS  A 241 ( 1.0A)
SER  A 273 ( 0.0A)
 1.23A 1nx9D-1rrvA:
3.8		 1nx9D-1rrvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 GLU A 262
HIS A 239
HIS A 208
HIS A 183
TYR A 155
 GLU  A 262 ( 0.6A)
HIS  A 239 (-1.0A)
HIS  A 208 ( 1.0A)
HIS  A 183 (-1.0A)
TYR  A 155 ( 1.3A)
 1.46A 1o86A-4kqnA:
undetectable		 1o86A-4kqnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 GLU A 262
HIS A 239
PHE A  65
HIS A 183
TYR A 155
 GLU  A 262 ( 0.6A)
HIS  A 239 (-1.0A)
PHE  A  65 ( 1.3A)
HIS  A 183 (-1.0A)
TYR  A 155 ( 1.3A)
 1.42A 1o86A-4kqnA:
undetectable		 1o86A-4kqnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 SER A 107
VAL A 231
PHE A  49
VAL A 202
 HIS  A 301 (-2.2A)
None
HIS  A 301 (-3.4A)
None
 1.13A 1o86A-4ohnA:
undetectable		 1o86A-4ohnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		3 / 3 GLU A 351
HIS A 377
HIS A 179
 GLU  A 351 ( 0.6A)
HIS  A 377 ( 1.0A)
HIS  A 179 ( 1.0A)
 0.70A 1oe2A-5gprA:
2.8		 1oe2A-5gprA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.28A 1os2A-5d7wA:
14.6		 1os2A-5d7wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.30A 1os2D-5d7wA:
14.7		 1os2D-5d7wA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.75A 1pg2A-4oudB:
8.2		 1pg2A-4oudB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A   9
VAL A  48
GLU A  49
SER A  69
ILE A  64
 None
None
None
HIS  A 239 (-4.6A)
None
 0.81A 1pk9C-1hslA:
undetectable		 1pk9C-1hslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.13A 1q23A-2vbfA:
undetectable		 1q23A-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.20A 1q23F-2vbfA:
undetectable		 1q23F-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 4 ALA A 218
VAL A 217
ALA A 183
HIS A 180
 ALA  A 218 ( 0.0A)
VAL  A 217 ( 0.6A)
ALA  A 183 ( 0.0A)
HIS  A 180 ( 1.0A)
 1.21A 1q23F-3gnrA:
undetectable		 1q23F-3gnrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		6 / 12 ASP A 300
GLY A  56
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.14A 1qtiA-4mwtA:
9.6		 1qtiA-4mwtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY B  50
HIS B  48
GLY B 198
ASP B 200
GLN B 201
 GLY  B  50 ( 0.0A)
HIS  B  48 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 1.02A 1qu2A-4oudB:
5.1		 1qu2A-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 12 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
GLN B 201
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 0.82A 1qu2A-4oudB:
5.1		 1qu2A-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
HIS B  51
ASP B 200
GLN B 201
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
ASP  B 200 ( 0.6A)
GLN  B 201 ( 0.6A)
 0.88A 1qu3A-4oudB:
undetectable		 1qu3A-4oudB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 10 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.49A 1r55A-5d7wA:
6.8		 1r55A-5d7wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 8 GLU A 329
HIS A 279
GLU A 252
ASP A 200
 GLU  A 329 ( 0.6A)
HIS  A 279 ( 1.0A)
GLU  A 252 ( 0.6A)
ASP  A 200 ( 0.6A)
 1.22A 1s3zA-3i4kA:
1.9
1s3zB-3i4kA:
1.9		 1s3zA-3i4kA:
17.51
1s3zB-3i4kA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 4pas GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLU A 789
VAL A 792
HIS B 797
ASP B 808
 GLU  A 789 ( 0.6A)
VAL  A 792 ( 0.6A)
HIS  B 797 ( 1.0A)
ASP  B 808 ( 0.6A)
 1.10A 1s3zA-4pasA:
undetectable
1s3zB-4pasA:
undetectable		 1s3zA-4pasA:
11.04
1s3zB-4pasA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 361
ILE A 367
GLY A 326
ILE A 207
ALA A 194
 HIS  A 501 (-3.8A)
None
None
None
None
 1.04A 1sh9B-4yrpA:
undetectable		 1sh9B-4yrpA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		5 / 12 ILE A 147
GLY A 287
TYR A 290
VAL A 308
ALA A 307
 None
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
None
None
 1.11A 1tlsA-5e3iA:
undetectable		 1tlsA-5e3iA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 382
SER A 383
GLN A 173
GLY A 361
GLY A 381
 None
HIS  A1001 (-4.5A)
HIS  A1001 (-3.0A)
None
HIS  A1001 (-3.7A)
 0.90A 1uakA-4phcA:
undetectable		 1uakA-4phcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 HIS A 135
ASN A 407
TYR A 402
VAL A 183
ALA A 182
 None
None
HIS  A 501 (-4.4A)
None
None
 1.21A 1udtA-5vldA:
undetectable		 1udtA-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 10 TYR A 159
HIS A 160
PHE A 340
GLN A 369
GLY A 371
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
GLY  A 371 ( 0.0A)
PHE  A 372 (-1.3A)
 0.37A 1uhoA-3sl5A:
36.4		 1uhoA-3sl5A:
28.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 1utdA-4b27A:
13.2
1utdB-4b27A:
13.1		 1utdA-4b27A:
76.32
1utdB-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.21A 1utdA-6gefA:
undetectable
1utdB-6gefA:
undetectable		 1utdA-6gefA:
undetectable
1utdB-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 1utdC-4b27A:
13.2
1utdD-4b27A:
13.1		 1utdC-4b27A:
76.32
1utdD-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.26A 1utdC-6gefA:
undetectable
1utdD-6gefA:
undetectable		 1utdC-6gefA:
undetectable
1utdD-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 1utdD-4b27A:
13.1
1utdE-4b27A:
13.3		 1utdD-4b27A:
76.32
1utdE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.16A 1utdE-4b27A:
13.3
1utdF-4b27A:
13.2		 1utdE-4b27A:
76.32
1utdF-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 1utdG-4b27A:
13.3
1utdH-4b27A:
13.1		 1utdG-4b27A:
76.32
1utdH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.22A 1utdG-6gefA:
undetectable
1utdH-6gefA:
undetectable		 1utdG-6gefA:
undetectable
1utdH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 1utdH-4b27A:
13.1
1utdI-4b27A:
13.2		 1utdH-4b27A:
76.32
1utdI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1utdI-4b27A:
13.2
1utdJ-4b27A:
13.1		 1utdI-4b27A:
76.32
1utdJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 1utdA-4b27A:
13.2
1utdK-4b27A:
13.2		 1utdA-4b27A:
76.32
1utdK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 12 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 1utdL-4b27A:
12.8
1utdM-4b27A:
13.1		 1utdL-4b27A:
76.32
1utdM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 12 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.21A 1utdL-4b27A:
12.8
1utdM-4b27A:
13.1		 1utdL-4b27A:
76.32
1utdM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 1utdM-4b27A:
13.1
1utdN-4b27A:
13.1		 1utdM-4b27A:
76.32
1utdN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.30A 1utdN-4b27A:
13.1
1utdO-4b27A:
13.0		 1utdN-4b27A:
76.32
1utdO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.25A 1utdN-6gefA:
undetectable
1utdO-6gefA:
undetectable		 1utdN-6gefA:
undetectable
1utdO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 12 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 1utdO-4b27A:
13.0
1utdP-4b27A:
13.1		 1utdO-4b27A:
76.32
1utdP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 12 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.14A 1utdO-4b27A:
13.0
1utdP-4b27A:
13.1		 1utdO-4b27A:
76.32
1utdP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 11 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.35A 1utdP-4b27A:
13.1
1utdQ-4b27A:
12.9		 1utdP-4b27A:
76.32
1utdQ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 11 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.14A 1utdP-4b27A:
13.1
1utdQ-4b27A:
12.9		 1utdP-4b27A:
76.32
1utdQ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 1utdQ-4b27A:
12.9
1utdR-4b27A:
13.0		 1utdQ-4b27A:
76.32
1utdR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 10 HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
 0.79A 1utdQ-4b27A:
12.9
1utdR-4b27A:
13.0		 1utdQ-4b27A:
76.32
1utdR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.37A 1utdR-4b27A:
13.0
1utdS-4b27A:
13.1		 1utdR-4b27A:
76.32
1utdS-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 1utdR-6gefA:
undetectable
1utdS-6gefA:
undetectable		 1utdR-6gefA:
undetectable
1utdS-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 1utdS-4b27A:
13.1
1utdT-4b27A:
13.1		 1utdS-4b27A:
76.32
1utdT-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 1utdT-4b27A:
13.1
1utdU-4b27A:
13.1		 1utdT-4b27A:
76.32
1utdU-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.17A 1utdT-4b27A:
13.1
1utdU-4b27A:
13.1		 1utdT-4b27A:
76.32
1utdU-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.38A 1utdU-4b27A:
13.1
1utdV-4b27A:
13.0		 1utdU-4b27A:
76.32
1utdV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 11 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 1utdL-4b27A:
12.8
1utdV-4b27A:
13.0		 1utdL-4b27A:
76.32
1utdV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		5 / 11 HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
 0.84A 1utdL-4b27A:
12.8
1utdV-4b27A:
13.0		 1utdL-4b27A:
76.32
1utdV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.37A 1uttA-5d7wA:
14.4		 1uttA-5d7wA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.29A 1utzA-5d7wA:
14.3		 1utzA-5d7wA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.31A 1utzB-5d7wA:
14.3		 1utzB-5d7wA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.20A 1uw6A-4yrpA:
undetectable
1uw6B-4yrpA:
undetectable		 1uw6A-4yrpA:
19.47
1uw6B-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.22A 1uw6D-4yrpA:
undetectable
1uw6E-4yrpA:
undetectable		 1uw6D-4yrpA:
19.47
1uw6E-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.19A 1uw6G-4yrpA:
undetectable
1uw6H-4yrpA:
undetectable		 1uw6G-4yrpA:
19.47
1uw6H-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  87
THR A 128
TRP A 148
LEU A 346
 None
HIS  A 501 (-3.7A)
None
None
 1.17A 1uw6P-4yrpA:
undetectable
1uw6Q-4yrpA:
undetectable		 1uw6P-4yrpA:
19.47
1uw6Q-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 TRP A 148
LEU A 346
TYR A  87
THR A 128
 None
None
None
HIS  A 501 (-3.7A)
 1.18A 1uw6P-4yrpA:
undetectable
1uw6T-4yrpA:
undetectable		 1uw6P-4yrpA:
19.47
1uw6T-4yrpA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 1v54A-5d7wA:
undetectable		 1v54A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 1v54N-5d7wA:
undetectable		 1v54N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 1v55A-5d7wA:
undetectable		 1v55A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 1v55N-5d7wA:
undetectable		 1v55N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 11 ASP A 300
GLY A  57
GLU A 149
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  57 ( 0.0A)
GLU  A 149 ( 0.5A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.03A 1w76A-4mwtA:
13.1		 1w76A-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens) 		5 / 10 ASP A 300
GLY A  56
GLY A  57
SER A 150
HIS A 429
 ASP  A 300 ( 0.6A)
GLY  A  56 ( 0.0A)
GLY  A  57 ( 0.0A)
SER  A 150 ( 0.0A)
HIS  A 429 ( 1.0A)
 1.00A 1w76B-4mwtA:
13.4		 1w76B-4mwtA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens) 		4 / 5 LEU A 282
GLY A 286
HIS A 287
ILE A 288
 LEU  A 282 ( 0.6A)
GLY  A 286 ( 0.0A)
HIS  A 287 ( 1.0A)
ILE  A 288 ( 0.7A)
 0.92A 1xf1A-3o96A:
undetectable		 1xf1A-3o96A:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 315
LEU A 399
THR A 333
SER A 368
GLN A 369
 HIS  A 315 ( 1.0A)
LEU  A 399 ( 0.6A)
THR  A 333 ( 0.8A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
 1.31A 1xlxA-3sl5A:
51.0		 1xlxA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
LEU A 319
ASN A 321
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.54A 1xlxA-3sl5A:
51.0		 1xlxA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.74A 1xlxB-3sl5A:
51.1		 1xlxB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
HIS A 204
MET A 273
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
MET  A 273 (-0.0A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.54A 1xlxB-3sl5A:
51.1		 1xlxB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.61A 1xmuA-3sl5A:
51.4		 1xmuA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.44A 1xmuB-3sl5A:
51.1		 1xmuB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.57A 1xomA-3sl5A:
53.0		 1xomA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
THR A 333
ILE A 336
MET A 337
PHE A 340
MET A 357
SER A 368
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.59A 1xomB-3sl5A:
52.8		 1xomB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.54A 1xoqA-3sl5A:
53.5		 1xoqA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.52A 1xoqA-3sl5A:
53.5		 1xoqA-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.49A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.50A 1xoqB-3sl5A:
53.4		 1xoqB-3sl5A:
94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
MET A 357
GLN A 369
PHE A 372
ILE A 376
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
 0.48A 1xosA-3sl5A:
51.3		 1xosA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
MET A 337
PHE A 340
SER A 355
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
MET  A 337 ( 0.0A)
PHE  A 340 (-1.3A)
SER  A 355 ( 0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.02A 1xosA-3sl5A:
51.3		 1xosA-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
GLN A 369
PHE A 372
ILE A 376
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
ILE  A 376 (-0.6A)
 0.74A 1xotA-3sl5A:
50.9		 1xotA-3sl5A:
84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 162
ILE A 155
SER A  83
SER A  59
ILE A  54
 None
None
None
HIS  A 601 ( 4.8A)
None
 1.21A 1xotA-4ls3A:
undetectable		 1xotA-4ls3A:
20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.59A 1xotB-3sl5A:
50.9		 1xotB-3sl5A:
84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
LEU A 319
ASN A 321
ILE A 336
MET A 337
SER A 355
MET A 357
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 355 ( 0.0A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.73A 1xotB-3sl5A:
50.9		 1xotB-3sl5A:
84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 342
ALA A 190
ASN A 172
TYR A 318
TYR A  87
 HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.4A)
None
None
 1.15A 1xvaB-4yrpA:
0.2		 1xvaB-4yrpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 6 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.30A 1y93A-5d7wA:
14.1		 1y93A-5d7wA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		5 / 8 GLY A 106
GLY A 105
GLY A  65
ILE A 242
HIS A 209
 GLY  A 106 ( 0.0A)
GLY  A 105 ( 0.0A)
GLY  A  65 ( 0.0A)
ILE  A 242 ( 0.7A)
HIS  A 209 ( 1.0A)
 1.01A 1yajC-2hk0A:
undetectable		 1yajC-2hk0A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5crc SDEA
(Legionella
pneumophila) 		4 / 4 GLY A  83
SER A  86
ILE A  66
HIS A  64
 GLY  A  83 ( 0.0A)
SER  A  86 ( 0.0A)
ILE  A  66 ( 0.7A)
HIS  A  64 ( 1.0A)
 1.25A 1yajJ-5crcA:
undetectable		 1yajJ-5crcA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 11 LEU A 152
ILE A 219
HIS A  14
PHE A  13
GLY A 229
 LEU  A 152 ( 0.6A)
ILE  A 219 ( 0.7A)
HIS  A  14 ( 1.0A)
PHE  A  13 ( 1.3A)
GLY  A 229 ( 0.0A)
 0.99A 1zz1A-1wsvA:
undetectable		 1zz1A-1wsvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 LEU A 152
ILE A 219
HIS A  14
PHE A  13
GLY A 229
 LEU  A 152 ( 0.6A)
ILE  A 219 ( 0.7A)
HIS  A  14 ( 1.0A)
PHE  A  13 ( 1.3A)
GLY  A 229 ( 0.0A)
 0.97A 1zz1C-1wsvA:
undetectable		 1zz1C-1wsvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1433_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 TYR A   5
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.50A 2a3aA-5jh8A:
31.2		 2a3aA-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2433_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 9 GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.52A 2a3aB-5jh8A:
31.6		 2a3aB-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2435_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 10 ASP A 109
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.89A 2a3bB-5jh8A:
31.5		 2a3bB-5jh8A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		3 / 3 SER A  59
GLU A 150
ASP A 211
 HIS  A 601 ( 4.8A)
None
None
 0.81A 2avdB-4ls3A:
undetectable		 2avdB-4ls3A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		5 / 10 LEU A3598
LEU A3620
HIS A3624
LEU A3638
ILE A3642
 LEU  A3598 ( 0.6A)
LEU  A3620 ( 0.6A)
HIS  A3624 ( 1.0A)
LEU  A3638 ( 0.6A)
ILE  A3642 ( 0.7A)
 1.08A 2bxeB-5w6lA:
3.7		 2bxeB-5w6lA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A3598
LEU A3620
HIS A3624
LEU A3638
ILE A3642
 LEU  A3598 ( 0.6A)
LEU  A3620 ( 0.6A)
HIS  A3624 ( 1.0A)
LEU  A3638 ( 0.6A)
ILE  A3642 ( 0.7A)
 1.05A 2bxpA-5w6lA:
undetectable		 2bxpA-5w6lA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		5 / 12 LEU A3598
LEU A3620
HIS A3624
LEU A3638
ILE A3642
 LEU  A3598 ( 0.6A)
LEU  A3620 ( 0.6A)
HIS  A3624 ( 1.0A)
LEU  A3638 ( 0.6A)
ILE  A3642 ( 0.7A)
 1.01A 2bxqA-5w6lA:
3.4		 2bxqA-5w6lA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 TYR A 263
GLY A  87
THR A  85
ALA A  86
VAL A  62
 None
None
HIS  A 450 ( 3.2A)
None
None
 1.41A 2coiA-1httA:
undetectable
2coiB-1httA:
undetectable		 2coiA-1httA:
22.73
2coiB-1httA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 TYR A 263
GLY A  87
THR A  85
ALA A  86
VAL A  62
 None
None
HIS  A 450 ( 3.2A)
None
None
 1.48A 2cojA-1httA:
undetectable
2cojB-1httA:
undetectable		 2cojA-1httA:
22.73
2cojB-1httA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1ted PKS18
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  88
HIS A 221
GLY A 225
ASP A 226
 LEU  A  88 ( 0.6A)
HIS  A 221 (-1.0A)
GLY  A 225 ( 0.0A)
ASP  A 226 ( 0.6A)
 0.96A 2ddwB-1tedA:
undetectable		 2ddwB-1tedA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 6 ALA A 154
HIS A 239
ASP A 315
LYS A 150
 ALA  A 154 ( 0.0A)
HIS  A 239 (-1.0A)
ASP  A 315 (-0.6A)
LYS  A 150 ( 0.0A)
 1.19A 2dpzA-4kqnA:
undetectable		 2dpzA-4kqnA:
11.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		6 / 10 HIS A  15
HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.32A 2dttA-2dj6A:
22.2
2dttC-2dj6A:
21.8		 2dttA-2dj6A:
100.00
2dttC-2dj6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		6 / 10 HIS A  15
HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.56A 2dttD-2dj6A:
21.5
2dttF-2dj6A:
21.7		 2dttD-2dj6A:
100.00
2dttF-2dj6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		6 / 11 HIS A  15
HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.46A 2dttD-2dj6A:
21.5
2dttE-2dj6A:
20.6		 2dttD-2dj6A:
100.00
2dttE-2dj6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		5 / 9 HIS A  29
THR A  76
THR A  77
GLU A  78
GLU A 105
 HIS  A  29 ( 1.0A)
THR  A  76 ( 0.8A)
THR  A  77 ( 0.8A)
GLU  A  78 ( 0.5A)
GLU  A 105 ( 0.6A)
 0.52A 2dttE-2dj6A:
20.6
2dttF-2dj6A:
21.7		 2dttE-2dj6A:
100.00
2dttF-2dj6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.73A 2dyrA-5d7wA:
undetectable		 2dyrA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 2dyrN-5d7wA:
undetectable		 2dyrN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 2dysA-5d7wA:
undetectable		 2dysA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 2eijA-5d7wA:
undetectable		 2eijA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 2eijN-5d7wA:
undetectable		 2eijN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.73A 2eikA-5d7wA:
undetectable		 2eikA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 2eikN-5d7wA:
undetectable		 2eikN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 2eilA-5d7wA:
undetectable		 2eilA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 2eilN-5d7wA:
0.2		 2eilN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 2eimA-5d7wA:
undetectable		 2eimA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.73A 2eimN-5d7wA:
undetectable		 2eimN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.71A 2einA-5d7wA:
undetectable		 2einA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.71A 2einN-5d7wA:
undetectable		 2einN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 GLY A 143
GLY A 141
HIS A 171
ALA A  61
THR A  27
 GLY  A 143 ( 0.0A)
GLY  A 141 ( 0.0A)
HIS  A 171 ( 1.0A)
ALA  A  61 ( 0.0A)
THR  A  27 ( 0.8A)
 1.00A 2gluB-2nvvA:
undetectable		 2gluB-2nvvA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 159
HIS A 160
PHE A 340
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.50A 2h42A-3sl5A:
36.2		 2h42A-3sl5A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4yzr POLYKETIDE
BIOSYNTHESIS
CYTOCHROME P450 PKSS
(Bacillus
subtilis) 		5 / 12 HIS A 342
ASN A 340
ALA A 358
ALA A 277
ILE A 274
 HIS  A 342 ( 1.0A)
ASN  A 340 ( 0.6A)
ALA  A 358 (-0.0A)
ALA  A 277 ( 0.0A)
ILE  A 274 ( 0.4A)
 1.08A 2h42B-4yzrA:
undetectable		 2h42B-4yzrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 6 HIS A 313
ASN A 374
ILE A 190
GLN A 415
 HIS  A 313 ( 1.0A)
ASN  A 374 ( 0.6A)
ILE  A 190 ( 0.7A)
GLN  A 415 ( 0.6A)
 1.16A 2hkkA-4iknA:
undetectable		 2hkkA-4iknA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.31A 2hu6A-5d7wA:
14.2		 2hu6A-5d7wA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3r6y ASPARTASE
(Bacillus
sp.
