SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'LLP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 301
VAL A 296
GLN A 281
HIS A 220
PHE A 197
 None
None
None
LLP  A 219 ( 4.8A)
None
 1.20A 1aqbA-3ndnA:
undetectable		 1aqbA-3ndnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		5 / 12 ASN A 227
GLY A 231
GLY A 230
ALA A 286
LEU A 315
 LLP  A 226 ( 4.7A)
None
None
None
None
 0.92A 1bx4A-3fd0A:
undetectable		 1bx4A-3fd0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
monocytogenes) 		5 / 12 ASN A 227
GLY A 231
GLY A 230
ALA A 286
LEU A 315
 LLP  A 226 ( 4.6A)
None
None
None
None
 0.92A 1bx4A-3jzlA:
undetectable		 1bx4A-3jzlA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.18A 1c9sN-4h27A:
undetectable
1c9sO-4h27A:
undetectable		 1c9sN-4h27A:
13.46
1c9sO-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.21A 1c9sQ-4h27A:
undetectable
1c9sR-4h27A:
undetectable		 1c9sQ-4h27A:
13.46
1c9sR-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A 128
GLU A 103
THR A  98
HIS A 233
 LLP  A 234 ( 4.3A)
None
None
LLP  A 234 ( 3.5A)
 1.39A 1d4fB-3wksA:
undetectable		 1d4fB-3wksA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
 None
None
LLP  A 227 ( 3.6A)
None
None
None
 0.94A 1dfoA-3h7fA:
54.3		 1dfoA-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.36A 1dfoA-3h7fA:
54.3		 1dfoA-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.97A 1dfoA-4j5uA:
59.7		 1dfoA-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.52A 1dfoA-5v7iA:
51.5		 1dfoA-5v7iA:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.63A 1dfoA-6cczA:
54.4		 1dfoA-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
 None
None
LLP  A 227 ( 3.6A)
None
None
None
 0.94A 1dfoB-3h7fA:
55.9		 1dfoB-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.36A 1dfoB-3h7fA:
55.9		 1dfoB-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.97A 1dfoB-4j5uA:
60.9		 1dfoB-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.53A 1dfoB-5v7iA:
51.9		 1dfoB-5v7iA:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 1dfoB-6cczA:
56.4		 1dfoB-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
 None
None
LLP  A 227 ( 3.6A)
None
None
None
 0.94A 1dfoC-3h7fA:
55.9		 1dfoC-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.36A 1dfoC-3h7fA:
55.9		 1dfoC-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.96A 1dfoC-4j5uA:
60.9		 1dfoC-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.52A 1dfoC-5v7iA:
51.9		 1dfoC-5v7iA:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.63A 1dfoC-6cczA:
56.4		 1dfoC-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
 None
None
LLP  A 227 ( 3.6A)
None
None
None
 0.94A 1dfoD-3h7fA:
54.4		 1dfoD-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 118
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.35A 1dfoD-3h7fA:
54.4		 1dfoD-3h7fA:
51.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.97A 1dfoD-4j5uA:
59.7		 1dfoD-4j5uA:
56.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.53A 1dfoD-5v7iA:
51.6		 1dfoD-5v7iA:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 1dfoD-6cczA:
54.4		 1dfoD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		4 / 6 LEU A 277
ILE A  68
GLU A 285
PRO A 218
 None
None
None
LLP  A 216 ( 4.0A)
 1.15A 1ditH-5b7sA:
undetectable
1ditP-5b7sA:
undetectable		 1ditH-5b7sA:
21.34
1ditP-5b7sA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ILE B 110
ALA B 112
ILE B  92
ASN B  93
LEU B  96
 None
None
LLP  B  91 ( 4.0A)
None
None
 1.24A 1dlsA-5kinB:
undetectable		 1dlsA-5kinB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 2odo ALANINE RACEMASE
(Pseudomonas
fluorescens) 		4 / 7 HIS A  39
GLY A  38
ALA A  36
TYR A  37
 None
None
None
LLP  A  33 ( 4.5A)
 0.88A 1dmaA-2odoA:
undetectable		 1dmaA-2odoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		4 / 7 HIS A  46
GLY A  45
ALA A  43
TYR A  44
 None
None
None
LLP  A  40 ( 4.6A)
 0.92A 1dmaA-3s46A:
undetectable		 1dmaA-3s46A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4dza LYSINE RACEMASE
(Proteus
mirabilis) 		4 / 7 HIS A  80
GLY A  79
ALA A  77
TYR A  78
 None
None
None
LLP  A  74 ( 4.4A)
 0.87A 1dmaA-4dzaA:
undetectable		 1dmaA-4dzaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		4 / 7 HIS A  40
GLY A  39
ALA A  37
TYR A  38
 None
None
None
LLP  A  34 ( 4.5A)
 0.89A 1dmaA-4qhrA:
undetectable		 1dmaA-4qhrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 6a2f -
(-) 		4 / 7 HIS A  40
GLY A  39
ALA A  37
TYR A  38
 None
None
None
LLP  A  34 ( 4.5A)
 0.91A 1dmaA-6a2fA:
undetectable		 1dmaA-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 9 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
 None
None
LLP  A  51 ( 4.2A)
None
None
 1.10A 1e7aB-3tbhA:
undetectable		 1e7aB-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ARG A 266
PHE A 299
TYR A 327
TYR A 131
MET A 183
 LLP  A 184 ( 4.7A)
None
LLP  A 184 ( 4.3A)
None
None
 1.34A 1e7wA-5uidA:
undetectable		 1e7wA-5uidA:
24.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		7 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.29A 1eqbA-3h7fA:
54.3		 1eqbA-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.99A 1eqbA-4j5uA:
59.6		 1eqbA-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.50A 1eqbA-5v7iA:
51.3		 1eqbA-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.62A 1eqbA-6cczA:
54.1		 1eqbA-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  32
HIS A 123
SER A 173
HIS A 201
 None
LLP  A 227 ( 3.6A)
None
LLP  A 227 ( 4.2A)
 0.74A 1eqbA-3h7fA:
54.3
1eqbB-3h7fA:
55.9		 1eqbA-3h7fA:
51.43
1eqbB-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		4 / 8 SER A  35
HIS A 126
SER A 176
HIS A 204
 LLP  A 230 ( 4.9A)
LLP  A 230 ( 3.5A)
None
LLP  A 230 ( 4.1A)
 0.68A 1eqbA-4j5uA:
59.6
1eqbB-4j5uA:
60.9		 1eqbA-4j5uA:
55.79
1eqbB-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbA-5v7iA:
51.3
1eqbB-5v7iA:
51.8		 1eqbA-5v7iA:
44.38
1eqbB-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.62A 1eqbA-6cczA:
54.1
1eqbB-6cczA:
56.2		 1eqbA-6cczA:
undetectable
1eqbB-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		7 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.29A 1eqbB-3h7fA:
55.9		 1eqbB-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.99A 1eqbB-4j5uA:
60.9		 1eqbB-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.51A 1eqbB-5v7iA:
51.7		 1eqbB-5v7iA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 166
GLY A 169
SER A 226
ALA A 227
ASN A 410
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 4.6A)
 0.99A 1eqbB-5v7iA:
51.7		 1eqbB-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.62A 1eqbB-6cczA:
56.2		 1eqbB-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  32
HIS A 123
SER A 173
HIS A 201
 None
LLP  A 227 ( 3.6A)
None
LLP  A 227 ( 4.2A)
 0.74A 1eqbA-3h7fA:
54.3
1eqbB-3h7fA:
55.9		 1eqbA-3h7fA:
51.43
1eqbB-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		4 / 8 SER A  35
HIS A 126
SER A 176
HIS A 204
 LLP  A 230 ( 4.9A)
LLP  A 230 ( 3.5A)
None
LLP  A 230 ( 4.1A)
 0.69A 1eqbA-4j5uA:
59.6
1eqbB-4j5uA:
60.9		 1eqbA-4j5uA:
55.79
1eqbB-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbA-5v7iA:
51.3
1eqbB-5v7iA:
51.8		 1eqbA-5v7iA:
44.38
1eqbB-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.61A 1eqbA-6cczA:
54.1
1eqbB-6cczA:
56.2		 1eqbA-6cczA:
undetectable
1eqbB-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		7 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.29A 1eqbC-3h7fA:
55.9		 1eqbC-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.99A 1eqbC-4j5uA:
60.8		 1eqbC-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.50A 1eqbC-5v7iA:
51.7		 1eqbC-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.62A 1eqbC-6cczA:
56.1		 1eqbC-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  32
HIS A 123
SER A 173
HIS A 201
 None
LLP  A 227 ( 3.6A)
None
LLP  A 227 ( 4.2A)
 0.75A 1eqbC-3h7fA:
55.9
1eqbD-3h7fA:
54.8		 1eqbC-3h7fA:
51.43
1eqbD-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		4 / 8 SER A  35
HIS A 126
SER A 176
HIS A 204
 LLP  A 230 ( 4.9A)
LLP  A 230 ( 3.5A)
None
LLP  A 230 ( 4.1A)
 0.69A 1eqbC-4j5uA:
60.8
1eqbD-4j5uA:
60.8		 1eqbC-4j5uA:
55.79
1eqbD-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.24A 1eqbC-5v7iA:
51.7
1eqbD-5v7iA:
51.3		 1eqbC-5v7iA:
44.38
1eqbD-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.62A 1eqbC-6cczA:
56.1
1eqbD-6cczA:
56.9		 1eqbC-6cczA:
undetectable
1eqbD-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		7 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
ARG A 363
 None
None
LLP  A 227 ( 3.6A)
None
None
None
None
 1.29A 1eqbD-3h7fA:
54.8		 1eqbD-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.99A 1eqbD-4j5uA:
60.8		 1eqbD-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.51A 1eqbD-5v7iA:
51.3		 1eqbD-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.63A 1eqbD-6cczA:
56.9		 1eqbD-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  32
HIS A 123
SER A 173
HIS A 201
 None
LLP  A 227 ( 3.6A)
None
LLP  A 227 ( 4.2A)
 0.74A 1eqbC-3h7fA:
55.9
1eqbD-3h7fA:
54.8		 1eqbC-3h7fA:
51.43
1eqbD-3h7fA:
51.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		4 / 8 SER A  35
HIS A 126
SER A 176
HIS A 204
 LLP  A 230 ( 4.9A)
LLP  A 230 ( 3.5A)
None
LLP  A 230 ( 4.1A)
 0.69A 1eqbC-4j5uA:
60.8
1eqbD-4j5uA:
60.8		 1eqbC-4j5uA:
55.79
1eqbD-4j5uA:
55.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.25A 1eqbC-5v7iA:
51.7
1eqbD-5v7iA:
51.3		 1eqbC-5v7iA:
44.38
1eqbD-5v7iA:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.62A 1eqbC-6cczA:
56.1
1eqbD-6cczA:
56.9		 1eqbC-6cczA:
undetectable
1eqbD-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 LEU A 197
SER A 193
GLY A  73
TYR A 173
 LLP  A 196 ( 3.7A)
LLP  A 196 ( 3.2A)
None
LLP  A 196 (-3.7A)
 0.83A 1fapB-4j8lA:
undetectable		 1fapB-4j8lA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 LEU A 197
SER A 193
GLY A  77
TYR A 173
 LLP  A 196 ( 3.7A)
LLP  A 196 ( 3.2A)
None
LLP  A 196 (-3.7A)
 0.97A 1fapB-4j8lA:
undetectable		 1fapB-4j8lA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.12A 1gtfD-4h27A:
undetectable
1gtfE-4h27A:
undetectable		 1gtfD-4h27A:
13.46
1gtfE-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 1gtfJ-4h27A:
undetectable
1gtfK-4h27A:
undetectable		 1gtfJ-4h27A:
13.46
1gtfK-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.20A 1gtfR-4h27A:
undetectable
1gtfS-4h27A:
undetectable		 1gtfR-4h27A:
13.46
1gtfS-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 SER A 219
ALA A 218
GLY A 184
ALA A 217
ILE A 183
 None
None
LLP  A  58 ( 3.5A)
None
None
 1.10A 1gtnB-2gn1A:
undetectable
1gtnC-2gn1A:
undetectable		 1gtnB-2gn1A:
11.99
1gtnC-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 SER A 219
ALA A 218
GLY A 185
ALA A 217
ILE A 183
 None
None
LLP  A  58 ( 3.8A)
None
None
 1.13A 1gtnB-2gn1A:
undetectable
1gtnC-2gn1A:
undetectable		 1gtnB-2gn1A:
11.99
1gtnC-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 9 VAL A  86
GLY A  82
HIS A 128
ALA A 136
THR A 122
 None
LLP  A  78 ( 4.2A)
None
None
None
 1.26A 1gtnL-5ygrA:
undetectable
1gtnM-5ygrA:
undetectable		 1gtnL-5ygrA:
undetectable
1gtnM-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 11 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.10A 1gtnM-2gn1A:
undetectable
1gtnN-2gn1A:
undetectable		 1gtnM-2gn1A:
11.99
1gtnN-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 11 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.10A 1gtnM-2gn1A:
undetectable
1gtnN-2gn1A:
undetectable		 1gtnM-2gn1A:
11.99
1gtnN-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		5 / 10 GLY A  85
ALA A  90
THR A  81
HIS A  82
ALA A  60
 MLI  A 347 ( 4.8A)
LLP  A  56 ( 3.6A)
None
None
LLP  A  56 ( 3.5A)
 1.24A 1gtnO-3l6rA:
undetectable
1gtnP-3l6rA:
undetectable		 1gtnO-3l6rA:
12.84
1gtnP-3l6rA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 10 GLY A  81
HIS A 123
ALA A 131
THR A 117
ALA A 138
 LLP  A  77 ( 4.0A)
None
None
None
None
 1.33A 1gtnO-4d9iA:
undetectable
1gtnP-4d9iA:
undetectable		 1gtnO-4d9iA:
11.42
1gtnP-4d9iA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 10 GLY A  90
ALA A  95
THR A  86
HIS A  87
ALA A  67
 None
LLP  A  63 ( 3.4A)
None
None
LLP  A  63 ( 3.2A)
 1.24A 1gtnO-5ybwA:
undetectable
1gtnP-5ybwA:
undetectable		 1gtnO-5ybwA:
undetectable
1gtnP-5ybwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 10 GLY A  82
HIS A 128
ALA A 136
THR A 122
ALA A 143
 LLP  A  78 ( 4.2A)
None
None
None
None
 1.25A 1gtnO-5ygrA:
undetectable
1gtnP-5ygrA:
undetectable		 1gtnO-5ygrA:
undetectable
1gtnP-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 9 GLY A  76
THR A  88
THR A  78
THR A  69
ALA A 147
 LLP  A  42 ( 4.6A)
None
None
None
None
 1.36A 1gtnQ-5jjcA:
undetectable
1gtnR-5jjcA:
undetectable		 1gtnQ-5jjcA:
12.87
1gtnR-5jjcA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.12A 1gtnU-2gn1A:
undetectable
1gtnV-2gn1A:
undetectable		 1gtnU-2gn1A:
11.99
1gtnV-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 1gtnU-2gn1A:
undetectable
1gtnV-2gn1A:
undetectable		 1gtnU-2gn1A:
11.99
1gtnV-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 197
ALA A 220
GLY A 168
ALA A 269
HIS A 199
 None
None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
 1.02A 1gtnL-4h27A:
undetectable
1gtnV-4h27A:
undetectable		 1gtnL-4h27A:
13.46
1gtnV-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 10 GLY A 239
CYH A 219
LEU A 129
THR A 101
GLY A 105
 None
LLP  A 243 ( 3.5A)
None
LLP  A 243 ( 3.3A)
None
 1.26A 1h4oA-3hvyA:
undetectable
1h4oB-3hvyA:
undetectable		 1h4oA-3hvyA:
17.65
1h4oB-3hvyA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 ASN A 199
ILE A 338
SER A 296
ASN A 151
 LLP  A 198 ( 4.3A)
None
None
None
 1.25A 1h7xA-1bjnA:
undetectable		 1h7xA-1bjnA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.20A 1h7xA-4xk1A:
undetectable		 1h7xA-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.25A 1h7xA-6czxA:
undetectable		 1h7xA-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 ASN A 199
ILE A 338
SER A 296
ASN A 151
 LLP  A 198 ( 4.3A)
None
None
None
 1.25A 1h7xB-1bjnA:
undetectable		 1h7xB-1bjnA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.21A 1h7xB-4xk1A:
undetectable		 1h7xB-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.25A 1h7xB-6czxA:
undetectable		 1h7xB-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 ASN A 199
ILE A 338
SER A 296
ASN A 151
 LLP  A 198 ( 4.3A)
None
None
None
 1.26A 1h7xC-1bjnA:
undetectable		 1h7xC-1bjnA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.21A 1h7xC-4xk1A:
undetectable		 1h7xC-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.26A 1h7xC-6czxA:
undetectable		 1h7xC-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 6 ASN A 199
ILE A 338
SER A 296
ASN A 151
 LLP  A 198 ( 4.3A)
None
None
None
 1.26A 1h7xD-1bjnA:
undetectable		 1h7xD-1bjnA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 198
ILE A 337
SER A 295
ASN A 151
 LLP  A 197 ( 4.2A)
None
None
None
 1.21A 1h7xD-4xk1A:
undetectable		 1h7xD-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 266
ILE A 406
SER A 364
ASN A 219
 LLP  A 265 ( 4.9A)
None
None
None
 1.26A 1h7xD-6czxA:
undetectable		 1h7xD-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 9 ALA A 243
ASP A 244
GLY A 322
VAL A 189
ILE A 246
 None
None
LLP  A  63 ( 3.8A)
LLP  A  63 ( 4.1A)
LLP  A  63 ( 4.5A)
 1.10A 1hpvB-5ybwA:
undetectable		 1hpvB-5ybwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 ASN A 172
LEU A 197
ALA A 242
LEU A 239
 LLP  A 196 ( 3.9A)
LLP  A 196 ( 3.7A)
None
None
 0.98A 1hwiB-4j8lA:
2.1		 1hwiB-4j8lA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 8 ASN A 172
LEU A 197
ALA A 242
LEU A 239
 LLP  A 196 ( 3.9A)
LLP  A 196 ( 3.7A)
None
None
 0.97A 1hwiC-4j8lA:
undetectable		 1hwiC-4j8lA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 9 ASP A 244
GLY A 245
GLY A 295
ILE A 290
PRO A 331
 None
LLP  A  63 ( 4.2A)
None
None
None
 1.07A 1hxwA-5ybwA:
undetectable		 1hxwA-5ybwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 11 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.47A 1hxwB-2gn1A:
undetectable		 1hxwB-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		5 / 12 GLY A 261
SER A 238
ALA A 236
GLN A  37
ASP A  34
 None
None
LLP  A  61 ( 4.8A)
None
None
 1.28A 1i9gA-4kbxA:
undetectable		 1i9gA-4kbxA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A  39
HIS A  59
ASP A 219
 LLP  A 161 ( 3.9A)
LLP  A 161 ( 4.9A)
None
 0.76A 1i9gA-4whxA:
undetectable		 1i9gA-4whxA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 6 LEU A 303
ALA A 256
LEU A 300
SER A 296
 None
LLP  A 255 ( 3.6A)
None
None
 1.07A 1ictB-3ruyA:
undetectable		 1ictB-3ruyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 VAL A 282
GLY A 283
TYR A 245
GLY A 278
GLU A 392
 None
None
None
LLP  A  61 ( 3.5A)
None
 1.34A 1iolA-3vabA:
2.2		 1iolA-3vabA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 177
LEU A  74
SER A  71
ASP A  72
 None
None
None
LLP  A 205 ( 4.6A)
 1.12A 1ismB-4isyA:
undetectable		 1ismB-4isyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 10 ILE A 247
ALA A 243
ASN A  91
SER A  61
THR A 241
 None
None
LLP  A  63 ( 3.7A)
LLP  A  63 ( 3.1A)
None
 1.29A 1j3jA-5ybwA:
2.6		 1j3jA-5ybwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		4 / 8 GLY A 185
GLY A 237
LEU A 214
GLY A 235
 LLP  A  42 ( 3.4A)
None
None
None
 0.75A 1jhaA-5jjcA:
undetectable		 1jhaA-5jjcA:
23.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_A_142A701_1
(DOPA DECARBOXYLASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 9 PHE A  80
THR A  82
HIS A 192
THR A 245
HIS A 301
 LLP  A 302 ( 4.7A)
None
LLP  A 302 ( 3.6A)
LLP  A 302 ( 4.5A)
LLP  A 302 ( 4.3A)
 0.60A 1js3A-3k40A:
55.6
1js3B-3k40A:
55.6		 1js3A-3k40A:
58.64
1js3B-3k40A:
58.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JS3_B_142B702_1
(DOPA DECARBOXYLASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 9 PHE A  80
THR A  82
HIS A 192
THR A 245
HIS A 301
 LLP  A 302 ( 4.7A)
None
LLP  A 302 ( 3.6A)
LLP  A 302 ( 4.5A)
LLP  A 302 ( 4.3A)
 0.61A 1js3A-3k40A:
55.6
1js3B-3k40A:
55.6		 1js3A-3k40A:
58.64
1js3B-3k40A:
58.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 191
ILE A 217
TYR A 224
ILE A  47
ALA A 266
 LLP  A 222 ( 4.4A)
None
None
None
None
 1.20A 1jtxA-2z61A:
undetectable		 1jtxA-2z61A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A 249
SER A 217
GLY A 283
ASP A 284
ILE A 316
 LLP  A 285 ( 3.0A)
LLP  A 285 ( 3.1A)
LLP  A 285 ( 4.4A)
LLP  A 285 ( 4.3A)
None
 1.09A 1jzsA-3w1hA:
undetectable		 1jzsA-3w1hA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 130
VAL A 126
ASP A 152
ALA A 290
TYR A 321
 None
LLP  A 181 ( 4.9A)
LLP  A 181 ( 2.7A)
None
None
 1.32A 1kiaD-6blgA:
undetectable		 1kiaD-6blgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3op7 AMINOTRANSFERASE
CLASS I AND II
(Streptococcus
suis) 		4 / 5 TRP A 232
ILE A  83
ASP A 192
ASN A 164
 None
None
LLP  A 221 ( 2.8A)
LLP  A 221 ( 3.9A)
 1.44A 1kiaD-3op7A:
2.3		 1kiaD-3op7A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		5 / 12 ALA A  15
VAL A 159
GLY A 162
ALA A  90
ILE A 104
 None
None
None
LLP  A  56 ( 3.6A)
None
 1.25A 1kxhA-3l6rA:
undetectable		 1kxhA-3l6rA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASN A  75
LEU A 418
ALA A  77
GLY A  79
PHE A 370
 None
None
None
LLP  A 265 ( 4.2A)
None
 1.44A 1l5rA-6czxA:
undetectable		 1l5rA-6czxA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 6 GLU A  86
ILE A  38
TYR A  33
GLY A 286
 LLP  A  61 ( 3.5A)
None
None
None
 1.09A 1maaB-3vabA:
undetectable
1maaD-3vabA:
undetectable		 1maaB-3vabA:
21.99
1maaD-3vabA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		3 / 3 PHE A 149
TYR A 153
PRO A 151
 None
LLP  A  58 ( 4.8A)
None
 0.91A 1mcnA-2gn1A:
undetectable
1mcnB-2gn1A:
undetectable
1mcnP-2gn1A:
undetectable		 1mcnA-2gn1A:
20.81
1mcnB-2gn1A:
20.81
1mcnP-2gn1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 ASP A 290
SER A 291
SER A 292
GLY A 265
 LLP  A  42 ( 3.2A)
None
None
None
 0.83A 1meiA-5b1hA:
undetectable		 1meiA-5b1hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 11 ILE A  76
HIS A 349
LEU A  70
PRO A 417
TYR A 378
 None
LLP  A 247 ( 4.5A)
None
None
None
 1.23A 1mrlA-4k2bA:
undetectable
1mrlB-4k2bA:
undetectable		 1mrlA-4k2bA:
19.82
1mrlB-4k2bA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 ILE A  76
HIS A 349
LEU A  70
PRO A 417
TYR A 378
 None
LLP  A 247 ( 4.5A)
None
None
None
 1.24A 1mrlB-4k2bA:
undetectable
1mrlC-4k2bA:
undetectable		 1mrlB-4k2bA:
19.82
1mrlC-4k2bA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 11 ALA A 173
ASP A 201
VAL A 224
ILE A 202
PRO A 219
 None
LLP  A 230 ( 2.9A)
None
None
None
 0.95A 1n49C-4j5uA:
undetectable		 1n49C-4j5uA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 GLY B 231
VAL B 308
ALA B 301
SER B 300
SER B 296
 LLP  B  86 ( 3.7A)
None
None
None
CA  B 402 (-4.2A)
 1.38A 1nbhA-5kzmB:
2.2		 1nbhA-5kzmB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 ARG A  10
ASP A  59
ASN A  88
 None
LLP  A  58 ( 4.7A)
LLP  A  58 (-3.9A)
 0.77A 1nbhA-4il5A:
3.0		 1nbhA-4il5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 GLY B 231
VAL B 308
ALA B 301
SER B 300
SER B 296
 LLP  B  86 ( 3.7A)
None
None
None
CA  B 402 (-4.2A)
 1.38A 1nbhD-5kzmB:
undetectable		 1nbhD-5kzmB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 ARG A  10
ASP A  59
ASN A  88
 None
LLP  A  58 ( 4.7A)
LLP  A  58 (-3.9A)
 0.78A 1nbhD-4il5A:
2.4		 1nbhD-4il5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 LEU A  46
LEU A 273
LEU A 287
PRO A 182
LEU A 188
 None
None
None
LLP  A  58 ( 4.6A)
LLP  A  58 ( 4.5A)
 1.23A 1og5A-2gn1A:
undetectable		 1og5A-2gn1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 ILE A 180
LEU A  46
LEU A 287
PRO A 182
LEU A 188
 None
None
None
LLP  A  58 ( 4.6A)
LLP  A  58 ( 4.5A)
 1.23A 1og5B-2gn1A:
undetectable		 1og5B-2gn1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 1.04A 1os6A-3w1hA:
undetectable		 1os6A-3w1hA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 LEU A 280
HIS A 200
SER A 203
ILE A 205
ILE A 243
 None
LLP  A  61 ( 3.6A)
LLP  A  61 ( 2.5A)
None
None
 1.25A 1ot7B-3vabA:
undetectable		 1ot7B-3vabA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ARG A 266
PHE A 299
TYR A 327
TYR A 131
MET A 183
 LLP  A 184 ( 4.7A)
None
LLP  A 184 ( 4.3A)
None
None
 1.37A 1p33B-5uidA:
undetectable		 1p33B-5uidA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		5 / 12 ARG A 266
PHE A 299
TYR A 327
TYR A 131
MET A 183
 LLP  A 184 ( 4.7A)
None
LLP  A 184 ( 4.3A)
None
None
 1.41A 1p33D-5uidA:
3.2		 1p33D-5uidA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 7 PHE A 214
VAL A 144
ASP A 216
ILE A 182
 None
None
LLP  A 253 ( 2.8A)
None
 0.99A 1p7rA-1bw0A:
0.0		 1p7rA-1bw0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 104
GLY A 244
GLY A  99
ILE A 205
LEU A 200
 None
LLP  A 234 ( 4.9A)
LLP  A 234 ( 3.5A)
LLP  A 234 ( 4.0A)
None
 1.21A 1p91A-1bjwA:
3.1		 1p91A-1bjwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3kw3 ALANINE RACEMASE
(Bartonella
henselae) 		5 / 12 GLY A  54
GLY A  52
TYR A  51
TYR A 232
ILE A  26
 None
None
LLP  A  47 ( 4.6A)
None
None
 0.91A 1p91B-3kw3A:
undetectable		 1p91B-3kw3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 10 GLY A 203
TYR A  58
SER A 246
ARG A 253
ALA A 197
 LLP  A 199 ( 3.2A)
None
None
None
None
 1.27A 1pbcA-6cjbA:
undetectable		 1pbcA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 2odo ALANINE RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 210
VAL A  31
ILE A  32
ALA A  73
ILE A  71
 LLP  A  33 ( 3.2A)
LLP  A  33 ( 4.6A)
LLP  A  33 ( 4.3A)
None
None
 0.98A 1pbkA-2odoA:
undetectable		 1pbkA-2odoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 11 THR A 315
LEU A 275
GLY A 289
VAL A 190
ILE A 313
 LLP  A  51 ( 3.4A)
None
None
None
None
 1.14A 1phgA-4d8uA:
undetectable		 1phgA-4d8uA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ALA A 210
VAL A 229
ALA A 101
HIS A 233
 LLP  A 234 ( 3.4A)
None
LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.5A)
 1.14A 1q23F-3wksA:
undetectable		 1q23F-3wksA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 ALA A 237
VAL A 236
ALA A 109
HIS A 240
 None
None
LLP  A 241 ( 3.9A)
LLP  A 241 ( 3.7A)
 1.26A 1q23F-4q76A:
undetectable		 1q23F-4q76A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3qqm MLR3007 PROTEIN
(Mesorhizobium
loti) 		4 / 8 GLU A 150
GLU A 138
THR A 105
ILE A 148
 LLP  A 117 ( 3.4A)
EDO  A 275 (-3.6A)
None
None
 1.02A 1qvtA-3qqmA:
undetectable		 1qvtA-3qqmA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 THR A 373
TYR A 316
TYR A 201
LEU A 204
 None
LLP  A 232 ( 4.6A)
LLP  A 232 ( 4.3A)
None
 1.08A 1qzrA-2o0rA:
undetectable		 1qzrA-2o0rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		4 / 7 THR A 373
TYR A 316
TYR A 201
LEU A 204
 None
LLP  A 232 ( 4.6A)
LLP  A 232 ( 4.3A)
None
 1.04A 1qzrB-2o0rA:
undetectable		 1qzrB-2o0rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		4 / 8 GLY A 191
GLY A 187
GLY A 186
LEU A 188
 None
LLP  A  58 ( 3.2A)
LLP  A  58 ( 3.4A)
LLP  A  58 ( 4.5A)
 0.65A 1qzzA-2gn1A:
2.5		 1qzzA-2gn1A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		5 / 8 GLY A 185
GLY A 187
GLY A 188
MET A 189
LEU A 190
 LLP  A  56 ( 3.4A)
LLP  A  56 ( 3.6A)
LLP  A  56 ( 3.3A)
None
None
 0.73A 1qzzA-3l6rA:
2.6		 1qzzA-3l6rA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 8 TYR A  58
GLY A 283
GLY A 278
LEU A 280
 None
None
LLP  A  61 ( 3.5A)
None
 0.66A 1qzzA-3vabA:
undetectable		 1qzzA-3vabA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ASN A 244
ILE A 245
ASP A 217
GLY A 239
ALA A 238
 LLP  A 243 ( 4.7A)
None
LLP  A 243 ( 2.9A)
None
None
 1.06A 1r9oA-3hvyA:
undetectable		 1r9oA-3hvyA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3bn1 PEROSAMINE
SYNTHETASE
(Caulobacter
vibrioides) 		5 / 12 LEU A 244
SER A 171
LEU A 251
ILE A 187
THR A 190
 None
None
None
LLP  A 186 ( 4.3A)
None
 0.96A 1rb3B-3bn1A:
undetectable		 1rb3B-3bn1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLN A 157
THR A 162
ALA A 164
GLY A 186
GLY A 190
 None
None
None
LLP  A  42 ( 3.7A)
None
 1.10A 1rjdB-5jjcA:
undetectable		 1rjdB-5jjcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLN A 157
THR A 162
ALA A 164
GLY A 186
GLY A 190
 None
None
None
LLP  A  42 ( 3.7A)
None
 1.06A 1rjdC-5jjcA:
undetectable		 1rjdC-5jjcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 11 ALA A 205
PRO A 263
LEU A 153
THR A 121
VAL A 154
 None
None
None
LLP  A 270 ( 3.5A)
None
 1.18A 1rv7A-3l44A:
undetectable
1rv7B-3l44A:
undetectable		 1rv7A-3l44A:
14.91
1rv7B-3l44A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 ASN A 186
SER A 185
ASP A 134
ALA A 207
ILE A 203
 None
LLP  A 252 ( 4.5A)
None
None
None
 1.35A 1s14B-3nraA:
undetectable		 1s14B-3nraA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		4 / 6 ASP A 173
LEU A 193
VAL A 192
ILE A 212
 LLP  A 198 ( 3.0A)
None
None
None
 1.03A 1s9qA-1cs1A:
undetectable		 1s9qA-1cs1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		5 / 12 ALA A  48
LEU A  17
ASN A  16
VAL A  33
ALA A  37
 None
None
None
LLP  A  34 ( 3.3A)
None
 0.98A 1sa1A-4qhrA:
undetectable
1sa1B-4qhrA:
undetectable		 1sa1A-4qhrA:
21.24
1sa1B-4qhrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		5 / 12 ALA A  48
LEU A  17
ASN A  16
VAL A  33
ALA A  37
 None
None
None
LLP  A  34 ( 3.3A)
None
 0.98A 1sa1C-4qhrA:
undetectable
1sa1D-4qhrA:
undetectable		 1sa1C-4qhrA:
21.24
1sa1D-4qhrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 8 PHE A  99
ILE A  80
ILE A  77
THR A 176
 LLP  A 200 ( 3.7A)
None
None
LLP  A 200 ( 3.3A)
 0.94A 1sbrA-3nnkA:
undetectable		 1sbrA-3nnkA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE
(Klebsiella
pneumoniae) 		4 / 7 PHE A  99
ILE A  80
ILE A  77
THR A 176
 LLP  A 200 ( 3.7A)
None
None
LLP  A 200 ( 3.3A)
 0.92A 1sbrB-3nnkA:
2.5		 1sbrB-3nnkA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 ASP A 244
GLY A 245
GLY A 295
ILE A 290
PRO A 331
 None
LLP  A  63 ( 4.2A)
None
None
None
 0.98A 1sduB-5ybwA:
undetectable		 1sduB-5ybwA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		6 / 10 LEU X 214
ALA X 201
ILE X 229
GLY X 177
GLY X 179
ILE X 210
 None
None
LLP  X  42 ( 4.7A)
LLP  X  42 ( 3.6A)
LLP  X  42 ( 3.5A)
None
 1.41A 1sdvA-4li3X:
undetectable		 1sdvA-4li3X:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 PHE A  57
GLY A  61
ILE A 159
VAL A  90
PHE A 149
 LLP  A  58 ( 3.8A)
LLP  A  58 ( 4.2A)
None
None
None
 1.24A 1sg9A-2gn1A:
3.4		 1sg9A-2gn1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 PRO A 297
ILE A 242
GLY A 247
ILE A 245
ASN A 244
 None
LLP  A 243 ( 4.3A)
None
None
LLP  A 243 ( 4.7A)
 1.10A 1sg9A-3hvyA:
4.6		 1sg9A-3hvyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(environmental
samples) 		5 / 12 PHE A 149
GLY A 150
ALA A 170
VAL A 114
SER A 113
 None
None
None
None
LLP  A 274 ( 2.7A)
 1.12A 1sg9C-5uc7A:
2.7		 1sg9C-5uc7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 280
ILE A 283
GLY A 390
HIS A 220
 None
None
None
LLP  A 219 ( 4.8A)
 0.73A 1sv9A-3ndnA:
undetectable		 1sv9A-3ndnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 10 LEU A 114
GLY A 226
ALA A 223
ILE A 129
GLY A 125
 None
None
None
None
LLP  A 247 ( 3.2A)
 1.02A 1t7iA-4k2bA:
undetectable		 1t7iA-4k2bA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		4 / 7 ASN A 134
HIS A 126
TYR A 106
ILE A 172
 None
LLP  A 230 ( 3.5A)
None
None
 1.37A 1tdnA-4j5uA:
undetectable		 1tdnA-4j5uA:
25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		6 / 9 HIS A 200
GLY A 202
SER A 203
ARG A 279
ARG A 315
TYR A 319
 LLP  A  61 ( 3.6A)
None
LLP  A  61 ( 2.5A)
None
None
None
 0.62A 1tufA-3vabA:
50.0
1tufB-3vabA:
50.2		 1tufA-3vabA:
37.04
1tufB-3vabA:
37.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		6 / 9 HIS A 200
GLY A 202
SER A 203
ARG A 277
ARG A 313
TYR A 317
 LLP  A 508 (-3.5A)
None
LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-3.8A)
LLP  A 508 (-4.2A)
 0.73A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 6 SER A 203
ARG A 279
ARG A 315
TYR A 319
TYR A 376
 LLP  A  61 ( 2.5A)
None
None
None
LLP  A  61 ( 4.6A)
 0.67A 1tufA-3vabA:
50.0
1tufB-3vabA:
50.2		 1tufA-3vabA:
37.04
1tufB-3vabA:
37.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 SER A 203
ARG A 277
ARG A 313
TYR A 376
 LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-3.8A)
LLP  A 508 (-3.4A)
 0.77A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		4 / 6 SER A 203
ARG A 277
TYR A 317
TYR A 376
 LLP  A 508 (-2.4A)
LLP  A 508 (-2.9A)
LLP  A 508 (-4.2A)
LLP  A 508 (-3.4A)
 0.32A 1tufA-4xg1A:
50.4
1tufB-4xg1A:
50.6		 1tufA-4xg1A:
41.63
1tufB-4xg1A:
41.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 GLU A 327
SER A 346
ARG A 106
TYR A 101
 None
None
None
LLP  A 199 (-3.7A)
 1.48A 1tufA-6cjbA:
undetectable
1tufB-6cjbA:
undetectable		 1tufA-6cjbA:
9.47
1tufB-6cjbA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE
(Klebsiella
pneumoniae) 		4 / 7 THR A  80
THR A  84
VAL A 149
MET A 135
 None
LLP  A 181 ( 4.9A)
None
None
 1.19A 1tv8B-6blgA:
undetectable		 1tv8B-6blgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		4 / 7 LEU A 203
THR A 207
LEU A 221
VAL A 217
 None
LLP  A 208 (-3.4A)
None
LLP  A 208 ( 4.9A)
 0.96A 1tyrB-3qi6A:
undetectable		 1tyrB-3qi6A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 11 SER A 348
ILE A 261
VAL A 263
LEU A 297
PHE A 242
 LLP  A  78 ( 4.4A)
None
None
None
None
 1.22A 1uduA-5ygrA:
undetectable		 1uduA-5ygrA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 11 GLY A 238
SER A  97
ALA A 101
ALA A 104
LEU A 259
 None
LLP  A 230 ( 3.4A)
None
None
None
 1.16A 1ukbA-4j5uA:
undetectable		 1ukbA-4j5uA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.15A 1utdE-4h27A:
undetectable
1utdF-4h27A:
undetectable		 1utdE-4h27A:
13.46
1utdF-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.15A 1utdH-4h27A:
undetectable
1utdI-4h27A:
undetectable		 1utdH-4h27A:
13.46
1utdI-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.96A 1utdL-4h27A:
undetectable
1utdM-4h27A:
undetectable		 1utdL-4h27A:
13.46
1utdM-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.97A 1utdO-4h27A:
undetectable
1utdP-4h27A:
undetectable		 1utdO-4h27A:
13.46
1utdP-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 168
ALA A 269
HIS A 199
GLY A 197
ALA A 220
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 0.96A 1utdP-4h27A:
undetectable
1utdQ-4h27A:
undetectable		 1utdP-4h27A:
13.46
1utdQ-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.12A 1utdT-2gn1A:
undetectable
1utdU-2gn1A:
undetectable		 1utdT-2gn1A:
11.99
1utdU-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 1utdT-2gn1A:
undetectable
1utdU-2gn1A:
undetectable		 1utdT-2gn1A:
11.99
1utdU-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 168
ALA A 269
THR A 195
HIS A 199
GLY A 197
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
None
 1.18A 1utdU-4h27A:
undetectable
1utdV-4h27A:
undetectable		 1utdU-4h27A:
13.46
1utdV-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE
(Pseudomonas
putida) 		5 / 11 GLY A 142
VAL A 177
ILE A 191
HIS A 242
ARG A 261
 None
None
None
None
LLP  A  75 ( 4.0A)
 1.16A 1vhwA-4dyjA:
undetectable
1vhwD-4dyjA:
undetectable		 1vhwA-4dyjA:
20.98
1vhwD-4dyjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE
(Pseudomonas
putida) 		5 / 11 GLY A 142
VAL A 177
ILE A 191
HIS A 242
ARG A 261
 None
None
None
None
LLP  A  75 ( 4.0A)
 1.13A 1vhwC-4dyjA:
undetectable
1vhwE-4dyjA:
undetectable		 1vhwC-4dyjA:
20.98
1vhwE-4dyjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE
(Pseudomonas
putida) 		5 / 11 HIS A 242
ARG A 261
GLY A 142
VAL A 177
ILE A 191
 None
LLP  A  75 ( 4.0A)
None
None
None
 1.14A 1vhwA-4dyjA:
undetectable
1vhwD-4dyjA:
undetectable		 1vhwA-4dyjA:
20.98
1vhwD-4dyjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE
(Pseudomonas
putida) 		5 / 11 HIS A 242
ARG A 261
GLY A 142
VAL A 177
ILE A 191
 None
LLP  A  75 ( 4.0A)
None
None
None
 1.17A 1vhwC-4dyjA:
undetectable
1vhwE-4dyjA:
undetectable		 1vhwC-4dyjA:
20.98
1vhwE-4dyjA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		5 / 12 SER A 194
ALA A 217
TYR A  38
GLY A 216
LEU A 230
 LLP  A  34 ( 2.4A)
None
LLP  A  34 ( 4.5A)
None
None
 1.04A 1vpoH-4qhrA:
undetectable
1vpoL-4qhrA:
undetectable		 1vpoH-4qhrA:
18.51
1vpoL-4qhrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2odo ALANINE RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 210
GLY A 215
VAL A  31
ALA A  30
LEU A  78
 LLP  A  33 ( 3.2A)
None
LLP  A  33 ( 4.6A)
None
LLP  A  33 ( 4.1A)
 0.95A 1vptA-2odoA:
undetectable		 1vptA-2odoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 12 THR A  69
ILE A 314
GLY A 313
GLY A 273
ILE A  76
 None
None
None
LLP  A 270 ( 4.0A)
None
 1.01A 1vq1B-3l44A:
3.1		 1vq1B-3l44A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 GLY A 178
GLY A 199
GLY A 354
SER A 177
HIS A 142
 None
LLP  A 198 ( 2.4A)
LLP  A 198 ( 4.8A)
None
None
 1.24A 1wg8A-3ke3A:
2.9		 1wg8A-3ke3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 ILE A 202
GLY A  81
ALA A  82
HIS A 123
 None
LLP  A  77 ( 4.0A)
None
None
 0.84A 1wmqA-4d9iA:
undetectable		 1wmqA-4d9iA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 ILE A 202
GLY A  81
ALA A  82
HIS A 123
 None
LLP  A  77 ( 4.0A)
None
None
 0.83A 1wmqB-4d9iA:
undetectable		 1wmqB-4d9iA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 ILE A 202
GLY A  81
ALA A  82
HIS A 123
 None
LLP  A  77 ( 4.0A)
None
None
 0.84A 1wpuA-4d9iA:
undetectable		 1wpuA-4d9iA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 ILE A 202
GLY A  81
ALA A  82
HIS A 123
 None
LLP  A  77 ( 4.0A)
None
None
 0.83A 1wpuB-4d9iA:
undetectable		 1wpuB-4d9iA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 ILE A 202
GLY A  81
ALA A  82
HIS A 123
 None
LLP  A  77 ( 4.0A)
None
None
 0.84A 1wrqA-4d9iA:
undetectable		 1wrqA-4d9iA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 6 ILE A 202
GLY A  81
ALA A  82
HIS A 123
 None
LLP  A  77 ( 4.0A)
None
None
 0.82A 1wrqB-4d9iA:
undetectable		 1wrqB-4d9iA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		3 / 3 PHE B 300
TYR B 371
TYR B 307
 None
None
LLP  B 304 ( 4.8A)
 1.04A 1x70B-4ritB:
undetectable		 1x70B-4ritB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5uid AMINOTRANSFERASE
TLMJ
(Streptoalloteich
us
hindustanus) 		3 / 3 PHE A   7
TYR A 327
TYR A 131
 None
LLP  A 184 ( 4.3A)
None
 0.95A 1x70B-5uidA:
undetectable		 1x70B-5uidA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		3 / 3 MET X  96
ASN X  72
GLN X 143
 None
LLP  X  42 ( 3.8A)
LLP  X  42 ( 4.9A)
 0.92A 1xoqB-4li3X:
undetectable		 1xoqB-4li3X:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		3 / 3 MET A  98
ASN A  74
GLN A 143
 None
LLP  A  44 ( 3.8A)
LLP  A  44 ( 4.8A)
 0.71A 1xoqB-5xa2A:
undetectable		 1xoqB-5xa2A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		4 / 5 ILE X 229
LEU X 238
ALA X 201
GLU X 203
 LLP  X  42 ( 4.7A)
None
None
None
 1.27A 1xvaA-4li3X:
undetectable
1xvaB-4li3X:
undetectable		 1xvaA-4li3X:
23.36
1xvaB-4li3X:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		4 / 6 ALA X 201
GLU X 203
ILE X 229
LEU X 238
 None
None
LLP  X  42 ( 4.7A)
None
 1.02A 1xvaA-4li3X:
2.1
1xvaB-4li3X:
undetectable		 1xvaA-4li3X:
23.36
1xvaB-4li3X:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 343
GLY A 289
GLY A 264
LEU A 268
GLY A 273
 None
LLP  A 288 ( 2.4A)
None
None
None
 1.25A 1y4lA-3fcrA:
undetectable		 1y4lA-3fcrA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		4 / 8 PRO A 218
MET A 219
LEU A 277
GLY A 273
 LLP  A 216 ( 4.0A)
None
None
None
 0.86A 1ya4A-5b7sA:
undetectable		 1ya4A-5b7sA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 238
GLY B 237
SER B 240
LEU B 309
LEU B 192
 LLP  B  91 ( 3.6A)
LLP  B  91 ( 3.6A)
LLP  B  91 ( 2.6A)
None
None
 1.13A 1ya4B-5kinB:
2.4		 1ya4B-5kinB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		5 / 12 GLY A 234
GLY A 233
SER A 195
LEU A 240
LEU A  61
 None
None
LLP  A 198 ( 2.8A)
None
None
 0.97A 1ya4C-1cs1A:
undetectable		 1ya4C-1cs1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 5 TYR A 339
SER A 337
THR A 153
ASN A 151
 LLP  A 198 ( 3.5A)
None
LLP  A 198 ( 3.5A)
None
 1.40A 1yvpA-1bjnA:
undetectable		 1yvpA-1bjnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 338
SER A 336
THR A 153
ASN A 151
 LLP  A 197 ( 4.0A)
None
LLP  A 197 ( 3.0A)
None
 1.38A 1yvpA-4xk1A:
undetectable		 1yvpA-4xk1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN
(Trichomonas
vaginalis) 		4 / 5 TYR A 350
SER A 348
THR A 158
ASN A 156
 LLP  A 202 ( 4.0A)
None
LLP  A 202 ( 3.0A)
None
 1.35A 1yvpA-5f8vA:
undetectable		 1yvpA-5f8vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 TYR A 407
SER A 405
THR A 221
ASN A 219
 LLP  A 265 ( 3.7A)
None
LLP  A 265 ( 2.9A)
None
 1.39A 1yvpA-6czxA:
undetectable		 1yvpA-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME
(Histophilus
somni) 		5 / 12 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.18A 1z95A-3cebA:
undetectable		 1z95A-3cebA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 8 TYR A  98
ARG A 100
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.50A 2a1hA-4whxA:
30.5
2a1hB-4whxA:
30.3		 2a1hA-4whxA:
28.19
2a1hB-4whxA:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 8 TYR A  87
ARG A  89
GLY A 245
THR A 246
ALA A 247
 None
None
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
 0.44A 2a1hA-5mqzA:
28.4
2a1hB-5mqzA:
28.4		 2a1hA-5mqzA:
13.00
2a1hB-5mqzA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 7 THR B 284
VAL B 245
GLY B 246
THR B 204
 None
LLP  B 101 ( 4.7A)
LLP  B 101 ( 3.3A)
LLP  B 101 ( 3.7A)
 0.89A 2a1mA-5tchB:
undetectable		 2a1mA-5tchB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3op7 AMINOTRANSFERASE
CLASS I AND II
(Streptococcus
suis) 		3 / 3 TRP A 232
THR A 222
TYR A 223
 None
LLP  A 221 ( 4.3A)
None
 1.11A 2a3aA-3op7A:
undetectable		 2a3aA-3op7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3op7 AMINOTRANSFERASE
CLASS I AND II
(Streptococcus
suis) 		3 / 3 TRP A 232
THR A 222
TYR A 223
 None
LLP  A 221 ( 4.3A)
None
 1.14A 2a3aB-3op7A:
undetectable		 2a3aB-3op7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3op7 AMINOTRANSFERASE
CLASS I AND II
(Streptococcus
suis) 		3 / 3 TRP A 232
THR A 222
TYR A 223
 None
LLP  A 221 ( 4.3A)
None
 1.11A 2a3bA-3op7A:
undetectable		 2a3bA-3op7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(environmental
samples) 		4 / 5 LEU A  37
ASP A  47
GLY A 279
ALA A  32
 None
None
LLP  A 274 ( 4.1A)
None
 0.94A 2aohA-5uc7A:
undetectable		 2aohA-5uc7A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		4 / 5 GLY A 245
PRO A 216
VAL A 270
ILE A 275
 LLP  A  63 ( 4.2A)
None
None
None
 0.98A 2aoiA-5ybwA:
undetectable		 2aoiA-5ybwA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 12 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.48A 2avvB-2gn1A:
undetectable		 2avvB-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 GLY A  55
GLY A 237
ASP A 236
ALA A 284
ALA A 286
 None
LLP  A  58 ( 4.4A)
None
LLP  A  58 ( 3.4A)
None
 1.03A 2bm9F-2gn1A:
3.5		 2bm9F-2gn1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 4 LEU A 182
SER A 405
ASP A 364
ASP A 345
 ABU  A 585 ( 3.9A)
LLP  A 396 ( 4.9A)
LLP  A 396 ( 2.6A)
None
 1.35A 2br4B-2okkA:
2.5		 2br4B-2okkA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 TYR A 111
ASP A 208
SER A 210
ALA A 105
ALA A 102
 None
LLP  A 234 ( 2.5A)
LLP  A 234 ( 3.3A)
None
LLP  A 234 ( 3.8A)
 1.10A 2br4C-4w91A:
3.8		 2br4C-4w91A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(environmental
samples) 		3 / 3 SER A 111
ASP A 147
CYH A 155
 LLP  A 274 ( 4.1A)
None
None
 1.11A 2br4E-5uc7A:
2.4		 2br4E-5uc7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		3 / 3 LYS A 278
ASP A 244
CYH A 166
 LLP  A 277 ( 3.2A)
LLP  A 277 ( 2.8A)
LLP  A 277 ( 4.0A)
 1.21A 2br4F-3hbxA:
2.6		 2br4F-3hbxA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 220
ASP A 194
CYH A 125
 LLP  A 219 ( 2.9A)
LLP  A 219 ( 3.1A)
LLP  A 219 ( 4.1A)
 1.40A 2br4F-3ndnA:
3.5		 2br4F-3ndnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
 None
None
LLP  A  51 ( 4.2A)
None
None
 1.16A 2bxeA-3tbhA:
undetectable		 2bxeA-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(environmental
samples) 		5 / 9 LEU A 257
PHE A 258
LEU A 327
LEU A 324
ALA A 275
 None
None
None
None
LLP  A 274 ( 3.7A)
 1.35A 2bxeA-5uc7A:
undetectable		 2bxeA-5uc7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 LEU A 244
ILE A 245
VAL A 185
GLY A 184
LEU A 240
 None
None
LLP  A  51 ( 4.2A)
None
None
 1.11A 2bxeB-3tbhA:
undetectable		 2bxeB-3tbhA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 10 GLY A 160
SER A 161
SER A 195
ASN A  50
GLN A  83
 None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
 1.29A 2c2bA-4d8uA:
24.7
2c2bB-4d8uA:
23.3		 2c2bA-4d8uA:
20.90
2c2bB-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_B_SAMB500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 10 ASN A  50
GLN A  83
GLY A 160
SER A 161
SER A 195
 LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
 1.24A 2c2bA-4d8uA:
24.7
2c2bB-4d8uA:
23.3		 2c2bA-4d8uA:
20.90
2c2bB-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_C_SAMC500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 10 GLY A 160
SER A 161
SER A 195
ASN A  50
GLN A  83
 None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
 1.33A 2c2bC-4d8uA:
24.7
2c2bD-4d8uA:
23.3		 2c2bC-4d8uA:
20.90
2c2bD-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_D_SAMD500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 9 ASN A  50
GLN A  83
GLY A 160
SER A 161
SER A 195
 LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
 1.24A 2c2bC-4d8uA:
24.7
2c2bD-4d8uA:
23.3		 2c2bC-4d8uA:
20.90
2c2bD-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 11 GLY A 160
SER A 161
SER A 195
ASN A  50
GLN A  83
 None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
 1.22A 2c2bE-4d8uA:
23.3
2c2bF-4d8uA:
24.8		 2c2bE-4d8uA:
20.90
2c2bF-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 10 ASN A  50
GLN A  83
GLY A 160
SER A 161
SER A 195
 LLP  A  51 ( 3.1A)
LLP  A  51 ( 3.5A)
None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 2.4A)
 1.29A 2c2bE-4d8uA:
23.3
2c2bF-4d8uA:
24.7		 2c2bE-4d8uA:
20.90
2c2bF-4d8uA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 7 HIS A 215
ALA A 248
GLY A 281
GLY A 249
ASN A 142
 None
None
None
LLP  A 285 ( 3.0A)
LLP  A 285 ( 4.5A)
 1.47A 2c49B-3w1hA:
undetectable		 2c49B-3w1hA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		4 / 7 GLY A 328
SER A 348
SER A 384
GLU A 386
 None
LLP  A  78 ( 4.4A)
None
LLP  A  78 ( 3.5A)
 1.05A 2c8aB-5ygrA:
undetectable		 2c8aB-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		4 / 7 GLY A 328
SER A 348
SER A 384
GLU A 386
 None
LLP  A  78 ( 4.4A)
None
LLP  A  78 ( 3.5A)
 1.03A 2c8aD-5ygrA:
undetectable		 2c8aD-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		5 / 12 PHE A  71
VAL A  78
LEU A  63
VAL A  66
GLY A 229
 None
None
None
None
LLP  A 226 ( 3.7A)
 1.10A 2cbrA-3fd0A:
undetectable		 2cbrA-3fd0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 PHE A  86
VAL A  93
LEU A  78
VAL A  81
GLY A 246
 None
None
None
None
LLP  A 243 ( 4.0A)
 1.04A 2cbrA-3hvyA:
undetectable		 2cbrA-3hvyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
monocytogenes) 		5 / 12 PHE A  71
VAL A  78
LEU A  63
VAL A  66
GLY A 229
 None
None
None
None
LLP  A 226 ( 3.6A)
 1.07A 2cbrA-3jzlA:
undetectable		 2cbrA-3jzlA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		6 / 10 TYR A  98
ARG A 100
TYR A 131
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.54A 2coiA-4whxA:
31.2
2coiB-4whxA:
31.5		 2coiA-4whxA:
26.49
2coiB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 10 TYR A  87
ARG A  89
GLY A 245
THR A 246
ALA A 247
 None
None
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
 0.32A 2coiA-5mqzA:
28.7
2coiB-5mqzA:
29.0		 2coiA-5mqzA:
10.78
2coiB-5mqzA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		6 / 10 TYR A  98
ARG A 100
TYR A 131
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.52A 2coiA-4whxA:
31.2
2coiB-4whxA:
31.5		 2coiA-4whxA:
26.49
2coiB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 10 TYR A 166
