SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'IPE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 GLY A 141
SER A 140
MET A 145
LEU A 176
LEU A 136
 None
None
IPE  A 301 ( 4.2A)
None
None
 1.47A 1a8uB-4lfeA:
undetectable		 1a8uB-4lfeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.02A 1k6cA-3ll5A:
undetectable		 1k6cA-3ll5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 127
ARG A 250
ARG A  89
 DPO  A1297 ( 3.0A)
IPE  A1298 (-3.7A)
DPO  A1297 (-2.7A)
 1.02A 1l7fA-2vg2A:
undetectable		 1l7fA-2vg2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 127
ARG A 250
ARG A  89
 DPO  A1297 ( 3.0A)
IPE  A1298 (-3.7A)
DPO  A1297 (-2.7A)
 1.03A 1l7hA-2vg2A:
undetectable		 1l7hA-2vg2A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ARG A  93
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.76A 1rqjA-3wjoA:
29.6		 1rqjA-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.95A 1rqjA-3wjoA:
29.6		 1rqjA-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ASP A  84
ARG A  93
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.69A 1rqjA-3wjoA:
29.6		 1rqjA-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.51A 1rqjA-3wjoA:
29.6		 1rqjA-3wjoA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.52A 1rqjA-4e1eA:
30.4		 1rqjA-4e1eA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.72A 1rqjA-4jzxA:
31.0		 1rqjA-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.46A 1rqjA-4jzxA:
31.0		 1rqjA-4jzxA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 1rqjA-4lfeA:
34.3		 1rqjA-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.68A 1rqjA-4lfeA:
34.3		 1rqjA-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.43A 1rqjA-4lfeA:
34.3		 1rqjA-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.57A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 1rqjA-4llsA:
42.4		 1rqjA-4llsA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.01A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ARG A  93
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.72A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.93A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ASP A  84
ARG A  93
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.65A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.47A 1rqjB-3wjoA:
29.4		 1rqjB-3wjoA:
30.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.51A 1rqjB-4e1eA:
30.4		 1rqjB-4e1eA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 1rqjB-4jzxA:
31.0		 1rqjB-4jzxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 1rqjB-4jzxA:
31.0		 1rqjB-4jzxA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.88A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.65A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.41A 1rqjB-4lfeA:
34.3		 1rqjB-4lfeA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		10 / 11 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 1rqjB-4llsA:
42.2		 1rqjB-4llsA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ILE A  47
LEU A 203
GLY A 204
PHE A 207
 None
None
None
IPE  A 402 (-4.5A)
 0.63A 1rtsA-3wjoA:
undetectable		 1rtsA-3wjoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 TYR A 324
THR A 208
THR A 209
VAL A 328
 None
IPE  A 405 ( 4.6A)
None
None
 1.19A 1tv8A-4e1eA:
undetectable		 1tv8A-4e1eA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 148
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.30A 1v54A-4llsA:
0.6
1v54B-4llsA:
undetectable
1v54T-4llsA:
undetectable		 1v54A-4llsA:
20.31
1v54B-4llsA:
22.93
1v54T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 1yhlA-1rqjA:
31.1		 1yhlA-1rqjA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.91A 1yhlA-3wjoA:
25.2		 1yhlA-3wjoA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.88A 1yhlA-3wjoA:
25.2		 1yhlA-3wjoA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.89A 1yhlA-3wjoA:
25.2		 1yhlA-3wjoA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.46A 1yhlA-4e1eA:
57.0		 1yhlA-4e1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.13A 1yhlA-4jzxA:
54.0		 1yhlA-4jzxA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 1yhlA-4jzxA:
54.0		 1yhlA-4jzxA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.44A 1yhlA-4jzxA:
54.0		 1yhlA-4jzxA:
63.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.88A 1yhlA-4lfeA:
25.9		 1yhlA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 1yhlA-4lfeA:
25.9		 1yhlA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.58A 1yhlA-4llsA:
28.9		 1yhlA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.34A 1yq7A-1rqjA:
29.4		 1yq7A-1rqjA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.89A 1yq7A-3wjoA:
25.1		 1yq7A-3wjoA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.87A 1yq7A-3wjoA:
25.1		 1yq7A-3wjoA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.91A 1yq7A-3wjoA:
25.1		 1yq7A-3wjoA:
26.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.49A 1yq7A-4e1eA:
43.6		 1yq7A-4e1eA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.45A 1yq7A-4jzxA:
43.7		 1yq7A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.71A 1yq7A-4jzxA:
43.7		 1yq7A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.53A 1yq7A-4jzxA:
43.7		 1yq7A-4jzxA:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 1yq7A-4lfeA:
26.0		 1yq7A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 1yq7A-4lfeA:
26.0		 1yq7A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.50A 1yq7A-4lfeA:
26.0		 1yq7A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 1yq7A-4llsA:
28.6		 1yq7A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.30A 1yv5A-1rqjA:
29.6		 1yv5A-1rqjA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.93A 1yv5A-3wjoA:
25.1		 1yv5A-3wjoA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.89A 1yv5A-3wjoA:
25.1		 1yv5A-3wjoA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.52A 1yv5A-3wjoA:
25.1		 1yv5A-3wjoA:
26.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.40A 1yv5A-4e1eA:
44.0		 1yv5A-4e1eA:
36.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.59A 1yv5A-4jzxA:
44.0		 1yv5A-4jzxA:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 1yv5A-4jzxA:
44.0		 1yv5A-4jzxA:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.93A 1yv5A-4lfeA:
26.0		 1yv5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.72A 1yv5A-4lfeA:
26.0		 1yv5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 1yv5A-4lfeA:
26.0		 1yv5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 1yv5A-4llsA:
28.7		 1yv5A-4llsA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.36A 1zw5A-1rqjA:
30.4		 1zw5A-1rqjA:
27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.42A 1zw5A-4e1eA:
45.0		 1zw5A-4e1eA:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 1zw5A-4jzxA:
45.1		 1zw5A-4jzxA:
38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.42A 1zw5A-4jzxA:
45.1		 1zw5A-4jzxA:
38.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.05A 1zw5A-4lfeA:
26.2		 1zw5A-4lfeA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.79A 1zw5A-4lfeA:
26.2		 1zw5A-4lfeA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.56A 1zw5A-4lfeA:
26.2		 1zw5A-4lfeA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 1zw5A-4llsA:
29.5		 1zw5A-4llsA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLY A  54
PRO A  61
VAL A  62
ILE A  86
 IPE  A 300 (-2.9A)
None
None
None
 0.94A 2aoiA-3k4yA:
undetectable		 2aoiA-3k4yA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
 0.45A 2e91A-1rqjA:
21.5		 2e91A-1rqjA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 9 ASP A 105
ASP A 111
GLN A 179
LYS A 202
THR A 203
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
MG  A 909 ( 4.2A)
 1.35A 2e91A-1rqjA:
21.5		 2e91A-1rqjA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.99A 2e91A-3wjoA:
22.0		 2e91A-3wjoA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.97A 2e91A-3wjoA:
22.0		 2e91A-3wjoA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 0.44A 2e91A-4e1eA:
24.6		 2e91A-4e1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.70A 2e91A-4jzxA:
24.5		 2e91A-4jzxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.52A 2e91A-4jzxA:
24.5		 2e91A-4jzxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.97A 2e91A-4lfeA:
20.1		 2e91A-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.77A 2e91A-4lfeA:
20.1		 2e91A-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.54A 2e91A-4lfeA:
20.1		 2e91A-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
 0.69A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.68A 2e91A-4llsA:
21.3		 2e91A-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
 0.62A 2e91B-1rqjA:
20.5		 2e91B-1rqjA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.99A 2e91B-3wjoA:
21.1		 2e91B-3wjoA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.97A 2e91B-3wjoA:
21.1		 2e91B-3wjoA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.92A 2e91B-3wjoA:
21.1		 2e91B-3wjoA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
 0.52A 2e91B-4e1eA:
23.7		 2e91B-4e1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.66A 2e91B-4jzxA:
23.7		 2e91B-4jzxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.15A 2e91B-4lfeA:
19.4		 2e91B-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.73A 2e91B-4lfeA:
19.4		 2e91B-4lfeA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
THR A 179
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
 0.86A 2e91B-4llsA:
20.5		 2e91B-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.75A 2e91B-4llsA:
20.5		 2e91B-4llsA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.36A 2eimG-4llsA:
undetectable
2eimN-4llsA:
0.9
2eimO-4llsA:
undetectable		 2eimG-4llsA:
14.29
2eimN-4llsA:
20.31
2eimO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 2f89F-1rqjA:
31.4		 2f89F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.02A 2f89F-3wjoA:
25.9		 2f89F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ARG A  93
THR A 171
GLN A 208
ASP A 211
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.67A 2f89F-3wjoA:
25.9		 2f89F-3wjoA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.23A 2f89F-4e1eA:
45.5		 2f89F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.07A 2f89F-4jzxA:
46.2		 2f89F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.29A 2f89F-4jzxA:
46.2		 2f89F-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 2f89F-4lfeA:
26.2		 2f89F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.70A 2f89F-4lfeA:
26.2		 2f89F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.65A 2f89F-4llsA:
30.3		 2f89F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 2f8cF-1rqjA:
30.6		 2f8cF-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.99A 2f8cF-3wjoA:
25.7		 2f8cF-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.94A 2f8cF-3wjoA:
25.7		 2f8cF-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.94A 2f8cF-3wjoA:
25.7		 2f8cF-3wjoA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.37A 2f8cF-4e1eA:
44.6		 2f8cF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.15A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.42A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.59A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.38A 2f8cF-4jzxA:
45.1		 2f8cF-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.96A 2f8cF-4lfeA:
26.2		 2f8cF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.73A 2f8cF-4lfeA:
26.2		 2f8cF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 2f8cF-4lfeA:
26.2		 2f8cF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 2f8cF-4llsA:
29.6		 2f8cF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.38A 2f8zF-1rqjA:
31.6		 2f8zF-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.03A 2f8zF-3wjoA:
25.8		 2f8zF-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.78A 2f8zF-3wjoA:
25.8		 2f8zF-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 0.91A 2f8zF-3wjoA:
25.8		 2f8zF-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.50A 2f8zF-3wjoA:
25.8		 2f8zF-3wjoA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.41A 2f8zF-4e1eA:
45.3		 2f8zF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.16A 2f8zF-4jzxA:
45.8		 2f8zF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 2f8zF-4jzxA:
45.8		 2f8zF-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.74A 2f8zF-4lfeA:
26.1		 2f8zF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 2f8zF-4lfeA:
26.1		 2f8zF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.81A 2f8zF-4lfeA:
26.1		 2f8zF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 2f8zF-4llsA:
30.3		 2f8zF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.68A 2f94F-1rqjA:
30.1		 2f94F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.92A 2f94F-3wjoA:
25.7		 2f94F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.83A 2f94F-3wjoA:
25.7		 2f94F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.83A 2f94F-3wjoA:
25.7		 2f94F-3wjoA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		12 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.42A 2f94F-4e1eA:
44.3		 2f94F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		12 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 2f94F-4jzxA:
44.8		 2f94F-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.07A 2f94F-4lfeA:
25.9		 2f94F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.88A 2f94F-4lfeA:
25.9		 2f94F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		10 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 2f94F-4llsA:
29.3		 2f94F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.30A 2f9kF-1rqjA:
30.2		 2f9kF-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.97A 2f9kF-3wjoA:
25.6		 2f9kF-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.93A 2f9kF-3wjoA:
25.6		 2f9kF-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.92A 2f9kF-3wjoA:
25.6		 2f9kF-3wjoA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 2f9kF-4e1eA:
44.5		 2f9kF-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.16A 2f9kF-4jzxA:
44.9		 2f9kF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 2f9kF-4jzxA:
44.9		 2f9kF-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.42A 2f9kF-4jzxA:
44.9		 2f9kF-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 2f9kF-4lfeA:
25.9		 2f9kF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.71A 2f9kF-4lfeA:
25.9		 2f9kF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 2f9kF-4lfeA:
25.9		 2f9kF-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 2f9kF-4llsA:
29.2		 2f9kF-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 TYR A 324
THR A 208
THR A 209
VAL A 328
 None
IPE  A 405 ( 4.6A)
None
None
 1.18A 2fb2A-4e1eA:
undetectable		 2fb2A-4e1eA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.40A 2o1oA-1rqjA:
25.8		 2o1oA-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.98A 2o1oA-3wjoA:
24.5		 2o1oA-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.80A 2o1oA-3wjoA:
24.5		 2o1oA-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.55A 2o1oA-4e1eA:
37.1		 2o1oA-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 0.76A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.53A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.85A 2o1oA-4lfeA:
24.8		 2o1oA-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.44A 2o1oA-4lfeA:
24.8		 2o1oA-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.53A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ASP A  86
ARG A  91
THR A 179
GLN A 213
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.73A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.42A 2o1oB-1rqjA:
26.6		 2o1oB-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 1.07A 2o1oB-3wjoA:
25.5		 2o1oB-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 1.03A 2o1oB-3wjoA:
25.5		 2o1oB-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.59A 2o1oB-4e1eA:
37.4		 2o1oB-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.75A 2o1oB-4jzxA:
37.7		 2o1oB-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.64A 2o1oB-4jzxA:
37.7		 2o1oB-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.82A 2o1oB-4lfeA:
25.8		 2o1oB-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.58A 2o1oB-4lfeA:
25.8		 2o1oB-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.65A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.82A 2o1oB-4llsA:
25.6		 2o1oB-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 245
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
None
 0.56A 2q58A-1rqjA:
11.1		 2q58A-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 212
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
None
 1.16A 2q58A-3wjoA:
24.7		 2q58A-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ASP A  84
ARG A  93
LYS A 170
THR A 171
ASP A 212
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
None
 1.24A 2q58A-3wjoA:
24.7		 2q58A-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 1.14A 2q58A-3wjoA:
24.7		 2q58A-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
ASP A 212
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
None
 1.21A 2q58A-3wjoA:
24.7		 2q58A-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 1.11A 2q58A-3wjoA:
24.7		 2q58A-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 10 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 251
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
None
 0.69A 2q58A-4e1eA:
36.9		 2q58A-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 251
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
None
 0.72A 2q58A-4e1eA:
36.9		 2q58A-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ASP A 102
GLN A 167
GLN A 247
ASP A 251
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
None
 0.84A 2q58A-4jzxA:
36.9		 2q58A-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.48A 2q58A-4jzxA:
36.9		 2q58A-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 251
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
None
 0.82A 2q58A-4jzxA:
36.9		 2q58A-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.90A 2q58A-4lfeA:
24.9		 2q58A-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
ASP A 217
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
None
 1.24A 2q58A-4lfeA:
24.9		 2q58A-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.69A 2q58A-4lfeA:
24.9		 2q58A-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.95A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 LEU A  77
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 217
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
None
 0.89A 2q58A-4llsA:
25.2		 2q58A-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.42A 2q58B-1rqjA:
26.5		 2q58B-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		6 / 9 ASP A 105
ASP A 111
GLN A 179
LYS A 202
THR A 203
LYS A 268
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
MG  A 909 ( 4.2A)
 1.23A 2q58B-1rqjA:
26.5		 2q58B-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.66A 2q58B-4e1eA:
36.8		 2q58B-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.79A 2q58B-4jzxA:
37.1		 2q58B-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.65A 2q58B-4jzxA:
37.1		 2q58B-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.90A 2q58B-4lfeA:
25.3		 2q58B-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.61A 2q58B-4lfeA:
25.3		 2q58B-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.66A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.86A 2q58B-4llsA:
25.2		 2q58B-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.99A 2qisA-3wjoA:
25.8		 2qisA-3wjoA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.89A 2qisA-3wjoA:
25.8		 2qisA-3wjoA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 0.87A 2qisA-3wjoA:
25.8		 2qisA-3wjoA:
26.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 2qisA-4jzxA:
44.5		 2qisA-4jzxA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 2qisA-4jzxA:
44.5		 2qisA-4jzxA:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.95A 2qisA-4lfeA:
25.9		 2qisA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.70A 2qisA-4lfeA:
25.9		 2qisA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 2qisA-4llsA:
29.0		 2qisA-4llsA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.04A 2r5pA-3ll5A:
undetectable		 2r5pA-3ll5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.04A 2r5pC-3ll5A:
undetectable		 2r5pC-3ll5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ILE A  47
LEU A 203
GLY A 204
PHE A 207
 None
None
None
IPE  A 402 (-4.5A)
 0.60A 2tsrA-3wjoA:
undetectable		 2tsrA-3wjoA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 LEU A 234
ILE A 336
ALA A 347
ARG A  51
LEU A 217
 None
None
None
IPE  A 405 (-2.5A)
None
 1.20A 2v0mA-4e1eA:
undetectable		 2v0mA-4e1eA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.32A 2zxwG-4llsA:
undetectable
2zxwN-4llsA:
1.3
2zxwO-4llsA:
undetectable		 2zxwG-4llsA:
14.29
2zxwN-4llsA:
20.31
2zxwO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 244
PHE A 254
SER A 252
VAL A 170
LEU A 174
 IPE  A1298 (-3.4A)
None
IPE  A1298 (-2.5A)
None
None
 1.23A 3a9eB-2vg2A:
undetectable		 3a9eB-2vg2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLN A 175
THR A 172
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.48A 3abkA-4llsA:
2.0
3abkB-4llsA:
undetectable
3abkT-4llsA:
undetectable		 3abkA-4llsA:
20.31
3abkB-4llsA:
22.93
3abkT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLN A 175
THR A 172
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.41A 3ag3A-4llsA:
0.8
3ag3B-4llsA:
undetectable
3ag3T-4llsA:
undetectable		 3ag3A-4llsA:
20.31
3ag3B-4llsA:
22.93
3ag3T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 148
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.13A 3ag3A-4llsA:
0.8
3ag3B-4llsA:
undetectable
3ag3T-4llsA:
undetectable		 3ag3A-4llsA:
20.31
3ag3B-4llsA:
22.93
3ag3T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.18A 3ag3G-4llsA:
undetectable
3ag3N-4llsA:
1.9
3ag3O-4llsA:
undetectable		 3ag3G-4llsA:
14.29
3ag3N-4llsA:
20.31
3ag3O-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.41A 3ag4A-4llsA:
1.3
3ag4B-4llsA:
undetectable
3ag4T-4llsA:
undetectable		 3ag4A-4llsA:
20.31
3ag4B-4llsA:
22.93
3ag4T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 5 VAL A 284
VAL A 285
THR A 179
THR A 280
 None
None
IPE  A 301 (-4.2A)
None
 1.22A 3bjwD-4llsA:
1.3		 3bjwD-4llsA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 6 GLY A 143
GLY A  44
GLY A  45
GLY A 128
GLY A  49
 IPE  A 247 (-3.3A)
IPE  A 247 (-3.3A)
IPE  A 247 (-3.8A)
IPE  A 247 (-3.5A)
IPE  A 247 (-3.3A)
 1.47A 3bogA-3ll5A:
undetectable
3bogC-3ll5A:
undetectable		 3bogA-3ll5A:
undetectable
3bogC-3ll5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A   7
PHE A  93
ALA A  57
GLY A  54
ILE A  29
THR A 100
 None
None
None
IPE  A 300 (-2.9A)
None
None
 1.39A 3c6gA-3k4yA:
undetectable		 3c6gA-3k4yA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  54
GLY A  55
GLY A  59
HIS A  60
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-2.8A)
IPE  A 300 (-3.1A)
 0.29A 3d41A-3k4yA:
22.8		 3d41A-3k4yA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A  54
GLY A  55
GLY A  59
ILE A  86
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-2.8A)
None
 0.67A 3d41A-3k4yA:
22.8		 3d41A-3k4yA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 GLY A  44
GLY A  45
GLY A  49
HIS A  50
 IPE  A 247 (-3.3A)
IPE  A 247 (-3.8A)
IPE  A 247 (-3.3A)
IPE  A 247 (-4.1A)
 0.39A 3d41A-3ll5A:
23.2		 3d41A-3ll5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.39A 3ez3A-1rqjA:
29.3		 3ez3A-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.94A 3ez3A-3wjoA:
25.7		 3ez3A-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.98A 3ez3A-3wjoA:
25.7		 3ez3A-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.57A 3ez3A-4e1eA:
45.1		 3ez3A-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.08A 3ez3A-4jzxA:
44.6		 3ez3A-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.83A 3ez3A-4jzxA:
44.6		 3ez3A-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 3ez3A-4jzxA:
44.6		 3ez3A-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3ez3A-4lfeA:
25.9		 3ez3A-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 3ez3A-4lfeA:
25.9		 3ez3A-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.82A 3ez3A-4lfeA:
25.9		 3ez3A-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.12A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.76A 3ez3A-4llsA:
28.4		 3ez3A-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 3ez3B-1rqjA:
29.1		 3ez3B-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.46A 3ez3B-4e1eA:
44.3		 3ez3B-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.06A 3ez3B-4jzxA:
44.0		 3ez3B-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.71A 3ez3B-4jzxA:
44.0		 3ez3B-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.49A 3ez3B-4jzxA:
44.0		 3ez3B-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.99A 3ez3B-4lfeA:
25.9		 3ez3B-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.75A 3ez3B-4lfeA:
25.9		 3ez3B-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.49A 3ez3B-4lfeA:
25.9		 3ez3B-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.15A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 3ez3B-4llsA:
28.3		 3ez3B-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.37A 3ez3C-1rqjA:
29.3		 3ez3C-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.96A 3ez3C-3wjoA:
25.9		 3ez3C-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 1.01A 3ez3C-3wjoA:
25.9		 3ez3C-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 1.06A 3ez3C-3wjoA:
25.9		 3ez3C-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.56A 3ez3C-4e1eA:
45.1		 3ez3C-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.05A 3ez3C-4jzxA:
44.6		 3ez3C-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 3ez3C-4jzxA:
44.6		 3ez3C-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.78A 3ez3C-4lfeA:
26.0		 3ez3C-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.54A 3ez3C-4lfeA:
26.0		 3ez3C-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.87A 3ez3C-4lfeA:
26.0		 3ez3C-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.11A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 3ez3C-4llsA:
27.8		 3ez3C-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.33A 3ez3D-1rqjA:
28.8		 3ez3D-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.95A 3ez3D-3wjoA:
25.1		 3ez3D-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ARG A  93
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.66A 3ez3D-3wjoA:
25.1		 3ez3D-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.93A 3ez3D-3wjoA:
25.1		 3ez3D-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ARG A  93
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.64A 3ez3D-3wjoA:
25.1		 3ez3D-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.49A 3ez3D-3wjoA:
25.1		 3ez3D-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.48A 3ez3D-4e1eA:
44.0		 3ez3D-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.13A 3ez3D-4jzxA:
43.7		 3ez3D-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.72A 3ez3D-4jzxA:
43.7		 3ez3D-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.46A 3ez3D-4jzxA:
43.7		 3ez3D-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.92A 3ez3D-4lfeA:
25.7		 3ez3D-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.72A 3ez3D-4lfeA:
25.7		 3ez3D-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 3ez3D-4lfeA:
25.7		 3ez3D-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.65A 3ez3D-4llsA:
28.2		 3ez3D-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.40A 3ibaA-1rqjA:
30.8		 3ibaA-1rqjA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.95A 3ibaA-3wjoA:
25.1		 3ibaA-3wjoA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.98A 3ibaA-3wjoA:
25.1		 3ibaA-3wjoA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.94A 3ibaA-3wjoA:
25.1		 3ibaA-3wjoA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.50A 3ibaA-4e1eA:
57.0		 3ibaA-4e1eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 3ibaA-4jzxA:
53.8		 3ibaA-4jzxA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.50A 3ibaA-4jzxA:
53.8		 3ibaA-4jzxA:
63.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.84A 3ibaA-4lfeA:
25.8		 3ibaA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.68A 3ibaA-4lfeA:
25.8		 3ibaA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.45A 3ibaA-4lfeA:
25.8		 3ibaA-4lfeA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.72A 3ibaA-4llsA:
28.8		 3ibaA-4llsA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.37A 3ldwA-1rqjA:
29.1		 3ldwA-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.92A 3ldwA-3wjoA:
25.7		 3ldwA-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.99A 3ldwA-3wjoA:
25.7		 3ldwA-3wjoA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.58A 3ldwA-4e1eA:
45.0		 3ldwA-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.05A 3ldwA-4jzxA:
44.6		 3ldwA-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.86A 3ldwA-4jzxA:
44.6		 3ldwA-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 3ldwA-4jzxA:
44.6		 3ldwA-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 3ldwA-4lfeA:
25.9		 3ldwA-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3ldwA-4lfeA:
25.9		 3ldwA-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 3ldwA-4lfeA:
25.9		 3ldwA-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.11A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.78A 3ldwA-4llsA:
28.3		 3ldwA-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 3ldwB-1rqjA:
29.1		 3ldwB-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.47A 3ldwB-4e1eA:
44.4		 3ldwB-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 3ldwB-4jzxA:
44.0		 3ldwB-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.73A 3ldwB-4jzxA:
44.0		 3ldwB-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.51A 3ldwB-4jzxA:
44.0		 3ldwB-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.02A 3ldwB-4lfeA:
25.9		 3ldwB-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 3ldwB-4lfeA:
25.9		 3ldwB-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.20A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3ldwB-4llsA:
28.3		 3ldwB-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.36A 3ldwC-1rqjA:
29.1		 3ldwC-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.56A 3ldwC-4e1eA:
45.0		 3ldwC-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.83A 3ldwC-4jzxA:
44.5		 3ldwC-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 3ldwC-4jzxA:
44.5		 3ldwC-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.98A 3ldwC-4lfeA:
26.0		 3ldwC-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.78A 3ldwC-4lfeA:
26.0		 3ldwC-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.56A 3ldwC-4lfeA:
26.0		 3ldwC-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.73A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.77A 3ldwC-4llsA:
28.3		 3ldwC-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.30A 3ldwD-1rqjA:
28.8		 3ldwD-1rqjA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.47A 3ldwD-4e1eA:
44.1		 3ldwD-4e1eA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 3ldwD-4jzxA:
43.7		 3ldwD-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.72A 3ldwD-4jzxA:
43.7		 3ldwD-4jzxA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.50A 3ldwD-4jzxA:
43.7		 3ldwD-4jzxA:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.01A 3ldwD-4lfeA:
25.6		 3ldwD-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3ldwD-4lfeA:
25.6		 3ldwD-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.53A 3ldwD-4lfeA:
25.6		 3ldwD-4lfeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 3ldwD-4llsA:
28.2		 3ldwD-4llsA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.28A 3n45F-1rqjA:
30.3		 3n45F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.98A 3n45F-3wjoA:
25.4		 3n45F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.94A 3n45F-3wjoA:
25.4		 3n45F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.94A 3n45F-3wjoA:
25.4		 3n45F-3wjoA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 3n45F-4e1eA:
44.7		 3n45F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.48A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.64A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.42A 3n45F-4jzxA:
45.1		 3n45F-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 3n45F-4lfeA:
25.9		 3n45F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.73A 3n45F-4lfeA:
25.9		 3n45F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 3n45F-4lfeA:
25.9		 3n45F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3n45F-4llsA:
29.2		 3n45F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 3n46F-1rqjA:
30.0		 3n46F-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.97A 3n46F-3wjoA:
25.5		 3n46F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.94A 3n46F-3wjoA:
25.5		 3n46F-3wjoA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.91A 3n46F-3wjoA:
25.5		 3n46F-3wjoA:
25.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.45A 3n46F-4e1eA:
44.4		 3n46F-4e1eA:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 3n46F-4jzxA:
44.8		 3n46F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.64A 3n46F-4jzxA:
44.8		 3n46F-4jzxA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 3n46F-4jzxA:
44.8		 3n46F-4jzxA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.96A 3n46F-4lfeA:
26.0		 3n46F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 3n46F-4lfeA:
26.0		 3n46F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.53A 3n46F-4lfeA:
26.0		 3n46F-4lfeA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 3n46F-4llsA:
29.0		 3n46F-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		3 / 3 LYS A  45
ARG A  48
ASP A  85
 IPE  A 402 (-3.0A)
IPE  A 402 (-2.9A)
None
 1.11A 3o7wA-3wjoA:
undetectable		 3o7wA-3wjoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 GLN A 213
ASP A  80
LEU A 151
GLY A 177
ALA A 154
 IPE  A 301 ( 4.1A)
CA  A 304 ( 2.9A)
None
None
None
 1.05A 3sufA-4llsA:
undetectable		 3sufA-4llsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  95
PHE A  89
GLY A  47
GLU A  88
PHE A   7
 None
None
IPE  A 405 (-3.6A)
None
None
 1.26A 3tbgC-4e1eA:
undetectable		 3tbgC-4e1eA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 203
GLY A 204
PHE A 207
ILE A  51
ALA A 179
 None
None
IPE  A 402 (-4.5A)
None
None
 1.02A 3uwlD-3wjoA:
undetectable		 3uwlD-3wjoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		3 / 3 LYS A 258
ARG A  69
LEU A 102
 RIS  A 901 (-2.7A)
IPE  A 900 (-3.2A)
None
 1.41A 3v4tE-1rqjA:
undetectable		 3v4tE-1rqjA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		3 / 3 LYS A 264
ARG A  51
LEU A  95
 0MW  A 404 ( 3.0A)
IPE  A 405 (-2.5A)
None
 1.40A 3v4tE-4e1eA:
undetectable		 3v4tE-4e1eA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		3 / 3 LYS A 264
ARG A  51
LEU A  95
 476  A 402 (-2.9A)
IPE  A 401 (-2.8A)
None
 1.42A 3v4tE-4jzxA:
undetectable		 3v4tE-4jzxA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 3wg7A-4llsA:
2.0
3wg7B-4llsA:
undetectable
3wg7T-4llsA:
undetectable		 3wg7A-4llsA:
20.31
3wg7B-4llsA:
22.93
3wg7T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.47A 3x2qA-4llsA:
0.6
3x2qB-4llsA:
undetectable
3x2qT-4llsA:
undetectable		 3x2qA-4llsA:
20.31
3x2qB-4llsA:
22.93
3x2qT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.96A 4feuB-3wjoA:
undetectable		 4feuB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.97A 4feuB-3wjoA:
undetectable		 4feuB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 1.00A 4feuD-3wjoA:
undetectable		 4feuD-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.95A 4feuF-3wjoA:
undetectable		 4feuF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.90A 4feuF-3wjoA:
undetectable		 4feuF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.93A 4fevB-3wjoA:
undetectable		 4fevB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.92A 4fevD-3wjoA:
undetectable		 4fevD-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.91A 4fevD-3wjoA:
undetectable		 4fevD-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.93A 4fevF-3wjoA:
undetectable		 4fevF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.91A 4fevF-3wjoA:
undetectable		 4fevF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.97A 4fewB-3wjoA:
undetectable		 4fewB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.94A 4fewD-3wjoA:
undetectable		 4fewD-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.90A 4fewD-3wjoA:
undetectable		 4fewD-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.96A 4fewF-3wjoA:
undetectable		 4fewF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.96A 4fewF-3wjoA:
undetectable		 4fewF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.99A 4fexB-3wjoA:
undetectable		 4fexB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.93A 4fexB-3wjoA:
undetectable		 4fexB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 142
LEU A 123
ASP A 160
GLY A 159
TYR A 220
 None
None
SO4  A 262 ( 4.4A)
IPE  A 300 (-3.4A)
None
 1.31A 4foxF-3k4yA:
undetectable		 4foxF-3k4yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.94A 4gkhB-3wjoA:
undetectable		 4gkhB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.92A 4gkhB-3wjoA:
undetectable		 4gkhB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.94A 4gkhD-3wjoA:
undetectable		 4gkhD-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.93A 4gkhF-3wjoA:
undetectable		 4gkhF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.93A 4gkhF-3wjoA:
undetectable		 4gkhF-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.95A 4gkhG-3wjoA:
undetectable		 4gkhG-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.94A 4gkhG-3wjoA:
undetectable		 4gkhG-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 6 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.90A 4gkhJ-3wjoA:
undetectable		 4gkhJ-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.93A 4gkhC-3wjoA:
undetectable
4gkhK-3wjoA:
undetectable		 4gkhC-3wjoA:
21.02
4gkhK-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.91A 4gkhC-3wjoA:
undetectable
4gkhK-3wjoA:
undetectable		 4gkhC-3wjoA:
21.02
4gkhK-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.97A 4gkiA-3wjoA:
undetectable		 4gkiA-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.94A 4gkiA-3wjoA:
undetectable		 4gkiA-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.96A 4gkiC-3wjoA:
undetectable		 4gkiC-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 1.01A 4gkiC-3wjoA:
undetectable		 4gkiC-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A  88
ASP A 211
ASP A 230
GLU A 233
 IPE  A 401 (-3.3A)
IPE  A 402 ( 4.6A)
None
None
 0.97A 4gkiE-3wjoA:
undetectable
4gkiG-3wjoA:
undetectable		 4gkiE-3wjoA:
21.02
4gkiG-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 211
GLU A 146
ASP A 230
GLU A 233
 IPE  A 402 ( 4.6A)
IPE  A 401 ( 4.9A)
None
None
 0.96A 4gkiE-3wjoA:
undetectable
4gkiG-3wjoA:
undetectable		 4gkiE-3wjoA:
21.02
4gkiG-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3k4y ISOPENTENYL
PHOSPHATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  54
GLY A  55
GLY A  56
SER A  10
HIS A 143
 IPE  A 300 (-2.9A)
IPE  A 300 (-3.3A)
IPE  A 300 (-3.4A)
None
None
 1.01A 4htfB-3k4yA:
3.2		 4htfB-3k4yA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 7 ASP A 245
THR A 203
GLN A 265
LEU A 266
 None
IPE  A 900 ( 3.3A)
None
None
 1.10A 4ib4A-1rqjA:
2.9		 4ib4A-1rqjA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A  81
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.01A 4kfaA-3wjoA:
25.5		 4kfaA-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.88A 4kfaA-3wjoA:
25.5		 4kfaA-3wjoA:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4kfaA-4jzxA:
43.9		 4kfaA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4kfaA-4jzxA:
43.9		 4kfaA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.69A 4kfaA-4lfeA:
25.8		 4kfaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.44A 4kfaA-4lfeA:
25.8		 4kfaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 LEU A  75
GLN A 149
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.88A 4kfaA-4lfeA:
25.8		 4kfaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		7 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.63A 4kfaA-4llsA:
29.1		 4kfaA-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 4kpdA-1rqjA:
31.2		 4kpdA-1rqjA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.94A 4kpdA-3wjoA:
25.6		 4kpdA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.86A 4kpdA-3wjoA:
25.6		 4kpdA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.85A 4kpdA-3wjoA:
25.6		 4kpdA-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.36A 4kpdA-4e1eA:
44.9		 4kpdA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 4kpdA-4jzxA:
45.3		 4kpdA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4kpdA-4jzxA:
45.3		 4kpdA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 4kpdA-4jzxA:
45.3		 4kpdA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.68A 4kpdA-4lfeA:
25.9		 4kpdA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.46A 4kpdA-4lfeA:
25.9		 4kpdA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.83A 4kpdA-4lfeA:
25.9		 4kpdA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4kpdA-4llsA:
30.3		 4kpdA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4kpjA-1rqjA:
29.9		 4kpjA-1rqjA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.98A 4kpjA-3wjoA:
25.4		 4kpjA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.92A 4kpjA-3wjoA:
25.4		 4kpjA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.91A 4kpjA-3wjoA:
25.4		 4kpjA-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.32A 4kpjA-4e1eA:
43.8		 4kpjA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 4kpjA-4jzxA:
43.9		 4kpjA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.43A 4kpjA-4jzxA:
43.9		 4kpjA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.97A 4kpjA-4lfeA:
25.8		 4kpjA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.74A 4kpjA-4lfeA:
25.8		 4kpjA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
 0.53A 4kpjA-4lfeA:
25.8		 4kpjA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.71A 4kpjA-4llsA:
29.2		 4kpjA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.32A 4kq5A-1rqjA:
29.9		 4kq5A-1rqjA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.02A 4kq5A-3wjoA:
25.4		 4kq5A-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.96A 4kq5A-3wjoA:
25.4		 4kq5A-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.93A 4kq5A-3wjoA:
25.4		 4kq5A-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.46A 4kq5A-4e1eA:
44.2		 4kq5A-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4kq5A-4jzxA:
44.3		 4kq5A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.68A 4kq5A-4jzxA:
44.3		 4kq5A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.47A 4kq5A-4jzxA:
44.3		 4kq5A-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.74A 4kq5A-4lfeA:
25.9		 4kq5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 4kq5A-4lfeA:
25.9		 4kq5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.86A 4kq5A-4lfeA:
25.9		 4kq5A-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.21A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.76A 4kq5A-4llsA:
29.2		 4kq5A-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4kqsA-1rqjA:
31.2		 4kqsA-1rqjA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.96A 4kqsA-3wjoA:
25.2		 4kqsA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.89A 4kqsA-3wjoA:
25.2		 4kqsA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.88A 4kqsA-3wjoA:
25.2		 4kqsA-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.38A 4kqsA-4e1eA:
44.6		 4kqsA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 4kqsA-4jzxA:
45.0		 4kqsA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 4kqsA-4jzxA:
45.0		 4kqsA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 4kqsA-4jzxA:
45.0		 4kqsA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.70A 4kqsA-4lfeA:
26.0		 4kqsA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.49A 4kqsA-4lfeA:
26.0		 4kqsA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.83A 4kqsA-4lfeA:
26.0		 4kqsA-4lfeA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4kqsA-4llsA:
30.3		 4kqsA-4llsA:
29.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 8 HIS A 155
ARG A  98
ASN A 125
ILE A 152
 IPE  A 701 ( 3.4A)
IPE  A 701 (-3.9A)
FNR  A 669 (-3.0A)
None
 1.01A 4l7iA-3b05A:
undetectable		 4l7iA-3b05A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4n9uA-1rqjA:
30.0		 4n9uA-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ARG A  93
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.73A 4n9uA-3wjoA:
25.7		 4n9uA-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ARG A  93
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.70A 4n9uA-3wjoA:
25.7		 4n9uA-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.59A 4n9uA-3wjoA:
25.7		 4n9uA-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 1.25A 4n9uA-3wjoA:
25.7		 4n9uA-3wjoA:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.49A 4n9uA-4e1eA:
43.6		 4n9uA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		5 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 208
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
IPE  A 405 ( 4.6A)
 1.30A 4n9uA-4e1eA:
43.6		 4n9uA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.46A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 208
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 ( 3.4A)
 1.34A 4n9uA-4jzxA:
44.1		 4n9uA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
None
None
 0.98A 4n9uA-4lfeA:
25.7		 4n9uA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
None
 0.77A 4n9uA-4lfeA:
25.7		 4n9uA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 0.53A 4n9uA-4lfeA:
25.7		 4n9uA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 4n9uA-4llsA:
29.0		 4n9uA-4llsA:
29.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 12 ASP A 105
ASP A 111
THR A 203
GLN A 179
ASP A 248
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
IPE  A 900 ( 3.3A)
RIS  A 901 (-3.2A)
MG  A 908 ( 4.7A)
 1.22A 4ng6A-1rqjA:
30.6		 4ng6A-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.60A 4ng6A-1rqjA:
30.6		 4ng6A-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  81
ARG A  93
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.76A 4ng6A-3wjoA:
25.2		 4ng6A-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  81
ASP A  84
ARG A  93
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.64A 4ng6A-3wjoA:
25.2		 4ng6A-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.41A 4ng6A-3wjoA:
25.2		 4ng6A-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 1.24A 4ng6A-3wjoA:
25.2		 4ng6A-3wjoA:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 4ng6A-4e1eA:
45.1		 4ng6A-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.11A 4ng6A-4jzxA:
45.3		 4ng6A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.41A 4ng6A-4jzxA:
45.3		 4ng6A-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 12 LEU A  75
ASP A  78
ARG A  89
GLN A 149
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
None
 0.94A 4ng6A-4lfeA:
25.9		 4ng6A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 0.79A 4ng6A-4lfeA:
25.9		 4ng6A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 12 LEU A  75
GLN A 149
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
None
None
None
 1.06A 4ng6A-4lfeA:
25.9		 4ng6A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 12 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.19A 4ng6A-4llsA:
29.7		 4ng6A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.62A 4ng6A-4llsA:
29.7		 4ng6A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.52A 4nkeA-1rqjA:
30.1		 4nkeA-1rqjA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.93A 4nkeA-3wjoA:
25.4		 4nkeA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.87A 4nkeA-3wjoA:
25.4		 4nkeA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.86A 4nkeA-3wjoA:
25.4		 4nkeA-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.55A 4nkeA-4e1eA:
44.0		 4nkeA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.74A 4nkeA-4jzxA:
44.2		 4nkeA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.60A 4nkeA-4jzxA:
44.2		 4nkeA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.96A 4nkeA-4lfeA:
25.8		 4nkeA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.73A 4nkeA-4lfeA:
25.8		 4nkeA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4nkeA-4lfeA:
25.8		 4nkeA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4nkeA-4llsA:
29.0		 4nkeA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.38A 4nkfA-1rqjA:
30.0		 4nkfA-1rqjA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.94A 4nkfA-3wjoA:
25.5		 4nkfA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.91A 4nkfA-3wjoA:
25.5		 4nkfA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.93A 4nkfA-3wjoA:
25.5		 4nkfA-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.35A 4nkfA-4e1eA:
43.8		 4nkfA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.09A 4nkfA-4jzxA:
44.2		 4nkfA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.47A 4nkfA-4jzxA:
44.2		 4nkfA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.87A 4nkfA-4lfeA:
25.7		 4nkfA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.68A 4nkfA-4lfeA:
25.7		 4nkfA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
 0.52A 4nkfA-4lfeA:
25.7		 4nkfA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.66A 4nkfA-4llsA:
29.3		 4nkfA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.56A 4nuaA-1rqjA:
30.3		 4nuaA-1rqjA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.94A 4nuaA-3wjoA:
25.5		 4nuaA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.88A 4nuaA-3wjoA:
25.5		 4nuaA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.89A 4nuaA-3wjoA:
25.5		 4nuaA-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.60A 4nuaA-4e1eA:
43.9		 4nuaA-4e1eA:
36.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.31A 4nuaA-4jzxA:
44.3		 4nuaA-4jzxA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.79A 4nuaA-4jzxA:
44.3		 4nuaA-4jzxA:
36.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4nuaA-4jzxA:
44.3		 4nuaA-4jzxA:
36.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.94A 4nuaA-4lfeA:
25.9		 4nuaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.72A 4nuaA-4lfeA:
25.9		 4nuaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.52A 4nuaA-4lfeA:
25.9		 4nuaA-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.79A 4nuaA-4llsA:
29.4		 4nuaA-4llsA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 LEU A 102
ASP A 105
ASP A 111
ARG A 116
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.35A 4oguA-1rqjA:
29.7		 4oguA-1rqjA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.93A 4oguA-3wjoA:
25.3		 4oguA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.91A 4oguA-3wjoA:
25.3		 4oguA-3wjoA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 9 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.89A 4oguA-3wjoA:
25.3		 4oguA-3wjoA:
26.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.29A 4oguA-4e1eA:
43.8		 4oguA-4e1eA:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.09A 4oguA-4jzxA:
44.1		 4oguA-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 4oguA-4jzxA:
44.1		 4oguA-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ARG A  89
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 0.93A 4oguA-4lfeA:
25.7		 4oguA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ARG A  89
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.73A 4oguA-4lfeA:
25.7		 4oguA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
 0.54A 4oguA-4lfeA:
25.7		 4oguA-4lfeA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 4oguA-4llsA:
29.1		 4oguA-4llsA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		9 / 9 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.31A 4p0vA-1rqjA:
31.2		 4p0vA-1rqjA:
27.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		9 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.38A 4p0vA-4e1eA:
45.3		 4p0vA-4e1eA:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.14A 4p0vA-4jzxA:
45.6		 4p0vA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4p0vA-4jzxA:
45.6		 4p0vA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		8 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 4p0vA-4jzxA:
45.6		 4p0vA-4jzxA:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 1.01A 4p0vA-4lfeA:
26.0		 4p0vA-4lfeA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.76A 4p0vA-4lfeA:
26.0		 4p0vA-4lfeA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 9 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 4p0vA-4lfeA:
26.0		 4p0vA-4lfeA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 9 ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.75A 4p0vA-4llsA:
30.2		 4p0vA-4llsA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 11 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.37A 4p0wA-1rqjA:
31.0		 4p0wA-1rqjA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.04A 4p0wA-3wjoA:
25.6		 4p0wA-3wjoA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.96A 4p0wA-3wjoA:
25.6		 4p0wA-3wjoA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 11 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.94A 4p0wA-3wjoA:
25.6		 4p0wA-3wjoA:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.39A 4p0wA-4e1eA:
45.3		 4p0wA-4e1eA:
37.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.10A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 11 LEU A  95
ARG A 107
THR A 212
TYR A 211
LYS A 264
 None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
None
476  A 402 (-2.9A)
 1.47A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.62A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 11 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.43A 4p0wA-4jzxA:
45.6		 4p0wA-4jzxA:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.74A 4p0wA-4lfeA:
25.9		 4p0wA-4lfeA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 11 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.55A 4p0wA-4lfeA:
25.9		 4p0wA-4lfeA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 11 LEU A  75
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.86A 4p0wA-4lfeA:
25.9		 4p0wA-4lfeA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ASP A  80
ARG A  91
GLN A 213
ASP A 216
LYS A 230
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 1.18A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 11 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.74A 4p0wA-4llsA:
30.0		 4p0wA-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ARG A  93
LYS A 170
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 1.02A 4q23A-3wjoA:
25.5		 4q23A-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.92A 4q23A-3wjoA:
25.5		 4q23A-3wjoA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 0.89A 4q23A-3wjoA:
25.5		 4q23A-3wjoA:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.63A 4q23A-4jzxA:
44.1		 4q23A-4jzxA:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.37A 4q23A-4jzxA:
44.1		 4q23A-4jzxA:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.99A 4q23A-4lfeA:
25.4		 4q23A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.73A 4q23A-4lfeA:
25.4		 4q23A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		6 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.48A 4q23A-4lfeA:
25.4		 4q23A-4lfeA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		8 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.70A 4q23A-4llsA:
28.7		 4q23A-4llsA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.29A 4rxdA-1rqjA:
30.1		 4rxdA-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.91A 4rxdA-3wjoA:
24.5		 4rxdA-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.89A 4rxdA-3wjoA:
24.5		 4rxdA-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.49A 4rxdA-3wjoA:
24.5		 4rxdA-3wjoA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.45A 4rxdA-4e1eA:
53.3		 4rxdA-4e1eA:
69.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.67A 4rxdA-4jzxA:
54.0		 4rxdA-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 4rxdA-4jzxA:
54.0		 4rxdA-4jzxA:
58.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.90A 4rxdA-4lfeA:
25.0		 4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.70A 4rxdA-4lfeA:
25.0		 4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4rxdA-4lfeA:
25.0		 4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.69A 4rxdA-4llsA:
27.7		 4rxdA-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.28A 4rxdB-1rqjA:
30.3		 4rxdB-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.91A 4rxdB-3wjoA:
24.8		 4rxdB-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.88A 4rxdB-3wjoA:
24.8		 4rxdB-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.49A 4rxdB-3wjoA:
24.8		 4rxdB-3wjoA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.43A 4rxdB-4e1eA:
53.8		 4rxdB-4e1eA:
69.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4rxdB-4jzxA:
54.4		 4rxdB-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.45A 4rxdB-4jzxA:
54.4		 4rxdB-4jzxA:
58.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.88A 4rxdB-4lfeA:
25.3		 4rxdB-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.67A 4rxdB-4lfeA:
25.3		 4rxdB-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4rxdB-4lfeA:
25.3		 4rxdB-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4rxdB-4llsA:
28.0		 4rxdB-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.28A 4rxdC-1rqjA:
30.4		 4rxdC-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.90A 4rxdC-3wjoA:
24.8		 4rxdC-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 10 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.87A 4rxdC-3wjoA:
24.8		 4rxdC-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.49A 4rxdC-3wjoA:
24.8		 4rxdC-3wjoA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		10 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.44A 4rxdC-4e1eA:
53.8		 4rxdC-4e1eA:
69.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 4rxdC-4jzxA:
54.4		 4rxdC-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		9 / 10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.44A 4rxdC-4jzxA:
54.4		 4rxdC-4jzxA:
58.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.89A 4rxdC-4lfeA:
25.0		 4rxdC-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 4rxdC-4lfeA:
25.0		 4rxdC-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 10 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.51A 4rxdC-4lfeA:
25.0		 4rxdC-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 10 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 4rxdC-4llsA:
28.0		 4rxdC-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 8 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 1.06A 4umjA-3wjoA:
29.0		 4umjA-3wjoA:
29.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 8 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.74A 4umjA-4lfeA:
33.0		 4umjA-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 8 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
MET A 145
LYS A 172
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 4.2A)
IPE  A 301 (-3.0A)
 0.78A 4umjA-4lfeA:
33.0		 4umjA-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		7 / 9 SER A 101
LEU A 102
ASP A 105
ARG A 116
MET A 175
LYS A 202
THR A 203
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 4.5A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
 0.68A 4umjB-1rqjA:
35.8		 4umjB-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		8 / 9 SER A 101
LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
 0.53A 4umjB-1rqjA:
35.8		 4umjB-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 9 SER A  79
LEU A  80
ASP A  83
ASP A  89
THR A 181
 None
None
None
None
IPE  A 902 ( 3.7A)
 0.84A 4umjB-3krcA:
39.3		 4umjB-3krcA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		5 / 9 SER A  79
LEU A  80
ASP A  89
ARG A  94
THR A 181
 None
None
None
None
IPE  A 902 ( 3.7A)
 0.73A 4umjB-3krcA:
39.3		 4umjB-3krcA:
48.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 1.00A 4umjB-3wjoA:
29.4		 4umjB-3wjoA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.38A 4umjB-3wjoA:
29.4		 4umjB-3wjoA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
 0.45A 4umjB-4e1eA:
23.5		 4umjB-4e1eA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
 0.53A 4umjB-4jzxA:
24.2		 4umjB-4jzxA:
27.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 9 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.54A 4umjB-4lfeA:
33.5		 4umjB-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		8 / 9 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
MET A 145
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 4.2A)
IPE  A 301 (-3.0A)
None
 0.70A 4umjB-4lfeA:
33.5		 4umjB-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 9 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
MET A 149
GLN A 153
LYS A 178
THR A 179
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 ( 4.1A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.45A 4umjB-4llsA:
35.4		 4umjB-4llsA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		3 / 3 ASP A  99
ARG A 360
ARG A  51
 None
IPE  A 405 ( 4.7A)
IPE  A 405 (-2.5A)
 0.87A 4x5iA-4e1eA:
undetectable		 4x5iA-4e1eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		5 / 12 ILE A 288
ALA A 284
ILE A 207
ARG A  69
ILE A 236
 None
None
None
IPE  A 900 (-3.2A)
None
 1.09A 4x5jA-1rqjA:
undetectable		 4x5jA-1rqjA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ARG A  93
ASP A 229
ASP A  88
ASP A  85
 IPE  A 401 ( 4.2A)
None
IPE  A 401 (-3.3A)
None
 1.17A 4xqgA-3wjoA:
undetectable		 4xqgA-3wjoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ARG A  93
ASP A 229
ASP A  88
ASP A  85
 IPE  A 401 ( 4.2A)
None
IPE  A 401 (-3.3A)
None
 1.15A 4xqgB-3wjoA:
undetectable		 4xqgB-3wjoA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		4 / 6 HIS A  98
GLY A  65
GLU A  95
ARG A  67
 IPE  A 900 (-4.0A)
IPE  A 900 (-3.4A)
IPE  A 900 ( 4.8A)
None
 1.13A 4zbqA-1rqjA:
3.2		 4zbqA-1rqjA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT
(Mentha
x
piperita) 		4 / 6 HIS A  76
GLY A  43
GLU A  73
ARG A  45
 IPE  A 902 (-4.3A)
IPE  A 902 (-3.6A)
IPE  A 902 ( 4.6A)
None
 1.17A 4zbqA-3krcA:
3.8		 4zbqA-3krcA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 HIS A  73
GLY A  40
GLU A  70
ARG A  42
 IPE  A 301 (-3.9A)
IPE  A 301 (-3.6A)
None
None
 1.29A 4zbqA-4llsA:
undetectable		 4zbqA-4llsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.47A 5b1aA-4llsA:
2.2
5b1aB-4llsA:
undetectable
5b1aT-4llsA:
undetectable		 5b1aA-4llsA:
20.31
5b1aB-4llsA:
22.93
5b1aT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.32A 5b1bA-4llsA:
2.0
5b1bB-4llsA:
undetectable
5b1bT-4llsA:
undetectable		 5b1bA-4llsA:
20.31
5b1bB-4llsA:
22.93
5b1bT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.34A 5b1bG-4llsA:
undetectable
5b1bN-4llsA:
1.5
5b1bO-4llsA:
undetectable		 5b1bG-4llsA:
14.29
5b1bN-4llsA:
20.31
5b1bO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.48A 5b3sA-4llsA:
1.9
5b3sB-4llsA:
undetectable
5b3sT-4llsA:
undetectable		 5b3sA-4llsA:
20.31
5b3sB-4llsA:
22.93
5b3sT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.35A 5cg5A-1rqjA:
29.2		 5cg5A-1rqjA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.94A 5cg5A-3wjoA:
25.1		 5cg5A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.88A 5cg5A-3wjoA:
25.1		 5cg5A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.89A 5cg5A-3wjoA:
25.1		 5cg5A-3wjoA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		12 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
None
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.42A 5cg5A-4e1eA:
44.4		 5cg5A-4e1eA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.18A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		10 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.66A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
LYS A 207
THR A 208
TYR A 211
GLN A 247
ASP A 250
LYS A 264
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
None
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.43A 5cg5A-4jzxA:
44.4		 5cg5A-4jzxA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.91A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.69A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.49A 5cg5A-4lfeA:
25.4		 5cg5A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.67A 5cg5A-4llsA:
28.5		 5cg5A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 1rqj GERANYLTRANSTRANSFER
ASE
(Escherichia
coli) 		10 / 12 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
 0.29A 5cg6A-1rqjA:
30.1		 5cg6A-1rqjA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
 0.94A 5cg6A-3wjoA:
25.7		 5cg6A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.87A 5cg6A-3wjoA:
25.7		 5cg6A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		6 / 12 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.84A 5cg6A-3wjoA:
25.7		 5cg6A-3wjoA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 1.23A 5cg6A-3wjoA:
25.7		 5cg6A-3wjoA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		11 / 12 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
 0.37A 5cg6A-4e1eA:
45.1		 5cg6A-4e1eA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 ASP A  98
ARG A 107
GLN A 247
ASP A 250
LYS A 264
 CA  A 403 (-2.5A)
476  A 402 (-2.9A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 1.12A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 12 PHE A  94
LEU A  95
ARG A 107
THR A 212
LYS A 264
 476  A 402 (-4.3A)
None
476  A 402 (-2.9A)
IPE  A 401 ( 4.6A)
476  A 402 (-2.9A)
 0.96A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 PHE A  94
LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
 476  A 402 (-4.3A)
None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.67A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		11 / 12 PHE A  94
LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
 476  A 402 (-4.3A)
None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
 0.40A 5cg6A-4jzxA:
45.2		 5cg6A-4jzxA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
 0.95A 5cg6A-4lfeA:
25.9		 5cg6A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.71A 5cg6A-4lfeA:
25.9		 5cg6A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		7 / 12 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.47A 5cg6A-4lfeA:
25.9		 5cg6A-4lfeA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		9 / 12 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
 0.68A 5cg6A-4llsA:
29.2		 5cg6A-4llsA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.74A 5eroA-4jzxA:
26.9		 5eroA-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 LEU A  75
ARG A  89
LYS A 172
GLN A 210
ASP A 213
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
 0.93A 5eroA-4lfeA:
24.4		 5eroA-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 LEU A  75
ASP A  78
ASP A  84
ARG A  89
LYS A 172
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
 0.76A 5eroA-4lfeA:
24.4		 5eroA-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 LEU A  77
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 None
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.46A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 9 LEU A  77
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.84A 5eroA-4llsA:
24.7		 5eroA-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 9 ARG A  93
LYS A 170
GLN A 208
ASP A 211
ASP A 212
 IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
None
 1.15A 5eroB-3wjoA:
25.0		 5eroB-3wjoA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 9 ASP A  98
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
None
 0.78A 5eroB-4jzxA:
26.6		 5eroB-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 9 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.44A 5eroB-4jzxA:
26.6		 5eroB-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 9 ARG A  89
LYS A 172
GLN A 210
ASP A 213
ASP A 214
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 1.16A 5eroB-4lfeA:
24.0		 5eroB-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 9 ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.89A 5eroB-4llsA:
24.3		 5eroB-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 10 ASP A  84
ASP A  85
ASP A  88
ARG A  93
ASP A 230
 IPE  A 401 (-2.6A)
None
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
None
 0.78A 5eroC-3wjoA:
25.1		 5eroC-3wjoA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 10 ASP A  98
ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
None
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 0.62A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 10 ASP A  98
ASP A 102
LYS A 207
GLN A 247
ASP A 250
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
 1.39A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		7 / 10 ASP A  99
ASP A 102
ARG A 107
LYS A 207
GLN A 247
ASP A 250
ASP A 251
 None
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
None
 0.72A 5eroC-4jzxA:
26.7		 5eroC-4jzxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 ARG A  89
LYS A 172
GLN A 210
ASP A 213
ASP A 214
 IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
None
None
None
 1.12A 5eroC-4lfeA:
24.4		 5eroC-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 10 ASP A  78
ASP A  79
ASP A  84
ARG A  89
LYS A 172
 MG  A 302 (-2.5A)
None
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 (-3.0A)
 0.84A 5eroC-4lfeA:
24.4		 5eroC-4lfeA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		6 / 10 ASP A  81
ASP A  86
ARG A  91
LYS A 178
GLN A 213
ASP A 216
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
 0.79A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ASP A  86
ARG A  91
LYS A 178
GLN A 213
LYS A 230
 CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 ( 4.1A)
GST  A 302 (-2.7A)
 1.28A 5eroC-4llsA:
24.5		 5eroC-4llsA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ILE A  47
LEU A 203
GLY A 204
PHE A 207
 None
None
None
IPE  A 402 (-4.5A)
 0.58A 5h3aB-3wjoA:
undetectable		 5h3aB-3wjoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 203
GLY A 204
PHE A 207
ILE A  51
ALA A 179
 None
None
IPE  A 402 (-4.5A)
None
None
 1.02A 5j7wC-3wjoA:
undetectable		 5j7wC-3wjoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 203
GLY A 204
PHE A 207
ILE A  51
ALA A 179
 None
None
IPE  A 402 (-4.5A)
None
None
 1.05A 5j7wD-3wjoA:
undetectable		 5j7wD-3wjoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 405 ( 4.6A)
None
None
 0.93A 5nzxA-4e1eA:
undetectable		 5nzxA-4e1eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 8 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 401 ( 3.4A)