YM55-1) 		5 / 11 HIS A 150
ASN A 359
PHE A 366
ASN A 226
ASP A 266
 HIS  A 150 ( 1.0A)
ASN  A 359 ( 0.6A)
PHE  A 366 ( 1.3A)
ASN  A 226 ( 0.6A)
ASP  A 266 ( 0.6A)
 1.22A 2iyfA-3r6yA:
undetectable		 2iyfA-3r6yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4yba REGULATORY PROTEIN C
(Klebsiella
pneumoniae) 		4 / 8 GLU A  62
ILE A  58
LYS A   5
ILE A   6
 GLU  A  62 ( 0.6A)
ILE  A  58 ( 0.6A)
HIS  A   5 ( 0.0A)
ILE  A   6 ( 0.6A)
 0.85A 2j9dJ-4ybaA:
undetectable
2j9dK-4ybaA:
undetectable
2j9dL-4ybaA:
undetectable		 2j9dJ-4ybaA:
23.53
2j9dK-4ybaA:
23.53
2j9dL-4ybaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.22A 2jfaA-4flxA:
undetectable		 2jfaA-4flxA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 9 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.40A 2jihA-5d7wA:
7.0		 2jihA-5d7wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 8 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.37A 2jihB-5d7wA:
6.8		 2jihB-5d7wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		3 / 3 HIS A 299
ILE A 161
LEU A 189
 HIS  A 299 ( 1.0A)
ILE  A 161 ( 0.6A)
LEU  A 189 ( 0.6A)
 0.66A 2kceA-1wlyA:
undetectable		 2kceA-1wlyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 6 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.18A 2ow9A-5d7wA:
14.6		 2ow9A-5d7wA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.25A 2ow9B-5d7wA:
14.4		 2ow9B-5d7wA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		4 / 5 SER A  59
GLY A 285
ASP A 165
ASP A 154
 HIS  A 601 ( 4.8A)
None
None
None
 1.02A 2oxtB-4ls3A:
undetectable		 2oxtB-4ls3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5xlu GAMMA GLUTAMYL
TRANSPEPTIDASE
(Bacillus
licheniformis) 		4 / 4 SER A 108
GLY A 145
HIS A 154
ASP A 164
 SER  A 108 ( 0.0A)
GLY  A 145 ( 0.0A)
HIS  A 154 ( 1.0A)
ASP  A 164 ( 0.5A)
 1.19A 2oxtC-5xluA:
undetectable		 2oxtC-5xluA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.23A 2ozrC-5d7wA:
14.6		 2ozrC-5d7wA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.26A 2ozrD-5d7wA:
14.7		 2ozrD-5d7wA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.39A 2ozrE-5d7wA:
14.4		 2ozrE-5d7wA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 176
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.28A 2ozrF-5d7wA:
14.6		 2ozrF-5d7wA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 ASP A 201
HIS A 200
ASP A 318
LEU A 319
HIS A 164
 ASP  A 201 ( 0.5A)
HIS  A 200 (-1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
HIS  A 164 (-1.0A)
 1.25A 2q0jB-3sl5A:
undetectable		 2q0jB-3sl5A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 7 TRP A 130
THR A 124
GLN A 122
PHE A 159
 None
None
HIS  A 239 (-3.6A)
None
 1.18A 2qx4A-1hslA:
undetectable
2qx4B-1hslA:
undetectable		 2qx4A-1hslA:
24.05
2qx4B-1hslA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.23A 2qxsA-4flxA:
undetectable		 2qxsA-4flxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4flx DNA POLYMERASE 1
(Pyrococcus
abyssi) 		4 / 5 LEU A 232
ASP A 235
LEU A 138
HIS A 257
 LEU  A 232 ( 0.5A)
ASP  A 235 ( 0.5A)
LEU  A 138 ( 0.5A)
HIS  A 257 ( 1.0A)
 1.20A 2qxsB-4flxA:
undetectable		 2qxsB-4flxA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3ig0 DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		3 / 3 SER A 453
TYR A 524
HIS A 525
 SER  A 453 ( 0.0A)
TYR  A 524 ( 1.3A)
HIS  A 525 ( 1.0A)
 0.74A 2r2vD-3ig0A:
undetectable		 2r2vD-3ig0A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		7 / 12 TRP A  85
ASN A 139
GLU A 140
HIS A 202
TYR A 204
GLU A 229
TRP A 268
 None
None
HIS  A 405 (-2.7A)
None
HIS  A 405 ( 3.5A)
HIS  A 406 (-3.2A)
HIS  A 406 ( 3.2A)
 0.46A 2v3dA-3kl0A:
32.8		 2v3dA-3kl0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		6 / 11 TRP A  85
ASN A 139
GLU A 140
TYR A 204
GLU A 229
TRP A 268
 None
None
HIS  A 405 (-2.7A)
HIS  A 405 ( 3.5A)
HIS  A 406 (-3.2A)
HIS  A 406 ( 3.2A)
 0.53A 2v3dB-3kl0A:
32.7		 2v3dB-3kl0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 340
GLY A 359
ILE A 322
ASP A 343
THR A 128
 None
HIS  A 501 (-3.5A)
None
None
HIS  A 501 (-3.7A)
 1.24A 2vdvE-4yrpA:
undetectable		 2vdvE-4yrpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 340
GLY A 359
ILE A 322
ASP A 343
THR A 128
 None
HIS  A 501 (-3.5A)
None
None
HIS  A 501 (-3.7A)
 1.24A 2vdvF-4yrpA:
undetectable		 2vdvF-4yrpA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 1joi AZURIN
(Pseudomonas
fluorescens) 		3 / 3 HIS A 117
MET A 121
MET A  44
 HIS  A 117 (-0.9A)
MET  A 121 (-0.0A)
MET  A  44 ( 0.0A)
 1.44A 2vj1A-1joiA:
0.0		 2vj1A-1joiA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 ILE A  68
PHE A 132
GLN A 134
ALA A 312
GLU A  72
 None
None
HIS  A 501 (-3.4A)
HIS  A 501 ( 3.8A)
None
 1.42A 2vppB-4e51A:
undetectable		 2vppB-4e51A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 159
HIS A 160
LEU A 319
ILE A 336
GLU A 339
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
GLU  A 339 ( 0.5A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.01A 2weyA-3sl5A:
37.9		 2weyA-3sl5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		8 / 12 TYR A 159
HIS A 160
LEU A 319
ILE A 336
GLU A 339
PHE A 340
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
ILE  A 336 ( 0.4A)
GLU  A 339 ( 0.5A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.83A 2weyA-3sl5A:
37.9		 2weyA-3sl5A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5l5n PLEXIN-A4
(Mus
musculus) 		5 / 8 GLY A  65
HIS A  52
ILE A  62
MET A 496
ALA A 128
 GLY  A  65 ( 0.0A)
HIS  A  52 ( 1.0A)
ILE  A  62 ( 0.6A)
MET  A 496 ( 0.0A)
ALA  A 128 ( 0.0A)
 1.10A 2x0pA-5l5nA:
undetectable		 2x0pA-5l5nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.75A 2x1lA-4oudB:
8.8		 2x1lA-4oudB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.70A 2x1lB-4oudB:
9.2		 2x1lB-4oudB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 HIS B  48
GLY B  50
HIS B  51
GLY B 198
ASP B 200
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
HIS  B  51 ( 1.0A)
GLY  B 198 ( 0.0A)
ASP  B 200 ( 0.6A)
 0.71A 2x1lC-4oudB:
9.3		 2x1lC-4oudB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		4 / 5 ARG A 116
ALA A 115
GLU A 114
TRP A 112
 None
HIS  A 520 (-3.5A)
HIS  A 520 (-4.4A)
None
 1.50A 2xrzA-6an0A:
2.7		 2xrzA-6an0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 2y69A-5d7wA:
undetectable		 2y69A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.77A 2y69N-5d7wA:
undetectable		 2y69N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.09A 2zj0A-2nvvA:
2.5		 2zj0A-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 0.99A 2zj0B-2nvvA:
2.2		 2zj0B-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.04A 2zj0C-2nvvA:
undetectable		 2zj0C-2nvvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 396
HIS A 397
GLY A 382
ILE A 381
 ALA  A 396 (-0.0A)
HIS  A 397 ( 1.0A)
GLY  A 382 (-0.0A)
ILE  A 381 ( 0.7A)
 0.79A 2zm9A-4g9kA:
undetectable		 2zm9A-4g9kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 ASN A 293
VAL A 294
MET A 224
ASN A 225
HIS A 220
 ASN  A 293 ( 0.6A)
VAL  A 294 ( 0.6A)
MET  A 224 ( 0.0A)
ASN  A 225 ( 0.6A)
HIS  A 220 ( 1.0A)
 1.49A 2zvjA-5nqfA:
undetectable		 2zvjA-5nqfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.96A 2zweA-3ulkA:
undetectable
2zweB-3ulkA:
undetectable		 2zweA-3ulkA:
19.11
2zweB-3ulkA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.96A 2zwfA-3ulkA:
undetectable
2zwfB-3ulkA:
undetectable		 2zwfA-3ulkA:
19.11
2zwfB-3ulkA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.97A 2zwgA-3ulkA:
undetectable
2zwgB-3ulkA:
undetectable		 2zwgA-3ulkA:
19.11
2zwgB-3ulkA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 2zxwN-5d7wA:
undetectable		 2zxwN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 GLU A 102
GLY A 304
ALA A 306
LEU A  33
THR A 148
 None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
None
None
 1.33A 3a3yA-1httA:
undetectable		 3a3yA-1httA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 3abkN-5d7wA:
undetectable		 3abkN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 3ablA-5d7wA:
undetectable		 3ablA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.79A 3ablN-5d7wA:
undetectable		 3ablN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 3abmA-5d7wA:
undetectable		 3abmA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		4 / 8 LYS A  52
GLY A  51
HIS A  98
TYR A  97
 LYS  A  52 ( 0.0A)
GLY  A  51 ( 0.0A)
HIS  A  98 ( 1.0A)
TYR  A  97 ( 1.3A)
 0.82A 3af0A-4g41A:
undetectable		 3af0A-4g41A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 3ag1A-5d7wA:
undetectable		 3ag1A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 6 GLN A 330
GLY A 705
HIS A 350
TRP A 328
 GLN  A 330 ( 0.6A)
GLY  A 705 ( 0.0A)
HIS  A 350 ( 1.0A)
TRP  A 328 ( 0.5A)
 1.46A 3ai8B-1v0fA:
undetectable		 3ai8B-1v0fA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 7 TRP A 369
VAL A 372
THR A 381
LEU A 382
 HIS  A 502 (-3.3A)
None
None
None
 1.23A 3arrA-4oflA:
undetectable		 3arrA-4oflA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 VAL A  70
SER A  21
HIS A  20
LEU A 157
 VAL  A  70 ( 0.6A)
SER  A  21 ( 0.0A)
HIS  A  20 ( 1.0A)
LEU  A 157 ( 0.6A)
 1.07A 3arrA-5ec3A:
undetectable		 3arrA-5ec3A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARR_A_PNXA607_1
(CHITINASE A)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		6 / 7 TRP A 160
SER A 203
HIS A 222
THR A 269
LEU A 270
TRP A 532
 TRP  A 160 ( 0.5A)
SER  A 203 ( 0.0A)
HIS  A 222 ( 1.0A)
THR  A 269 ( 0.8A)
LEU  A 270 ( 0.6A)
TRP  A 532 ( 0.5A)
 0.59A 3arrA-5gprA:
56.3		 3arrA-5gprA:
50.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ARU_A_PNXA608_1
(CHITINASE A)		 5gpr CHITINASE
(Ostrinia
furnacalis) 		5 / 6 TRP A 160
SER A 203
ALA A 206
HIS A 222
ASP A 223
 TRP  A 160 ( 0.5A)
SER  A 203 ( 0.0A)
ALA  A 206 ( 0.0A)
HIS  A 222 ( 1.0A)
ASP  A 223 ( 0.5A)
 0.57A 3aruA-5gprA:
56.0		 3aruA-5gprA:
50.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 3asnN-5d7wA:
undetectable		 3asnN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 3asoN-5d7wA:
undetectable		 3asoN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		5 / 11 VAL A3665
LEU A3598
HIS A3624
ILE A3642
ASN A3639
 VAL  A3665 ( 0.6A)
LEU  A3598 ( 0.6A)
HIS  A3624 ( 1.0A)
ILE  A3642 ( 0.7A)
ASN  A3639 ( 0.6A)
 1.31A 3avoA-5w6lA:
undetectable		 3avoA-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 12 TYR A 159
HIS A 160
LEU A 319
PHE A 340
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
PHE  A 340 (-1.3A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.55A 3b2rA-3sl5A:
31.7		 3b2rA-3sl5A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 159
HIS A 160
LEU A 319
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.45A 3b2rB-3sl5A:
31.6		 3b2rB-3sl5A:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 6 ASP A 134
ASP A 127
LEU A 188
HIS A 186
 ASP  A 134 ( 0.6A)
ASP  A 127 ( 0.6A)
LEU  A 188 ( 0.5A)
HIS  A 186 ( 1.0A)
 0.78A 3bj8C-3qviA:
undetectable
3bj8D-3qviA:
undetectable		 3bj8C-3qviA:
17.18
3bj8D-3qviA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 293
ALA A 244
LEU A 278
HIS A 269
GLN A 267
 LEU  A 293 ( 0.5A)
ALA  A 244 ( 0.0A)
LEU  A 278 ( 0.5A)
HIS  A 269 ( 1.0A)
GLN  A 267 ( 0.6A)
 1.30A 3bszE-4g9kA:
undetectable		 3bszE-4g9kA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.71A 3bvdA-5d7wA:
undetectable		 3bvdA-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 8 HIS A 366
HIS A 411
ASP A 102
GLY A 375
 HIS  A 366 ( 1.0A)
HIS  A 411 (-1.0A)
ASP  A 102 ( 0.6A)
GLY  A 375 ( 0.0A)
 0.87A 3c0zB-2nvvA:
undetectable		 3c0zB-2nvvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		4 / 8 HIS A  22
GLY A  11
ASN A  23
TYR A  17
 HIS  A  22 ( 1.0A)
GLY  A  11 ( 0.0A)
ASN  A  23 ( 0.6A)
TYR  A  17 ( 1.3A)
 1.40A 3ccfA-1rynA:
undetectable		 3ccfA-1rynA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.10A 3ce6A-2nvvA:
2.6		 3ce6A-2nvvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.09A 3ce6B-2nvvA:
undetectable		 3ce6B-2nvvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.11A 3ce6C-2nvvA:
undetectable		 3ce6C-2nvvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 12 HIS A 164
HIS A 200
PHE A 372
THR A 271
VAL A 377
 HIS  A 164 (-1.0A)
HIS  A 200 (-1.0A)
PHE  A 372 (-1.3A)
THR  A 271 ( 0.8A)
VAL  A 377 ( 0.6A)
 1.20A 3czvA-3sl5A:
undetectable
3czvB-3sl5A:
undetectable		 3czvA-3sl5A:
20.73
3czvB-3sl5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 8 GLY A 338
GLY A 339
GLY A 340
ILE A 322
 None
HIS  A 501 ( 4.3A)
None
None
 0.66A 3d41A-4yrpA:
undetectable		 3d41A-4yrpA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4gvo LMO2349 PROTEIN
(Listeria
monocytogenes) 		5 / 12 PHE A  45
GLY A  42
VAL A  62
THR A  43
LEU A  51
 HIS  A 703 ( 4.0A)
None
None
None
None
 1.12A 3dh0B-4gvoA:
undetectable		 3dh0B-4gvoA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4gvo LMO2349 PROTEIN
(Listeria
monocytogenes) 		5 / 12 MET A 103
PHE A  45
VAL A  48
ILE A 195
THR A 182
 CSX  A 704 ( 4.4A)
HIS  A 703 ( 4.0A)
None
None
None
 1.25A 3dl9A-4gvoA:
undetectable		 3dl9A-4gvoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 3dtuA-5d7wA:
undetectable		 3dtuA-5d7wA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 3dtuC-5d7wA:
undetectable		 3dtuC-5d7wA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3bpo INTERLEUKIN 13
(Homo
sapiens) 		3 / 3 VAL A  34
LYS A  89
HIS A  84
 VAL  A  34 ( 0.6A)
LYS  A  89 ( 0.0A)
HIS  A  84 ( 1.0A)
 0.94A 3elzA-3bpoA:
undetectable		 3elzA-3bpoA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 728
HIS A 678
VAL A 719
 ASN  A 728 ( 0.6A)
HIS  A 678 ( 1.0A)
VAL  A 719 ( 0.6A)
 0.82A 3elzB-4zkeA:
undetectable		 3elzB-4zkeA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 VAL  A 342 ( 0.6A)
VAL  A 369 ( 0.6A)
PHE  A 371 ( 1.3A)
HIS  A 303 ( 1.0A)
 1.02A 3fhxB-3wd7A:
undetectable		 3fhxB-3wd7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 HIS A 264
VAL A 246
ILE A 280
LEU A 308
THR A 304
 HIS  A 264 ( 1.0A)
VAL  A 246 ( 0.6A)
ILE  A 280 ( 0.7A)
LEU  A 308 ( 0.6A)
THR  A 304 ( 0.8A)
 0.95A 3fw3A-3whlA:
undetectable		 3fw3A-3whlA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 3g1uA-2nvvA:
undetectable		 3g1uA-2nvvA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.08A 3g1uC-2nvvA:
undetectable		 3g1uC-2nvvA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		10 / 12 TYR A 159
HIS A 160
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
 0.52A 3g4lA-3sl5A:
53.4		 3g4lA-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		11 / 12 TYR A 159
HIS A 160
MET A 273
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
 0.44A 3g4lA-3sl5A:
53.4		 3g4lA-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
MET A 357
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
MET  A 357 (-0.0A)
PHE  A 372 (-1.3A)
 0.53A 3g4lB-3sl5A:
52.8		 3g4lB-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
 0.46A 3g4lC-3sl5A:
53.0		 3g4lC-3sl5A:
98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		12 / 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
 0.33A 3g4lD-3sl5A:
52.9		 3g4lD-3sl5A:
98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G6M_A_CFFA1_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 TYR A   5
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 ( 4.1A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.59A 3g6mA-5jh8A:
31.8		 3g6mA-5jh8A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.06A 3glqA-2nvvA:
undetectable		 3glqA-2nvvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.10A 3glqB-2nvvA:
undetectable		 3glqB-2nvvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		5 / 12 THR A 337
HIS A 266
LEU A 269
HIS A 183
LEU A 367
 THR  A 337 ( 0.8A)
HIS  A 266 (-1.0A)
LEU  A 269 ( 0.6A)
HIS  A 183 (-1.0A)
LEU  A 367 ( 0.6A)
 1.29A 3gwxA-5ec3A:
undetectable		 3gwxA-5ec3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		5 / 12 THR A 337
HIS A 266
LEU A 269
HIS A 183
LEU A 367
 THR  A 337 ( 0.8A)
HIS  A 266 (-1.0A)
LEU  A 269 ( 0.6A)
HIS  A 183 (-1.0A)
LEU  A 367 ( 0.6A)
 1.33A 3gwxB-5ec3A:
undetectable		 3gwxB-5ec3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		5 / 10 LEU A 156
GLN A 207
THR A 206
GLY A 134
HIS A 135
 LEU  A 156 ( 0.5A)
GLN  A 207 ( 0.6A)
THR  A 206 ( 0.8A)
GLY  A 134 (-0.0A)
HIS  A 135 ( 1.0A)
 1.31A 3h9uD-4w65A:
undetectable		 3h9uD-4w65A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 9 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.32A 3hy7A-5d7wA:
7.7		 3hy7A-5d7wA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5d7w SERRALYSIN
(Serratia
marcescens) 		5 / 9 THR A 173
HIS A 176
GLU A 177
HIS A 180
HIS A 186
 THR  A 173 ( 0.8A)
HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.33A 3hy7B-5d7wA:
7.6		 3hy7B-5d7wA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		3 / 3 SER A 150
ASP A  88
ASP A 174
 None
None
HIS  A 501 (-2.9A)
 0.94A 3iv6C-4yrpA:
undetectable		 3iv6C-4yrpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.20A 3jq7B-4ohnA:
undetectable		 3jq7B-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.22A 3jqaA-4ohnA:
undetectable		 3jqaA-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.22A 3jqaB-4ohnA:
undetectable		 3jqaB-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.20A 3jqaC-4ohnA:
undetectable		 3jqaC-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.20A 3jqaD-4ohnA:
undetectable		 3jqaD-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 9 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.01A 3jwqA-3sl5A:
39.2		 3jwqA-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 11 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.94A 3jwqB-3sl5A:
39.0
3jwqC-3sl5A:
39.2		 3jwqB-3sl5A:
28.41
3jwqC-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 7 TYR A 159
HIS A 160
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.91A 3jwqC-3sl5A:
39.2		 3jwqC-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		6 / 11 TYR A 159
HIS A 160
PHE A 340
MET A 357
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 1.01A 3jwqA-3sl5A:
39.2
3jwqD-3sl5A:
38.8		 3jwqA-3sl5A:
28.41
3jwqD-3sl5A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.28A 3kecA-5d7wA:
14.6		 3kecA-5d7wA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KL3_B_DHIB404_0
(GLUCURONOXYLANASE
XYNC)		 3kl0 GLUCURONOXYLANASE
XYNC
(Bacillus
subtilis) 		4 / 4 GLU A 140