TYR A 131
GLY A 257
THR A 258
ALA A 259
 LLP  A 161 ( 4.2A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 1.13A 2coiA-4whxA:
31.2
2coiB-4whxA:
31.5		 2coiA-4whxA:
26.49
2coiB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 10 TYR A  87
ARG A  89
GLY A 245
THR A 246
ALA A 247
 None
None
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
 0.26A 2coiA-5mqzA:
28.8
2coiB-5mqzA:
29.0		 2coiA-5mqzA:
10.78
2coiB-5mqzA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		7 / 11 PHE A  38
TYR A  98
ARG A 100
TYR A 131
GLY A 257
THR A 258
ALA A 259
 LLP  A 161 ( 4.4A)
ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.53A 2cojA-4whxA:
31.1
2cojB-4whxA:
31.4		 2cojA-4whxA:
26.49
2cojB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		6 / 11 PHE A  32
TYR A  87
ARG A  89
GLY A 245
THR A 246
ALA A 247
 LLP  A 150 ( 3.9A)
None
None
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
 0.47A 2cojA-5mqzA:
28.4
2cojB-5mqzA:
28.6		 2cojA-5mqzA:
10.78
2cojB-5mqzA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 9 TYR A  98
ARG A 100
GLY A 257
THR A 258
ALA A 259
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
 0.43A 2cojA-4whxA:
31.1
2cojB-4whxA:
31.4		 2cojA-4whxA:
26.49
2cojB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 9 TYR A  87
ARG A  89
GLY A 245
THR A 246
ALA A 247
 None
None
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
 0.35A 2cojA-5mqzA:
28.4
2cojB-5mqzA:
28.6		 2cojA-5mqzA:
10.78
2cojB-5mqzA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.06A 2dcfA-4li3X:
undetectable		 2dcfA-4li3X:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.16A 2dcfA-5xa2A:
undetectable		 2dcfA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 GLY A 172
THR A 173
ALA A 174
ALA A 175
 LLP  A 312 ( 3.5A)
LLP  A 312 ( 3.6A)
None
None
 0.51A 2ej3A-3f6tA:
undetectable		 2ej3A-3f6tA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		8 / 8 TYR A  98
ARG A 100
GLY A 198
GLU A 199
GLY A 257
THR A 258
ALA A 259
ALA A 260
 ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
ALA  A 401 (-4.0A)
None
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
None
 0.26A 2ej3A-4whxA:
42.8		 2ej3A-4whxA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		7 / 8 TYR A  87
ARG A  89
GLY A 186
GLY A 245
THR A 246
ALA A 247
ALA A 248
 None
None
LLP  A 150 ( 3.9A)
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
None
 0.28A 2ej3A-5mqzA:
39.3		 2ej3A-5mqzA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 PHE A  82
GLY A 232
GLY A 100
THR A  98
ALA A 101
 None
LLP  A 234 ( 4.3A)
LLP  A 234 ( 3.1A)
None
LLP  A 234 ( 3.5A)
 1.11A 2ej3B-3wksA:
undetectable		 2ej3B-3wksA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		10 / 10 PHE A  38
TYR A  98
ARG A 100
TYR A 166
GLY A 198
GLU A 199
GLY A 257
THR A 258
ALA A 259
ALA A 260
 LLP  A 161 ( 4.4A)
ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
LLP  A 161 ( 4.2A)
ALA  A 401 (-4.0A)
None
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
None
 0.31A 2ej3B-4whxA:
42.5		 2ej3B-4whxA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Archaeoglobus
fulgidus) 		9 / 10 PHE A  32
TYR A  87
ARG A  89
TYR A 154
GLY A 186
GLY A 245
THR A 246
ALA A 247
ALA A 248
 LLP  A 150 ( 3.9A)
None
None
LLP  A 150 ( 4.3A)
LLP  A 150 ( 3.9A)
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
None
 0.36A 2ej3B-5mqzA:
39.2		 2ej3B-5mqzA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 GLY A 172
THR A 173
ALA A 174
ALA A 175
 LLP  A 312 ( 3.5A)
LLP  A 312 ( 3.6A)
None
None
 0.53A 2ej3C-3f6tA:
undetectable		 2ej3C-3f6tA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 THR A 319
ALA A 258
ARG A 250
GLY A 200
SER A   6
 None
None
None
LLP  A 199 ( 2.4A)
None
 1.17A 2f162-1m6sA:
undetectable		 2f162-1m6sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3b46 AMINOTRANSFERASE
BNA3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 130
ALA A 297
ALA A 124
GLY A 123
THR A 122
 None
None
LLP  A 271 ( 3.4A)
LLP  A 271 ( 3.6A)
None
 1.04A 2f16H-3b46A:
undetectable
2f16I-3b46A:
undetectable		 2f16H-3b46A:
18.57
2f16I-3b46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 THR A 319
ALA A 258
ARG A 250
GLY A 200
SER A   6
 None
None
None
LLP  A 199 ( 2.4A)
None
 1.17A 2f16N-1m6sA:
undetectable		 2f16N-1m6sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3b46 AMINOTRANSFERASE
BNA3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 130
ALA A 297
ALA A 124
GLY A 123
THR A 122
 None
None
LLP  A 271 ( 3.4A)
LLP  A 271 ( 3.6A)
None
 1.05A 2f16V-3b46A:
undetectable
2f16W-3b46A:
undetectable		 2f16V-3b46A:
18.57
2f16W-3b46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(environmental
samples) 		4 / 7 HIS A  57
ASN A  65
THR A 277
GLY A 278
 None
None
LLP  A 274 ( 4.3A)
None
 0.99A 2f6dA-5uc7A:
undetectable		 2f6dA-5uc7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 LEU A 286
LEU A 253
LEU A 252
ILE A 254
TYR A 331
 LLP  A 285 ( 4.3A)
None
None
None
None
 1.25A 2f7aA-3w1hA:
undetectable		 2f7aA-3w1hA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE
(Klebsiella
pneumoniae) 		4 / 7 THR A  80
THR A  84
VAL A 149
MET A 135
 None
LLP  A 181 ( 4.9A)
None
None
 1.20A 2fb2B-6blgA:
undetectable		 2fb2B-6blgA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 ILE A  75
GLY A  76
GLY A  46
GLY A  71
ALA A  78
 None
LLP  A  42 ( 3.5A)
LLP  A  42 ( 3.8A)
SO4  A 404 (-3.3A)
None
 0.98A 2fk8A-5b1hA:
3.3		 2fk8A-5b1hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 11 ILE A 266
GLY A 237
THR A 233
ARG A 319
GLU A 282
 None
LLP  A  58 ( 4.4A)
None
None
LLP  A  58 ( 3.7A)
 1.35A 2fn1B-2gn1A:
undetectable		 2fn1B-2gn1A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 ILE A 216
SER A  91
VAL A 214
PHE A 154
LEU A 122
 None
LLP  A 221 ( 2.6A)
None
None
None
 1.24A 2ft9A-6c9bA:
undetectable		 2ft9A-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 11 ILE A 126
ASP A 208
GLY A 209
ALA A 210
GLY A 101
 None
LLP  A 234 ( 2.6A)
None
LLP  A 234 ( 3.3A)
LLP  A 234 ( 4.3A)
 1.09A 2fxdA-6c9eA:
undetectable		 2fxdA-6c9eA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 144
ALA A 143
GLY A 249
GLY A 281
ILE A 294
 None
LLP  A 285 ( 3.1A)
LLP  A 285 ( 3.0A)
None
None
 0.81A 2fxeA-3w1hA:
undetectable		 2fxeA-3w1hA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 173
THR A  46
ALA A 154
ALA A 191
PHE A 177
 None
None
LLP  A 181 ( 3.3A)
None
None
 0.80A 2gluB-6blgA:
2.5		 2gluB-6blgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 TYR X  79
ILE X  45
VAL X  80
ALA X  81
ILE X  65
 None
LLP  X  42 ( 4.0A)
None
None
None
 1.05A 2h42B-4li3X:
undetectable		 2h42B-4li3X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 TYR X  79
ILE X  45
VAL X  80
ALA X  81
ILE X  65
 None
LLP  X  42 ( 4.0A)
None
None
None
 1.04A 2h42C-4li3X:
undetectable		 2h42C-4li3X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 240
GLY A 278
ASP A 212
PRO A 253
TYR A 376
 LLP  A  61 ( 3.3A)
LLP  A  61 ( 3.5A)
None
None
LLP  A  61 ( 4.6A)
 1.09A 2hmyB-3vabA:
undetectable		 2hmyB-3vabA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 4 LEU A  87
PRO A  88
LEU A 283
ARG A 281
 None
None
LLP  A 280 ( 4.5A)
None
 1.30A 2hrcA-3pdxA:
undetectable		 2hrcA-3pdxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE
(Bacillus
cereus) 		5 / 12 GLY A 164
ALA A 161
ASP A 160
GLY A 198
ILE A 182
 None
None
LLP  A 190 ( 2.8A)
None
None
 0.96A 2hs2A-3ju7A:
undetectable		 2hs2A-3ju7A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3oks 4-AMINOBUTYRATE
TRANSAMINASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 291
GLY A 268
GLY A  63
LEU A 423
LEU A 411
 LLP  A 292 ( 2.7A)
None
None
None
None
 0.96A 2hw2A-3oksA:
undetectable		 2hw2A-3oksA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 12 ALA A 290
GLY A 267
GLY A  62
LEU A 422
LEU A 410
 LLP  A 291 ( 2.7A)
None
None
None
None
 0.93A 2hw2A-3r4tA:
undetectable		 2hw2A-3r4tA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)
(Mycobacteroides
abscessus) 		5 / 12 ALA A 289
GLY A 266
GLY A  66
LEU A 421
LEU A 409
 LLP  A 290 ( 2.7A)
None
None
None
None
 1.04A 2hw2A-4ffcA:
undetectable		 2hw2A-4ffcA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A  89
ARG A 215
GLY A 214
LYS A 235
 None
LLP  A 234 ( 3.9A)
None
LLP  A 234 ( 3.6A)
 1.44A 2i30A-3wksA:
undetectable		 2i30A-3wksA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 SER A 130
SER A 281
SER A 163
THR A 162
 None
None
None
LLP  A 185 ( 3.4A)
 1.06A 2i91A-1iugA:
3.9		 2i91A-1iugA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 SER A 130
SER A 281
SER A 163
THR A 162
 None
None
None
LLP  A 185 ( 3.4A)
 1.06A 2i91B-1iugA:
3.7		 2i91B-1iugA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 12 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.43A 2ienA-2gn1A:
undetectable		 2ienA-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ALA A 319
ALA A 301
ALA A 321
PRO A 243
GLY A 318
 None
None
None
None
LLP  A  91 ( 4.4A)
 1.23A 2igtC-3iauA:
3.2		 2igtC-3iauA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		4 / 8 HIS A 188
HIS A 260
ALA A 264
VAL A 349
 LLP  A 187 ( 4.8A)
None
None
None
 0.84A 2it4A-4zwvA:
undetectable		 2it4A-4zwvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		3 / 3 ALA A 268
GLY A 217
SER A 344
 None
LLP  A  91 ( 3.4A)
LLP  A  91 ( 2.7A)
 0.54A 2ivuA-3iauA:
undetectable		 2ivuA-3iauA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 11 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.45A 2iyfA-4xg1A:
undetectable		 2iyfA-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		4 / 8 SER A 158
SER A 157
ASP A 160
ARG A 140
 LLP  A  63 ( 4.6A)
None
None
None
 1.02A 2j2pA-5ybwA:
undetectable
2j2pB-5ybwA:
undetectable		 2j2pA-5ybwA:
18.96
2j2pB-5ybwA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE
(Campylobacter
jejuni) 		4 / 6 SER A 152
LEU A 189
ASP A 180
GLU A  72
 None
None
LLP  A 205 ( 3.2A)
None
 1.12A 2j2pE-4oc9A:
undetectable
2j2pF-4oc9A:
undetectable		 2j2pE-4oc9A:
17.72
2j2pF-4oc9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ASP A 208
LEU A 214
PHE A 217
VAL A 182
ALA A 181
 None
None
None
LLP  A  42 ( 4.0A)
None
 1.08A 2kceB-5jjcA:
undetectable		 2kceB-5jjcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 11 GLY A 322
ILE A 318
ALA A 301
THR A 303
ILE A 275
 LLP  A  63 ( 3.8A)
None
None
None
None
 1.11A 2nnhA-5ybwA:
undetectable		 2nnhA-5ybwA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		6 / 12 SER A 311
SER A 309
ASN A  41
THR A 396
ALA A 288
VAL A 418
 LLP  A 312 ( 2.6A)
LLP  A 312 ( 2.5A)
None
None
None
None
 1.49A 2nniA-3f6tA:
undetectable		 2nniA-3f6tA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE
(Pseudomonas
putida) 		5 / 12 ASN A 245
ASN A 175
THR A 270
ALA A  72
VAL A 119
 LLP  A  75 ( 4.2A)
None
None
None
None
 1.28A 2nniA-4dyjA:
undetectable		 2nniA-4dyjA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ASP A 244
ILE A 271
GLY A 249
ILE A 251
VAL A 221
 LLP  A 277 ( 2.8A)
None
None
None
None
 0.88A 2nnkA-3hbxA:
undetectable		 2nnkA-3hbxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.78A 2nnkA-2z61A:
undetectable		 2nnkA-2z61A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 9 THR A 107
GLY A 262
THR A 110
ALA A 113
LEU A 116
 None
None
LLP  A 252 ( 4.2A)
None
None
 1.25A 2npnA-3nraA:
undetectable		 2npnA-3nraA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 249
ALA A 245
ASP A 244
GLY A 286
ILE A 271
 None
None
LLP  A 277 ( 2.8A)
None
None
 0.88A 2o4sA-3hbxA:
undetectable		 2o4sA-3hbxA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE
(Bacillus
cereus) 		5 / 12 GLY A 164
ALA A 161
ASP A 160
GLY A 198
ILE A 182
 None
None
LLP  A 190 ( 2.8A)
None
None
 0.96A 2o4sA-3ju7A:
undetectable		 2o4sA-3ju7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 ILE A  57
GLY A 203
VAL A 182
SER A  28
PRO A 212
 None
None
LLP  A 206 ( 4.1A)
LLP  A 206 ( 2.6A)
None
 1.03A 2okcA-2hufA:
3.3		 2okcA-2hufA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 ILE A 218
ALA A 120
GLY A 113
VAL A 144
PHE A 277
 LLP  A 253 ( 3.9A)
None
LLP  A 253 ( 3.6A)
None
None
 1.17A 2okcB-1bw0A:
3.1		 2okcB-1bw0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 ILE A  57
GLY A 203
VAL A 182
SER A  28
PRO A 212
 None
None
LLP  A 206 ( 4.1A)
LLP  A 206 ( 2.6A)
None
 1.06A 2okcB-2hufA:
3.2		 2okcB-2hufA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		6 / 12 GLY A 164
GLY A 162
GLY A  59
THR A 165
LEU A 168
ILE A 193
 None
None
LLP  A  56 ( 3.9A)
None
None
None
 1.46A 2oxtB-3l6rA:
undetectable		 2oxtB-3l6rA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE
(Pseudomonas
putida) 		4 / 5 SER A 246
GLY A 263
ASP A 409
ASP A 269
 LLP  A  75 ( 2.6A)
LLP  A  75 ( 3.5A)
SO4  A 503 (-4.6A)
None
 1.04A 2oxtB-4dyjA:
undetectable		 2oxtB-4dyjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		4 / 7 GLN A  42
TYR A 393
TYR A 236
ILE A 342
 None
None
LLP  A 234 ( 4.3A)
None
 1.27A 2ph9A-4w91A:
undetectable
2ph9B-4w91A:
undetectable		 2ph9A-4w91A:
19.13
2ph9B-4w91A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Legionella
pneumophila) 		3 / 3 LEU A 136
PRO A 135
LEU A 139
 None
None
LLP  A 140 ( 4.2A)
 0.56A 2po7B-3lulA:
undetectable		 2po7B-3lulA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		5 / 12 SER A 346
LEU A 105
VAL A 100
HIS A 161
LEU A   4
 None
None
None
LLP  A 187 ( 3.6A)
None
 1.32A 2prgB-4zwvA:
undetectable		 2prgB-4zwvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 9 ALA A 235
ASP A 236
GLY A 312
ILE A 310
VAL A 208
 None
None
LLP  A  58 ( 3.5A)
None
None
 1.03A 2q5kA-2gn1A:
undetectable		 2q5kA-2gn1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 9 ALA A 243
ASP A 244
GLY A 322
ILE A 290
VAL A 214
 None
None
LLP  A  63 ( 3.8A)
None
None
 0.90A 2q5kA-5ybwA:
undetectable		 2q5kA-5ybwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 12 ALA A 173
ASP A 201
VAL A 224
ILE A 202
PRO A 219
 None
LLP  A 230 ( 2.9A)
None
None
None
 0.81A 2q5kB-4j5uA:
undetectable		 2q5kB-4j5uA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 6 ASP A 256
VAL A 258
PHE A 221
THR A 161
 LLP  A 285 ( 3.0A)
LLP  A 285 ( 4.1A)
None
None
 1.26A 2q6oB-4grxA:
undetectable		 2q6oB-4grxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		5 / 12 LEU A 322
ASN A 170
GLY A 173
VAL A 325
ARG A 302
 None
LLP  A 233 ( 3.9A)
None
None
PEG  A 397 (-4.1A)
 1.39A 2q7lA-3dzzA:
undetectable		 2q7lA-3dzzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3nu8 AMINOTRANSFERASE
WBPE
(Pseudomonas
aeruginosa) 		5 / 10 THR A  60
THR A  80
VAL A  86
VAL A 130
ILE A 128
 LLP  A 185 ( 3.7A)
None
None
None
None
 1.28A 2qboA-3nu8A:
undetectable		 2qboA-3nu8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		4 / 8 LEU A  55
SER A 103
VAL A 195
GLY A 196
 None
LLP  A  61 ( 3.9A)
None
None
 1.11A 2qd5A-3vabA:
2.8		 2qd5A-3vabA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		5 / 12 GLY A 269
ILE A 233
ASP A  69
ARG A 237
VAL A 275
 LLP  A 172 ( 3.5A)
LLP  A 172 ( 4.1A)
None
None
None
 1.06A 2qe6B-4tviA:
undetectable		 2qe6B-4tviA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 11 ALA A 243
ASP A 244
GLY A 322
ILE A 290
VAL A 214
 None
None
LLP  A  63 ( 3.8A)
None
None
 1.02A 2qhcA-5ybwA:
undetectable		 2qhcA-5ybwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE
(Bacillus
cereus) 		4 / 6 TYR A 135
THR A  90
ALA A  89
PRO A  83
 LLP  A 190 ( 3.8A)
None
LLP  A 190 ( 3.3A)
None
 1.23A 2ql8A-3ju7A:
undetectable
2ql8B-3ju7A:
undetectable		 2ql8A-3ju7A:
15.30
2ql8B-3ju7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bn1 PEROSAMINE
SYNTHETASE
(Caulobacter
vibrioides) 		4 / 7 GLY A  60
THR A  62
CYH A  57
PHE A  41
 LLP  A 186 ( 3.4A)
None
None
None
 1.09A 2qx4A-3bn1A:
undetectable
2qx4B-3bn1A:
undetectable		 2qx4A-3bn1A:
20.63
2qx4B-3bn1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3bn1 PEROSAMINE
SYNTHETASE
(Caulobacter
vibrioides) 		4 / 7 GLY A  60
THR A  62
CYH A  57
PHE A  45
 LLP  A 186 ( 3.4A)
None
None
None
 1.16A 2qx4A-3bn1A:
undetectable
2qx4B-3bn1A:
undetectable		 2qx4A-3bn1A:
20.63
2qx4B-3bn1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A 235
HIS A 233
ALA A 210
ALA A 230
ALA A 101
 LLP  A 234 ( 3.2A)
LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.4A)
None
LLP  A 234 ( 3.5A)
 1.22A 2r2vC-3wksA:
undetectable
2r2vF-3wksA:
undetectable
2r2vG-3wksA:
undetectable		 2r2vC-3wksA:
7.14
2r2vF-3wksA:
7.14
2r2vG-3wksA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 12 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.46A 2r5pD-2gn1A:
undetectable		 2r5pD-2gn1A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 11 ALA A 284
GLU A 282
VAL A 208
GLY A 312
ILE A 310
 LLP  A  58 ( 3.4A)
LLP  A  58 ( 3.7A)
None
LLP  A  58 ( 3.5A)
None
 1.11A 2uxpB-2gn1A:
undetectable		 2uxpB-2gn1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3dzz PUTATIVE PYRIDOXAL
5'-PHOSPHATE-DEPENDE
NT C-S LYASE
(Lactobacillus
delbrueckii) 		4 / 7 ALA A  96
VAL A 124
ASP A 198
LEU A 228
 None
None
LLP  A 233 ( 2.8A)
None
 0.85A 2uyqA-3dzzA:
3.6		 2uyqA-3dzzA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		4 / 7 ALA A 286
GLY A 289
VAL A 396
LEU A 371
 None
None
None
LLP  A 226 ( 4.1A)
 0.76A 2uyqA-3fd0A:
3.9		 2uyqA-3fd0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 7 ASN A  48
LEU A  49
THR A  44
VAL A 256
 None
None
None
LLP  A 253 ( 4.1A)
 1.17A 2uz2A-1bw0A:
undetectable		 2uz2A-1bw0A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 7 ASN A  86
LEU A  87
THR A  82
VAL A 289
 None
None
None
LLP  A 286 ( 3.7A)
 1.17A 2uz2A-4ix8A:
undetectable		 2uz2A-4ix8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		4 / 7 ILE A  35
THR A 315
ILE A 299
GLY A 217
 None
LLP  A  51 ( 3.4A)
None
None
 0.90A 2v0mB-4d8uA:
undetectable		 2v0mB-4d8uA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 12 LEU A 371
LEU A 381
ALA A 366
THR A 391
MET A 361
 None
None
LLP  A 396 ( 3.5A)
None
None
 1.26A 2v0mC-2okkA:
undetectable		 2v0mC-2okkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 LEU A 173
VAL A 167
GLY A 168
GLY A 175
ALA A 232
 None
LLP  A  41 ( 4.1A)
LLP  A  41 ( 3.5A)
None
None
 0.94A 2v3kA-4h27A:
undetectable		 2v3kA-4h27A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		5 / 12 GLY A 237
GLY A  85
ILE A 225
ALA A 233
THR A  91
 None
LLP  A 226 ( 3.5A)
LLP  A 226 ( 4.3A)
None
None
 1.25A 2vdvE-3fd0A:
undetectable		 2vdvE-3fd0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		5 / 11 GLY A 237
GLY A  85
ILE A 225
ALA A 233
THR A  91
 None
LLP  A 226 ( 3.5A)
LLP  A 226 ( 4.3A)
None
None
 1.25A 2vdvF-3fd0A:
undetectable		 2vdvF-3fd0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 9 ALA B  91
SER B 251
GLY B 247
SER B  87
ALA B  86
 None
None
None
LLP  B 210 ( 3.7A)
None
 1.38A 2vh3A-4iyoB:
undetectable		 2vh3A-4iyoB:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		6 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
 0.97A 2vmyB-4j5uA:
60.1		 2vmyB-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 12 LEU A 121
HIS A 126
LEU A 127
SER A 176
ARG A 362
 None
LLP  A 230 ( 3.5A)
None
None
None
 1.02A 2vmyB-4j5uA:
60.1		 2vmyB-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 LEU A 166
GLY A 169
HIS A 171
LEU A 172
SER A 226
ALA A 227
ARG A 425
 8Z1  A 601 (-4.7A)
8Z1  A 601 ( 3.8A)
LLP  A 280 (-3.3A)
8Z1  A 601 (-4.1A)
LLP  A 280 (-3.4A)
8Z1  A 601 ( 4.3A)
8Z1  A 601 ( 3.8A)
 0.56A 2vmyB-5v7iA:
52.1		 2vmyB-5v7iA:
43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		9 / 12 LEU A 204
GLY A 207
HIS A 209
LEU A 210
VAL A 221
SER A 264
ALA A 265
ASN A 439
ARG A 454
 None
None
LLP  A 318 (-3.5A)
None
None
ACT  A 612 (-2.7A)
None
None
ACT  A 612 (-2.9A)
 0.64A 2vmyB-6cczA:
57.4		 2vmyB-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER A  76
HIS A 171
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.27A 2vmyA-5v7iA:
52.1
2vmyB-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
2vmyB-5v7iA:
43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 7 SER A 114
HIS A 209
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.63A 2vmyA-6cczA:
57.3
2vmyB-6cczA:
57.4		 2vmyA-6cczA:
undetectable
2vmyB-6cczA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		7 / 12 LEU A 118
GLY A 121
HIS A 123
LEU A 124
SER A 173
ALA A 174
ASN A 345
 None
None
LLP  A 227 ( 3.6A)
None
None
None
None
 0.93A 2vmyA-3h7fA:
54.1		 2vmyA-3h7fA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		7 / 12 LEU A 118
HIS A 123
LEU A 124
SER A 173
ALA A 174
ASN A 345
ARG A 363
 None
LLP  A 227 ( 3.6A)
None
None
None
None
None
 1.41A 2vmyA-3h7fA:
54.1		 2vmyA-3h7fA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 176
ALA A 177
ARG A 362
 None
None
LLP  A 230 ( 3.5A)
None
None
None
None
 0.99A 2vmyA-4j5uA:
60.2		 2vmyA-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		7 / 12 LEU A 121
HIS A 126
LEU A 127
SER A 176
ALA A 177
ASN A 344
ARG A 362
 None
LLP  A 230 ( 3.5A)
None
None
None
None
None
 1.16A 2vmyA-4j5uA:
60.2		 2vmyA-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		4 / 8 SER A  32
HIS A 123
SER A 173
HIS A 201
 None
LLP  A 227 ( 3.6A)
None
LLP  A 227 ( 4.2A)
 0.75A 2vmyA-3h7fA:
54.1
2vmyB-3h7fA:
54.0		 2vmyA-3h7fA:
55.15
2vmyB-3h7fA:
55.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		4 / 8 SER A  35
HIS A 126
SER A 176
HIS A 204
 LLP  A 230 ( 4.9A)
LLP  A 230 ( 3.5A)
None
LLP  A 230 ( 4.1A)
 0.68A 2vmyA-4j5uA:
60.2
2vmyB-4j5uA:
60.1		 2vmyA-4j5uA:
57.69
2vmyB-4j5uA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
 None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
 0.33A 2vmyA-5v7iA:
52.1
2vmyB-5v7iA:
52.1		 2vmyA-5v7iA:
43.79
2vmyB-5v7iA:
43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 8 SER A 114
HIS A 209
SER A 264
HIS A 292
ARG A 454
 ACT  A 612 (-2.3A)
LLP  A 318 (-3.5A)
ACT  A 612 (-2.7A)
LLP  A 318 (-3.4A)
ACT  A 612 (-2.9A)
 0.58A 2vmyA-6cczA:
57.3
2vmyB-6cczA:
57.4		 2vmyA-6cczA:
undetectable
2vmyB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 11 ILE X 234
ALA X 231
ILE X 210
SER X 181
ILE X 182
 None
None
None
LLP  X  42 ( 2.4A)
None
 0.97A 2w9sA-4li3X:
2.7		 2w9sA-4li3X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 11 ILE X 234
ALA X 231
ILE X 210
SER X 181
ILE X 182
 None
None
None
LLP  X  42 ( 2.4A)
None
 0.96A 2w9sB-4li3X:
2.7		 2w9sB-4li3X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 10 ILE X 234
ALA X 231
ILE X 210
SER X 181
ILE X 182
 None
None
None
LLP  X  42 ( 2.4A)
None
 0.94A 2w9sC-4li3X:
2.7		 2w9sC-4li3X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		4 / 7 TYR A 218
VAL A 182
GLY A 235
ALA A 212
 None
LLP  A  42 ( 4.0A)
None
None
 0.93A 2wekB-5jjcA:
2.6		 2wekB-5jjcA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE
(Klebsiella
pneumoniae) 		6 / 12 ALA A 371
GLY A 180
HIS A 295
GLY A 203
ILE A  22
LEU A 179
 None
None
None
LLP  A 200 ( 4.9A)
LLP  A 200 ( 4.1A)
None
 1.46A 2x1lB-3nnkA:
undetectable		 2x1lB-3nnkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ASN A 256
PRO A 403
LEU A 417
ILE A 416
SER A 249
 LLP  A 405 ( 4.6A)
None
None
None
None
 1.31A 2xrlA-2okjA:
undetectable		 2xrlA-2okjA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		5 / 12 SER A 309
PHE A 314
LEU A 166
ILE A 146
SER A 394
 LLP  A 312 ( 2.5A)
None
None
None
None
 1.32A 2xrlA-3f6tA:
2.0		 2xrlA-3f6tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		4 / 7 TYR A 251
TYR A 214
CYH A 180
CYH A 181
 LLP  A 246 ( 4.6A)
LLP  A 246 ( 4.0A)
None
None
 1.31A 2xytG-4wd2A:
undetectable		 2xytG-4wd2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 THR A 300
ILE A 388
ALA A 307
GLY A 306
GLY A 407
 None
LLP  A 243 ( 3.8A)
None
None
None
 1.08A 2y7hB-3hvyA:
undetectable		 2y7hB-3hvyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 THR A 300
ILE A 388
ALA A 307
GLY A 306
GLY A 407
 None
LLP  A 243 ( 3.8A)
None
None
None
 1.08A 2y7hC-3hvyA:
undetectable		 2y7hC-3hvyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 10 THR A 101
ILE A 104
GLY A 105
HIS A 180
THR A 128
 LLP  A 243 ( 3.3A)
None
None
None
LLP  A 243 ( 4.8A)
 1.26A 2y7wB-3hvyA:
undetectable		 2y7wB-3hvyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 HIS A 162
VAL A 185
GLY A 186
ILE A 182
ALA A 183
 None
LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.5A)
None
None
 1.18A 2yy8A-3tbhA:
2.9
2yy8B-3tbhA:
undetectable		 2yy8A-3tbhA:
20.59
2yy8B-3tbhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 12 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.46A 2z54B-2gn1A:
undetectable		 2z54B-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 11 VAL A  92
LEU A  95
TYR A 116
CYH A 163
ASP A 195
 LLP  A 230 ( 3.8A)
None
LLP  A 230 ( 3.8A)
LLP  A 230 ( 3.5A)
LLP  A 230 ( 3.0A)
 0.84A 2z9xB-3t32A:
22.6		 2z9xB-3t32A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 11 THR A 136
VAL A 131
MET A 146
ILE A 147
ALA A 165
 LLP  A 187 ( 3.0A)
None
None
None
None
 1.19A 2zbzA-3f0hA:
undetectable		 2zbzA-3f0hA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		4 / 5 LEU A 321
GLN A  77
THR A 288
HIS A 314
 None
None
LLP  A  51 ( 4.5A)
None
 1.19A 2zj0B-4d8uA:
3.2		 2zj0B-4d8uA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 12 LEU A 234
SER A 161
SER A 193
LEU A 206
LEU A   3
 None
LLP  A  51 ( 3.4A)
None
None
None
 1.43A 2zlcA-4d8uA:
undetectable		 2zlcA-4d8uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 11 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.04A 2zmaA-4li3X:
undetectable		 2zmaA-4li3X:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.14A 2zmaA-5xa2A:
undetectable		 2zmaA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		5 / 12 SER A 222
ASN A  99
ILE A  30
THR A 228
ASN A 345
 None
LLP  A 227 ( 4.7A)
None
LLP  A 227 ( 4.1A)
None
 1.12A 3a25A-3h7fA:
4.0		 3a25A-3h7fA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.08A 3a65A-4li3X:
undetectable		 3a65A-4li3X:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.17A 3a65A-5xa2A:
undetectable		 3a65A-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 10 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.06A 3a66A-4li3X:
0.0		 3a66A-4li3X:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.15A 3a66A-5xa2A:
0.0		 3a66A-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 MET A 301
ILE A 309
PHE A  87
ASP A 208
GLU A 130
 None
None
None
LLP  A 234 ( 2.5A)
None
 1.47A 3aocC-4w91A:
undetectable		 3aocC-4w91A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 PHE B 269
ALA B 243
PHE B 285
GLY B 248
LEU B 330
 None
None
None
LLP  B 101 ( 3.3A)
None
 1.44A 3aodC-5tchB:
undetectable		 3aodC-5tchB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  65
PHE A  76
LEU A 301
SER A 308
TYR A  61
 None
None
None
LLP  A  83 ( 4.7A)
None
 1.43A 3apvA-1tufA:
undetectable		 3apvA-1tufA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  65
PHE A  76
LEU A 301
SER A 308
TYR A  61
 None
None
None
LLP  A  83 ( 4.7A)
None
 1.45A 3apvB-1tufA:
undetectable		 3apvB-1tufA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 6 TRP A 105
SER A 109
ALA A 110
ASP A 107
 LLP  A 206 ( 3.5A)
None
None
None
 1.36A 3aruA-2hufA:
undetectable		 3aruA-2hufA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 VAL A 331
GLY A 327
LYS A 326
THR A 153
GLY A 156
 None
None
None
LLP  A 198 ( 3.5A)
None
 1.11A 3bjwG-1bjnA:
0.0		 3bjwG-1bjnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN
(Trichomonas
vaginalis) 		5 / 9 VAL A 342
GLY A 338
LYS A 337
THR A 158
GLY A 161
 None
None
None
LLP  A 202 ( 3.0A)
None
 1.13A 3bjwG-5f8vA:
undetectable		 3bjwG-5f8vA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.15A 3bjwA-4iyoB:
undetectable		 3bjwA-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		4 / 6 VAL A  79
GLY A  61
ARG A  20
LEU A  21
 None
LLP  A  58 ( 4.2A)
None
None
 1.05A 3bjwE-2gn1A:
undetectable		 3bjwE-2gn1A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.22A 3bjwG-4iyoB:
undetectable		 3bjwG-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.17A 3bjwC-4iyoB:
undetectable		 3bjwC-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 VAL B 205
VAL B 204
THR B  94
THR B 187
 None
None
None
LLP  B 210 ( 3.8A)
 1.15A 3bjwD-4iyoB:
undetectable		 3bjwD-4iyoB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 GLY A 249
GLY A 262
GLY A 109
GLY A 112
 None
None
LLP  A 252 ( 3.5A)
None
 0.45A 3bogA-3nraA:
undetectable
3bogC-3nraA:
undetectable		 3bogA-3nraA:
undetectable
3bogC-3nraA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 GLY A 112
GLY A 250
GLY A 263
 LLP  A 253 ( 4.6A)
None
None
 0.39A 3bogC-1bw0A:
0.0		 3bogC-1bw0A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  97
GLY A 219
GLY A 232
 LLP  A 222 ( 3.8A)
None
None
 0.44A 3bogC-2z61A:
undetectable		 3bogC-2z61A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		3 / 3 GLY A 143
GLY A 277
GLY A 290
 LLP  A 280 ( 3.1A)
None
None
 0.39A 3bogC-3pdxA:
undetectable		 3bogC-3pdxA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 GLY A  99
GLY A 231
GLY A 244
 LLP  A 234 ( 3.5A)
None
LLP  A 234 ( 4.9A)
 0.37A 3bogD-1bjwA:
0.0		 3bogD-1bjwA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 GLY A 112
GLY A 250
GLY A 263
 LLP  A 253 ( 4.6A)
None
None
 0.34A 3bogD-1bw0A:
0.0		 3bogD-1bw0A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  97
GLY A 219
GLY A 232
 LLP  A 222 ( 3.8A)
None
None
 0.37A 3bogD-2z61A:
undetectable		 3bogD-2z61A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 GLY A 109
GLY A 249
GLY A 262
 LLP  A 252 ( 3.5A)
None
None
 0.41A 3bogD-3nraA:
undetectable		 3bogD-3nraA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		3 / 3 GLY A 143
GLY A 277
GLY A 290
 LLP  A 280 ( 3.1A)
None
None
 0.42A 3bogD-3pdxA:
undetectable		 3bogD-3pdxA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.14A 3bwmA-6cczA:
3.8		 3bwmA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.14A 3bwyA-6cczA:
4.1		 3bwyA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 ALA A  24
GLY A 275
THR A 190
VAL A 194
THR A 166
 None
None
LLP  A  51 ( 3.7A)
None
None
 1.14A 3c6gB-3tbhA:
undetectable		 3c6gB-3tbhA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 4 THR B  94
VAL B 205
GLY B 220
THR B 209
 None
None
None
LLP  B 210 ( 3.5A)
 1.05A 3cflA-4iyoB:
undetectable		 3cflA-4iyoB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		4 / 4 THR A  94
VAL A 205
GLY A 220
THR A 209
 None
None
LLP  A 210 ( 4.8A)
LLP  A 210 ( 3.4A)
 1.04A 3cflA-4p7yA:
undetectable		 3cflA-4p7yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 ASP A 244
GLY A 245
GLY A 295
ILE A 290
PRO A 331
 None
LLP  A  63 ( 4.2A)
None
None
None
 1.01A 3d20A-5ybwA:
undetectable		 3d20A-5ybwA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 8 GLY A 313
GLY A 273
GLY A 275
ILE A  67
THR A  69
 None
LLP  A 270 ( 4.0A)
None
None
None
 1.29A 3d41A-3l44A:
undetectable		 3d41A-3l44A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 VAL A 191