None
None
 0.95A 5nzxA-4jzxA:
undetectable		 5nzxA-4jzxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 405 ( 4.6A)
None
None
 0.92A 5nzyA-4e1eA:
undetectable		 5nzyA-4e1eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 7 PHE A 321
THR A 208
GLN A 249
GLY A 243
 None
IPE  A 401 ( 3.4A)
None
None
 0.95A 5nzyA-4jzxA:
undetectable		 5nzyA-4jzxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 LEU A 176
ALA A 175
VAL A 192
HIS A 155
ILE A 212
 None
None
None
IPE  A 701 ( 3.4A)
None
 1.22A 5om2A-3b05A:
undetectable
5om2B-3b05A:
undetectable		 5om2A-3b05A:
11.17
5om2B-3b05A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 148
THR A 172
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.41A 5x1bG-4llsA:
undetectable
5x1bN-4llsA:
1.6
5x1bO-4llsA:
undetectable		 5x1bG-4llsA:
14.29
5x1bN-4llsA:
20.31
5x1bO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ARG A  44
GLY A 184
MET A 149
GLY A 177
GLN A 175
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.44A 5x1fG-4llsA:
undetectable
5x1fN-4llsA:
1.9
5x1fO-4llsA:
undetectable		 5x1fG-4llsA:
14.29
5x1fN-4llsA:
20.31
5x1fO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A  47
LEU A 203
GLY A 204
PHE A 207
ALA A 179
 None
None
None
IPE  A 402 (-4.5A)
None
 1.19A 5x5qB-3wjoA:
undetectable		 5x5qB-3wjoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 8 ILE A  47
LEU A 203
GLY A 204
PHE A 207
 None
None
None
IPE  A 402 (-4.5A)
 0.61A 5x5qD-3wjoA:
undetectable		 5x5qD-3wjoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 5xdqA-4llsA:
0.0
5xdqB-4llsA:
undetectable
5xdqT-4llsA:
undetectable		 5xdqA-4llsA:
20.31
5xdqB-4llsA:
22.93
5xdqT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.43A 5xdxA-4llsA:
1.7
5xdxB-4llsA:
undetectable
5xdxT-4llsA:
undetectable		 5xdxA-4llsA:
20.31
5xdxB-4llsA:
22.93
5xdxT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		3 / 3 ARG A  92
PHE A  17
ARG A  42
 IPE  A 301 (-3.8A)
None
None
 0.94A 5y9yA-4llsA:
undetectable		 5y9yA-4llsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.44A 5z84A-4llsA:
0.1
5z84B-4llsA:
undetectable
5z84T-4llsA:
undetectable		 5z84A-4llsA:
20.31
5z84B-4llsA:
22.93
5z84T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.46A 5z86A-4llsA:
2.2
5z86B-4llsA:
undetectable
5z86T-4llsA:
undetectable		 5z86A-4llsA:
20.31
5z86B-4llsA:
22.93
5z86T-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.44A 5zcoA-4llsA:
2.0
5zcoB-4llsA:
undetectable
5zcoT-4llsA:
undetectable		 5zcoA-4llsA:
20.31
5zcoB-4llsA:
22.93
5zcoT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.46A 5zcpA-4llsA:
1.5
5zcpB-4llsA:
undetectable
5zcpT-4llsA:
undetectable		 5zcpA-4llsA:
20.31
5zcpB-4llsA:
22.93
5zcpT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 MET A 149
GLY A 177
GLN A 175
ARG A  44
GLY A 184
 GST  A 302 ( 4.1A)
None
None
IPE  A 301 (-3.1A)
None
 1.45A 5zcqA-4llsA:
0.6
5zcqB-4llsA:
undetectable
5zcqT-4llsA:
undetectable		 5zcqA-4llsA:
20.31
5zcqB-4llsA:
22.93
5zcqT-4llsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		3 / 3 ARG A   7
LYS A 133
ARG A 232
 IPE  A 701 (-3.9A)
None
None
 1.38A 6az3C-3b05A:
undetectable
6az3L-3b05A:
undetectable
6az3M-3b05A:
undetectable		 6az3C-3b05A:
12.46
6az3L-3b05A:
12.53
6az3M-3b05A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 11 ASP A 217
ILE A 218
LEU A 259
ARG A 287
ILE A 183
 None
None
None
IPE  A 301 ( 4.3A)
None
 1.40A 6fgcA-4llsA:
undetectable		 6fgcA-4llsA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  84
ARG A  93
LYS A 170
GLN A 208
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.88A 6g31A-3wjoA:
24.8		 6g31A-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 ASP A  84
ASP A  88
ARG A  93
LYS A 170
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 0.62A 6g31A-3wjoA:
24.8		 6g31A-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 7 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 1.04A 6g31A-4jzxA:
25.3		 6g31A-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 1.20A 6g31A-4lfeA:
23.3		 6g31A-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.88A 6g31A-4lfeA:
23.3		 6g31A-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 153
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 ( 4.1A)
 0.83A 6g31A-4llsA:
23.7		 6g31A-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.83A 6g31B-4jzxA:
25.2		 6g31B-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 ASP A  78
ASP A  84
ARG A  89
GLN A 149
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.88A 6g31B-4lfeA:
23.5		 6g31B-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 153
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 ( 4.1A)
 0.91A 6g31B-4llsA:
23.8		 6g31B-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 5 ASP A  84
ASP A  88
ARG A  93
LYS A 170
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 0.71A 6g31C-3wjoA:
24.6		 6g31C-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 5 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 1.04A 6g31C-4lfeA:
23.2		 6g31C-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A  81
ASP A  84
ARG A  93
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 (-3.6A)
 0.69A 6g31D-3wjoA:
24.3		 6g31D-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 7 LEU A  81
ASP A  84
ASP A  88
ARG A  93
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
 0.42A 6g31D-3wjoA:
24.3		 6g31D-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.67A 6g31D-4jzxA:
24.9		 6g31D-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 LEU A  75
ASP A  78
ARG A  89
GLN A 149
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 0.82A 6g31D-4lfeA:
22.6		 6g31D-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.71A 6g31D-4lfeA:
22.6		 6g31D-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 7 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.76A 6g31D-4llsA:
23.1		 6g31D-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 4 LEU A  81
ASP A  84
ASP A  88
ARG A  93
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
 0.49A 6g31E-3wjoA:
19.1		 6g31E-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 4 LEU A  75
ASP A  78
ASP A  84
ARG A  89
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
 0.45A 6g31E-4lfeA:
17.4		 6g31E-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 5 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.89A 6g31F-4jzxA:
25.4		 6g31F-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 5 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.88A 6g31F-4llsA:
24.0		 6g31F-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 7 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 0.82A 6g31G-4jzxA:
24.3		 6g31G-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.87A 6g31G-4lfeA:
22.4		 6g31G-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 7 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.70A 6g31G-4lfeA:
22.4		 6g31G-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 7 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.84A 6g31G-4llsA:
22.8		 6g31G-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 5 ASP A  98
ASP A 102
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.59A 6g31H-4jzxA:
24.3		 6g31H-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 4 ASP A  98
ASP A 102
LYS A 207
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 0.96A 6g31I-4jzxA:
24.2		 6g31I-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 6 LEU A  81
ASP A  84
ARG A  93
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 (-3.6A)
 0.92A 6g31J-3wjoA:
24.7		 6g31J-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		4 / 6 LEU A  81
ASP A  84
ASP A  88
ARG A  93
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
 0.76A 6g31J-3wjoA:
24.7		 6g31J-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		6 / 6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 1.01A 6g31J-4jzxA:
25.7		 6g31J-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 6 LEU A  75
ASP A  78
ARG A  89
GLN A 149
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 1.02A 6g31J-4lfeA:
23.5		 6g31J-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		5 / 6 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 1.01A 6g31J-4lfeA:
23.5		 6g31J-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 6 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 1.01A 6g31J-4llsA:
23.8		 6g31J-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 4 ASP A  78
ASP A  84
ARG A  89
GLN A 149
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.63A 6g31K-4lfeA:
21.8		 6g31K-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		5 / 6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 1.07A 6g31L-4jzxA:
25.2		 6g31L-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE
(Leishmania
major) 		4 / 6 ASP A  98
GLN A 167
GLN A 247
LYS A 273
 CA  A 403 (-2.5A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
CA  A 403 ( 4.9A)
 1.34A 6g31L-4jzxA:
25.2		 6g31L-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE
(Streptococcus
uberis) 		4 / 6 ASP A  78
ASP A  84
ARG A  89
GLN A 149
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.74A 6g31L-4lfeA:
23.3		 6g31L-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		4 / 6 ASP A  80
ASP A  86
ARG A  91
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 1.10A 6g31L-4llsA:
23.5		 6g31L-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4lls GERANYLTRANSTRANSFER
ASE
(Roseobacter
denitrificans) 		5 / 10 ARG A  44
GLY A 184
MET A 149
GLY A 148
THR A 172
 IPE  A 301 (-3.1A)
None
GST  A 302 ( 4.1A)
None
None
 1.49A 6nmfG-4llsA:
undetectable
6nmfN-4llsA:
0.7
6nmfO-4llsA:
undetectable		 6nmfG-4llsA:
14.29
6nmfN-4llsA:
20.31
6nmfO-4llsA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 203
GLY A 204
PHE A 207
ILE A  51
ALA A 179
 None
None
IPE  A 402 (-4.5A)
None
None
 1.05A 6qyaB-3wjoA:
undetectable		 6qyaB-3wjoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 203
GLY A 204
PHE A 207
ILE A  51
ALA A 179
 None
None
IPE  A 402 (-4.5A)
None
None
 1.04A 6qyaD-3wjoA:
undetectable		 6qyaD-3wjoA:
20.46