TYR A 143
TYR A 204
TYR A 231
 HIS  A 405 (-2.7A)
HIS  A 405 (-4.1A)
HIS  A 405 ( 3.5A)
HIS  A 405 (-4.5A)
 0.35A 3kl3B-3kl0A:
68.8		 3kl3B-3kl0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.30A 3likA-5d7wA:
14.3		 3likA-5d7wA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.31A 3lilA-5d7wA:
14.3		 3lilA-5d7wA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.34A 3ljgA-5d7wA:
14.3		 3ljgA-5d7wA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.31A 3lkaA-5d7wA:
14.2		 3lkaA-5d7wA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.32A 3mekA-5nqfA:
undetectable		 3mekA-5nqfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1joi AZURIN
(Pseudomonas
fluorescens) 		3 / 3 HIS A 117
HIS A  46
MET A  44
 HIS  A 117 (-0.9A)
HIS  A  46 (-0.9A)
MET  A  44 ( 0.0A)
 0.98A 3mihA-1joiA:
undetectable		 3mihA-1joiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.09A 3n58A-2nvvA:
2.2		 3n58A-2nvvA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2f06 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A  82
VAL A 130
VAL A  86
LEU A  83
 HIS  A 152 (-3.8A)
None
None
HIS  A 152 (-3.7A)
 0.83A 3o14A-2f06A:
undetectable		 3o14A-2f06A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 655
ASN A 727
HIS A 678
LEU A 657
 ILE  A 655 ( 0.7A)
ASN  A 727 ( 0.6A)
HIS  A 678 ( 1.0A)
LEU  A 657 ( 0.6A)
 0.97A 3oi8A-4zkeA:
undetectable		 3oi8A-4zkeA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 6 GLN A 444
ILE A 445
SER A 370
SER A 236
 GOL  A 507 ( 3.9A)
None
HIS  A 502 ( 4.1A)
None
 1.13A 3pmzD-4xkqA:
undetectable		 3pmzD-4xkqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 ALA A  86
SER A 112
TRP A 110
VAL A  89
ALA A  56
 None
None
HIS  A 401 (-3.7A)
None
HIS  A 401 (-3.5A)
 1.22A 3qxvE-4pdyA:
undetectable		 3qxvE-4pdyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 GLY A  84
THR A  85
GLN A 127
GLU A 131
 None
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
 0.67A 3rglA-1httA:
10.6		 3rglA-1httA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		4 / 8 GLY A  86
THR A  87
ARG A 115
GLN A 129
 None
HIS  A 502 (-3.4A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
 0.88A 3rglA-5e3iA:
10.4		 3rglA-5e3iA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		4 / 8 GLY A  86
THR A  87
GLN A 129
GLU A 133
 None
HIS  A 502 (-3.4A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
 0.62A 3rglA-5e3iA:
10.4		 3rglA-5e3iA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 3s33A-5d7wA:
undetectable		 3s33A-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 3s38A-5d7wA:
undetectable		 3s38A-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.77A 3s39A-5d7wA:
undetectable		 3s39A-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 3s3aA-5d7wA:
undetectable		 3s3aA-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.79A 3s3bA-5d7wA:
undetectable		 3s3bA-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.78A 3s3cA-5d7wA:
undetectable		 3s3cA-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 3s3dA-5d7wA:
undetectable		 3s3dA-5d7wA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_1
(CATECHOL
O-METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 ASN A 293
VAL A 294
MET A 224
ASN A 225
HIS A 220
 ASN  A 293 ( 0.6A)
VAL  A 294 ( 0.6A)
MET  A 224 ( 0.0A)
ASN  A 225 ( 0.6A)
HIS  A 220 ( 1.0A)
 1.48A 3s68A-5nqfA:
undetectable		 3s68A-5nqfA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 4 PHE A 383
TYR A 407
ILE A 462
LEU A 460
 HIS  A 502 (-4.6A)
None
None
None
 1.47A 3sudA-4oflA:
undetectable		 3sudA-4oflA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_A_DAHA351_1
(PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 9 HIS A 302
SER A 277
VAL A 409
ALA A 274
GLY A 250
 NAD  A 502 (-3.9A)
HIS  A 501 ( 2.6A)
NAD  A 502 (-3.4A)
NAD  A 502 (-3.7A)
NAD  A 502 (-3.0A)
 1.10A 3tehA-5vldA:
undetectable		 3tehA-5vldA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 LEU A 330
HIS A 171
MET A 170
 LEU  A 330 ( 0.6A)
HIS  A 171 ( 1.0A)
ILE  A 167 ( 3.7A)
 0.90A 3thrD-2nvvA:
2.1		 3thrD-2nvvA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 HIS A 385
SER A 386
THR A 360
ASP A 227
 HIS  A 385 ( 1.0A)
SER  A 386 ( 0.0A)
THR  A 360 ( 0.8A)
ASP  A 227 ( 0.6A)
 1.14A 3tm4A-3wd7A:
undetectable		 3tm4A-3wd7A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 HIS A 385
SER A 386
THR A 360
ASP A 227
 HIS  A 385 ( 1.0A)
SER  A 386 ( 0.0A)
THR  A 360 ( 0.8A)
ASP  A 227 ( 0.6A)
 1.13A 3tm4B-3wd7A:
undetectable		 3tm4B-3wd7A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A   9
VAL A  48
GLU A  49
SER A  69
ILE A  64
 None
None
None
HIS  A 239 (-4.6A)
None
 0.79A 3uawA-1hslA:
undetectable		 3uawA-1hslA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ASN A  95
ASP A 413
ILE A 376
ASP A 102
HIS A 411
 ASN  A  95 ( 0.6A)
ASP  A 413 (-0.5A)
ILE  A 376 ( 0.7A)
ASP  A 102 ( 0.6A)
HIS  A 411 (-1.0A)
 1.29A 3w37A-2nvvA:
undetectable		 3w37A-2nvvA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ASN A  95
ASP A 413
ILE A 376
ASP A 102
HIS A 411
 ASN  A  95 ( 0.6A)
ASP  A 413 (-0.5A)
ILE  A 376 ( 0.7A)
ASP  A 102 ( 0.6A)
HIS  A 411 (-1.0A)
 1.29A 3welA-2nvvA:
undetectable		 3welA-2nvvA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 3wg7A-5d7wA:
undetectable		 3wg7A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 3wg7N-5d7wA:
undetectable		 3wg7N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 ASP A 109
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.40A 3wqvA-5jh8A:
33.3		 3wqvA-5jh8A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		6 / 11 ASP A 109
GLU A 111
MET A 174
TYR A 176
ASP A 177
TYR A 217
 HIS  A 505 (-2.3A)
HIS  A 505 (-2.8A)
HIS  A 505 (-3.8A)
6KY  A 504 (-4.0A)
6KY  A 504 (-2.6A)
6KY  A 504 (-3.1A)
 0.40A 3wqwA-5jh8A:
33.4		 3wqwA-5jh8A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  39
ALA A  52
LYS A  54
LEU A  73
PHE A 107
GLY A 111
LEU A 144
HIS A 151
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.71A 3wzeA-5d7aA:
8.8		 3wzeA-5d7aA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 3x2qA-5d7wA:
undetectable		 3x2qA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.71A 3x2qN-5d7wA:
undetectable		 3x2qN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2f06 CONSERVED
HYPOTHETICAL PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  90
LEU A  87
LEU A  83
ILE A  74
ILE A  97
 None
None
HIS  A 152 (-3.7A)
None
None
 0.95A 4a7aB-2f06A:
undetectable		 4a7aB-2f06A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 6 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.25A 4a7bA-5d7wA:
14.6		 4a7bA-5d7wA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 5 LEU A 323
HIS A 183
GLU A 349
HIS A 266
 LEU  A 323 ( 0.6A)
HIS  A 183 (-1.0A)
GLU  A 349 (-0.6A)
HIS  A 266 (-1.0A)
 1.32A 4a7bB-5ec3A:
undetectable		 4a7bB-5ec3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 ASP A  32
ILE A  31
GLY A  28
ARG A  77
 None
None
None
HIS  A 239 (-3.0A)
 0.87A 4acbB-1hslA:
undetectable
4acbC-1hslA:
undetectable		 4acbB-1hslA:
19.03
4acbC-1hslA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 HIS A 578
GLY A 580
TYR A 584
GLU A 586
 HIS  A 578 ( 1.0A)
GLY  A 580 ( 0.0A)
TYR  A 584 ( 1.3A)
GLU  A 586 ( 0.5A)
 1.37A 4ae1B-5c6dA:
undetectable		 4ae1B-5c6dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 HIS A 490
LEU A 333
LEU A 314
ASP A 331
 HIS  A 490 ( 1.0A)
LEU  A 333 ( 0.5A)
LEU  A 314 ( 0.5A)
ASP  A 331 ( 0.5A)
 1.26A 4aqlA-5l5nA:
undetectable		 4aqlA-5l5nA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 VAL A  39
ALA A  52
LYS A  54
GLU A  69
LEU A  73
PHE A 107
GLY A 111
LEU A 144
HIS A 151
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.79A 4asdA-5d7aA:
10.1		 4asdA-5d7aA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 11 GLN A 568
THR A 681
PHE A 715
ILE A 710
HIS A 678
 GLN  A 568 ( 0.6A)
THR  A 681 ( 0.8A)
PHE  A 715 ( 1.3A)
ILE  A 710 ( 0.7A)
HIS  A 678 ( 1.0A)
 1.03A 4bb2A-4zkeA:
undetectable
4bb2B-4zkeA:
undetectable		 4bb2A-4zkeA:
23.00
4bb2B-4zkeA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 12 SER A 148
GLY A 377
ALA A 373
HIS A  58
PHE A  92
 SER  A 148 ( 0.0A)
GLY  A 377 ( 0.0A)
ALA  A 373 ( 0.0A)
HIS  A  58 (-1.0A)
PHE  A  92 ( 1.3A)
 1.34A 4bupB-4kqnA:
undetectable		 4bupB-4kqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		5 / 12 SER A 385
GLN A 196
THR A 253
ILE A 391
HIS A  73
 SER  A 385 ( 0.0A)
GLN  A 196 ( 0.6A)
THR  A 253 ( 0.8A)
ILE  A 391 ( 0.6A)
HIS  A  73 ( 1.0A)
 1.33A 4c49B-5nksA:
undetectable		 4c49B-5nksA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 568
THR A 681
PHE A 715
ILE A 710
HIS A 678
 GLN  A 568 ( 0.6A)
THR  A 681 ( 0.8A)
PHE  A 715 ( 1.3A)
ILE  A 710 ( 0.7A)
HIS  A 678 ( 1.0A)
 1.06A 4c49C-4zkeA:
undetectable		 4c49C-4zkeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 ALA A  52
LYS A  54
GLU A  69
LEU A  73
ILE A  82
HIS A 151
LEU A 160
 ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
ILE  A  82 ( 0.7A)
HIS  A 151 ( 1.0A)
LEU  A 160 (-0.6A)
 0.91A 4c8bB-5d7aA:
25.6		 4c8bB-5d7aA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 HIS A 704
GLN A 574
VAL A 570
ILE A 569
ILE A 620
 HIS  A 704 ( 1.0A)
GLN  A 574 ( 0.6A)
VAL  A 570 ( 0.6A)
ILE  A 569 ( 0.7A)
ILE  A 620 ( 0.7A)
 1.31A 4drhA-5c6dA:
undetectable		 4drhA-5c6dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5c6d UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 12 HIS A 704
GLN A 574
VAL A 570
ILE A 569
ILE A 620
 HIS  A 704 ( 1.0A)
GLN  A 574 ( 0.6A)
VAL  A 570 ( 0.6A)
ILE  A 569 ( 0.7A)
ILE  A 620 ( 0.7A)
 1.23A 4drhD-5c6dA:
undetectable		 4drhD-5c6dA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 8 ASP A 182
VAL A 228
LEU A 332
HIS A 183
 ASP  A 182 ( 0.6A)
VAL  A 228 ( 0.6A)
LEU  A 332 ( 0.6A)
HIS  A 183 (-1.0A)
 1.18A 4f5zA-5ec3A:
undetectable		 4f5zA-5ec3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 HIS A 423
TYR A 406
GLY A  58
SER A 414
 HIS  A 423 ( 1.0A)
TYR  A 406 ( 1.3A)
GLY  A  58 ( 0.0A)
SER  A 414 ( 0.0A)
 1.30A 4fu8A-2vbfA:
undetectable		 4fu8A-2vbfA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 418
ALA A 124
HIS A 128
TYR A 444
 HIS  A 418 ( 1.0A)
ALA  A 124 ( 0.0A)
HIS  A 128 ( 1.0A)
TYR  A 444 ( 1.3A)
 0.96A 4gboA-2ogsA:
undetectable		 4gboA-2ogsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 HIS A  58
HIS A 183
HIS A 239
ASP A 315
 HIS  A  58 (-1.0A)
HIS  A 183 (-1.0A)
HIS  A 239 (-1.0A)
ASP  A 315 (-0.6A)
 0.43A 4h9mA-4kqnA:
25.1		 4h9mA-4kqnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.14A 4hvcA-5vldA:
2.3		 4hvcA-5vldA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		4 / 7 GLU A  19
HIS A   8
PRO A  61
VAL A  21
 GLU  A  19 ( 0.6A)
HIS  A   8 ( 1.0A)
PRO  A  61 ( 1.1A)
VAL  A  21 ( 0.6A)
 1.03A 4hvrA-1wlyA:
undetectable		 4hvrA-1wlyA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4gvo LMO2349 PROTEIN
(Listeria
monocytogenes) 		4 / 9 PHE A  84
HIS A 101
PHE A 123
ILE A 195
 HIS  A 703 ( 3.7A)
CSX  A 704 ( 4.5A)
CSX  A 704 ( 3.4A)
None
 1.30A 4jvlA-4gvoA:
undetectable		 4jvlA-4gvoA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 3ig0 DNA GYRASE SUBUNIT B
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 560
VAL A 561
LEU A 544
LEU A 509
THR A 511
 HIS  A 560 ( 1.0A)
VAL  A 561 ( 0.6A)
LEU  A 544 ( 0.6A)
LEU  A 509 ( 0.6A)
THR  A 511 ( 0.8A)
 1.08A 4k0sA-3ig0A:
undetectable		 4k0sA-3ig0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 7 ASP A  36
PRO A  96
HIS A 101
SER A  99
 ASP  A  36 ( 0.6A)
PRO  A  96 ( 1.1A)
HIS  A 101 ( 1.0A)
SER  A  99 ( 0.0A)
 1.16A 4k7gB-5wpiA:
undetectable		 4k7gB-5wpiA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 251
GLY A 252
GLY A 224
ALA A 231
HIS A 262
 GLY  A 251 (-0.0A)
GLY  A 252 (-0.0A)
GLY  A 224 (-0.0A)
ALA  A 231 ( 0.0A)
HIS  A 262 ( 1.0A)
 1.16A 4l8fB-3c3nA:
undetectable		 4l8fB-3c3nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3c3n DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 251
GLY A 252
GLY A 224
ALA A 231
HIS A 262
 GLY  A 251 (-0.0A)
GLY  A 252 (-0.0A)
GLY  A 224 (-0.0A)
ALA  A 231 ( 0.0A)
HIS  A 262 ( 1.0A)
 1.15A 4l8fD-3c3nA:
undetectable		 4l8fD-3c3nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		3 / 3 HIS A 223
TRP A 295
SER A 304
 HIS  A 223 ( 1.0A)
TRP  A 295 ( 0.5A)
SER  A 304 ( 0.0A)
 1.18A 4lrhD-5nksA:
undetectable		 4lrhD-5nksA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 ALA A 251
HIS A 387
PHE A 383
LEU A 318
 ALA  A 251 ( 0.0A)
HIS  A 387 ( 1.0A)
PHE  A 383 ( 1.3A)
LEU  A 318 ( 0.6A)
 1.34A 4lufA-5hxkA:
0.0		 4lufA-5hxkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 5hxk ZINC-DEPENDENT
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 ALA A 251
HIS A 387
PHE A 383
LEU A 318
 ALA  A 251 ( 0.0A)
HIS  A 387 ( 1.0A)
PHE  A 383 ( 1.3A)
LEU  A 318 ( 0.6A)
 1.36A 4luhA-5hxkA:
0.4		 4luhA-5hxkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 PHE A 134
ARG A 376
SER A  96
ALA A 392
 HIS  A 503 ( 4.8A)
None
None
None
 1.05A 4lv9A-4xkqA:
undetectable
4lv9B-4xkqA:
undetectable		 4lv9A-4xkqA:
21.06
4lv9B-4xkqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 4lvcA-2nvvA:
2.4		 4lvcA-2nvvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 THR  A 176 ( 0.8A)
THR  A 130 ( 0.8A)
HIS  A  42 ( 1.0A)
LEU  A  25 ( 0.5A)
 1.30A 4lvcA-2v9uA:
undetectable		 4lvcA-2v9uA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 4lvcC-2nvvA:
2.0		 4lvcC-2nvvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 THR  A 176 ( 0.8A)
THR  A 130 ( 0.8A)
HIS  A  42 ( 1.0A)
LEU  A  25 ( 0.5A)
 1.30A 4lvcC-2v9uA:
undetectable		 4lvcC-2v9uA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 1k5d RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 11 THR B 124
HIS B 102
LEU B 138
LEU B  55
ARG B  70
 THR  B 124 ( 0.8A)
HIS  B 102 ( 1.0A)
LEU  B 138 ( 0.6A)
LEU  B  55 ( 0.6A)
ARG  B  70 ( 0.6A)
 1.46A 4m7tA-1k5dB:
undetectable		 4m7tA-1k5dB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 7 GLU A  52
THR A 311
HIS A  24
LEU A  20
 GLU  A  52 ( 0.6A)
THR  A 311 ( 0.8A)
HIS  A  24 ( 1.0A)
LEU  A  20 ( 0.6A)
 1.13A 4pfjA-3i4kA:
undetectable		 4pfjA-3i4kA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.84A 4pgfA-5d7aA:
undetectable		 4pgfA-5d7aA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 GLU  A 360 ( 0.6A)
THR  A 335 ( 0.8A)
HIS  A 333 ( 1.0A)
 0.51A 4q15A-5nksA:
undetectable		 4q15A-5nksA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		3 / 3 GLU A 367
THR A 177
HIS A 408
 HIS  A 501 ( 2.7A)
None
HIS  A 501 ( 3.4A)
 0.86A 4q15A-5vldA:
3.0		 4q15A-5vldA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		3 / 3 GLU A 359
THR A 335
HIS A 333
 GLU  A 359 ( 0.6A)
THR  A 335 ( 0.8A)
HIS  A 333 ( 1.0A)
 0.87A 4q15B-5nksA:
undetectable		 4q15B-5nksA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 GLU  A 360 ( 0.6A)
THR  A 335 ( 0.8A)
HIS  A 333 ( 1.0A)
 0.50A 4q15B-5nksA:
undetectable		 4q15B-5nksA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		3 / 3 GLU A 367
THR A 177
HIS A 408
 HIS  A 501 ( 2.7A)
None
HIS  A 501 ( 3.4A)
 0.83A 4q15B-5vldA:
2.8		 4q15B-5vldA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 SER A  70
PHE A  17
LEU A  71
GLU A 188
GLY A 194
 HIS  A 239 (-4.8A)
None
HIS  A 239 (-4.7A)
None
None
 1.21A 4qb9E-1hslA:
0.0		 4qb9E-1hslA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 282
TYR A 206
ILE A  50
THR A 213
 HIS  A 800 (-3.0A)
HIS  A 800 (-4.4A)
HIS  A 800 ( 4.2A)
HIS  A 800 ( 4.5A)
 1.43A 4qwpA-4uy6A:
undetectable		 4qwpA-4uy6A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLU A 282
TYR A 206
ILE A  50
THR A 213
 HIS  A 800 (-3.0A)
HIS  A 800 (-4.4A)
HIS  A 800 ( 4.2A)
HIS  A 800 ( 4.5A)
 1.44A 4qwpB-4uy6A:
undetectable		 4qwpB-4uy6A:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 GLU A 131
ARG A 259
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.0A)
AMP  A 451 ( 3.3A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 1.23A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 GLU A 131
TYR A 263
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 1.01A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 THR A  85
GLU A 131
GLY A 285
TYR A 288
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
 0.44A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 THR A  85
GLU A 131
GLY A 286
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.2A)
 0.81A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 7 THR A  85
GLU A 131
TYR A 264
TYR A 288
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 0.74A 4rdxA-1httA:
35.6		 4rdxA-1httA:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 7 GLU A 138
TYR A 269
GLY A 291
TYR A 294
GLY A 310
 HIS  A 501 (-2.7A)
None
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 1.14A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		6 / 7 THR A  92
GLU A 138
ARG A 265
GLY A 291
TYR A 294
GLY A 310
 HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
HIS  A 501 (-3.8A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 1.15A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 7 THR A  92
GLU A 138
GLY A 292
GLY A 310
 HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-3.3A)
 0.81A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 7 THR A  92
GLU A 138
TYR A 270
TYR A 294
GLY A 310
 HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
HIS  A 501 (-4.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
 0.70A 4rdxA-4e51A:
39.9		 4rdxA-4e51A:
40.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 132
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.45A 4rdxA-4phcA:
31.2		 4rdxA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 132
TYR A 331
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.7A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.81A 4rdxA-4phcA:
31.2		 4rdxA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		4 / 7 THR A 128
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.42A 4rdxA-4yrpA:
31.6		 4rdxA-4yrpA:
29.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		5 / 7 GLU A 133
TYR A 265
GLY A 287
TYR A 290
GLY A 309
 HIS  A 502 (-2.6A)
None
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
HIS  A 502 (-3.5A)
 1.04A 4rdxA-5e3iA:
37.0		 4rdxA-5e3iA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		6 / 7 THR A  87
GLU A 133
ARG A 261
GLY A 287
TYR A 290