SER A 189
ILE A 257
ALA A 287
ILE A 304
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.20A 3ddyA-4il5A:
undetectable		 3ddyA-4il5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2odo ALANINE RACEMASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A  66
ALA A  73
LEU A  29
LEU A  78
ALA A  63
 None
None
None
LLP  A  33 ( 4.1A)
None
 1.13A 3dfrA-2odoA:
undetectable		 3dfrA-2odoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 235
GLY A  95
SER A 222
VAL A  90
ARG A 233
 None
LLP  A 227 ( 3.2A)
None
None
None
 1.01A 3dlcA-3h7fA:
undetectable		 3dlcA-3h7fA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 PHE A  90
TYR A  45
GLY A  94
GLY A 194
VAL A 123
 LLP  A  91 ( 3.9A)
None
LLP  A  91 ( 4.5A)
None
None
 1.28A 3dlcA-3iauA:
2.2		 3dlcA-3iauA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 4 ILE A 121
GLN A 182
ILE A 202
LEU A 129
 None
LLP  A 243 ( 4.0A)
None
None
 1.29A 3dzyD-3hvyA:
undetectable		 3dzyD-3hvyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
monocytogenes) 		4 / 4 ILE A 106
GLN A 165
ILE A 185
LEU A 114
 None
LLP  A 226 ( 4.1A)
None
None
 1.31A 3dzyD-3jzlA:
undetectable		 3dzyD-3jzlA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 11 GLY A 244
ILE A 222
VAL A 208
GLY A  88
ILE A  89
 None
None
None
LLP  A 210 ( 3.5A)
LLP  A 210 ( 4.3A)
 1.04A 3ebzB-4p7yA:
undetectable		 3ebzB-4p7yA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.81A 3eeyC-3hvyA:
5.6		 3eeyC-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.75A 3eeyC-3w1hA:
undetectable		 3eeyC-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.83A 3eeyD-3hvyA:
5.5		 3eeyD-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.77A 3eeyD-3w1hA:
3.9		 3eeyD-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASN A  99
ASP A 217
GLN A 182
 LLP  A 243 ( 3.3A)
LLP  A 243 ( 2.9A)
LLP  A 243 ( 4.0A)
 0.83A 3eeyE-3hvyA:
4.3		 3eeyE-3hvyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.75A 3eeyE-3w1hA:
4.0		 3eeyE-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)
(Mycobacteroides
abscessus) 		5 / 12 ILE A  54
VAL A  53
GLY A  52
ILE A 426
ALA A  70
 None
None
None
None
LLP  A 290 ( 3.9A)
 0.99A 3ekwB-4ffcA:
undetectable		 3ekwB-4ffcA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		5 / 9 VAL A 150
ILE A 255
ILE A 220
ALA A 157
ILE A 154
 LLP  A 286 ( 3.3A)
LLP  A 286 ( 3.8A)
None
None
None
 1.03A 3el0B-4ix8A:
undetectable		 3el0B-4ix8A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ASP A 244
ILE A 271
GLY A 249
ILE A 251
VAL A 221
 LLP  A 277 ( 2.8A)
None
None
None
None
 0.91A 3el4A-3hbxA:
undetectable		 3el4A-3hbxA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 10 ASP A 244
GLY A 245
GLY A 295
ILE A 290
PRO A 331
 None
LLP  A  63 ( 4.2A)
None
None
None
 1.06A 3el9B-5ybwA:
undetectable		 3el9B-5ybwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 VAL A  34
LYS A  31
HIS A  44
 None
None
LLP  A  46 ( 3.6A)
 0.95A 3elzA-3llxA:
undetectable		 3elzA-3llxA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		3 / 3 ASN A  79
HIS A  80
VAL A 158
 LLP  A  51 (-3.6A)
LLP  A  51 (-4.8A)
None
 0.65A 3elzB-4d8uA:
undetectable		 3elzB-4d8uA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 11 GLY A 358
ALA A 359
ILE A 245
LEU A 258
ILE A 217
 None
None
LLP  A 270 ( 4.2A)
None
None
 0.87A 3em4A-3l44A:
undetectable		 3em4A-3l44A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 8 GLY A 285
ALA A 284
ASP A 236
GLY A 184
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
 1.27A 3em6A-2gn1A:
undetectable		 3em6A-2gn1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		3 / 3 TYR A 327
TYR A 129
GLY A  37
 None
LLP  A 244 (-3.5A)
MES  A 400 (-3.9A)
 0.69A 3eteB-3jtxA:
2.3
3eteD-3jtxA:
2.2
3eteF-3jtxA:
2.3		 3eteB-3jtxA:
22.46
3eteD-3jtxA:
22.46
3eteF-3jtxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 SER A 391
TYR A 220
ALA A 392
GLY A 402
TYR A 187
 None
LLP  A 243 ( 3.6A)
None
None
None
 1.12A 3f8wA-3hvyA:
undetectable		 3f8wA-3hvyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 SER A 391
TYR A 220
ALA A 392
GLY A 402
TYR A 187
 None
LLP  A 243 ( 3.6A)
None
None
None
 1.12A 3f8wC-3hvyA:
undetectable		 3f8wC-3hvyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 MET A 125
ILE A 192
GLU A 145
LEU A 142
VAL A  84
 None
None
LLP  A 199 ( 3.7A)
None
None
 1.23A 3fpjB-6cjbA:
4.1		 3fpjB-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 12 MET A 125
ILE A 192
VAL A 193
GLU A 145
LEU A 142
 None
None
None
LLP  A 199 ( 3.7A)
None
 1.22A 3fpjB-6cjbA:
4.1		 3fpjB-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 7 GLY A 203
GLY A 194
GLU A 224
ALA A 236
 None
LLP  A 196 ( 4.4A)
None
None
 0.82A 3fpjB-4ixoA:
2.6		 3fpjB-4ixoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 7 GLN B 246
GLY B  88
GLY B 220
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
 0.82A 3fpjB-4iyoB:
2.4		 3fpjB-4iyoB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 12 GLY A 209
HIS A 233
LEU A 294
VAL A  84
ILE A  88
 None
LLP  A 234 ( 3.7A)
None
None
None
 1.17A 3g9eA-6c9eA:
undetectable		 3g9eA-6c9eA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 LEU A 129
LEU A 110
ILE A 118
THR A 156
ASP A 120
 None
None
None
LLP  A 221 ( 3.5A)
None
 1.01A 3gcsA-6c9bA:
undetectable		 3gcsA-6c9bA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 7 TYR A 281
ILE A 446
THR A 403
GLY A 253
 LLP  A 312 ( 4.0A)
None
None
None
 0.85A 3gssA-4tv7A:
undetectable		 3gssA-4tv7A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 7 TYR A 281
ILE A 446
THR A 403
GLY A 253
 LLP  A 312 ( 4.0A)
None
None
None
 0.81A 3gssB-4tv7A:
undetectable		 3gssB-4tv7A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 CYH A 375
THR A 378
THR A 379
ILE A  22
LEU A 302
 None
None
None
LLP  A 200 ( 4.1A)
None
 1.06A 3gwxA-3nnkA:
undetectable		 3gwxA-3nnkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 7 MET A 261
LEU A 301
SER A 398
GLY A 252
 None
None
None
LLP  A 405 ( 3.4A)
 1.10A 3hcnA-2okjA:
4.2		 3hcnA-2okjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Legionella
pneumophila) 		3 / 3 LEU A 136
PRO A 135
LEU A 139
 None
None
LLP  A 140 ( 4.2A)
 0.55A 3hcrA-3lulA:
undetectable		 3hcrA-3lulA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 305
GLY A 304
LEU A 265
SER A 309
ALA A 222
 LLP  A  41 ( 3.9A)
LLP  A  41 ( 4.6A)
None
None
LLP  A  41 ( 3.7A)
 1.19A 3i5uB-4h27A:
2.7		 3i5uB-4h27A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 176
GLY A 221
PRO A 202
SER A 264
ALA A  70
 LLP  A  42 ( 3.7A)
None
None
None
SO4  A 404 (-3.7A)
 1.05A 3i5uB-5b1hA:
2.3		 3i5uB-5b1hA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 GLY A 109
ALA A 113
GLU A 112
ILE A 264
GLN A 293
 LLP  A 255 ( 3.2A)
None
None
None
None
 0.99A 3id6C-5vehA:
undetectable		 3id6C-5vehA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
LEU A  73
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
None
None
LLP  A 226 ( 2.9A)
None
 1.20A 3ijxB-3getA:
undetectable
3ijxD-3getA:
undetectable		 3ijxB-3getA:
22.58
3ijxD-3getA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 10 ILE A 285
SER A 280
GLY A 282
SER A 308
LEU A  29
 None
LLP  A  58 ( 2.5A)
None
LLP  A  58 ( 3.3A)
None
 1.38A 3ik6B-4il5A:
undetectable
3ik6E-4il5A:
undetectable		 3ik6B-4il5A:
22.81
3ik6E-4il5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 PHE A 254
GLY A 279
SER A 247
ILE A 285
THR A 123
 None
LLP  A 277 ( 4.4A)
LLP  A 277 ( 4.6A)
None
None
 1.24A 3iv6A-3hbxA:
undetectable		 3iv6A-3hbxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		5 / 12 TRP A 323
GLY A 340
THR A 338
ILE A 212
ARG A 346
 None
None
None
LLP  A  34 ( 3.9A)
None
 1.27A 3iv6C-4qhrA:
undetectable		 3iv6C-4qhrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 GLY A 185
THR A 247
ASP A 239
ASP A 154
ARG A 242
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.04A 3iv6D-2gn1A:
2.3		 3iv6D-2gn1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		5 / 12 TRP A 323
GLY A 340
THR A 338
ILE A 212
ARG A 346
 None
None
None
LLP  A  34 ( 3.9A)
None
 1.15A 3iv6D-4qhrA:
undetectable		 3iv6D-4qhrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		6 / 12 ILE A  66
GLY A  63
ALA A  90
PHE A  55
ALA A  58
VAL A  57
 None
None
None
None
LLP  A  34 ( 3.9A)
LLP  A  34 ( 4.8A)
 1.29A 3jb2A-4qhrA:
undetectable		 3jb2A-4qhrA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		6 / 12 ILE A  66
GLY A  63
ALA A  90
PHE A  55
ALA A  58
VAL A  57
 None
None
None
None
LLP  A  34 ( 3.9A)
LLP  A  34 ( 4.8A)
 1.34A 3jb3A-4qhrA:
undetectable		 3jb3A-4qhrA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 ILE A 241
GLY A 232
ALA A 213
ALA A  41
ALA A 102
 None
LLP  A 234 ( 4.3A)
None
LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.8A)
 1.03A 3jb3A-4w91A:
undetectable		 3jb3A-4w91A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
LLP  A 197 ( 4.5A)
LLP  A 197 ( 3.5A)
None
 0.81A 3jusA-4xk1A:
undetectable		 3jusA-4xk1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
LLP  A 197 ( 4.5A)
LLP  A 197 ( 3.5A)
None
 0.81A 3jusA-4xk1A:
undetectable		 3jusA-4xk1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 GLU B 295
PHE B 305
GLY B 231
ALA B 283
ASP A  57
 CA  B 402 (-3.2A)
None
LLP  B  86 ( 3.7A)
None
None
 1.32A 3jzjA-5kzmB:
1.5		 3jzjA-5kzmB:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 GLY A  92
VAL A  38
GLY A 281
ASN A 278
ILE A 285
 LLP  A 225 ( 3.8A)
None
None
None
None
 1.28A 3k13A-5vprA:
undetectable		 3k13A-5vprA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		5 / 12 GLY A  92
VAL A  38
GLY A 281
ASN A 278
ILE A 285
 LLP  A 225 ( 3.8A)
None
None
None
None
 1.28A 3k13C-5vprA:
undetectable		 3k13C-5vprA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.73A 3k4vA-2z61A:
undetectable		 3k4vA-2z61A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.70A 3k4vD-2z61A:
undetectable		 3k4vD-2z61A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 6 SER A 308
GLY A 233
GLU A 219
GLU A 220
 LLP  A  58 ( 3.3A)
None
None
None
 1.14A 3k9fA-4il5A:
undetectable
3k9fB-4il5A:
undetectable
3k9fD-4il5A:
undetectable		 3k9fA-4il5A:
22.91
3k9fB-4il5A:
22.91
3k9fD-4il5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 SER A  59
GLY A  60
THR A  61
 LLP  A 185 ( 2.8A)
LLP  A 185 ( 3.7A)
LLP  A 185 ( 3.6A)
 0.21A 3k9wA-1iugA:
2.0		 3k9wA-1iugA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 SER A  57
GLY A  58
THR A  59
 LLP  A 199 ( 3.9A)
LLP  A 199 ( 3.3A)
LLP  A 199 ( 3.5A)
 0.16A 3k9wA-1m6sA:
undetectable		 3k9wA-1m6sA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		3 / 3 SER A  84
GLY A  85
THR A  86
 LLP  A 226 ( 3.3A)
LLP  A 226 ( 3.5A)
LLP  A 226 ( 3.6A)
 0.08A 3k9wA-3fd0A:
undetectable		 3k9wA-3fd0A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
monocytogenes) 		3 / 3 SER A  84
GLY A  85
THR A  86
 LLP  A 226 ( 3.3A)
LLP  A 226 ( 3.5A)
LLP  A 226 ( 3.4A)
 0.03A 3k9wA-3jzlA:
undetectable		 3k9wA-3jzlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		3 / 3 SER A  58
GLY A  59
THR A  60
 LLP  A 198 ( 2.9A)
LLP  A 198 ( 3.6A)
LLP  A 198 ( 3.6A)
 0.21A 3k9wA-3ke3A:
undetectable		 3k9wA-3ke3A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		3 / 3 SER A 119
GLY A 120
THR A 121
 LLP  A 270 ( 3.9A)
LLP  A 270 ( 3.2A)
LLP  A 270 ( 3.5A)
 0.17A 3k9wA-3l44A:
undetectable		 3k9wA-3l44A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		3 / 3 SER A  71
GLY A  72
THR A  73
 LLP  A 196 ( 3.8A)
LLP  A 196 ( 3.5A)
LLP  A 196 ( 3.6A)
 0.18A 3k9wA-4ixoA:
undetectable		 3k9wA-4ixoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		3 / 3 SER A 124
GLY A 125
THR A 126
 LLP  A 247 ( 3.7A)
LLP  A 247 ( 3.2A)
LLP  A 247 ( 3.6A)
 0.14A 3k9wA-4k2bA:
undetectable		 3k9wA-4k2bA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		3 / 3 SER A  53
GLY A  54
THR A  55
 LLP  A 187 ( 3.7A)
LLP  A 187 ( 3.4A)
LLP  A 187 ( 3.6A)
 0.16A 3k9wA-4zwvA:
undetectable		 3k9wA-4zwvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 GLN B 246
GLY B  88
GLY B 220
LEU B 212
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
None
 0.94A 3kkzA-4iyoB:
undetectable		 3kkzA-4iyoB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 323
GLY A 283
GLY A 288
LEU A 253
ALA A 292
 None
LLP  A 285 ( 4.4A)
LLP  A 285 ( 3.4A)
None
None
 1.10A 3kkzB-3w1jA:
3.0		 3kkzB-3w1jA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		5 / 12 GLN B 246
GLY B  88
GLY B 220
LEU B 212
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
None
 0.98A 3kkzB-4iyoB:
2.4		 3kkzB-4iyoB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 7 GLY A 206
PHE A 315
PHE A 271
PHE A 289
 LLP  A 205 ( 2.4A)
None
None
None
 1.10A 3ko0L-3lwsA:
undetectable
3ko0N-3lwsA:
undetectable		 3ko0L-3lwsA:
15.81
3ko0N-3lwsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 7 PHE A 289
GLY A 206
PHE A 315
PHE A 271
 None
LLP  A 205 ( 2.4A)
None
None
 1.04A 3ko0R-3lwsA:
undetectable
3ko0T-3lwsA:
undetectable		 3ko0R-3lwsA:
15.81
3ko0T-3lwsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6a2f -
(-) 		4 / 7 GLU A  66
VAL A  46
VAL A  58
ALA A  64
 None
None
LLP  A  34 ( 4.5A)
None
 1.02A 3kp6B-6a2fA:
undetectable		 3kp6B-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 GLY A 188
VAL A 236
ALA A 183
GLY A 184
ILE A 245
 LLP  A  51 ( 3.4A)
None
None
None
None
 1.08A 3ku1G-3tbhA:
3.3		 3ku1G-3tbhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 12 TYR A 116
HIS A 198
SER A 317
ILE A 115
LEU A 135
 LLP  A 230 ( 3.8A)
LLP  A 230 ( 3.9A)
None
None
None
 1.19A 3lcvB-3t32A:
undetectable		 3lcvB-3t32A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 ALA A  70
GLY A 192
ALA A 191
SER A 190
LEU A 248
 None
LLP  A  63 ( 3.3A)
LLP  A  63 ( 3.5A)
LLP  A  63 ( 4.2A)
None
 1.02A 3ln1A-5ybwA:
undetectable		 3ln1A-5ybwA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 ALA A  70
GLY A 192
ALA A 191
SER A 190
LEU A 248
 None
LLP  A  63 ( 3.3A)
LLP  A  63 ( 3.5A)
LLP  A  63 ( 4.2A)
None
 1.01A 3ln1B-5ybwA:
undetectable		 3ln1B-5ybwA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 ALA A  70
GLY A 192
ALA A 191
SER A 190
LEU A 248
 None
LLP  A  63 ( 3.3A)
LLP  A  63 ( 3.5A)
LLP  A  63 ( 4.2A)
None
 1.01A 3ln1C-5ybwA:
undetectable		 3ln1C-5ybwA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC
(Cytophaga
hutchinsonii) 		4 / 4 SER A  94
SER A 142
THR A 140
SER A 141
 None
None
LLP  A 190 ( 2.9A)
None
 1.38A 3loqA-3ffrA:
3.9		 3loqA-3ffrA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		4 / 4 SER A  85
SER A 147
THR A 145
SER A 146
 None
None
LLP  A 198 (-3.0A)
None
 1.39A 3loqA-3ke3A:
2.7		 3loqA-3ke3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 3g0t PUTATIVE
AMINOTRANSFERASE
(Porphyromonas
gingivalis) 		3 / 3 ASP A 220
ASN A 145
SER A 256
 LLP  A 259 ( 2.8A)
None
LLP  A 259 ( 2.5A)
 0.88A 3lslA-3g0tA:
undetectable
3lslD-3g0tA:
0.7		 3lslA-3g0tA:
20.50
3lslD-3g0tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		3 / 3 PRO A 161
SER A 303
ASN A 163
 None
None
LLP  A 226 ( 3.6A)
 0.85A 3lslG-3getA:
undetectable		 3lslG-3getA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		5 / 12 SER A 165
HIS A 104
LEU A 190
THR A 191
HIS A 192
 None
LLP  A  61 ( 4.5A)
None
None
None
 1.30A 3lxeA-4kbxA:
undetectable		 3lxeA-4kbxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		5 / 12 SER A 165
HIS A 104
LEU A 190
THR A 191
HIS A 192
 None
LLP  A  61 ( 4.5A)
None
None
None
 1.29A 3lxeB-4kbxA:
undetectable		 3lxeB-4kbxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_G_P77G203_1
(PROTEIN S100-A4)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 9 ASP A  88
PHE A 100
ILE A 215
LEU A 186
ASP A 188
 CL  A 381 ( 3.0A)
None
None
None
LLP  A 222 ( 2.7A)
 1.37A 3m0wG-3fdbA:
undetectable
3m0wH-3fdbA:
undetectable
3m0wI-3fdbA:
undetectable
3m0wJ-3fdbA:
undetectable		 3m0wG-3fdbA:
14.55
3m0wH-3fdbA:
14.55
3m0wI-3fdbA:
14.55
3m0wJ-3fdbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 10 LEU A 186
ASP A 188
PHE A 100
ILE A 215
ASP A  88
 None
LLP  A 222 ( 2.7A)
None
None
CL  A 381 ( 3.0A)
 1.42A 3m0wE-3fdbA:
undetectable
3m0wF-3fdbA:
0.0
3m0wG-3fdbA:
undetectable
3m0wH-3fdbA:
undetectable		 3m0wE-3fdbA:
14.55
3m0wF-3fdbA:
14.55
3m0wG-3fdbA:
14.55
3m0wH-3fdbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		5 / 10 LEU A 186
ASP A 188
PHE A 100
ILE A 215
ASP A  88
 None
LLP  A 222 ( 2.7A)
None
None
CL  A 381 ( 3.0A)
 1.43A 3m0wA-3fdbA:
0.2
3m0wB-3fdbA:
undetectable
3m0wI-3fdbA:
undetectable
3m0wJ-3fdbA:
undetectable		 3m0wA-3fdbA:
14.55
3m0wB-3fdbA:
14.55
3m0wI-3fdbA:
14.55
3m0wJ-3fdbA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 239
GLY A 238
VAL A 282
ASP A  80
LEU A  69
 LLP  A  61 ( 3.6A)
LLP  A  61 ( 4.8A)
None
LLP  A  61 ( 4.0A)
None
 1.05A 3m6vA-3vabA:
undetectable		 3m6vA-3vabA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 239
GLY A 238
VAL A 282
ASP A  80
LEU A  69
 LLP  A  61 ( 3.6A)
LLP  A  61 ( 4.8A)
None
LLP  A  61 ( 4.0A)
None
 1.06A 3m6vB-3vabA:
undetectable		 3m6vB-3vabA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3gju PUTATIVE
AMINOTRANSFERASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A 120
SER A 121
LEU A 118
ILE A 103
LEU A 291
 PLP  A 460 (-3.2A)
LLP  A 289 (-2.7A)
None
None
None
 1.03A 3mb5A-3gjuA:
undetectable		 3mb5A-3gjuA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 6 ILE A 254
ALA A 253
ALA A 375
THR A 400
 None
LLP  A 405 ( 3.4A)
LLP  A 405 ( 3.6A)
None
 1.03A 3mdrB-2okjA:
undetectable		 3mdrB-2okjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 6 ILE A 245
ALA A 244
ALA A 366
THR A 391
 None
LLP  A 396 ( 3.3A)
LLP  A 396 ( 3.5A)
None
 0.99A 3mdrB-2okkA:
undetectable		 3mdrB-2okkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3nu8 AMINOTRANSFERASE
WBPE
(Pseudomonas
aeruginosa) 		4 / 6 ILE A  65
ALA A  62
ALA A  87
THR A  91
 None
None
LLP  A 185 ( 3.6A)
None
 1.07A 3mdrB-3nu8A:
undetectable		 3mdrB-3nu8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3oks 4-AMINOBUTYRATE
TRANSAMINASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 VAL A 265
LEU A 160
ALA A 130
GLU A 132
THR A 158
 LLP  A 292 ( 4.2A)
None
None
None
None
 1.01A 3mdvA-3oksA:
undetectable		 3mdvA-3oksA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 9 VAL A 264
LEU A 159
ALA A 129
GLU A 131
THR A 157
 LLP  A 291 ( 4.3A)
None
None
None
None
 1.02A 3mdvA-3r4tA:
undetectable		 3mdvA-3r4tA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)
(Mycobacteroides
abscessus) 		5 / 9 VAL A 263
LEU A 163
ALA A 133
GLU A 135
THR A 161
 LLP  A 290 ( 4.2A)
None
None
None
None
 1.02A 3mdvA-4ffcA:
undetectable		 3mdvA-4ffcA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4xq2 CALE6
(Micromonospora
echinospora) 		5 / 12 VAL A 205
LEU A  61
THR A 196
ILE A 199
ALA A 200
 None
None
LLP  A 197 ( 3.5A)
None
LLP  A 197 ( 4.7A)
 0.94A 3mdvB-4xq2A:
undetectable		 3mdvB-4xq2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 VAL A 167
PHE A 236
ALA A 203
THR A 206
VAL A 245
 LLP  A  41 ( 4.1A)
None
None
None
None
 1.07A 3me6C-4h27A:
undetectable		 3me6C-4h27A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 11 THR A 319
ALA A 258
ARG A 250
GLY A 200
SER A   6
 None
None
None
LLP  A 199 ( 2.4A)
None
 1.20A 3mg0N-1m6sA:
undetectable		 3mg0N-1m6sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3b46 AMINOTRANSFERASE
BNA3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 130
ALA A 297
ALA A 124
GLY A 123
THR A 122
 None
None
LLP  A 271 ( 3.4A)
LLP  A 271 ( 3.6A)
None
 1.03A 3mg0V-3b46A:
undetectable
3mg0W-3b46A:
undetectable		 3mg0V-3b46A:
18.57
3mg0W-3b46A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		5 / 12 GLY A 231
GLY A 229
THR A 392
LEU A 391
SER A 223
 None
LLP  A 226 ( 3.7A)
None
EDO  A 418 (-3.9A)
LLP  A 226 ( 3.7A)
 1.24A 3mteA-3fd0A:
undetectable		 3mteA-3fd0A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 GLY A 248
GLY A 246
THR A 409
LEU A 408
SER A 240
 None
LLP  A 243 ( 4.0A)
None
None
LLP  A 243 ( 3.8A)
 1.20A 3mteA-3hvyA:
2.1		 3mteA-3hvyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 9 HIS A 200
GLY A 202
SER A 203
TYR A 376
LEU A 380
 LLP  A  61 ( 3.6A)
None
LLP  A  61 ( 2.5A)
LLP  A  61 ( 4.6A)
None
 0.79A 3n2oA-3vabA:
28.1
3n2oB-3vabA:
28.2		 3n2oA-3vabA:
24.25
3n2oB-3vabA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 10 HIS A 200
GLY A 202
ARG A 279
TYR A 376
LEU A 380
 LLP  A  61 ( 3.6A)
None
None
LLP  A  61 ( 4.6A)
None
 0.64A 3n2oC-3vabA:
28.1
3n2oD-3vabA:
28.1		 3n2oC-3vabA:
24.25
3n2oD-3vabA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		5 / 12 LEU A  72
GLY A  76
ALA A  79
SER A  78
LEU A  82
 None
LLP  A 198 ( 3.2A)
None
None
None
 1.22A 3n8xA-1cs1A:
0.0		 3n8xA-1cs1A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 VAL A 323
VAL A  64
LEU A  50
GLY A 340
ALA A 341
 None
None
None
LLP  A  77 ( 4.7A)
None
 1.08A 3n8zA-4d9iA:
undetectable		 3n8zA-4d9iA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.67A 3nduD-2z61A:
undetectable		 3nduD-2z61A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 11 GLU A 386
GLY A 126
ILE A 159
ALA A 156
ASP A 125
 LLP  A  78 ( 3.5A)
PO4  A 504 (-4.5A)
None
None
PO4  A 504 (-4.5A)
 1.15A 3nmuB-5ygrA:
undetectable
3nmuJ-5ygrA:
undetectable		 3nmuB-5ygrA:
undetectable
3nmuJ-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 VAL A  64
LEU A  50
GLY A 340
ALA A 341
LEU A 344
 None
None
LLP  A  77 ( 4.7A)
None
None
 1.00A 3nt1A-4d9iA:
undetectable		 3nt1A-4d9iA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 VAL A  64
LEU A  50
GLY A 340
ALA A 341
LEU A 344
 None
None
LLP  A  77 ( 4.7A)
None
None
 0.98A 3nt1B-4d9iA:
undetectable		 3nt1B-4d9iA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 10 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.34A 3nu9B-2gn1A:
undetectable		 3nu9B-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 10 ALA A 173
ASP A 201
VAL A 224
ILE A 202
PRO A 219
 None
LLP  A 230 ( 2.9A)
None
None
None
 0.99A 3nujA-4j5uA:
undetectable		 3nujA-4j5uA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 GLU A 304
GLY A 148
ALA A 299
ALA A 176
VAL A 308
 None
None
None
LLP  A 198 ( 3.3A)
None
 1.07A 3nvkF-3ke3A:
undetectable
3nvkJ-3ke3A:
2.6		 3nvkF-3ke3A:
23.23
3nvkJ-3ke3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 ALA A 330
LEU A 339
LEU A 333
ARG A 367
ILE A 214
 None
None
LLP  A 205 ( 4.3A)
SO4  A2001 (-2.9A)
LLP  A 205 ( 4.5A)
 1.30A 3olsB-3aczA:
undetectable		 3olsB-3aczA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ALA A 246
GLY A 249
TRP A 287
GLY A 211
HIS A 242
 LLP  A 277 ( 3.3A)
None
None
None
None
 1.02A 3ou6B-3hbxA:
undetectable		 3ou6B-3hbxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 ALA A 246
GLY A 249
TRP A 287
GLY A 211
HIS A 242
 LLP  A 277 ( 3.3A)
None
None
None
None
 1.07A 3ou7B-3hbxA:
undetectable		 3ou7B-3hbxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 221
PHE A  65
GLY A 262
GLY A 263
ILE A 225
 None
None
LLP  A  83 ( 4.6A)
LLP  A  83 ( 3.9A)
None
 1.34A 3owxA-1tufA:
undetectable
3owxB-1tufA:
undetectable		 3owxA-1tufA:
20.20
3owxB-1tufA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 259
PHE A  65
GLY A 263
GLY A 264
ILE A 225
 None
None
LLP  A  83 ( 3.9A)
LLP  A  83 ( 3.4A)
None
 1.21A 3owxA-1tufA:
undetectable
3owxB-1tufA:
undetectable		 3owxA-1tufA:
20.20
3owxB-1tufA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 PHE A  49
PHE A  45
GLY A 238
GLY A 239
ILE A 201
 None
None
LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
 1.27A 3owxA-3vabA:
undetectable
3owxB-3vabA:
undetectable		 3owxA-3vabA:
20.95
3owxB-3vabA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		5 / 11 VAL A 158
PHE A  38
GLY A 198
TYR A 131
GLU A 195
 None
LLP  A 161 ( 4.4A)
ALA  A 401 (-4.0A)
EDO  A 402 (-3.7A)
LLP  A 161 ( 3.1A)
 1.10A 3owxA-4whxA:
undetectable
3owxB-4whxA:
undetectable		 3owxA-4whxA:
23.10
3owxB-4whxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ASP A 393
GLY A 406
ILE A 388
PRO A 356
VAL A 357
 None
None
LLP  A 243 ( 3.8A)
None
None
 0.95A 3oxcA-3hvyA:
undetectable		 3oxcA-3hvyA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 425
LEU A 381
THR A 281
 8Z1  A 601 ( 3.8A)
None
LLP  A 280 ( 3.9A)
 0.73A 3oxcA-5v7iA:
undetectable		 3oxcA-5v7iA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 GLY X 158
ILE X  45
GLY X 180
ILE X 182
PRO X 299
 None
LLP  X  42 ( 4.0A)
LLP  X  42 ( 4.0A)
None
LLP  X  42 ( 4.0A)
 1.02A 3oxcB-4li3X:
undetectable		 3oxcB-4li3X:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 158
ILE A  47
GLY A 180
ILE A 182
PRO A 293
 None
LLP  A  44 ( 4.1A)
LLP  A  44 ( 3.9A)
None
LLP  A  44 ( 4.1A)
 0.93A 3oxcB-5xa2A:
undetectable		 3oxcB-5xa2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 10 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.47A 3oy4B-2gn1A:
undetectable		 3oy4B-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 10 ALA A 243
ASP A 244
GLY A 322
ILE A 290
VAL A 214
 None
None
LLP  A  63 ( 3.8A)
None
None
 0.99A 3oy4B-5ybwA:
undetectable		 3oy4B-5ybwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 9 LEU B 125
THR B  87
ALA B 121
LEU B 127
THR B 118
 None
LLP  B  86 ( 4.4A)
None
None
None
 1.20A 3ozkA-5kzmB:
undetectable		 3ozkA-5kzmB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 12 TYR A 312
HIS A 448
ALA A 385
LEU A 382
LEU A 282
 LLP  A 311 ( 4.8A)
None
None
None
None
 1.13A 3ozwB-5eueA:
2.2		 3ozwB-5eueA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		5 / 12 GLY A 211
ALA A 220
ALA A  82
LEU A 250
LEU A  67
 LLP  A 208 ( 4.2A)
None
None
None
None
 0.96A 3p2kA-3qi6A:
undetectable		 3p2kA-3qi6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		4 / 6 TYR A 385
GLN A  10
ILE A   7
SER A  32
 None
None
None
LLP  A 225 ( 3.3A)
 1.10A 3peoG-5vprA:
undetectable		 3peoG-5vprA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ix8 TYROSINE
AMINOTRANSFERASE
(Leishmania
infantum) 		4 / 6 ILE A 255
PHE A 266
ALA A 257
ASN A 222
 LLP  A 286 ( 3.8A)
None
None
None
 1.14A 3pgyA-4ix8A:
22.9
3pgyB-4ix8A:
23.4		 3pgyA-4ix8A:
22.08
3pgyB-4ix8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 GLY A 313
ASN A  85
PHE A  48
ILE A 280
GLY A 285
 None
LLP  A  58 ( 3.8A)
None
None
LLP  A  58 ( 4.8A)
 1.23A 3ps9A-2gn1A:
4.4		 3ps9A-2gn1A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 TYR A 101
GLY A 103
THR A 104
LEU A 100
 LLP  A 199 (-3.7A)
None
None
None
 1.02A 3ps9A-6cjbA:
undetectable		 3ps9A-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 ASP A 244
GLY A 245
GLY A 295
ILE A 290
PRO A 331
 None
LLP  A  63 ( 4.2A)
None
None
None
 1.03A 3pwmA-5ybwA:
undetectable		 3pwmA-5ybwA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.84A 3pwrA-2z61A:
undetectable		 3pwrA-2z61A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		4 / 8 SER A 167
SER A 370
ASP A 200
THR A  86
 LLP  A 226 ( 4.1A)
LLP  A 226 ( 4.2A)
LLP  A 226 ( 2.8A)
LLP  A 226 ( 3.6A)
 0.81A 3pwwA-3fd0A:
undetectable		 3pwwA-3fd0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
monocytogenes) 		4 / 8 SER A 167
SER A 370
ASP A 200
THR A  86
 LLP  A 226 ( 4.1A)
LLP  A 226 ( 3.0A)
LLP  A 226 ( 2.8A)
LLP  A 226 ( 3.4A)
 0.78A 3pwwA-3jzlA:
undetectable		 3pwwA-3jzlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 11 THR A 153
ALA A  45
ILE A  49
THR A  12
GLU A  33
 None
LLP  A  42 ( 4.1A)
None
None
None
 1.22A 3qelA-5jjcA:
3.4
3qelB-5jjcA:
undetectable		 3qelA-5jjcA:
23.96
3qelB-5jjcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 10 ILE A 247
ALA A 243
ASN A  91
SER A  61
THR A 241
 None
None
LLP  A  63 ( 3.7A)
LLP  A  63 ( 3.1A)
None
 1.30A 3qg2A-5ybwA:
undetectable		 3qg2A-5ybwA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 12 ILE A 344
GLY A 346
GLU A 386
SER A 390
THR A 389
 None
None
LLP  A  78 ( 3.5A)
None
None
 1.16A 3r75A-5ygrA:
3.2		 3r75A-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 10 LEU A 296
ALA A 291
THR A 314
VAL A 312
VAL A 309
 None
LLP  A 318 (-3.3A)
FMT  A 613 ( 4.6A)
None
None
 1.45A 3r9cA-6cczA:
undetectable		 3r9cA-6cczA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3nu8 AMINOTRANSFERASE
WBPE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  62
ILE A 196
ALA A 157
ALA A 158
 None
None
None
LLP  A 185 ( 3.3A)
 0.76A 3r9tA-3nu8A:
undetectable		 3r9tA-3nu8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 11 VAL A 342
ALA A 341
GLY A 320
TYR A 385
LEU A 289
 None
None
None
None
LLP  A  77 (-4.8A)
 1.25A 3rc0A-4d9iA:
undetectable		 3rc0A-4d9iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		4 / 7 TYR A  77
ASP A 190
ALA A 191
TYR A 220
 None
LLP  A 226 ( 2.6A)
None
None
 1.20A 3rodD-3getA:
undetectable		 3rodD-3getA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 11 ALA A 287
PHE A  50
GLY A 246
ALA A 245
VAL A  96
 None
None
LLP  A 247 ( 2.4A)
None
None
 1.20A 3rukD-4wlhA:
undetectable		 3rukD-4wlhA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		4 / 5 VAL A 176
GLU A  69
LYS A 145
PHE A 232
 LLP  A  44 ( 4.0A)
None
None
None
 1.44A 3rv5C-5xa2A:
undetectable
3rv5D-5xa2A:
undetectable		 3rv5C-5xa2A:
16.56
3rv5D-5xa2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 8 ASP A  59
GLY A  22
TYR A  14
ARG A  10
 LLP  A  58 ( 4.7A)
None
None
None
 0.92A 3s3nA-4il5A:
undetectable		 3s3nA-4il5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 100
SER A 148
ASN A  73
 LLP  A 205 ( 3.6A)
None
None
 0.84A 3s8pB-4isyA:
undetectable		 3s8pB-4isyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 GLY A 209
GLY A  62
THR A  63
TYR A 196
GLY A 199
 None
LLP  A 202 ( 3.5A)
LLP  A 202 ( 3.6A)
None
LLP  A 202 ( 4.3A)
 1.06A 3sglA-4zasA:
undetectable		 3sglA-4zasA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		3 / 3 LYS B 395
SER B  99
GLN B 128
 None
LLP  B 101 ( 2.9A)
LLP  B 101 (-3.9A)
 1.17A 3si7A-5tchB:
undetectable		 3si7A-5tchB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 0.92A 3sj1X-3w1hA:
undetectable		 3sj1X-3w1hA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 2.9A)
None
 1.02A 3sj1X-3w1jA:
undetectable		 3sj1X-3w1jA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 8 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
 1.31A 3so9A-2gn1A:
undetectable		 3so9A-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		5 / 12 TYR A 150
GLY A 355
ILE A 184
ALA A 407
ALA A 403
 LLP  A 353 (-3.8A)
LLP  A 353 ( 4.1A)
None
None
None
 1.02A 3sudB-4q6rA:
undetectable		 3sudB-4q6rA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 ASP A 173
LEU A 204
GLY A 199
SER A 197
ALA A 177
 LLP  A 202 ( 2.9A)
None
LLP  A 202 ( 4.3A)
LLP  A 202 ( 2.8A)
None
 1.05A 3sufA-4zasA:
undetectable		 3sufA-4zasA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 GLY A 234
GLY A 232
LEU A 229
ALA A 235
TYR A 206
 LLP  A  77 ( 3.3A)
LLP  A  77 (-3.4A)
None
LLP  A  77 ( 3.3A)
LLP  A  77 ( 4.9A)
 1.24A 3sxjA-4d9iA:
2.4		 3sxjA-4d9iA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 GLY A 234
GLY A 232