GLY A 309
 HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
ATP  A 501 (-2.8A)
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
HIS  A 502 (-3.5A)
 1.06A 4rdxA-5e3iA:
37.0		 4rdxA-5e3iA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		6 / 7 THR A  87
GLU A 133
ARG A 261
TYR A 266
TYR A 290
GLY A 309
 HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
ATP  A 501 (-2.8A)
HIS  A 502 (-4.7A)
HIS  A 502 (-4.5A)
HIS  A 502 (-3.5A)
 1.20A 4rdxA-5e3iA:
37.0		 4rdxA-5e3iA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		4 / 7 THR A  87
GLU A 133
GLY A 288
GLY A 309
 HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
HIS  A 502 (-3.5A)
 0.73A 4rdxA-5e3iA:
37.0		 4rdxA-5e3iA:
38.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2qc5 STREPTOGRAMIN B
LACTONASE
(Staphylococcus
cohnii) 		5 / 12 TYR A 102
ILE A  20
GLY A  19
HIS A 228
ILE A 272
 TYR  A 102 ( 1.3A)
ILE  A  20 ( 0.7A)
GLY  A  19 (-0.0A)
HIS  A 228 ( 1.0A)
ILE  A 272 ( 0.7A)
 1.11A 4rvdA-2qc5A:
undetectable		 4rvdA-2qc5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  44
GLY A   4
ALA A 182
PHE A  66
HIS A  41
 ILE  A  44 ( 0.5A)
GLY  A   4 ( 0.0A)
ALA  A 182 ( 0.0A)
PHE  A  66 ( 1.3A)
HIS  A  41 ( 1.0A)
 0.95A 4rvdA-4g41A:
undetectable		 4rvdA-4g41A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 10 ALA A  56
LYS A  58
THR A 108
VAL A 111
LEU A 232
 HIS  A 401 (-3.5A)
None
None
HIS  A 401 (-4.2A)
HIS  A 401 (-4.3A)
 0.91A 4rz7A-4pdyA:
8.2		 4rz7A-4pdyA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		5 / 6 HIS A  58
HIS A  60
HIS A 183
HIS A 239
ASP A 315
 HIS  A  58 (-1.0A)
HIS  A  60 (-1.0A)
HIS  A 183 (-1.0A)
HIS  A 239 (-1.0A)
ASP  A 315 (-0.6A)
 0.44A 4ubpC-4kqnA:
24.0		 4ubpC-4kqnA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  79
PHE A  74
TYR A  18
HIS A 120
 PHE  A  79 ( 1.3A)
PHE  A  74 ( 1.3A)
TYR  A  18 ( 1.3A)
HIS  A 120 ( 1.0A)
 1.12A 4uciB-5hfiA:
undetectable		 4uciB-5hfiA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		8 / 12 HIS H  35
GLY H 101
PHE H 111
GLN L  89
GLN L  90
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
GLY  H 101 ( 0.0A)
PHE  H 111 ( 1.3A)
GLN  L  89 ( 0.6A)
GLN  L  90 ( 0.6A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.85A 4uilH-1fgvH:
20.2
4uilL-1fgvH:
5.2		 4uilH-1fgvH:
53.23
4uilL-1fgvH:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		8 / 12 HIS H  35
SER H  59
PHE H 111
GLN L  89
GLN L  90
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
SER  H  59 ( 0.0A)
PHE  H 111 ( 1.3A)
GLN  L  89 ( 0.6A)
GLN  L  90 ( 0.6A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 1.00A 4uilH-1fgvH:
20.2
4uilL-1fgvH:
5.2		 4uilH-1fgvH:
53.23
4uilL-1fgvH:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS H  35
GLY H 101
PHE H 111
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
GLY  H 101 ( 0.0A)
PHE  H 111 ( 1.3A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.84A 4uinH-1fgvH:
21.2
4uinL-1fgvH:
13.6		 4uinH-1fgvH:
52.42
4uinL-1fgvH:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS H  35
TRP H  47
PHE H 111
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
TRP  H  47 ( 0.4A)
PHE  H 111 ( 1.3A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.73A 4uinH-1fgvH:
21.2
4uinL-1fgvH:
13.6		 4uinH-1fgvH:
52.42
4uinL-1fgvH:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 11 LEU A 297
GLN A 299
ALA A 300
HIS A 408
VAL A 279
 None
HIS  A 501 ( 3.3A)
None
HIS  A 501 ( 3.4A)
None
 1.40A 4uuuA-5vldA:
undetectable
4uuuB-5vldA:
undetectable		 4uuuA-5vldA:
17.73
4uuuB-5vldA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5w0a GLUCANASE
(Trichoderma
harzianum) 		4 / 5 GLY A   4
THR A   5
HIS A  42
GLU A  73
 GLY  A   4 ( 0.0A)
THR  A   5 ( 0.8A)
HIS  A  42 ( 1.0A)
GLU  A  73 ( 0.6A)
 0.44A 4v20A-5w0aA:
50.4		 4v20A-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 12 GLY A 667
ASP A 668
ILE A 665
ALA A 664
HIS A 803
 GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
ILE  A 665 ( 0.7A)
ALA  A 664 ( 0.0A)
HIS  A 803 ( 1.0A)
 1.28A 4wh5A-4mtpA:
undetectable		 4wh5A-4mtpA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		5 / 12 THR A 341
ALA A 343
ASP A 344
HIS A 202
LEU A 201
 THR  A 341 ( 0.8A)
ALA  A 343 ( 0.0A)
ASP  A 344 ( 0.6A)
HIS  A 202 ( 1.0A)
LEU  A 201 ( 0.6A)
 1.21A 4xi3A-3gnrA:
undetectable		 4xi3A-3gnrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 SER A 488
HIS A 523
LEU A 472
LEU A 467
LEU A 465
 SER  A 488 ( 0.0A)
HIS  A 523 ( 1.0A)
LEU  A 472 ( 0.5A)
LEU  A 467 ( 0.6A)
LEU  A 465 ( 0.5A)
 1.31A 4xumA-5svdA:
undetectable		 4xumA-5svdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 4 GLY A 310
LEU A 250
PHE A 257
ILE A 171
 HIS  A 501 (-3.3A)
None
None
None
 0.98A 4xv2A-4e51A:
undetectable		 4xv2A-4e51A:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.00A 4yb6A-4yb6A:
40.8
4yb6E-4yb6A:
39.1		 4yb6A-4yb6A:
100.00
4yb6E-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.03A 4yb6B-4yb6A:
38.7
4yb6C-4yb6A:
38.7		 4yb6B-4yb6A:
100.00
4yb6C-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.29A 4yb6C-4yb6A:
38.6
4yb6F-4yb6A:
38.4		 4yb6C-4yb6A:
100.00
4yb6F-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.29A 4yb6A-4yb6A:
40.8
4yb6D-4yb6A:
39.3		 4yb6A-4yb6A:
100.00
4yb6D-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.29A 4yb6D-4yb6A:
39.3
4yb6E-4yb6A:
39.1		 4yb6D-4yb6A:
100.00
4yb6E-4yb6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4yb6 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 247
VAL A 248
GLU A 249
THR A 252
VAL A 268
 HIS  A 302 (-3.2A)
HIS  A 302 (-4.0A)
None
HIS  A 302 (-4.0A)
HIS  A 302 (-3.8A)
 0.08A 4yb6B-4yb6A:
38.7
4yb6F-4yb6A:
38.4		 4yb6B-4yb6A:
100.00
4yb6F-4yb6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.19A 4ydqA-5vldA:
2.9		 4ydqA-5vldA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens) 		3 / 3 GLU A 360
THR A 335
HIS A 333
 GLU  A 360 ( 0.6A)
THR  A 335 ( 0.8A)
HIS  A 333 ( 1.0A)
 0.52A 4ydqB-5nksA:
undetectable		 4ydqB-5nksA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 HIS A  80
GLY A  78
GLU A  29
ARG A  81
 HIS  A  80 (-1.0A)
GLY  A  78 (-0.0A)
GLU  A  29 (-0.5A)
ARG  A  81 (-0.6A)
 1.30A 4zbqA-3gwmA:
undetectable		 4zbqA-3gwmA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2ixq PROTEIN AFAD
(Escherichia
coli) 		3 / 3 LYS A  57
ARG A  60
HIS A  61
 LYS  A  57 ( 0.0A)
ARG  A  60 ( 0.6A)
HIS  A  61 ( 1.0A)
 1.06A 4zbrA-2ixqA:
undetectable		 4zbrA-2ixqA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 5 ARG A 107
HIS A 274
ALA A 270
GLU A 268
 ARG  A 107 (-0.6A)
HIS  A 274 (-1.0A)
ALA  A 270 ( 0.0A)
GLU  A 268 (-0.6A)
 1.41A 5a06C-4dlkA:
undetectable
5a06D-4dlkA:
undetectable		 5a06C-4dlkA:
21.81
5a06D-4dlkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 ALA A 216
ARG A 292
HIS A 183
ALA A 184
 ALA  A 216 ( 0.0A)
ARG  A 292 ( 0.6A)
HIS  A 183 (-1.0A)
ALA  A 184 ( 0.0A)
 1.26A 5a06C-4kqnA:
2.4
5a06D-4kqnA:
2.0		 5a06C-4kqnA:
21.91
5a06D-4kqnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Mycobacteroides
abscessus) 		4 / 4 ARG A  34
HIS A  10
ALA A  12
GLU A  18
 ARG  A  34 ( 0.6A)
HIS  A  10 ( 1.0A)
ALA  A  12 ( 0.0A)
GLU  A  18 ( 0.5A)
 1.34A 5a06A-3r9rA:
0.0
5a06F-3r9rA:
0.0		 5a06A-3r9rA:
22.82
5a06F-3r9rA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 4 ARG A 107
HIS A 274
ALA A 270
GLU A 268
 ARG  A 107 (-0.6A)
HIS  A 274 (-1.0A)
ALA  A 270 ( 0.0A)
GLU  A 268 (-0.6A)
 1.34A 5a06A-4dlkA:
undetectable
5a06F-4dlkA:
1.2		 5a06A-4dlkA:
21.81
5a06F-4dlkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN
(Vibrio
vulnificus) 		4 / 7 MET A3674
GLY A3705
ASN A3704
HIS A3707
 ALA  A3699 ( 3.5A)
GLY  A3705 ( 0.0A)
ASN  A3704 ( 0.6A)
HIS  A3707 ( 1.0A)
 1.22A 5a5zC-5w6lA:
undetectable		 5a5zC-5w6lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1vho ENDOGLUCANASE
(Thermotoga
maritima) 		3 / 3 THR A 160
HIS A 307
LEU A 303
 THR  A 160 ( 0.8A)
HIS  A 307 ( 1.0A)
LEU  A 303 ( 0.6A)
 0.78A 5axdC-1vhoA:
undetectable		 5axdC-1vhoA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 5b1aA-5d7wA:
undetectable		 5b1aA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 5b1aN-5d7wA:
undetectable		 5b1aN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 5b1bA-5d7wA:
undetectable		 5b1bA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 5b1bN-5d7wA:
undetectable		 5b1bN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 5b3sN-5d7wA:
undetectable		 5b3sN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 7 HIS A 219
ASP A 304
THR A 302
HIS A 220
 HIS  A 219 ( 1.0A)
ASP  A 304 ( 0.6A)
THR  A 302 ( 0.8A)
HIS  A 220 ( 1.0A)
 1.46A 5b3sN-3gnrA:
undetectable
5b3sP-3gnrA:
undetectable		 5b3sN-3gnrA:
21.63
5b3sP-3gnrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE
(Bacillus
subtilis) 		5 / 12 GLY A 364
GLY A 115
GLY A 113
ALA A 358
HIS A 116
 GLY  A 364 ( 0.0A)
GLY  A 115 ( 0.0A)
GLY  A 113 ( 0.0A)
ALA  A 358 ( 0.0A)
HIS  A 116 ( 1.0A)
 1.07A 5c0oE-5ep8A:
undetectable		 5c0oE-5ep8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.31A 5ccmA-5nqfA:
undetectable		 5ccmA-5nqfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4kqn D-HYDANTOINASE
(Bacillus
sp.
AR9) 		4 / 5 TYR A 210
HIS A 208
LEU A 291
PRO A 214
 TYR  A 210 ( 1.3A)
HIS  A 208 ( 1.0A)
LEU  A 291 ( 0.6A)
PRO  A 214 ( 1.1A)
 1.18A 5csyB-4kqnA:
3.6		 5csyB-4kqnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.20A 5dzkb-1gc7A:
0.0
5dzkp-1gc7A:
undetectable		 5dzkb-1gc7A:
19.68
5dzkp-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 6 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.23A 5dzkB-1gc7A:
0.0
5dzkP-1gc7A:
undetectable		 5dzkB-1gc7A:
19.68
5dzkP-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3h7a SHORT CHAIN
DEHYDROGENASE
(Rhodopseudomonas
palustris) 		4 / 6 PHE A 158
ALA A 162
HIS A 180
LEU A 160
 PHE  A 158 ( 1.3A)
ALA  A 162 ( 0.0A)
HIS  A 180 ( 1.0A)
LEU  A 160 ( 0.6A)
 1.25A 5dzkB-3h7aA:
3.1
5dzkP-3h7aA:
undetectable		 5dzkB-3h7aA:
23.99
5dzkP-3h7aA:
0.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.22A 5dzkc-1gc7A:
0.0
5dzkq-1gc7A:
undetectable		 5dzkc-1gc7A:
19.68
5dzkq-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 7 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.08A 5dzkD-1gc7A:
undetectable
5dzkR-1gc7A:
undetectable		 5dzkD-1gc7A:
19.68
5dzkR-1gc7A:
1.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1gc7 RADIXIN
(Mus
musculus) 		4 / 5 SER A 127
ALA A 126
HIS A 179
LEU A 124
 SER  A 127 ( 0.0A)
ALA  A 126 ( 0.0A)
HIS  A 179 ( 1.0A)
LEU  A 124 ( 0.6A)
 1.06A 5dzkf-1gc7A:
0.0
5dzkt-1gc7A:
undetectable		 5dzkf-1gc7A:
19.68
5dzkt-1gc7A:
1.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		12 / 12 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.29A 5e3iA-1httA:
43.6		 5e3iA-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 12 GLU A  83
THR A  85
GLN A 127
TYR A 263
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 1.39A 5e3iA-1httA:
43.6		 5e3iA-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 12 THR A  85
GLU A 131
LEU A 261
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
AMP  A 451 (-4.6A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.11A 5e3iA-1httA:
43.6		 5e3iA-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 ARG A 120
GLN A 134
GLU A 138
LEU A 267
TYR A 270
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 1.44A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		12 / 12 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.37A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		8 / 12 GLU A  90
THR A  92
GLU A 138
LEU A 267
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.11A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A  90
TYR A 270
GLY A 310
TYR A 269
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
None
HIS  A 501 ( 3.8A)
 1.20A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 GLU A 138
GLU A  90
TYR A 294
TYR A 269
ALA A  94
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
None
None
 0.87A 5e3iA-4e51A:
42.1		 5e3iA-4e51A:
47.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		9 / 12 THR A 132
ARG A 157
GLN A 173
LEU A 328
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.47A 5e3iA-4phcA:
34.1		 5e3iA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.23A 5e3iA-4phcA:
34.1		 5e3iA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		9 / 12 GLU A 126
THR A 128
GLN A 170
LEU A 316
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.59A 5e3iA-4yrpA:
33.9		 5e3iA-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 12 GLU A 126
THR A 128
GLN A 170
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-3.5A)
 1.13A 5e3iA-4yrpA:
33.9		 5e3iA-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		6 / 12 THR A 128
LEU A 316
TYR A 318
TYR A 319
GLY A 340
GLY A 359
 HIS  A 501 (-3.7A)
HIS  A 501 (-4.6A)
None
HIS  A 501 (-4.9A)
None
HIS  A 501 (-3.5A)
 1.27A 5e3iA-4yrpA:
33.9		 5e3iA-4yrpA:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		7 / 12 GLU A  85
ARG A 115
GLN A 129
TYR A 265
GLY A 287
TYR A 290
GLY A 288
 HIS  A 502 (-3.8A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
None
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
None
 1.49A 5e3iA-5e3iA:
56.6		 5e3iA-5e3iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		12 / 12 GLU A  85
THR A  87
ARG A 115
GLN A 129
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 287
TYR A 290
GLY A 309
ALA A 311
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
HIS  A 502 (-3.5A)
HIS  A 502 (-3.8A)
 0.03A 5e3iA-5e3iA:
56.6		 5e3iA-5e3iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		8 / 12 GLU A  85
THR A  87
GLU A 133
LEU A 263
TYR A 265
TYR A 266
GLY A 288
GLY A 309
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
None
HIS  A 502 (-4.7A)
None
HIS  A 502 (-3.5A)
 1.03A 5e3iA-5e3iA:
56.6		 5e3iA-5e3iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		11 / 11 GLU A  83
THR A  85
ARG A 113
GLN A 127
GLU A 131
TYR A 263
TYR A 264
GLY A 285
TYR A 288
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
AMP  A 451 ( 2.3A)
HIS  A 450 (-3.1A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.6A)
HIS  A 450 ( 3.8A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 0.23A 5e3iB-1httA:
44.0		 5e3iB-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		6 / 11 GLU A  83
THR A  85
GLN A 127
TYR A 263
GLY A 304
ALA A 306
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 (-3.1A)
None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
 1.37A 5e3iB-1httA:
44.0		 5e3iB-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 11 GLU A  83
THR A  85
GLU A 131
TYR A 263
TYR A 264
GLY A 286
GLY A 304
 HIS  A 450 ( 3.8A)
HIS  A 450 ( 3.2A)
HIS  A 450 ( 3.0A)
None
HIS  A 450 ( 4.6A)
None
HIS  A 450 ( 4.2A)
 1.13A 5e3iB-1httA:
44.0		 5e3iB-1httA:
55.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		7 / 11 ARG A 120
GLN A 134
GLU A 138
TYR A 270
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
HIS  A 501 (-4.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 1.34A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		11 / 11 GLU A  90
THR A  92
ARG A 120
GLN A 134
GLU A 138
TYR A 269
TYR A 270
GLY A 291
TYR A 294
GLY A 310
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.4A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
HIS  A 501 ( 4.1A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
HIS  A 501 ( 3.8A)
 0.39A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		7 / 11 GLU A  90
THR A  92
GLU A 138
TYR A 269
TYR A 270
GLY A 292
GLY A 310
 HIS  A 501 (-3.6A)
HIS  A 501 (-3.5A)
HIS  A 501 (-2.7A)
None
HIS  A 501 (-4.5A)
None
HIS  A 501 (-3.3A)
 1.17A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 11 GLU A  90
TYR A 270
GLY A 310
TYR A 269
ALA A 312
 HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
HIS  A 501 (-3.3A)
None
HIS  A 501 ( 3.8A)
 1.24A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4e51 HISTIDINE--TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 11 GLU A 138
GLU A  90
TYR A 294
TYR A 269
ALA A  94
 HIS  A 501 (-2.7A)
HIS  A 501 (-3.6A)
HIS  A 501 (-4.5A)
None
None
 0.90A 5e3iB-4e51A:
42.6		 5e3iB-4e51A:
47.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ARG A 157
TYR A 330
TYR A 363
GLY A 361
ALA A 359
 HIS  A1001 (-3.6A)
None
HIS  A1001 (-4.6A)
None
None
 1.35A 5e3iB-4phcA:
34.0		 5e3iB-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		8 / 11 THR A 132
ARG A 157
GLN A 173
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.42A 5e3iB-4phcA:
34.0		 5e3iB-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 THR A 132
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.28A 5e3iB-4phcA:
34.0		 5e3iB-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		5 / 11 GLU A 126
THR A 128
GLN A 170
TYR A 318
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-3.5A)
 1.10A 5e3iB-4yrpA:
33.7		 5e3iB-4yrpA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4yrp HISTIDYL-TRNA
SYNTHETASE
(Trypanosoma
cruzi) 		8 / 11 GLU A 126
THR A 128
GLN A 170
TYR A 318
TYR A 319
GLY A 339
TYR A 342
GLY A 359
 HIS  A 501 (-3.8A)
HIS  A 501 (-3.7A)
HIS  A 501 (-3.4A)
None
HIS  A 501 (-4.9A)
HIS  A 501 ( 4.3A)
HIS  A 501 (-4.6A)
HIS  A 501 (-3.5A)
 0.57A 5e3iB-4yrpA:
33.7		 5e3iB-4yrpA:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		11 / 11 GLU A  85
THR A  87
ARG A 115
GLN A 129
GLU A 133
TYR A 265
TYR A 266
GLY A 287
TYR A 290
GLY A 309
ALA A 311
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
ATP  A 501 ( 2.5A)
HIS  A 502 ( 3.1A)
HIS  A 502 (-2.6A)
None
HIS  A 502 (-4.7A)
HIS  A 502 ( 3.8A)
HIS  A 502 (-4.5A)
HIS  A 502 (-3.5A)
HIS  A 502 (-3.8A)
 0.08A 5e3iB-5e3iA:
53.3		 5e3iB-5e3iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		7 / 11 GLU A  85
THR A  87
GLU A 133
TYR A 265
TYR A 266
GLY A 288
GLY A 309
 HIS  A 502 (-3.8A)
HIS  A 502 (-3.4A)
HIS  A 502 (-2.6A)
None
HIS  A 502 (-4.7A)
None
HIS  A 502 (-3.5A)
 1.08A 5e3iB-5e3iA:
53.3		 5e3iB-5e3iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		5 / 11 ALA A  69
ALA A  37
VAL A 328
HIS A 122
VAL A 302
 ALA  A  69 ( 0.0A)
ALA  A  37 ( 0.0A)
VAL  A 328 ( 0.6A)
HIS  A 122 ( 1.0A)
VAL  A 302 ( 0.6A)
 1.32A 5eb5A-1wlyA:
undetectable		 5eb5A-1wlyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 1wly 2-HALOACRYLATE
REDUCTASE
(Burkholderia
sp.
WS) 		5 / 10 ALA A  69
ALA A  37
VAL A 328
LEU A 118
HIS A 122
 ALA  A  69 ( 0.0A)
ALA  A  37 ( 0.0A)
VAL  A 328 ( 0.6A)
LEU  A 118 ( 0.6A)
HIS  A 122 ( 1.0A)
 1.44A 5eb5B-1wlyA:
undetectable		 5eb5B-1wlyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Escherichia
coli) 		4 / 6 THR A 285
VAL A 284
VAL A 290
HIS A 268
 THR  A 285 ( 0.8A)
VAL  A 284 ( 0.6A)
VAL  A 290 ( 0.6A)
HIS  A 268 ( 1.0A)
 1.04A 5eclA-1fxjA:
0.6		 5eclA-1fxjA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		5 / 9 HIS A 209
ALA A 240
THR A 103
THR A  63
ILE A  32
 HIS  A 209 ( 1.0A)
ALA  A 240 ( 0.0A)
THR  A 103 ( 0.8A)
THR  A  63 ( 0.8A)
ILE  A  32 ( 0.6A)
 1.41A 5eeuA-2hk0A:
undetectable
5eeuB-2hk0A:
undetectable		 5eeuA-2hk0A:
13.40
5eeuB-2hk0A:
13.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 5eeuA-4b27A:
13.3
5eeuB-4b27A:
13.3		 5eeuA-4b27A:
76.32
5eeuB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeuB-4b27A:
13.3
5eeuC-4b27A:
13.2		 5eeuB-4b27A:
76.32
5eeuC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eeuC-4b27A:
13.2
5eeuD-4b27A:
13.3		 5eeuC-4b27A:
76.32
5eeuD-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5eeuD-4b27A:
13.3
5eeuE-4b27A:
13.4		 5eeuD-4b27A:
76.32
5eeuE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeuE-4b27A:
13.4
5eeuF-4b27A:
13.3		 5eeuE-4b27A:
76.32
5eeuF-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.26A 5eeuE-6gefA:
undetectable
5eeuF-6gefA:
undetectable		 5eeuE-6gefA:
undetectable
5eeuF-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5eeuF-4b27A:
13.3
5eeuG-4b27A:
13.4		 5eeuF-4b27A:
76.32
5eeuG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5eeuF-4b27A:
13.3
5eeuG-4b27A:
13.4		 5eeuF-4b27A:
76.32
5eeuG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eeuG-4b27A:
13.4
5eeuH-4b27A:
13.4		 5eeuG-4b27A:
76.32
5eeuH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eeuG-6gefA:
undetectable
5eeuH-6gefA:
undetectable		 5eeuG-6gefA:
undetectable
5eeuH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeuH-4b27A:
13.4
5eeuI-4b27A:
13.4		 5eeuH-4b27A:
76.32
5eeuI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 12 ALA A  46
GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.06A 5eeuI-4b27A:
13.4
5eeuJ-4b27A:
13.5		 5eeuI-4b27A:
76.32
5eeuJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 12 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eeuI-4b27A:
13.4
5eeuJ-4b27A:
13.5		 5eeuI-4b27A:
76.32
5eeuJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeuJ-4b27A:
13.5
5eeuK-4b27A:
13.3		 5eeuJ-4b27A:
76.32
5eeuK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5eeuJ-6gefA:
undetectable
5eeuK-6gefA:
undetectable		 5eeuJ-6gefA:
undetectable
5eeuK-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eeuA-4b27A:
13.3
5eeuK-4b27A:
13.3		 5eeuA-4b27A:
76.32
5eeuK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5eeuL-4b27A:
13.0
5eeuV-4b27A:
13.1		 5eeuL-4b27A:
76.32
5eeuV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.38A 5eeuL-4b27A:
13.0
5eeuM-4b27A:
13.1		 5eeuL-4b27A:
76.32
5eeuM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5eeuM-4b27A:
13.1
5eeuN-4b27A:
13.0		 5eeuM-4b27A:
76.32
5eeuN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5eeuN-4b27A:
13.0
5eeuO-4b27A:
13.1		 5eeuN-4b27A:
76.32
5eeuO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5eeuN-6gefA:
undetectable
5eeuO-6gefA:
undetectable		 5eeuN-6gefA:
undetectable
5eeuO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5eeuO-4b27A:
13.1
5eeuP-4b27A:
13.1		 5eeuO-4b27A:
76.32
5eeuP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.15A 5eeuO-4b27A:
13.1
5eeuP-4b27A:
13.1		 5eeuO-4b27A:
76.32
5eeuP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eeuP-4b27A:
13.1
5eeuQ-4b27A:
13.0		 5eeuP-4b27A:
76.32
5eeuQ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eeuP-6gefA:
undetectable
5eeuQ-6gefA:
undetectable		 5eeuP-6gefA:
undetectable
5eeuQ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 5eeuQ-4b27A:
13.0
5eeuR-4b27A:
13.0		 5eeuQ-4b27A:
76.32
5eeuR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.14A 5eeuQ-4b27A:
13.0
5eeuR-4b27A:
13.0		 5eeuQ-4b27A:
76.32
5eeuR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.30A 5eeuR-4b27A:
13.0
5eeuS-4b27A:
13.0		 5eeuR-4b27A:
76.32
5eeuS-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5eeuR-6gefA:
undetectable
5eeuS-6gefA:
undetectable		 5eeuR-6gefA:
undetectable
5eeuS-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eeuS-4b27A:
13.0
5eeuT-4b27A:
13.1		 5eeuS-4b27A:
76.32
5eeuT-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eeuS-6gefA:
undetectable
5eeuT-6gefA:
undetectable		 5eeuS-6gefA:
undetectable
5eeuT-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eeuT-4b27A:
13.1
5eeuU-4b27A:
13.1		 5eeuT-4b27A:
76.32
5eeuU-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5eeuT-6gefA:
undetectable
5eeuU-6gefA:
undetectable		 5eeuT-6gefA:
undetectable
5eeuU-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5eeuU-4b27A:
13.1
5eeuV-4b27A:
13.1		 5eeuU-4b27A:
76.32
5eeuV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5eeuU-6gefA:
undetectable
5eeuV-6gefA:
undetectable		 5eeuU-6gefA:
undetectable
5eeuV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 5eevA-4b27A:
13.3
5eevB-4b27A:
13.3		 5eevA-4b27A:
76.32
5eevB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eevB-4b27A:
13.3
5eevC-4b27A:
13.3		 5eevB-4b27A:
76.32
5eevC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eevC-4b27A:
13.3
5eevD-4b27A:
13.3		 5eevC-4b27A:
76.32
5eevD-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5eevD-4b27A:
13.3
5eevE-4b27A:
13.4		 5eevD-4b27A:
76.32
5eevE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eevE-4b27A:
13.4
5eevF-4b27A:
13.3		 5eevE-4b27A:
76.32
5eevF-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.26A 5eevE-6gefA:
undetectable
5eevF-6gefA:
undetectable		 5eevE-6gefA:
undetectable
5eevF-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5eevF-4b27A:
13.3
5eevG-4b27A:
13.4		 5eevF-4b27A:
76.32
5eevG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5eevF-4b27A:
13.3
5eevG-4b27A:
13.4		 5eevF-4b27A:
76.32
5eevG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eevG-4b27A:
13.4
5eevH-4b27A:
13.4		 5eevG-4b27A:
76.32
5eevH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eevG-6gefA:
undetectable
5eevH-6gefA:
undetectable		 5eevG-6gefA:
undetectable
5eevH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eevH-4b27A:
13.4
5eevI-4b27A:
13.4		 5eevH-4b27A:
76.32
5eevI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 12 ALA A  46
GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.06A 5eevI-4b27A:
13.4
5eevJ-4b27A:
13.5		 5eevI-4b27A:
76.32
5eevJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 12 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eevI-4b27A:
13.4
5eevJ-4b27A:
13.5		 5eevI-4b27A:
76.32
5eevJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eevJ-4b27A:
13.5
5eevK-4b27A:
13.4		 5eevJ-4b27A:
76.32
5eevK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5eevJ-6gefA:
undetectable
5eevK-6gefA:
undetectable		 5eevJ-6gefA:
undetectable
5eevK-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eevA-4b27A:
13.3
5eevK-4b27A:
13.4		 5eevA-4b27A:
76.32
5eevK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5eevL-4b27A:
13.1
5eevV-4b27A:
13.1		 5eevL-4b27A:
76.32
5eevV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.37A 5eevL-4b27A:
13.1
5eevM-4b27A:
13.1		 5eevL-4b27A:
76.32
5eevM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5eevM-4b27A:
13.1
5eevN-4b27A:
13.0		 5eevM-4b27A:
76.32
5eevN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5eevN-4b27A:
13.0
5eevO-4b27A:
13.1		 5eevN-4b27A:
76.32
5eevO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5eevN-6gefA:
undetectable
5eevO-6gefA:
undetectable		 5eevN-6gefA:
undetectable
5eevO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5eevO-4b27A:
13.1
5eevP-4b27A:
13.1		 5eevO-4b27A:
76.32
5eevP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5eevO-4b27A:
13.1
5eevP-4b27A:
13.1		 5eevO-4b27A:
76.32
5eevP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eevP-4b27A:
13.1
5eevQ-4b27A:
13.0		 5eevP-4b27A:
76.32
5eevQ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eevP-6gefA:
undetectable
5eevQ-6gefA:
undetectable		 5eevP-6gefA:
undetectable
5eevQ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 5eevQ-4b27A:
13.0
5eevR-4b27A:
13.0		 5eevQ-4b27A:
76.32
5eevR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.14A 5eevQ-4b27A:
13.0
5eevR-4b27A:
13.0		 5eevQ-4b27A:
76.32
5eevR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5eevR-4b27A:
13.0
5eevS-4b27A:
13.0		 5eevR-4b27A:
76.32
5eevS-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5eevR-6gefA:
undetectable
5eevS-6gefA:
undetectable		 5eevR-6gefA:
undetectable
5eevS-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eevS-4b27A:
13.0
5eevT-4b27A:
13.1		 5eevS-4b27A:
76.32
5eevT-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eevS-6gefA:
undetectable
5eevT-6gefA:
undetectable		 5eevS-6gefA:
undetectable
5eevT-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eevT-4b27A:
13.1
5eevU-4b27A:
13.1		 5eevT-4b27A:
76.32
5eevU-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5eevT-6gefA:
undetectable
5eevU-6gefA:
undetectable		 5eevT-6gefA:
undetectable
5eevU-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5eevU-4b27A:
13.1
5eevV-4b27A:
13.1		 5eevU-4b27A:
76.32
5eevV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5eevU-6gefA:
undetectable
5eevV-6gefA:
undetectable		 5eevU-6gefA:
undetectable
5eevV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eewA-4b27A:
13.3
5eewB-4b27A:
13.3		 5eewA-4b27A:
76.32
5eewB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eewB-4b27A:
13.3
5eewC-4b27A:
13.3		 5eewB-4b27A:
76.32
5eewC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eewC-4b27A:
13.3
5eewD-4b27A:
13.3		 5eewC-4b27A:
76.32
5eewD-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5eewD-4b27A:
13.3
5eewE-4b27A:
13.4		 5eewD-4b27A:
76.32
5eewE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eewE-4b27A:
13.4
5eewF-4b27A:
13.3		 5eewE-4b27A:
76.32
5eewF-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eewE-6gefA:
undetectable
5eewF-6gefA:
undetectable		 5eewE-6gefA:
undetectable
5eewF-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5eewF-4b27A:
13.3
5eewG-4b27A:
13.4		 5eewF-4b27A:
76.32
5eewG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5eewF-4b27A:
13.3
5eewG-4b27A:
13.4		 5eewF-4b27A:
76.32
5eewG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eewG-4b27A:
13.4
5eewH-4b27A:
13.4		 5eewG-4b27A:
76.32
5eewH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eewG-6gefA:
undetectable
5eewH-6gefA:
undetectable		 5eewG-6gefA:
undetectable
5eewH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eewH-4b27A:
13.4
5eewI-4b27A:
13.4		 5eewH-4b27A:
76.32
5eewI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 12 ALA A  46
GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.06A 5eewI-4b27A:
13.4
5eewJ-4b27A:
13.5		 5eewI-4b27A:
76.32
5eewJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 12 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eewI-4b27A:
13.4
5eewJ-4b27A:
13.5		 5eewI-4b27A:
76.32
5eewJ-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eewJ-4b27A:
13.5
5eewK-4b27A:
13.4		 5eewJ-4b27A:
76.32
5eewK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5eewJ-6gefA:
undetectable
5eewK-6gefA:
undetectable		 5eewJ-6gefA:
undetectable
5eewK-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eewA-4b27A:
13.3
5eewK-4b27A:
13.4		 5eewA-4b27A:
76.32
5eewK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5eewL-4b27A:
13.1
5eewV-4b27A:
13.1		 5eewL-4b27A:
76.32
5eewV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.38A 5eewL-4b27A:
13.1
5eewM-4b27A:
13.1		 5eewL-4b27A:
76.32
5eewM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5eewM-4b27A:
13.1
5eewN-4b27A:
13.0		 5eewM-4b27A:
76.32
5eewN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5eewN-4b27A:
13.0
5eewO-4b27A:
13.1		 5eewN-4b27A:
76.32
5eewO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5eewN-6gefA:
undetectable
5eewO-6gefA:
undetectable		 5eewN-6gefA:
undetectable
5eewO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5eewO-4b27A:
13.1
5eewP-4b27A:
13.1		 5eewO-4b27A:
76.32
5eewP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5eewO-4b27A:
13.1
5eewP-4b27A:
13.1		 5eewO-4b27A:
76.32
5eewP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eewP-4b27A:
13.1
5eewQ-4b27A:
13.1		 5eewP-4b27A:
76.32
5eewQ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eewP-6gefA:
undetectable
5eewQ-6gefA:
undetectable		 5eewP-6gefA:
undetectable
5eewQ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eewQ-4b27A:
13.1
5eewR-4b27A:
13.1		 5eewQ-4b27A:
76.32
5eewR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.14A 5eewQ-4b27A:
13.1
5eewR-4b27A:
13.1		 5eewQ-4b27A:
76.32
5eewR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5eewR-4b27A:
13.1
5eewS-4b27A:
13.0		 5eewR-4b27A:
76.32
5eewS-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5eewR-6gefA:
undetectable
5eewS-6gefA:
undetectable		 5eewR-6gefA:
undetectable
5eewS-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eewS-4b27A:
13.0
5eewT-4b27A:
13.1		 5eewS-4b27A:
76.32
5eewT-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eewS-6gefA:
undetectable
5eewT-6gefA:
undetectable		 5eewS-6gefA:
undetectable
5eewT-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eewT-4b27A:
13.1
5eewU-4b27A:
13.2		 5eewT-4b27A:
76.32
5eewU-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5eewT-6gefA:
undetectable
5eewU-6gefA:
undetectable		 5eewT-6gefA:
undetectable
5eewU-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5eewU-4b27A:
13.2
5eewV-4b27A:
13.1		 5eewU-4b27A:
76.32
5eewV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5eewU-6gefA:
undetectable
5eewV-6gefA:
undetectable		 5eewU-6gefA:
undetectable
5eewV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 5eexA-4b27A:
13.3
5eexB-4b27A:
13.3		 5eexA-4b27A:
76.32
5eexB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eexB-4b27A:
13.3
5eexC-4b27A:
13.3		 5eexB-4b27A:
76.32
5eexC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eexC-4b27A:
13.3
5eexD-4b27A:
13.3		 5eexC-4b27A:
76.32
5eexD-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5eexD-4b27A:
13.3
5eexE-4b27A:
13.4		 5eexD-4b27A:
76.32
5eexE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eexE-4b27A:
13.4
5eexF-4b27A:
13.3		 5eexE-4b27A:
76.32
5eexF-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.26A 5eexE-6gefA:
undetectable
5eexF-6gefA:
undetectable		 5eexE-6gefA:
undetectable
5eexF-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5eexF-4b27A:
13.3
5eexG-4b27A:
13.4		 5eexF-4b27A:
76.32
5eexG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5eexF-4b27A:
13.3
5eexG-4b27A:
13.4		 5eexF-4b27A:
76.32
5eexG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eexG-4b27A:
13.4
5eexH-4b27A:
13.4		 5eexG-4b27A:
76.32
5eexH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eexG-6gefA:
undetectable
5eexH-6gefA:
undetectable		 5eexG-6gefA:
undetectable
5eexH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eexH-4b27A:
13.4
5eexI-4b27A:
13.5		 5eexH-4b27A:
76.32
5eexI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eexI-4b27A:
13.5
5eexJ-4b27A:
13.5		 5eexI-4b27A:
76.32
5eexJ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 5eexI-6gefA:
undetectable
5eexJ-6gefA:
undetectable		 5eexI-6gefA:
undetectable
5eexJ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eexJ-4b27A:
13.5
5eexK-4b27A:
13.4		 5eexJ-4b27A:
76.32
5eexK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5eexJ-6gefA:
undetectable
5eexK-6gefA:
undetectable		 5eexJ-6gefA:
undetectable
5eexK-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eexA-4b27A:
13.3
5eexK-4b27A:
13.4		 5eexA-4b27A:
76.32
5eexK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5eexL-4b27A:
13.0
5eexV-4b27A:
13.1		 5eexL-4b27A:
76.32
5eexV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.37A 5eexL-4b27A:
13.0
5eexM-4b27A:
13.1		 5eexL-4b27A:
76.32
5eexM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5eexM-4b27A:
13.1
5eexN-4b27A:
13.0		 5eexM-4b27A:
76.32
5eexN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5eexN-4b27A:
13.0
5eexO-4b27A:
13.1		 5eexN-4b27A:
76.32
5eexO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5eexN-6gefA:
undetectable
5eexO-6gefA:
undetectable		 5eexN-6gefA:
undetectable
5eexO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5eexO-4b27A:
13.1
5eexP-4b27A:
13.1		 5eexO-4b27A:
76.32
5eexP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.15A 5eexO-4b27A:
13.1
5eexP-4b27A:
13.1		 5eexO-4b27A:
76.32
5eexP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eexP-4b27A:
13.1
5eexQ-4b27A:
13.0		 5eexP-4b27A:
76.32
5eexQ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eexP-6gefA:
undetectable
5eexQ-6gefA:
undetectable		 5eexP-6gefA:
undetectable
5eexQ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 5eexQ-4b27A:
13.0
5eexR-4b27A:
13.1		 5eexQ-4b27A:
76.32
5eexR-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5eexQ-6gefA:
undetectable
5eexR-6gefA:
undetectable		 5eexQ-6gefA:
undetectable
5eexR-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5eexR-4b27A:
13.1
5eexS-4b27A:
13.0		 5eexR-4b27A:
76.32
5eexS-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5eexR-6gefA:
undetectable
5eexS-6gefA:
undetectable		 5eexR-6gefA:
undetectable
5eexS-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eexS-4b27A:
13.0
5eexT-4b27A:
13.1		 5eexS-4b27A:
76.32
5eexT-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eexS-6gefA:
undetectable
5eexT-6gefA:
undetectable		 5eexS-6gefA:
undetectable
5eexT-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eexT-4b27A:
13.1
5eexU-4b27A:
13.1		 5eexT-4b27A:
76.32
5eexU-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5eexT-6gefA:
undetectable
5eexU-6gefA:
undetectable		 5eexT-6gefA:
undetectable
5eexU-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5eexU-4b27A:
13.1
5eexV-4b27A:
13.1		 5eexU-4b27A:
76.32
5eexV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5eexU-6gefA:
undetectable
5eexV-6gefA:
undetectable		 5eexU-6gefA:
undetectable
5eexV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eeyA-4b27A:
13.3
5eeyB-4b27A:
13.4		 5eeyA-4b27A:
76.32
5eeyB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeyB-4b27A:
13.4
5eeyC-4b27A:
13.3		 5eeyB-4b27A:
76.32
5eeyC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eeyC-4b27A:
13.3
5eeyD-4b27A:
13.3		 5eeyC-4b27A:
76.32
5eeyD-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5eeyD-4b27A:
13.3
5eeyE-4b27A:
13.4		 5eeyD-4b27A:
76.32
5eeyE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeyE-4b27A:
13.4
5eeyF-4b27A:
13.3		 5eeyE-4b27A:
76.32
5eeyF-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eeyE-6gefA:
undetectable
5eeyF-6gefA:
undetectable		 5eeyE-6gefA:
undetectable
5eeyF-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5eeyF-4b27A:
13.3
5eeyG-4b27A:
13.4		 5eeyF-4b27A:
76.32
5eeyG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5eeyF-4b27A:
13.3
5eeyG-4b27A:
13.4		 5eeyF-4b27A:
76.32
5eeyG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eeyG-4b27A:
13.4
5eeyH-4b27A:
13.4		 5eeyG-4b27A:
76.32
5eeyH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eeyG-6gefA:
undetectable
5eeyH-6gefA:
undetectable		 5eeyG-6gefA:
undetectable
5eeyH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeyH-4b27A:
13.4
5eeyI-4b27A:
13.4		 5eeyH-4b27A:
76.32
5eeyI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeyI-4b27A:
13.4
5eeyJ-4b27A:
13.5		 5eeyI-4b27A:
76.32
5eeyJ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 5eeyI-6gefA:
undetectable
5eeyJ-6gefA:
undetectable		 5eeyI-6gefA:
undetectable
5eeyJ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eeyJ-4b27A:
13.5
5eeyK-4b27A:
13.4		 5eeyJ-4b27A:
76.32
5eeyK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5eeyJ-6gefA:
undetectable
5eeyK-6gefA:
undetectable		 5eeyJ-6gefA:
undetectable
5eeyK-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eeyA-4b27A:
13.3
5eeyK-4b27A:
13.4		 5eeyA-4b27A:
76.32
5eeyK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5eeyL-4b27A:
13.0
5eeyV-4b27A:
13.1		 5eeyL-4b27A:
76.32
5eeyV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.38A 5eeyL-4b27A:
13.0
5eeyM-4b27A:
13.2		 5eeyL-4b27A:
76.32
5eeyM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5eeyM-4b27A:
13.2
5eeyN-4b27A:
13.0		 5eeyM-4b27A:
76.32
5eeyN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5eeyN-4b27A:
13.0
5eeyO-4b27A:
13.1		 5eeyN-4b27A:
76.32
5eeyO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5eeyN-6gefA:
undetectable
5eeyO-6gefA:
undetectable		 5eeyN-6gefA:
undetectable
5eeyO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5eeyO-4b27A:
13.1
5eeyP-4b27A:
13.1		 5eeyO-4b27A:
76.32
5eeyP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5eeyO-4b27A:
13.1
5eeyP-4b27A:
13.1		 5eeyO-4b27A:
76.32
5eeyP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eeyP-4b27A:
13.1
5eeyQ-4b27A:
13.0		 5eeyP-4b27A:
76.32
5eeyQ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eeyP-6gefA:
undetectable
5eeyQ-6gefA:
undetectable		 5eeyP-6gefA:
undetectable
5eeyQ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 5eeyQ-4b27A:
13.0
5eeyR-4b27A:
13.0		 5eeyQ-4b27A:
76.32
5eeyR-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5eeyQ-6gefA:
undetectable
5eeyR-6gefA:
undetectable		 5eeyQ-6gefA:
undetectable
5eeyR-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5eeyR-4b27A:
13.0
5eeyS-4b27A:
13.0		 5eeyR-4b27A:
76.32
5eeyS-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5eeyR-6gefA:
undetectable
5eeyS-6gefA:
undetectable		 5eeyR-6gefA:
undetectable
5eeyS-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eeyS-4b27A:
13.0
5eeyT-4b27A:
13.1		 5eeyS-4b27A:
76.32
5eeyT-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eeyS-6gefA:
undetectable
5eeyT-6gefA:
undetectable		 5eeyS-6gefA:
undetectable
5eeyT-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eeyT-4b27A:
13.1
5eeyU-4b27A:
13.1		 5eeyT-4b27A:
76.32
5eeyU-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5eeyT-6gefA:
undetectable
5eeyU-6gefA:
undetectable		 5eeyT-6gefA:
undetectable
5eeyU-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5eeyU-4b27A:
13.1
5eeyV-4b27A:
13.1		 5eeyU-4b27A:
76.32
5eeyV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5eeyU-6gefA:
undetectable
5eeyV-6gefA:
undetectable		 5eeyU-6gefA:
undetectable
5eeyV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 5eezA-4b27A:
13.3
5eezB-4b27A:
13.4		 5eezA-4b27A:
76.32
5eezB-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eezB-4b27A:
13.4
5eezC-4b27A:
13.3		 5eezB-4b27A:
76.32
5eezC-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5eezC-4b27A:
13.3
5eezD-4b27A:
13.3		 5eezC-4b27A:
76.32
5eezD-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5eezD-4b27A:
13.3
5eezE-4b27A:
13.4		 5eezD-4b27A:
76.32
5eezE-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eezE-4b27A:
13.4
5eezF-4b27A:
13.3		 5eezE-4b27A:
76.32
5eezF-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.26A 5eezE-6gefA:
undetectable
5eezF-6gefA:
undetectable		 5eezE-6gefA:
undetectable
5eezF-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5eezF-4b27A:
13.3
5eezG-4b27A:
13.4		 5eezF-4b27A:
76.32
5eezG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5eezF-4b27A:
13.3
5eezG-4b27A:
13.4		 5eezF-4b27A:
76.32
5eezG-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eezG-4b27A:
13.4
5eezH-4b27A:
13.4		 5eezG-4b27A:
76.32
5eezH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5eezG-6gefA:
undetectable
5eezH-6gefA:
undetectable		 5eezG-6gefA:
undetectable
5eezH-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eezH-4b27A:
13.4
5eezI-4b27A:
13.4		 5eezH-4b27A:
76.32
5eezI-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eezI-4b27A:
13.4
5eezJ-4b27A:
13.5		 5eezI-4b27A:
76.32
5eezJ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 5eezI-6gefA:
undetectable
5eezJ-6gefA:
undetectable		 5eezI-6gefA:
undetectable
5eezJ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5eezJ-4b27A:
13.5
5eezK-4b27A:
13.4		 5eezJ-4b27A:
76.32
5eezK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5eezJ-6gefA:
undetectable
5eezK-6gefA:
undetectable		 5eezJ-6gefA:
undetectable
5eezK-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5eezA-4b27A:
13.3
5eezK-4b27A:
13.4		 5eezA-4b27A:
76.32
5eezK-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5eezL-4b27A:
13.0
5eezV-4b27A:
13.0		 5eezL-4b27A:
76.32
5eezV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.37A 5eezL-4b27A:
13.0
5eezM-4b27A:
13.2		 5eezL-4b27A:
76.32
5eezM-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5eezM-4b27A:
13.2
5eezN-4b27A:
13.0		 5eezM-4b27A:
76.32
5eezN-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5eezN-4b27A:
13.0
5eezO-4b27A:
13.1		 5eezN-4b27A:
76.32
5eezO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5eezN-6gefA:
undetectable
5eezO-6gefA:
undetectable		 5eezN-6gefA:
undetectable
5eezO-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5eezO-4b27A:
13.1
5eezP-4b27A:
13.0		 5eezO-4b27A:
76.32
5eezP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5eezO-4b27A:
13.1
5eezP-4b27A:
13.0		 5eezO-4b27A:
76.32
5eezP-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eezP-4b27A:
13.0
5eezQ-4b27A:
13.0		 5eezP-4b27A:
76.32
5eezQ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5eezP-6gefA:
undetectable
5eezQ-6gefA:
undetectable		 5eezP-6gefA:
undetectable
5eezQ-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5eezQ-4b27A:
13.0
5eezR-4b27A:
13.0		 5eezQ-4b27A:
76.32
5eezR-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5eezQ-6gefA:
undetectable
5eezR-6gefA:
undetectable		 5eezQ-6gefA:
undetectable
5eezR-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5eezR-4b27A:
13.0
5eezS-4b27A:
13.0		 5eezR-4b27A:
76.32
5eezS-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5eezR-6gefA:
undetectable
5eezS-6gefA:
undetectable		 5eezR-6gefA:
undetectable
5eezS-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5eezS-4b27A:
13.0
5eezT-4b27A:
13.1		 5eezS-4b27A:
76.32
5eezT-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5eezS-6gefA:
undetectable
5eezT-6gefA:
undetectable		 5eezS-6gefA:
undetectable
5eezT-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5eezT-4b27A:
13.1
5eezU-4b27A:
13.1		 5eezT-4b27A:
76.32
5eezU-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5eezT-6gefA:
undetectable
5eezU-6gefA:
undetectable		 5eezT-6gefA:
undetectable
5eezU-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5eezU-4b27A:
13.1
5eezV-4b27A:
13.0		 5eezU-4b27A:
76.32
5eezV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5eezU-6gefA:
undetectable
5eezV-6gefA:
undetectable		 5eezU-6gefA:
undetectable
5eezV-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef0A-4b27A:
13.3
5ef0B-4b27A:
13.4		 5ef0A-4b27A:
76.32
5ef0B-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef0B-4b27A:
13.4
5ef0C-4b27A:
13.3		 5ef0B-4b27A:
76.32
5ef0C-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef0C-4b27A:
13.3
5ef0D-4b27A:
13.3		 5ef0C-4b27A:
76.32
5ef0D-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5ef0D-4b27A:
13.3
5ef0E-4b27A:
13.4		 5ef0D-4b27A:
76.32
5ef0E-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef0E-4b27A:
13.4
5ef0F-4b27A:
13.3		 5ef0E-4b27A:
76.32
5ef0F-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5ef0E-6gefA:
undetectable
5ef0F-6gefA:
undetectable		 5ef0E-6gefA:
undetectable
5ef0F-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5ef0F-4b27A:
13.3
5ef0G-4b27A:
13.4		 5ef0F-4b27A:
76.32
5ef0G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5ef0F-4b27A:
13.3
5ef0G-4b27A:
13.4		 5ef0F-4b27A:
76.32
5ef0G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5ef0G-4b27A:
13.4
5ef0H-4b27A:
13.4		 5ef0G-4b27A:
76.32
5ef0H-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5ef0G-6gefA:
undetectable
5ef0H-6gefA:
undetectable		 5ef0G-6gefA:
undetectable
5ef0H-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef0H-4b27A:
13.4
5ef0I-4b27A:
13.4		 5ef0H-4b27A:
76.32
5ef0I-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef0I-4b27A:
13.4
5ef0J-4b27A:
13.5		 5ef0I-4b27A:
76.32
5ef0J-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 5ef0I-6gefA:
undetectable
5ef0J-6gefA:
undetectable		 5ef0I-6gefA:
undetectable
5ef0J-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef0J-4b27A:
13.5
5ef0K-4b27A:
13.3		 5ef0J-4b27A:
76.32
5ef0K-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5ef0J-6gefA:
undetectable
5ef0K-6gefA:
undetectable		 5ef0J-6gefA:
undetectable
5ef0K-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef0A-4b27A:
13.3
5ef0K-4b27A:
13.3		 5ef0A-4b27A:
76.32
5ef0K-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5ef0L-4b27A:
13.0
5ef0V-4b27A:
13.1		 5ef0L-4b27A:
76.32
5ef0V-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.38A 5ef0L-4b27A:
13.0
5ef0M-4b27A:
13.1		 5ef0L-4b27A:
76.32
5ef0M-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5ef0M-4b27A:
13.1
5ef0N-4b27A:
13.0		 5ef0M-4b27A:
76.32
5ef0N-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5ef0N-4b27A:
13.0
5ef0O-4b27A:
13.1		 5ef0N-4b27A:
76.32
5ef0O-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5ef0N-6gefA:
undetectable
5ef0O-6gefA:
undetectable		 5ef0N-6gefA:
undetectable
5ef0O-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5ef0O-4b27A:
13.1
5ef0P-4b27A:
13.1		 5ef0O-4b27A:
76.32
5ef0P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5ef0O-4b27A:
13.1
5ef0P-4b27A:
13.1		 5ef0O-4b27A:
76.32
5ef0P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef0P-4b27A:
13.1
5ef0Q-4b27A:
13.1		 5ef0P-4b27A:
76.32
5ef0Q-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5ef0P-6gefA:
undetectable
5ef0Q-6gefA:
undetectable		 5ef0P-6gefA:
undetectable
5ef0Q-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 5ef0Q-4b27A:
13.1
5ef0R-4b27A:
13.0		 5ef0Q-4b27A:
76.32
5ef0R-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef0Q-6gefA:
undetectable
5ef0R-6gefA:
undetectable		 5ef0Q-6gefA:
undetectable
5ef0R-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5ef0R-4b27A:
13.0
5ef0S-4b27A:
13.0		 5ef0R-4b27A:
76.32
5ef0S-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5ef0R-6gefA:
undetectable
5ef0S-6gefA:
undetectable		 5ef0R-6gefA:
undetectable
5ef0S-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5ef0S-4b27A:
13.0
5ef0T-4b27A:
13.1		 5ef0S-4b27A:
76.32
5ef0T-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef0S-6gefA:
undetectable
5ef0T-6gefA:
undetectable		 5ef0S-6gefA:
undetectable
5ef0T-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef0T-4b27A:
13.1
5ef0U-4b27A:
13.1		 5ef0T-4b27A:
76.32
5ef0U-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5ef0U-4b27A:
13.1
5ef0V-4b27A:
13.1		 5ef0U-4b27A:
76.32
5ef0V-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5ef0U-6gefA:
undetectable
5ef0V-6gefA:
undetectable		 5ef0U-6gefA:
undetectable
5ef0V-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef1A-4b27A:
13.2
5ef1B-4b27A:
13.4		 5ef1A-4b27A:
76.32
5ef1B-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef1B-4b27A:
13.4
5ef1C-4b27A:
13.3		 5ef1B-4b27A:
76.32
5ef1C-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef1C-4b27A:
13.3
5ef1D-4b27A:
13.3		 5ef1C-4b27A:
76.32
5ef1D-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5ef1D-4b27A:
13.3
5ef1E-4b27A:
13.4		 5ef1D-4b27A:
76.32
5ef1E-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef1E-4b27A:
13.4
5ef1F-4b27A:
13.3		 5ef1E-4b27A:
76.32
5ef1F-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.26A 5ef1E-6gefA:
undetectable
5ef1F-6gefA:
undetectable		 5ef1E-6gefA:
undetectable
5ef1F-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5ef1F-4b27A:
13.3
5ef1G-4b27A:
13.4		 5ef1F-4b27A:
76.32
5ef1G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5ef1F-4b27A:
13.3
5ef1G-4b27A:
13.4		 5ef1F-4b27A:
76.32
5ef1G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5ef1G-4b27A:
13.4
5ef1H-4b27A:
13.4		 5ef1G-4b27A:
76.32
5ef1H-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5ef1G-6gefA:
undetectable
5ef1H-6gefA:
undetectable		 5ef1G-6gefA:
undetectable
5ef1H-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef1H-4b27A:
13.4
5ef1I-4b27A:
13.4		 5ef1H-4b27A:
76.32
5ef1I-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef1I-4b27A:
13.4
5ef1J-4b27A:
13.5		 5ef1I-4b27A:
76.32
5ef1J-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 5ef1I-6gefA:
undetectable
5ef1J-6gefA:
undetectable		 5ef1I-6gefA:
undetectable
5ef1J-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef1J-4b27A:
13.5
5ef1K-4b27A:
13.4		 5ef1J-4b27A:
76.32
5ef1K-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5ef1J-6gefA:
undetectable
5ef1K-6gefA:
undetectable		 5ef1J-6gefA:
undetectable
5ef1K-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef1A-4b27A:
13.2
5ef1K-4b27A:
13.4		 5ef1A-4b27A:
76.32
5ef1K-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5ef1L-4b27A:
13.0
5ef1V-4b27A:
13.1		 5ef1L-4b27A:
76.32
5ef1V-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.37A 5ef1L-4b27A:
13.0
5ef1M-4b27A:
13.2		 5ef1L-4b27A:
76.32
5ef1M-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5ef1M-4b27A:
13.2
5ef1N-4b27A:
13.0		 5ef1M-4b27A:
76.32
5ef1N-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5ef1N-4b27A:
13.0
5ef1O-4b27A:
13.1		 5ef1N-4b27A:
76.32
5ef1O-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5ef1N-6gefA:
undetectable
5ef1O-6gefA:
undetectable		 5ef1N-6gefA:
undetectable
5ef1O-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5ef1O-4b27A:
13.1
5ef1P-4b27A:
13.1		 5ef1O-4b27A:
76.32
5ef1P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5ef1O-4b27A:
13.1
5ef1P-4b27A:
13.1		 5ef1O-4b27A:
76.32
5ef1P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef1P-4b27A:
13.1
5ef1Q-4b27A:
13.0		 5ef1P-4b27A:
76.32
5ef1Q-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5ef1P-6gefA:
undetectable
5ef1Q-6gefA:
undetectable		 5ef1P-6gefA:
undetectable
5ef1Q-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5ef1Q-4b27A:
13.0
5ef1R-4b27A:
13.0		 5ef1Q-4b27A:
76.32
5ef1R-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef1Q-6gefA:
undetectable
5ef1R-6gefA:
undetectable		 5ef1Q-6gefA:
undetectable
5ef1R-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5ef1R-4b27A:
13.0
5ef1S-4b27A:
13.0		 5ef1R-4b27A:
76.32
5ef1S-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5ef1R-6gefA:
undetectable
5ef1S-6gefA:
undetectable		 5ef1R-6gefA:
undetectable
5ef1S-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5ef1S-4b27A:
13.0
5ef1T-4b27A:
13.1		 5ef1S-4b27A:
76.32
5ef1T-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef1S-6gefA:
undetectable
5ef1T-6gefA:
undetectable		 5ef1S-6gefA:
undetectable
5ef1T-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef1T-4b27A:
13.1
5ef1U-4b27A:
13.1		 5ef1T-4b27A:
76.32
5ef1U-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.28A 5ef1T-6gefA:
undetectable
5ef1U-6gefA:
undetectable		 5ef1T-6gefA:
undetectable
5ef1U-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5ef1U-4b27A:
13.1
5ef1V-4b27A:
13.1		 5ef1U-4b27A:
76.32
5ef1V-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5ef1U-6gefA:
undetectable
5ef1V-6gefA:
undetectable		 5ef1U-6gefA:
undetectable
5ef1V-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef2A-4b27A:
13.3
5ef2B-4b27A:
13.4		 5ef2A-4b27A:
76.32
5ef2B-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef2B-4b27A:
13.4
5ef2C-4b27A:
13.3		 5ef2B-4b27A:
76.32
5ef2C-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef2C-4b27A:
13.3
5ef2D-4b27A:
13.3		 5ef2C-4b27A:
76.32
5ef2D-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5ef2D-4b27A:
13.3
5ef2E-4b27A:
13.4		 5ef2D-4b27A:
76.32
5ef2E-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef2E-4b27A:
13.4
5ef2F-4b27A:
13.3		 5ef2E-4b27A:
76.32
5ef2F-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.26A 5ef2E-6gefA:
undetectable
5ef2F-6gefA:
undetectable		 5ef2E-6gefA:
undetectable
5ef2F-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5ef2F-4b27A:
13.3
5ef2G-4b27A:
13.4		 5ef2F-4b27A:
76.32
5ef2G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5ef2F-4b27A:
13.3
5ef2G-4b27A:
13.4		 5ef2F-4b27A:
76.32
5ef2G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5ef2G-4b27A:
13.4
5ef2H-4b27A:
13.4		 5ef2G-4b27A:
76.32
5ef2H-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5ef2G-6gefA:
undetectable
5ef2H-6gefA:
undetectable		 5ef2G-6gefA:
undetectable
5ef2H-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef2H-4b27A:
13.4
5ef2I-4b27A:
13.4		 5ef2H-4b27A:
76.32
5ef2I-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef2I-4b27A:
13.4
5ef2J-4b27A:
13.5		 5ef2I-4b27A:
76.32
5ef2J-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 5ef2I-6gefA:
undetectable
5ef2J-6gefA:
undetectable		 5ef2I-6gefA:
undetectable
5ef2J-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef2J-4b27A:
13.5
5ef2K-4b27A:
13.4		 5ef2J-4b27A:
76.32
5ef2K-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5ef2J-6gefA:
undetectable
5ef2K-6gefA:
undetectable		 5ef2J-6gefA:
undetectable
5ef2K-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef2A-4b27A:
13.3
5ef2K-4b27A:
13.4		 5ef2A-4b27A:
76.32
5ef2K-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5ef2L-4b27A:
13.0
5ef2V-4b27A:
13.1		 5ef2L-4b27A:
76.32
5ef2V-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.38A 5ef2L-4b27A:
13.0
5ef2M-4b27A:
13.2		 5ef2L-4b27A:
76.32
5ef2M-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5ef2M-4b27A:
13.2
5ef2N-4b27A:
13.0		 5ef2M-4b27A:
76.32
5ef2N-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5ef2N-4b27A:
13.0
5ef2O-4b27A:
13.1		 5ef2N-4b27A:
76.32
5ef2O-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5ef2N-6gefA:
undetectable
5ef2O-6gefA:
undetectable		 5ef2N-6gefA:
undetectable
5ef2O-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5ef2O-4b27A:
13.1
5ef2P-4b27A:
13.1		 5ef2O-4b27A:
76.32
5ef2P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5ef2O-4b27A:
13.1
5ef2P-4b27A:
13.1		 5ef2O-4b27A:
76.32
5ef2P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef2P-4b27A:
13.1
5ef2Q-4b27A:
13.1		 5ef2P-4b27A:
76.32
5ef2Q-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5ef2P-6gefA:
undetectable
5ef2Q-6gefA:
undetectable		 5ef2P-6gefA:
undetectable
5ef2Q-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 5ef2Q-4b27A:
13.1
5ef2R-4b27A:
13.1		 5ef2Q-4b27A:
76.32
5ef2R-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef2Q-6gefA:
undetectable
5ef2R-6gefA:
undetectable		 5ef2Q-6gefA:
undetectable
5ef2R-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5ef2R-4b27A:
13.1
5ef2S-4b27A:
13.0		 5ef2R-4b27A:
76.32
5ef2S-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5ef2R-6gefA:
undetectable
5ef2S-6gefA:
undetectable		 5ef2R-6gefA:
undetectable
5ef2S-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5ef2S-4b27A:
13.0
5ef2T-4b27A:
13.1		 5ef2S-4b27A:
76.32
5ef2T-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef2S-6gefA:
undetectable
5ef2T-6gefA:
undetectable		 5ef2S-6gefA:
undetectable
5ef2T-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef2T-4b27A:
13.1
5ef2U-4b27A:
13.1		 5ef2T-4b27A:
76.32
5ef2U-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5ef2T-6gefA:
undetectable
5ef2U-6gefA:
undetectable		 5ef2T-6gefA:
undetectable
5ef2U-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5ef2U-4b27A:
13.1
5ef2V-4b27A:
13.1		 5ef2U-4b27A:
76.32
5ef2V-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5ef2U-6gefA:
undetectable
5ef2V-6gefA:
undetectable		 5ef2U-6gefA:
undetectable
5ef2V-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef3A-4b27A:
13.3
5ef3B-4b27A:
13.3		 5ef3A-4b27A:
76.32
5ef3B-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef3B-4b27A:
13.3
5ef3C-4b27A:
13.3		 5ef3B-4b27A:
76.32
5ef3C-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef3C-4b27A:
13.3
5ef3D-4b27A:
13.3		 5ef3C-4b27A:
76.32
5ef3D-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.22A 5ef3D-4b27A:
13.3
5ef3E-4b27A:
13.4		 5ef3D-4b27A:
76.32
5ef3E-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.18A 5ef3E-4b27A:
13.4
5ef3F-4b27A:
13.3		 5ef3E-4b27A:
76.32
5ef3F-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.26A 5ef3E-6gefA:
undetectable
5ef3F-6gefA:
undetectable		 5ef3E-6gefA:
undetectable
5ef3F-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 ALA A  46
GLY A  23
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.12A 5ef3F-4b27A:
13.3
5ef3G-4b27A:
13.4		 5ef3F-4b27A:
76.32
5ef3G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 5ef3F-4b27A:
13.3
5ef3G-4b27A:
13.4		 5ef3F-4b27A:
76.32
5ef3G-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.25A 5ef3G-4b27A:
13.4
5ef3H-4b27A:
13.4		 5ef3G-4b27A:
76.32
5ef3H-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.27A 5ef3G-6gefA:
undetectable
5ef3H-6gefA:
undetectable		 5ef3G-6gefA:
undetectable
5ef3H-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef3H-4b27A:
13.4
5ef3I-4b27A:
13.4		 5ef3H-4b27A:
76.32
5ef3I-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 11 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef3I-4b27A:
13.4
5ef3J-4b27A:
13.5		 5ef3I-4b27A:
76.32
5ef3J-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 11 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.24A 5ef3I-6gefA:
undetectable
5ef3J-6gefA:
undetectable		 5ef3I-6gefA:
undetectable
5ef3J-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.19A 5ef3J-4b27A:
13.5
5ef3K-4b27A:
13.4		 5ef3J-4b27A:
76.32
5ef3K-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.23A 5ef3J-6gefA:
undetectable
5ef3K-6gefA:
undetectable		 5ef3J-6gefA:
undetectable
5ef3K-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 5ef3A-4b27A:
13.3
5ef3K-4b27A:
13.4		 5ef3A-4b27A:
76.32
5ef3K-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 8 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.29A 5ef3L-4b27A:
13.0
5ef3V-4b27A:
13.1		 5ef3L-4b27A:
76.32
5ef3V-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_M_TRPM101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.38A 5ef3L-4b27A:
13.0
5ef3M-4b27A:
13.1		 5ef3L-4b27A:
76.32
5ef3M-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_N_TRPN101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.28A 5ef3M-4b27A:
13.1
5ef3N-4b27A:
13.0		 5ef3M-4b27A:
76.32
5ef3N-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.40A 5ef3N-4b27A:
13.0
5ef3O-4b27A:
13.1		 5ef3N-4b27A:
76.32
5ef3O-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.33A 5ef3N-6gefA:
undetectable
5ef3O-6gefA:
undetectable		 5ef3N-6gefA:
undetectable
5ef3O-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 10 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.34A 5ef3O-4b27A:
13.1
5ef3P-4b27A:
13.1		 5ef3O-4b27A:
76.32
5ef3P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		6 / 10 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.16A 5ef3O-4b27A:
13.1
5ef3P-4b27A:
13.1		 5ef3O-4b27A:
76.32
5ef3P-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef3P-4b27A:
13.1
5ef3Q-4b27A:
13.0		 5ef3P-4b27A:
76.32
5ef3Q-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.30A 5ef3P-6gefA:
undetectable
5ef3Q-6gefA:
undetectable		 5ef3P-6gefA:
undetectable
5ef3Q-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		7 / 9 GLY A  23
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.26A 5ef3Q-4b27A:
13.0
5ef3R-4b27A:
13.1		 5ef3Q-4b27A:
76.32
5ef3R-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 9 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef3Q-6gefA:
undetectable
5ef3R-6gefA:
undetectable		 5ef3Q-6gefA:
undetectable
5ef3R-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.31A 5ef3R-4b27A:
13.1
5ef3S-4b27A:
13.0		 5ef3R-4b27A:
76.32
5ef3S-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.29A 5ef3R-6gefA:
undetectable
5ef3S-6gefA:
undetectable		 5ef3R-6gefA:
undetectable
5ef3S-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.32A 5ef3S-4b27A:
13.0
5ef3T-4b27A:
13.1		 5ef3S-4b27A:
76.32
5ef3T-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.31A 5ef3S-6gefA:
undetectable
5ef3T-6gefA:
undetectable		 5ef3S-6gefA:
undetectable
5ef3T-6gefA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.33A 5ef3T-4b27A:
13.1
5ef3U-4b27A:
13.1		 5ef3T-4b27A:
76.32
5ef3U-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB
(Bacillus
subtilis) 		8 / 10 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.27A 5ef3U-4b27A:
13.1
5ef3V-4b27A:
13.1		 5ef3U-4b27A:
76.32
5ef3V-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB
(Yersinia
pseudotuberculos
is) 		5 / 10 GLY A 164
HIS A 268
ALA A 260
ILE A 165
THR A 266
 GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
THR  A 266 ( 0.8A)
 1.32A 5ef3U-6gefA:
undetectable
5ef3V-6gefA:
undetectable		 5ef3U-6gefA:
undetectable
5ef3V-6gefA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 201
SER A 205
VAL A 202
HIS A 287
 GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
VAL  A 202 ( 0.6A)
HIS  A 287 ( 1.0A)
 1.09A 5ewuA-2ogsA:
undetectable		 5ewuA-2ogsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 201
SER A 205
VAL A 202
HIS A 287
 GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
VAL  A 202 ( 0.6A)
HIS  A 287 ( 1.0A)
 1.06A 5ewuB-2ogsA:
undetectable		 5ewuB-2ogsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 8 GLU A 339
VAL A 157
HIS A 160
ASP A 201
HIS A 233
 GLU  A 339 ( 0.5A)
VAL  A 157 ( 0.6A)
HIS  A 160 ( 1.0A)
ASP  A 201 ( 0.5A)
HIS  A 233 ( 1.0A)
 1.31A 5f8yA-3sl5A:
undetectable		 5f8yA-3sl5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		5 / 8 GLU A 339
VAL A 157
HIS A 160
ASP A 201
HIS A 233
 GLU  A 339 ( 0.5A)
VAL  A 157 ( 0.6A)
HIS  A 160 ( 1.0A)
ASP  A 201 ( 0.5A)
HIS  A 233 ( 1.0A)
 1.34A 5f8yB-3sl5A:
undetectable		 5f8yB-3sl5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 ASN A 293
VAL A 294
MET A 224
ASN A 225
HIS A 220
 ASN  A 293 ( 0.6A)
VAL  A 294 ( 0.6A)
MET  A 224 ( 0.0A)
ASN  A 225 ( 0.6A)
HIS  A 220 ( 1.0A)
 1.48A 5fhrA-5nqfA:
undetectable		 5fhrA-5nqfA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 6 LEU A  43
LEU A  99
LEU A  51
HIS A  66
 LEU  A  43 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  51 ( 0.5A)
HIS  A  66 ( 1.0A)
 0.93A 5gs4A-3eqzA:
undetectable		 5gs4A-3eqzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 3eqz RESPONSE REGULATOR
(Colwellia
psychrerythraea) 		4 / 5 LEU A  43
LEU A  99
LEU A  51
HIS A  66
 LEU  A  43 ( 0.6A)
LEU  A  99 ( 0.6A)
LEU  A  51 ( 0.5A)
HIS  A  66 ( 1.0A)
 0.91A 5gtrA-3eqzA:
undetectable		 5gtrA-3eqzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 4 THR A  25
LEU A 462
HIS A 420
GLY A 461
 THR  A  25 ( 0.8A)
LEU  A 462 ( 0.6A)
HIS  A 420 ( 1.0A)
GLY  A 461 ( 0.0A)
 1.34A 5gwyA-3gnrA:
undetectable		 5gwyA-3gnrA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4oud TYROSYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 HIS B  48
GLY B  50
GLN B 179
ASP B 200
THR B 229
 HIS  B  48 ( 1.0A)
GLY  B  50 ( 0.0A)
GLN  B 179 ( 0.6A)
ASP  B 200 ( 0.6A)
THR  B 229 ( 0.8A)
 1.03A 5hg0A-4oudB:
6.8		 5hg0A-4oudB:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 ALA A  52
LYS A  54
GLU A  69
LEU A  73
LEU A 144
HIS A 151
 ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.92A 5hi2A-5d7aA:
24.7		 5hi2A-5d7aA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.15A 5hm8A-6f85A:
undetectable		 5hm8A-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8B-6f85A:
undetectable		 5hm8B-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8C-6f85A:
undetectable		 5hm8C-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8D-6f85A:
undetectable		 5hm8D-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8E-6f85A:
undetectable		 5hm8E-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8F-6f85A:
undetectable		 5hm8F-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		4 / 5 GLU A 153
THR A 151
GLU A 232
THR A 233
 None
None
None
HIS  A 502 ( 3.5A)
 1.16A 5hm8H-6f85A:
undetectable		 5hm8H-6f85A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ASP A 177
TYR A 336
GLY A 360
TYR A 330
 HIS  A1001 (-3.2A)
None
HIS  A1001 (-3.6A)
None
 1.00A 5hwaA-4phcA:
undetectable		 5hwaA-4phcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A   9
VAL A  48
GLU A  49
SER A  69
ILE A  64
 None
None
None
HIS  A 239 (-4.6A)
None
 0.91A 5i3cC-1hslA:
undetectable		 5i3cC-1hslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 SER A  66
ASP A  44
SER A 142
GLU A 111
TYR A 295
 None
None
HIS  A 505 ( 3.6A)
HIS  A 505 (-2.8A)
6KY  A 504 (-3.4A)
 1.26A 5iqbA-5jh8A:
undetectable		 5iqbA-5jh8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 5jh8 PROBABLE CHITINASE
(Chromobacterium
violaceum) 		5 / 12 SER A  66
ASP A  44
SER A 142
GLU A 111
TYR A 295
 None
None
HIS  A 505 ( 3.6A)
HIS  A 505 (-2.8A)
6KY  A 504 (-3.4A)
 1.33A 5iqbD-5jh8A:
undetectable		 5iqbD-5jh8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.73A 5iy5A-5d7wA:
undetectable		 5iy5A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 5iy5N-5d7wA:
undetectable		 5iy5N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ryn PROTEIN CRS2
(Zea
mays) 		4 / 5 ILE A  32
LEU A  60
HIS A  88
VAL A 177
 ILE  A  32 ( 0.6A)
LEU  A  60 ( 0.6A)
HIS  A  88 ( 1.0A)
VAL  A 177 ( 0.5A)
 1.24A 5jmnB-1rynA:
undetectable		 5jmnB-1rynA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		3 / 3 VAL A 316
HIS A 320
VAL A 250
 VAL  A 316 ( 0.6A)
HIS  A 320 ( 1.0A)
VAL  A 250 ( 0.6A)
 0.65A 5jmnC-3gnrA:
undetectable		 5jmnC-3gnrA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 ILE A 358
PRO A 469
LEU A 460
PHE A 359
HIS A 417
 ILE  A 358 ( 0.7A)
PRO  A 469 ( 1.1A)
LEU  A 460 ( 0.6A)
PHE  A 359 ( 1.3A)
HIS  A 417 (-1.0A)
 1.34A 5k7uA-2nvvA:
undetectable		 5k7uA-2nvvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 7 HIS A 319
ILE A 320
VAL A 323
ARG A 325
 HIS  A 319 ( 1.0A)
ILE  A 320 ( 0.4A)
VAL  A 323 ( 0.6A)
ARG  A 325 ( 0.6A)
 1.16A 5kkzK-4dlkA:
undetectable
5kkzQ-4dlkA:
undetectable		 5kkzK-4dlkA:
21.21
5kkzQ-4dlkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 1aoa T-FIMBRIN
(Homo
sapiens) 		3 / 3 HIS A 304
LYS A 300
PHE A 328
 HIS  A 304 ( 1.0A)
LYS  A 300 ( 0.0A)
PHE  A 328 ( 1.3A)
 1.45A 5klaA-1aoaA:
undetectable		 5klaA-1aoaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 THR A  74
SER A  72
ASP A  91
 None
HIS  A 239 (-2.7A)
None
 0.70A 5kvaA-1hslA:
undetectable		 5kvaA-1hslA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1hsl HISTIDINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 THR A  74
SER A  72
ASP A  91
 None
HIS  A 239 (-2.7A)
None
 0.68A 5kvaB-1hslA:
0.1		 5kvaB-1hslA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		4 / 8 HIS A 302
SER A 388
HIS A 408
SER A 176
 NAD  A 502 (-3.9A)
None
HIS  A 501 ( 3.4A)
HIS  A 501 (-3.4A)
 0.99A 5m8rB-5vldA:
undetectable		 5m8rB-5vldA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 HIS A 193
ASN A 194
ALA A 196
 HIS  A 193 ( 1.0A)
ASN  A 194 ( 0.6A)
ALA  A 196 ( 0.0A)
 0.78A 5n4tB-4w65A:
undetectable		 5n4tB-4w65A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 4 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.31A 5n5jA-5d7wA:
14.2		 5n5jA-5d7wA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5d7w SERRALYSIN
(Serratia
marcescens) 		4 / 5 HIS A 176
GLU A 177
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
GLU  A 177 ( 0.6A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.27A 5n5kA-5d7wA:
13.8		 5n5kA-5d7wA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		5 / 12 VAL A 406
ASP A 357
HIS A 479
LEU A 482
LEU A 354
 VAL  A 406 ( 0.6A)
ASP  A 357 ( 0.6A)
HIS  A 479 ( 1.0A)
LEU  A 482 ( 0.6A)
LEU  A 354 ( 0.6A)
 1.14A 5nd7B-2nvvA:
undetectable		 5nd7B-2nvvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.62A 5oexA-1rynA:
undetectable		 5oexA-1rynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.08A 5oexA-2dj6A:
undetectable		 5oexA-2dj6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens) 		3 / 3 HIS A 164
HIS A 160
HIS A 204
 HIS  A 164 (-1.0A)
HIS  A 160 ( 1.0A)
HIS  A 204 ( 1.0A)
 1.00A 5oexA-3sl5A:
undetectable		 5oexA-3sl5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.65A 5oexB-1rynA:
undetectable		 5oexB-1rynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.10A 5oexB-2dj6A:
undetectable		 5oexB-2dj6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.64A 5oexC-1rynA:
undetectable		 5oexC-1rynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.07A 5oexC-2dj6A:
undetectable		 5oexC-2dj6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 1ryn PROTEIN CRS2
(Zea
mays) 		3 / 3 HIS A  22
ASP A  94
HIS A 114
 HIS  A  22 ( 1.0A)
ASP  A  94 ( 0.6A)
HIS  A 114 ( 1.0A)
 0.65A 5oexD-1rynA:
undetectable		 5oexD-1rynA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2dj6 HYPOTHETICAL PROTEIN
PH0634
(Pyrococcus
horikoshii) 		3 / 3 LYS A  27
HIS A  15
HIS A  29
 HIS  A  27 ( 0.0A)
HIS  A  15 ( 1.0A)
HIS  A  29 ( 1.0A)
 1.03A 5oexD-2dj6A:
undetectable		 5oexD-2dj6A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 251
SER A 252
PHE A 255
HIS A 299
 LEU  A 251 ( 0.5A)
SER  A 252 ( 0.0A)
PHE  A 255 ( 1.3A)
HIS  A 299 ( 1.0A)
 1.09A 5om3A-5hiuA:
undetectable
5om3B-5hiuA:
undetectable		 5om3A-5hiuA:
11.93
5om3B-5hiuA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3qvi HISTO-ASPARTIC
PROTEASE
(Plasmodium
falciparum) 		4 / 7 TYR A 151
TYR A 313
ASP A 316
HIS A 318
 TYR  A 151 ( 1.3A)
TYR  A 313 ( 1.3A)
ASP  A 316 ( 0.6A)
HIS  A 318 ( 1.0A)
 1.48A 5ov9B-3qviA:
undetectable		 5ov9B-3qviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		3 / 3 GLU A 141
HIS A 111
VAL A 115
 GLU  A 141 ( 0.6A)
HIS  A 111 (-1.0A)
VAL  A 115 ( 0.6A)
 0.81A 5trqB-3ulkA:
undetectable		 5trqB-3ulkA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		3 / 3 GLY E  64
LEU E  68
HIS E 172
 None
None
HIS  E1205 (-3.4A)
 0.60A 5u63A-1usyE:
undetectable		 5u63A-1usyE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermotoga
maritima) 		3 / 3 GLY E  64
LEU E  68
HIS E 172
 None
None
HIS  E1205 (-3.4A)
 0.57A 5u63B-1usyE:
undetectable		 5u63B-1usyE:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4mtp RNA DEPENDENT RNA
POLYMERASE
(Japanese
encephalitis
virus) 		5 / 12 GLY A 507
VAL A 672
SER A 501
HIS A 386
LEU A 387
 GLY  A 507 ( 0.0A)
VAL  A 672 ( 0.6A)
SER  A 501 ( 0.0A)
HIS  A 386 ( 1.0A)
LEU  A 387 ( 0.5A)
 1.04A 5ubbA-4mtpA:
undetectable		 5ubbA-4mtpA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 5 HIS A 418
ALA A 124
HIS A 128
TYR A 444
 HIS  A 418 ( 1.0A)
ALA  A 124 ( 0.0A)
HIS  A 128 ( 1.0A)
TYR  A 444 ( 1.3A)
 0.94A 5uizA-2ogsA:
undetectable		 5uizA-2ogsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1rrv GLYCOSYLTRANSFERASE
GTFD
(Amycolatopsis
orientalis) 		3 / 3 GLU A 315
HIS A 316
ARG A 320
 GLU  A 315 ( 0.6A)
HIS  A 316 ( 1.0A)
ARG  A 320 ( 0.6A)
 0.91A 5uunA-1rrvA:
0.6		 5uunA-1rrvA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A  56
LEU A 291
GLU A 131
ALA A  91
GLY A  92
 None
None
HIS  A 450 ( 3.0A)
None
None
 1.12A 5uxdB-1httA:
0.2		 5uxdB-1httA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 183
ILE A 131
LEU A 103
HIS A  46
 ILE  A 183 ( 0.6A)
ILE  A 131 ( 0.7A)
LEU  A 103 ( 0.6A)
HIS  A  46 ( 1.0A)
 1.01A 5vkqA-5cdnA:
3.2
5vkqB-5cdnA:
3.1		 5vkqA-5cdnA:
14.36
5vkqB-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A 279
HIS A 287
PRO A 288
ILE A 289
 VAL  A 279 ( 0.6A)
HIS  A 287 ( 1.0A)
PRO  A 288 ( 1.1A)
ILE  A 289 ( 0.7A)
 1.01A 5vkqA-2ogsA:
undetectable
5vkqD-2ogsA:
undetectable		 5vkqA-2ogsA:
14.51
5vkqD-2ogsA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 THR A 486
PHE A 218
HIS A 186
ILE A 213
 THR  A 486 ( 0.8A)
PHE  A 218 ( 1.3A)
HIS  A 186 ( 1.0A)
ILE  A 213 ( 0.6A)
 1.15A 5vkqA-5cdnA:
3.2
5vkqB-5cdnA:
3.2		 5vkqA-5cdnA:
14.36
5vkqB-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 ILE A  11
ILE A  45
LEU A 213
HIS A 211
 ILE  A  11 ( 0.7A)
ILE  A  45 ( 0.7A)
LEU  A 213 ( 0.6A)
HIS  A 211 ( 1.0A)
 0.99A 5vkqB-2j5bA:
undetectable
5vkqC-2j5bA:
undetectable		 5vkqB-2j5bA:
12.28
5vkqC-2j5bA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 8 THR A 486
PHE A 218
HIS A 186
ILE A 213
 THR  A 486 ( 0.8A)
PHE  A 218 ( 1.3A)
HIS  A 186 ( 1.0A)
ILE  A 213 ( 0.6A)
 1.15A 5vkqB-5cdnA:
3.2
5vkqC-5cdnA:
3.2		 5vkqB-5cdnA:
14.36
5vkqC-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2j5b TYROSYL-TRNA
SYNTHETASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 ILE A  11
ILE A  45
LEU A 213
HIS A 211
 ILE  A  11 ( 0.7A)
ILE  A  45 ( 0.7A)
LEU  A 213 ( 0.6A)
HIS  A 211 ( 1.0A)
 0.96A 5vkqC-2j5bA:
undetectable
5vkqD-2j5bA:
undetectable		 5vkqC-2j5bA:
12.28
5vkqD-2j5bA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 7 THR A 486
PHE A 218
HIS A 186
ILE A 213
 THR  A 486 ( 0.8A)
PHE  A 218 ( 1.3A)
HIS  A 186 ( 1.0A)
ILE  A 213 ( 0.6A)
 1.12A 5vkqC-5cdnA:
3.2
5vkqD-5cdnA:
3.2		 5vkqC-5cdnA:
14.36
5vkqD-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5cdn DNA GYRASE SUBUNIT A
(Staphylococcus
aureus) 		4 / 6 ILE A 183
ILE A 131
LEU A 103
HIS A  46
 ILE  A 183 ( 0.6A)
ILE  A 131 ( 0.7A)
LEU  A 103 ( 0.6A)
HIS  A  46 ( 1.0A)
 0.99A 5vkqA-5cdnA:
3.2
5vkqD-5cdnA:
3.2		 5vkqA-5cdnA:
14.36
5vkqD-5cdnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 5w97a-5d7wA:
undetectable		 5w97a-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.71A 5x19N-5d7wA:
undetectable		 5x19N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.70A 5x1bA-5d7wA:
undetectable		 5x1bA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.68A 5x1bN-5d7wA:
undetectable		 5x1bN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3gnr OS03G0212800 PROTEIN
(Oryza
sativa) 		4 / 6 HIS A 219
ASP A 304
THR A 302
HIS A 220
 HIS  A 219 ( 1.0A)
ASP  A 304 ( 0.6A)
THR  A 302 ( 0.8A)
HIS  A 220 ( 1.0A)
 1.46A 5x1bN-3gnrA:
undetectable
5x1bP-3gnrA:
undetectable		 5x1bN-3gnrA:
21.63
5x1bP-3gnrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.73A 5x1fA-5d7wA:
undetectable		 5x1fA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.66A 5x1fN-5d7wA:
undetectable		 5x1fN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1htt HISTIDYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A 145
GLY A 285
TYR A 288
ALA A 302
VAL A 132
 None
HIS  A 450 ( 3.8A)
None
None
None
 0.99A 5x66F-1httA:
undetectable		 5x66F-1httA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5e3i HISTIDINE--TRNA
LIGASE
(Acinetobacter
baumannii) 		4 / 6 TYR A 266
GLU A 172
GLY A 288
GLY A 287
 HIS  A 502 (-4.7A)
None
None
HIS  A 502 ( 3.8A)
 0.96A 5x7pB-5e3iA:
undetectable		 5x7pB-5e3iA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5l5n PLEXIN-A4
(Mus
musculus) 		4 / 5 HIS A 630
ASN A 654
VAL A 619
LEU A 597
 HIS  A 630 ( 1.0A)
ASN  A 654 ( 0.6A)
VAL  A 619 ( 0.6A)
LEU  A 597 ( 0.5A)
 1.38A 5xdhD-5l5nA:
undetectable		 5xdhD-5l5nA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 5xdqA-5d7wA:
undetectable		 5xdqA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 5xdqN-5d7wA:
undetectable		 5xdqN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.73A 5xdxA-5d7wA:
undetectable		 5xdxA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 5xdxN-5d7wA:
undetectable		 5xdxN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.28A 5xioA-5vldA:
2.4		 5xioA-5vldA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN
(Mycolicibacteriu
m
fortuitum) 		3 / 3 GLU A 168
TRP A 175
HIS A 182
 GLU  A 168 (-0.5A)
TRP  A 175 ( 0.5A)
HIS  A 182 ( 1.0A)
 1.03A 5xipA-4w65A:
undetectable		 5xipA-4w65A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.18A 5xiqA-5vldA:
2.6		 5xiqA-5vldA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.16A 5xiqB-5vldA:
2.7		 5xiqB-5vldA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC
(Medicago
truncatula) 		5 / 12 VAL A 167
PRO A 249
GLU A 367
HIS A 368
SER A 388
 None
NAD  A 502 (-4.1A)
HIS  A 501 ( 2.7A)
HIS  A 501 (-3.9A)
None
 1.22A 5xiqC-5vldA:
2.6		 5xiqC-5vldA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 5nqf APICAL MEMBRANE
ANTIGEN 1
(Plasmodium
falciparum) 		5 / 12 GLY A 222
ASN A 223
TYR A 202
HIS A 248
TYR A 240
 GLY  A 222 ( 0.0A)
ASN  A 223 ( 0.6A)
TYR  A 202 ( 1.3A)
HIS  A 248 ( 1.0A)
TYR  A 240 ( 1.3A)
 1.32A 5xxdA-5nqfA:
undetectable		 5xxdA-5nqfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		3 / 3 SER A 110
HIS A 158
TYR A 116
 SER  A 110 ( 0.0A)
HIS  A 158 ( 1.0A)
TYR  A 116 ( 1.3A)
 1.04A 5y2tA-2hk0A:
undetectable		 5y2tA-2hk0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 8 HIS A  20
PHE A  69
PHE A  42
LEU A 348
 HIS  A  20 ( 1.0A)
PHE  A  69 ( 1.3A)
PHE  A  42 ( 1.3A)
LEU  A 348 ( 0.6A)
 1.11A 5y2tB-5ec3A:
undetectable		 5y2tB-5ec3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT
(Caldanaerobacter
subterraneus) 		4 / 8 LEU D  67
ILE D  74
ALA D  29
LEU D  25
 HIS  D 301 ( 4.7A)
None
None
None
 0.63A 5y7pC-4ymwD:
undetectable		 5y7pC-4ymwD:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 5wpi HSVA
(Erwinia
amylovora) 		4 / 8 HIS A  56
HIS A 217
TRP A 176
TRP A 139
 HIS  A  56 ( 1.0A)
HIS  A 217 ( 1.0A)
TRP  A 176 ( 0.5A)
TRP  A 139 ( 0.5A)
 1.13A 5yj1k-5wpiA:
undetectable
5yj1t-5wpiA:
undetectable		 5yj1k-5wpiA:
12.05
5yj1t-5wpiA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens) 		4 / 5 HIS C 343
SER C 332
TYR C 211
GLY C 333
 HIS  C 343 ( 1.0A)
SER  C 332 ( 0.0A)
TYR  C 211 ( 1.3A)
GLY  C 333 ( 0.0A)
 1.37A 5yodH-3ghgC:
undetectable		 5yodH-3ghgC:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 6 GLY A 367
THR A 381
VAL A 372
TRP A 369
 None
None
None
HIS  A 502 (-3.3A)
 0.96A 5ysiA-4oflA:
undetectable		 5ysiA-4oflA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 1.04A 5z0fA-3ulkA:
undetectable
5z0fB-3ulkA:
undetectable		 5z0fA-3ulkA:
10.71
5z0fB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.97A 5z0gA-3ulkA:
undetectable
5z0gB-3ulkA:
undetectable		 5z0gA-3ulkA:
10.71
5z0gB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.95A 5z0hA-3ulkA:
undetectable
5z0hB-3ulkA:
undetectable		 5z0hA-3ulkA:
10.71
5z0hB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.97A 5z0iA-3ulkA:
undetectable
5z0iB-3ulkA:
undetectable		 5z0iA-3ulkA:
10.71
5z0iB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.97A 5z0jA-3ulkA:
undetectable
5z0jB-3ulkA:
undetectable		 5z0jA-3ulkA:
10.71
5z0jB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.97A 5z0kA-3ulkA:
undetectable
5z0kB-3ulkA:
undetectable		 5z0kA-3ulkA:
10.71
5z0kB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.96A 5z0lA-3ulkA:
undetectable
5z0lB-3ulkA:
undetectable		 5z0lA-3ulkA:
10.71
5z0lB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 11 ASN A 181
HIS A 178
VAL A 177
ASP A 182
PRO A 183
 ASN  A 181 ( 0.6A)
HIS  A 178 ( 1.0A)
VAL  A 177 ( 0.6A)
ASP  A 182 ( 0.6A)
PRO  A 183 ( 1.1A)
 0.97A 5z0mA-3ulkA:
undetectable
5z0mB-3ulkA:
undetectable		 5z0mA-3ulkA:
10.71
5z0mB-3ulkA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.77A 5z84A-5d7wA:
undetectable		 5z84A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 5z84N-5d7wA:
undetectable		 5z84N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.77A 5z85A-5d7wA:
undetectable		 5z85A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 5z85N-5d7wA:
undetectable		 5z85N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 5z86A-5d7wA:
undetectable		 5z86A-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 5z86N-5d7wA:
undetectable		 5z86N-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Saccharomonospor
a
viridis) 		5 / 10 ARG A  98
ALA A  34
HIS A  95
LEU A  23
VAL A 140
 ARG  A  98 (-0.6A)
ALA  A  34 ( 0.0A)
HIS  A  95 ( 1.0A)
LEU  A  23 ( 0.5A)
VAL  A 140 ( 0.6A)
 1.28A 5zbdA-4jbeA:
1.6		 5zbdA-4jbeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 5zcoA-5d7wA:
undetectable		 5zcoA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 5zcoN-5d7wA:
undetectable		 5zcoN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 5zcpA-5d7wA:
undetectable		 5zcpA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 5zcpN-5d7wA:
undetectable		 5zcpN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 5zcqA-5d7wA:
undetectable		 5zcqA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 5zcqN-5d7wA:
undetectable		 5zcqN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		3 / 3 ASN A  51
VAL A  15
HIS A  16
 ASN  A  51 ( 0.6A)
VAL  A  15 ( 0.6A)
HIS  A  16 ( 1.0A)
 0.83A 6a5yD-2nvvA:
undetectable		 6a5yD-2nvvA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 6an0 HISTIDINOL
DEHYDROGENASE
(Elizabethkingia
anophelis) 		6 / 6 GLU A  98
LYS A 100
ARG A 113
GLU A 114
ALA A 115
LYS A 385
 HIS  A 520 (-3.5A)
None
HIS  A 520 (-4.9A)
HIS  A 520 (-4.4A)
HIS  A 520 (-3.5A)
HIS  A 520 (-3.7A)
 0.00A 6an0A-6an0A:
60.4		 6an0A-6an0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.05A 6aphA-2nvvA:
undetectable		 6aphA-2nvvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.92A 6aphA-5d7aA:
undetectable		 6aphA-5d7aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4zke SUPERKILLER PROTEIN
7
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 573
HIS A 566
ARG A 634
 HIS  A 573 ( 1.0A)
HIS  A 566 ( 1.0A)
ARG  A 634 ( 0.6A)
 1.11A 6b58A-4zkeA:
undetectable		 6b58A-4zkeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6czm -
(-) 		5 / 10 GLY A 300
LEU A 301
THR A 305
VAL A 325
CYH A 327
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
HIS  A 402 (-4.2A)
 0.00A 6czmA-6czmA:
46.0
6czmC-6czmA:
41.8		 6czmA-6czmA:
undetectable
6czmC-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6czm -
(-) 		5 / 9 GLY A 300
LEU A 301
GLN A 302
THR A 305
VAL A 325
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
None
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
 0.52A 6czmA-6czmA:
46.0
6czmB-6czmA:
37.0		 6czmA-6czmA:
undetectable
6czmB-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6czm -
(-) 		5 / 9 GLY A 300
LEU A 301
GLN A 302
THR A 305
VAL A 325
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
None
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
 0.58A 6czmB-6czmA:
37.0
6czmC-6czmA:
41.8		 6czmB-6czmA:
undetectable
6czmC-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6czm -
(-) 		5 / 9 GLY A 300
LEU A 301
THR A 305
VAL A 325
CYH A 327
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
HIS  A 402 (-4.2A)
 0.23A 6czmD-6czmA:
41.2
6czmE-6czmA:
42.8		 6czmD-6czmA:
undetectable
6czmE-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 6czm -
(-) 		6 / 10 GLY A 300
LEU A 301
GLN A 302
THR A 305
VAL A 325
CYH A 327
 HIS  A 402 (-3.4A)
HIS  A 402 (-4.0A)
None
HIS  A 402 (-4.2A)
HIS  A 402 (-4.4A)
HIS  A 402 (-4.2A)
 0.24A 6czmE-6czmA:
42.8
6czmF-6czmA:
37.6		 6czmE-6czmA:
undetectable
6czmF-6czmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5wo1 PERIPLASMIC
CHAPERONE SPY
(Escherichia
coli) 		3 / 3 ARG A  61
HIS A  65
ARG A  62
 ARG  A  61 ( 0.6A)
HIS  A  65 ( 1.0A)
ARG  A  62 ( 0.6A)
 1.15A 6dwdD-5wo1A:
undetectable		 6dwdD-5wo1A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 211
LEU A 208
ARG A 207
HIS A 204
 LEU  A 211 ( 0.6A)
LEU  A 208 ( 0.5A)
ARG  A 207 ( 0.6A)
HIS  A 204 ( 1.0A)
 0.90A 6e43A-5svdA:
1.7		 6e43A-5svdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 211
LEU A 208
ARG A 207
HIS A 204
 LEU  A 211 ( 0.6A)
LEU  A 208 ( 0.5A)
ARG  A 207 ( 0.6A)
HIS  A 204 ( 1.0A)
 0.92A 6e43B-5svdA:
3.3		 6e43B-5svdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 211
LEU A 208
ARG A 207
HIS A 204
 LEU  A 211 ( 0.6A)
LEU  A 208 ( 0.5A)
ARG  A 207 ( 0.6A)
HIS  A 204 ( 1.0A)
 0.85A 6e43D-5svdA:
1.9		 6e43D-5svdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 6f3nA-2nvvA:
0.6		 6f3nA-2nvvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 6f3nC-2nvvA:
undetectable		 6f3nC-2nvvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 4 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.07A 6f3nD-2nvvA:
undetectable		 6f3nD-2nvvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1k5d RAN-SPECIFIC
GTPASE-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 6 GLU B 136
TRP B 122
HIS B 102
ALA B 100
 GLU  B 136 ( 0.5A)
TRP  B 122 ( 0.5A)
HIS  B 102 ( 1.0A)
ALA  B 100 ( 0.0A)
 1.39A 6f6jC-1k5dB:
0.0
6f6jD-1k5dB:
0.0		 6f6jC-1k5dB:
19.34
6f6jD-1k5dB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 HIS A 264
ASN A 263
LEU A 262
 HIS  A 264 ( 1.0A)
ASN  A 263 ( 0.6A)
LEU  A 262 ( 0.6A)
 0.89A 6f7lB-3sagA:
undetectable		 6f7lB-3sagA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		6 / 6 PHE A  64
LEU A  69
ALA A  74
SER A 225
THR A 233
ASN A 276
 None
HIS  A 502 (-4.9A)
HEM  A 501 (-3.8A)
HEM  A 501 ( 4.0A)
HIS  A 502 ( 3.5A)
HEM  A 501 (-4.3A)
 0.34A 6f88A-6f85A:
67.2		 6f88A-6f85A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 6f85 CYTOCHROME P450
CYP260A1
(Sorangium
cellulosum) 		6 / 6 LEU A  69
ALA A  74
LEU A 159
SER A 225
THR A 233
ASN A 276
 HIS  A 502 (-4.9A)
HEM  A 501 (-3.8A)
HIS  A 502 (-4.6A)
HEM  A 501 ( 4.0A)
HIS  A 502 ( 3.5A)
HEM  A 501 (-4.3A)
 0.47A 6f88B-6f85A:
69.6		 6f88B-6f85A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 6gbnA-2nvvA:
undetectable		 6gbnA-2nvvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 THR  A 176 ( 0.8A)
THR  A 130 ( 0.8A)
HIS  A  42 ( 1.0A)
LEU  A  25 ( 0.5A)
 1.30A 6gbnA-2v9uA:
undetectable		 6gbnA-2v9uA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.03A 6gbnB-2nvvA:
undetectable		 6gbnB-2nvvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.92A 6gbnB-5d7aA:
undetectable		 6gbnB-5d7aA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.02A 6gbnC-2nvvA:
undetectable		 6gbnC-2nvvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN
(Porphyromonas
gingivalis) 		4 / 5 GLN A 333
THR A 107
THR A 383
HIS A 414
 GLN  A 333 ( 0.6A)
THR  A 107 ( 0.8A)
THR  A 383 ( 0.8A)
HIS  A 414 ( 1.0A)
 1.03A 6gbnD-2nvvA:
undetectable		 6gbnD-2nvvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 2v9u MSPA
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A 176
THR A 130
HIS A  42
LEU A  25
 THR  A 176 ( 0.8A)
THR  A 130 ( 0.8A)
HIS  A  42 ( 1.0A)
LEU  A  25 ( 0.5A)
 1.27A 6gbnD-2v9uA:
undetectable		 6gbnD-2v9uA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		4 / 5 ASN A 732
TYR A 325
GLY A 346
HIS A 743
 ASN  A 732 ( 0.6A)
TYR  A 325 ( 1.3A)
GLY  A 346 ( 0.0A)
HIS  A 743 ( 1.0A)
 1.29A 6gh9A-1v0fA:
undetectable		 6gh9A-1v0fA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		4 / 6 TRP A 112
HIS A 186
ASN A 157
GLU A 165
 TRP  A 112 ( 0.5A)
HIS  A 186 ( 1.0A)
ASN  A 157 ( 0.6A)
GLU  A 165 ( 0.6A)
 1.42A 6gneA-2hk0A:
undetectable		 6gneA-2hk0A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3ulk KETOL-ACID
REDUCTOISOMERASE
(Escherichia
coli) 		5 / 12 GLY A 204
TRP A 194
HIS A 201
GLU A  27
GLY A  24
 GLY  A 204 ( 0.0A)
TRP  A 194 ( 0.5A)
HIS  A 201 (-1.0A)
GLU  A  27 ( 0.6A)
GLY  A  24 ( 0.0A)
 1.18A 6gngA-3ulkA:
3.8		 6gngA-3ulkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_0
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1v0f ENDO-ALPHA-SIALIDASE
(Enterobacteria
phage
K1F) 		5 / 12 PRO A 548
ILE A 571
TYR A 541
HIS A 542
THR A 524
 PRO  A 548 ( 1.1A)
ILE  A 571 ( 0.7A)
TYR  A 541 ( 1.3A)
HIS  A 542 ( 1.0A)
THR  A 524 ( 0.9A)
 1.29A 6hloA-1v0fA:
0.0		 6hloA-1v0fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.73A 6hu9a-5d7wA:
undetectable		 6hu9a-5d7wA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.74A 6hu9m-5d7wA:
undetectable		 6hu9m-5d7wA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1wqa PHOSPHO-SUGAR MUTASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 158
HIS A 336
ALA A 347
GLY A 342
ALA A  82
 ILE  A 158 ( 0.7A)
HIS  A 336 ( 1.0A)
ALA  A 347 ( 0.0A)
GLY  A 342 ( 0.0A)
ALA  A  82 ( 0.0A)
 1.17A 6ieyA-1wqaA:
2.4
6ieyB-1wqaA:
2.2		 6ieyA-1wqaA:
23.79
6ieyB-1wqaA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.76A 6nknA-5d7wA:
undetectable		 6nknA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 6nknN-5d7wA:
undetectable		 6nknN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.71A 6nmfA-5d7wA:
undetectable		 6nmfA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.72A 6nmfN-5d7wA:
undetectable		 6nmfN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 6nmpA-5d7wA:
undetectable		 6nmpA-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5d7w SERRALYSIN
(Serratia
marcescens) 		3 / 3 HIS A 186
HIS A 180
HIS A 176
 HIS  A 186 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 176 (-1.0A)
 0.75A 6nmpN-5d7wA:
undetectable		 6nmpN-5d7wA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2hk0 D-PSICOSE
3-EPIMERASE
(Agrobacterium
tumefaciens) 		4 / 6 LEU A 108
HIS A 207
HIS A 209
GLU A  34
 LEU  A 108 ( 0.6A)
HIS  A 207 ( 1.0A)
HIS  A 209 ( 1.0A)
GLU  A  34 ( 0.6A)
 0.90A 6pahA-2hk0A:
undetectable		 6pahA-2hk0A:
22.41