LEU A 229
ALA A 235
TYR A 206
 LLP  A  77 ( 3.3A)
LLP  A  77 (-3.4A)
None
LLP  A  77 ( 3.3A)
LLP  A  77 ( 4.9A)
 1.24A 3sxjB-4d9iA:
2.4		 3sxjB-4d9iA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 7 GLY A 337
ALA A 336
ASP A 364
VAL A 384
 None
None
LLP  A 396 ( 2.6A)
None
 0.68A 3t3cA-2okkA:
undetectable		 3t3cA-2okkA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		4 / 8 PHE B 278
ALA B 283
ALA B 191
THR B 189
 None
None
None
LLP  B  86 ( 3.8A)
 1.05A 3t3sE-5kzmB:
undetectable		 3t3sE-5kzmB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 12 PHE B 285
THR B 284
GLY B 324
GLY B 322
GLY B 248
 None
None
None
None
LLP  B 101 ( 3.3A)
 1.08A 3tegA-5tchB:
undetectable		 3tegA-5tchB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		4 / 6 GLY A  86
VAL A 217
SER A  85
THR A 207
 LLP  A 208 ( 3.4A)
LLP  A 208 ( 4.9A)
LLP  A 208 ( 3.5A)
LLP  A 208 (-3.4A)
 1.14A 3tj7A-3qi6A:
undetectable
3tj7B-3qi6A:
undetectable		 3tj7A-3qi6A:
17.09
3tj7B-3qi6A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 GLY B  88
VAL B 219
SER B  87
THR B 209
 LLP  B 210 ( 3.3A)
LLP  B 210 ( 4.8A)
LLP  B 210 ( 3.7A)
LLP  B 210 ( 3.5A)
 1.13A 3tj7A-4iyoB:
undetectable
3tj7B-4iyoB:
undetectable		 3tj7A-4iyoB:
18.23
3tj7B-4iyoB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 GLY A  77
VAL A 208
SER A  76
THR A 198
 LLP  A 199 ( 3.2A)
LLP  A 199 ( 4.8A)
LLP  A 199 ( 3.5A)
LLP  A 199 ( 3.3A)
 1.09A 3tj7A-6cjbA:
undetectable
3tj7B-6cjbA:
undetectable		 3tj7A-6cjbA:
undetectable
3tj7B-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		4 / 6 GLY A  86
VAL A 217
SER A  85
THR A 207
 LLP  A 208 ( 3.4A)
LLP  A 208 ( 4.9A)
LLP  A 208 ( 3.5A)
LLP  A 208 (-3.4A)
 1.13A 3tj7C-3qi6A:
undetectable
3tj7D-3qi6A:
undetectable		 3tj7C-3qi6A:
17.09
3tj7D-3qi6A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 GLY B  88
VAL B 219
SER B  87
THR B 209
 LLP  B 210 ( 3.3A)
LLP  B 210 ( 4.8A)
LLP  B 210 ( 3.7A)
LLP  B 210 ( 3.5A)
 1.12A 3tj7C-4iyoB:
undetectable
3tj7D-4iyoB:
undetectable		 3tj7C-4iyoB:
18.23
3tj7D-4iyoB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 GLY A  77
VAL A 208
SER A  76
THR A 198
 LLP  A 199 ( 3.2A)
LLP  A 199 ( 4.8A)
LLP  A 199 ( 3.5A)
LLP  A 199 ( 3.3A)
 1.08A 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable		 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		4 / 6 VAL A 217
SER A  85
THR A 207
GLY A  86
 LLP  A 208 ( 4.9A)
LLP  A 208 ( 3.5A)
LLP  A 208 (-3.4A)
LLP  A 208 ( 3.4A)
 1.12A 3tj7C-3qi6A:
undetectable
3tj7D-3qi6A:
undetectable		 3tj7C-3qi6A:
17.09
3tj7D-3qi6A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 6 VAL A 172
SER A 193
THR A 191
GLY A  72
 LLP  A 196 ( 4.3A)
LLP  A 196 ( 2.7A)
None
LLP  A 196 ( 3.5A)
 1.15A 3tj7C-4ixoA:
undetectable
3tj7D-4ixoA:
undetectable		 3tj7C-4ixoA:
20.17
3tj7D-4ixoA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 6 VAL B 219
SER B  87
THR B 209
GLY B  88
 LLP  B 210 ( 4.8A)
LLP  B 210 ( 3.7A)
LLP  B 210 ( 3.5A)
LLP  B 210 ( 3.3A)
 1.11A 3tj7C-4iyoB:
undetectable
3tj7D-4iyoB:
undetectable		 3tj7C-4iyoB:
18.23
3tj7D-4iyoB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 6 VAL A 208
SER A  76
THR A 198
GLY A  77
 LLP  A 199 ( 4.8A)
LLP  A 199 ( 3.5A)
LLP  A 199 ( 3.3A)
LLP  A 199 ( 3.2A)
 1.07A 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable		 3tj7C-6cjbA:
undetectable
3tj7D-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 158
ILE A  47
GLY A 180
ILE A 182
PRO A 293
 None
LLP  A  44 ( 4.1A)
LLP  A  44 ( 3.9A)
None
LLP  A  44 ( 4.1A)
 1.03A 3tkgB-5xa2A:
undetectable		 3tkgB-5xa2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.73A 3tl9A-2z61A:
undetectable		 3tl9A-2z61A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 5 HIS B 100
SER B  99
THR B  97
ASP B 319
 LLP  B 101 ( 3.5A)
LLP  B 101 ( 2.9A)
None
None
 1.43A 3tm4A-5tchB:
2.5		 3tm4A-5tchB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		4 / 5 HIS B 100
SER B  99
THR B  97
ASP B 319
 LLP  B 101 ( 3.5A)
LLP  B 101 ( 2.9A)
None
None
 1.38A 3tm4B-5tchB:
2.0		 3tm4B-5tchB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ASN A   7
ALA A  14
TYR A 338
ALA A  10
 None
None
LLP  A 197 ( 4.0A)
None
 1.36A 3twpD-4xk1A:
undetectable		 3twpD-4xk1A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN
(Trichomonas
vaginalis) 		4 / 5 ASN A   8
ALA A  15
TYR A 350
ALA A  11
 None
None
LLP  A 202 ( 4.0A)
None
 1.38A 3twpD-5f8vA:
undetectable		 3twpD-5f8vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 PHE A 143
PRO A 226
GLY A 179
PHE A 228
 None
None
LLP  A  42 ( 3.8A)
None
 1.10A 3tzfB-5b1hA:
undetectable		 3tzfB-5b1hA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 10 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.17A 3u9fE-4w91A:
undetectable		 3u9fE-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 10 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.19A 3u9fI-4w91A:
undetectable		 3u9fI-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.19A 3u9fJ-4w91A:
undetectable
3u9fK-4w91A:
undetectable		 3u9fJ-4w91A:
18.98
3u9fK-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 11 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.22A 3u9fN-4w91A:
undetectable
3u9fO-4w91A:
undetectable		 3u9fN-4w91A:
18.98
3u9fO-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 9 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.23A 3u9fP-4w91A:
undetectable		 3u9fP-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE
(Klebsiella
pneumoniae) 		5 / 12 CYH A 104
HIS A 101
THR A 151
SER A 150
VAL A 145
 None
None
None
None
LLP  A 200 ( 4.8A)
 1.37A 3u9fP-3nnkA:
undetectable
3u9fS-3nnkA:
undetectable		 3u9fP-3nnkA:
18.18
3u9fS-3nnkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 12 SER A  80
LEU A 298
VAL A 235
PHE A 230
VAL A  84
 None
None
LLP  A 234 ( 3.1A)
None
None
 1.17A 3u9fP-4w91A:
undetectable
3u9fS-4w91A:
undetectable		 3u9fP-4w91A:
18.98
3u9fS-4w91A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3pj0 LMO0305 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 209
GLY A 210
ASN A  19
GLY A 336
ASP A 337
 None
LLP  A 207 ( 3.6A)
None
None
None
 0.92A 3uboA-3pj0A:
3.6		 3uboA-3pj0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A 144
ALA A 143
GLY A 249
GLY A 281
ILE A 294
 None
LLP  A 285 ( 3.1A)
LLP  A 285 ( 3.0A)
None
None
 0.80A 3ufnA-3w1hA:
undetectable		 3ufnA-3w1hA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A 144
ALA A 143
GLY A 249
GLY A 281
ILE A 294
 None
LLP  A 285 ( 3.0A)
LLP  A 285 ( 2.9A)
None
None
 0.87A 3ufnA-3w1jA:
undetectable		 3ufnA-3w1jA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		3 / 3 TYR A 129
GLU A 154
TYR A 111
 None
LLP  A 208 ( 4.2A)
LLP  A 208 (-3.7A)
 0.86A 3ug8A-3qi6A:
undetectable		 3ug8A-3qi6A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3pdx TYROSINE
AMINOTRANSFERASE
(Mus
musculus) 		4 / 7 TYR A 260
ASN A 215
PRO A 165
TYR A 172
 None
LLP  A 280 ( 3.5A)
None
None
 1.30A 3ugrA-3pdxA:
undetectable		 3ugrA-3pdxA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Mus
musculus) 		4 / 4 SER A 174
ASP A 283
ASP A 321
ALA A 143
 LLP  A 284 ( 2.7A)
LLP  A 284 ( 3.2A)
None
LLP  A 284 ( 3.3A)
 1.33A 3uj6A-3bc8A:
3.2		 3uj6A-3bc8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		4 / 5 TYR A 209
SER A 180
ASP A 206
ILE A 131
 LLP  A 244 ( 4.3A)
None
LLP  A 244 ( 2.8A)
None
 1.17A 3uj7B-3jtxA:
3.2		 3uj7B-3jtxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ASN A  88
ILE A 106
GLY A  62
THR A  85
GLY A  97
 LLP  A  58 (-3.9A)
None
LLP  A  58 ( 3.8A)
ILE  A 401 (-4.2A)
None
 1.03A 3uq6A-4il5A:
3.1		 3uq6A-4il5A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ASN A  88
ILE A 106
GLY A  62
THR A  85
GLY A  97
 LLP  A  58 (-3.9A)
None
LLP  A  58 ( 3.8A)
ILE  A 401 (-4.2A)
None
 0.99A 3vaqA-4il5A:
undetectable		 3vaqA-4il5A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 LEU A 209
GLY A 169
THR A 202
LEU A 176
GLY A 193
 None
None
None
None
LLP  A  63 ( 3.5A)
 1.04A 3vaqA-5ybwA:
2.4		 3vaqA-5ybwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 LEU A 209
GLY A 169
THR A 202
LEU A 176
GLY A 193
 None
None
None
None
LLP  A  63 ( 3.5A)
 1.01A 3vaqB-5ybwA:
undetectable		 3vaqB-5ybwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ASN A  88
ILE A 106
GLY A  62
THR A  85
GLY A  97
 LLP  A  58 (-3.9A)
None
LLP  A  58 ( 3.8A)
ILE  A 401 (-4.2A)
None
 1.00A 3vasA-4il5A:
3.2		 3vasA-4il5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 LEU A 209
GLY A 169
THR A 202
LEU A 176
GLY A 193
 None
None
None
None
LLP  A  63 ( 3.5A)
 1.04A 3vasA-5ybwA:
undetectable		 3vasA-5ybwA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 339
LEU A 223
TYR A 220
ALA A 228
TYR A 225
 None
None
LLP  A 252 ( 3.7A)
GOL  A 519 (-3.3A)
None
 1.05A 3vw7A-3nraA:
undetectable		 3vw7A-3nraA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 10 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.05A 3vwpA-4li3X:
undetectable		 3vwpA-4li3X:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.15A 3vwpA-5xa2A:
undetectable		 3vwpA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.06A 3vwqA-4li3X:
undetectable		 3vwqA-4li3X:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.15A 3vwqA-5xa2A:
undetectable		 3vwqA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 11 ALA X  76
SER X  40
ASN X  72
GLY X  46
ILE X  45
 LLP  X  42 ( 3.2A)
LLP  X  42 ( 3.0A)
LLP  X  42 ( 3.8A)
LLP  X  42 ( 3.7A)
LLP  X  42 ( 4.0A)
 1.05A 3vwrA-4li3X:
undetectable		 3vwrA-4li3X:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 LLP  A  44 ( 3.2A)
LLP  A  44 ( 3.1A)
LLP  A  44 ( 3.8A)
LLP  A  44 ( 3.7A)
LLP  A  44 ( 4.1A)
 1.14A 3vwrA-5xa2A:
undetectable		 3vwrA-5xa2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 6 ASP A 137
ASP A 198
ASN A 166
GLU A 138
 None
LLP  A 235 ( 2.8A)
EDO  A 403 ( 4.7A)
EDO  A 405 ( 4.6A)
 1.29A 3vywA-6c3bA:
2.4		 3vywA-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 GLY A 345
GLY A 196
LEU A 195
ASN A 193
LEU A 321
 None
None
None
LLP  A 255 ( 3.9A)
None
 1.26A 3vywB-5vehA:
undetectable		 3vywB-5vehA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3qqm MLR3007 PROTEIN
(Mesorhizobium
loti) 		5 / 12 TYR A 196
GLY A 151
GLY A 208
ASN A 155
ALA A 127
 None
None
None
LLP  A 117 ( 3.7A)
None
 1.13A 3vywC-3qqmA:
undetectable		 3vywC-3qqmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 5 ASP A 137
ASP A 198
ASN A 166
GLU A 138
 None
LLP  A 235 ( 2.8A)
EDO  A 403 ( 4.7A)
EDO  A 405 ( 4.6A)
 1.23A 3vywD-6c3bA:
2.2		 3vywD-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 9 ILE X  88
LEU X  90
PRO X  37
SER X  10
GLY X  46
 None
None
None
None
LLP  X  42 ( 3.7A)
 1.30A 3w1wB-4li3X:
2.1		 3w1wB-4li3X:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 12 VAL A  96
LEU A  93
ILE A 156
VAL A  59
LEU A  55
 None
None
None
None
LLP  A  51 ( 3.7A)
 1.18A 3w68A-4d8uA:
undetectable		 3w68A-4d8uA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 190
CYH A 217
ASP A 215
ILE A 113
 LLP  A 241 ( 3.9A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 2.7A)
None
 1.40A 3w9tB-4q76A:
undetectable		 3w9tB-4q76A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		4 / 6 THR A 114
ASN A 159
ASP A 188
ILE A 216
 None
None
LLP  A 221 ( 2.8A)
None
 1.16A 3w9tB-6c9bA:
undetectable		 3w9tB-6c9bA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		4 / 4 ASP A 314
GLY A 169
TYR A 203
GLN A 388
 None
EDO  A 411 (-3.8A)
LLP  A 226 ( 3.5A)
EDO  A 411 (-3.5A)
 1.17A 3w9tC-3fd0A:
0.0		 3w9tC-3fd0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		4 / 5 ASP A 314
GLY A 169
TYR A 203
GLN A 388
 None
EDO  A 411 (-3.8A)
LLP  A 226 ( 3.5A)
EDO  A 411 (-3.5A)
 1.06A 3w9tD-3fd0A:
undetectable		 3w9tD-3fd0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		4 / 5 ASP A 314
GLY A 169
TYR A 203
GLN A 388
 None
EDO  A 411 (-3.8A)
LLP  A 226 ( 3.5A)
EDO  A 411 (-3.5A)
 1.12A 3w9tE-3fd0A:
undetectable		 3w9tE-3fd0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		4 / 6 THR A  75
ASN A  74
GLY A 234
ASP A 237
 LLP  A 198 ( 4.0A)
None
None
None
 1.24A 3w9tE-1cs1A:
0.0		 3w9tE-1cs1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		4 / 6 ASN A 136
GLY A 169
ASP A 168
ILE A  84
 None
None
LLP  A 199 ( 2.8A)
None
 0.99A 3w9tF-1m6sA:
0.0		 3w9tF-1m6sA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		4 / 5 ASP A 314
GLY A 169
TYR A 203
GLN A 388
 None
EDO  A 411 (-3.8A)
LLP  A 226 ( 3.5A)
EDO  A 411 (-3.5A)
 1.08A 3w9tG-3fd0A:
undetectable		 3w9tG-3fd0A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 288
THR A 327
ILE A  94
VAL A  93
 LLP  A 285 ( 3.8A)
None
None
None
 0.92A 3wriA-3w1hA:
undetectable		 3wriA-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		4 / 5 LEU A 259
GLY A 256
ILE A  81
VAL A  82
 None
LLP  A  61 ( 3.4A)
None
None
 0.84A 3wriA-4kbxA:
undetectable		 3wriA-4kbxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 288
THR A 327
ILE A  94
VAL A  93
 LLP  A 285 ( 3.8A)
None
None
None
 0.91A 3wriB-3w1hA:
undetectable		 3wriB-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		4 / 5 LEU A 259
GLY A 256
ILE A  81
VAL A  82
 None
LLP  A  61 ( 3.4A)
None
None
 0.84A 3wriB-4kbxA:
undetectable		 3wriB-4kbxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE
(Corynebacterium
diphtheriae) 		4 / 7 ILE A 235
HIS A 191
VAL A 279
PHE A  69
 None
LLP  A 222 ( 4.0A)
EDO  A 384 (-4.6A)
None
 1.03A 4a97H-3fdbA:
undetectable		 4a97H-3fdbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 9 ASP A 107
GLY A 106
VAL A 182
THR A 151
GLY A 153
 None
None
LLP  A 206 ( 4.1A)
LLP  A 206 ( 4.6A)
None
 1.41A 4acaB-2hufA:
2.7
4acaC-2hufA:
2.9		 4acaB-2hufA:
22.16
4acaC-2hufA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 7 GLY A  75
THR A  76
ILE A  79
THR A 143
 LLP  A 196 ( 3.3A)
LLP  A 196 ( 3.6A)
None
LLP  A 196 ( 4.7A)
 0.72A 4acaC-4j8lA:
3.8		 4acaC-4j8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 ASP A 290
SER A 291
SER A 292
GLY A 265
 LLP  A  42 ( 3.2A)
None
None
None
 0.83A 4af0A-5b1hA:
undetectable		 4af0A-5b1hA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ALA A 375
ASN A 402
ILE A 393
VAL A 372
HIS A 371
 LLP  A 405 ( 3.6A)
LLP  A 405 ( 3.8A)
None
None
None
 1.26A 4azsA-2okjA:
2.5		 4azsA-2okjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 12 ALA B 274
ASN B 301
ILE B 292
VAL B 271
HIS B 270
 LLP  B 304 ( 3.5A)
LLP  B 304 ( 3.7A)
None
None
None
 1.26A 4azsA-4ritB:
2.9		 4azsA-4ritB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		4 / 4 ASN A 158
ALA A 159
GLY A 189
THR A 190
 LLP  A  51 ( 4.9A)
None
LLP  A  51 ( 3.8A)
LLP  A  51 ( 3.7A)
 1.38A 4bboC-3tbhA:
undetectable		 4bboC-3tbhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 ASP A 198
HIS A 234
GLY A 239
LEU A 271
GLY A 196
 None
None
LLP  A  61 ( 3.6A)
None
None
 1.14A 4blvA-3vabA:
undetectable		 4blvA-3vabA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 12 TYR A  90
GLY A 265
GLY A 254
LEU A 105
GLY A  78
 None
None
LLP  A 255 ( 2.4A)
None
None
 1.10A 4blvA-5vehA:
3.8		 4blvA-5vehA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 12 ASP A  80
GLY A 238
SER A 103
LEU A 241
GLY A 276
 LLP  A 508 (-4.0A)
LLP  A 508 ( 4.7A)
LLP  A 508 (-3.5A)
None
LLP  A 508 (-3.2A)
 1.24A 4blvB-4xg1A:
undetectable		 4blvB-4xg1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 VAL A 273
GLY A 217
VAL A 216
SER A 252
ARG A 258
 None
LLP  A  91 ( 3.4A)
LLP  A  91 ( 4.3A)
None
None
 1.42A 4bvaA-3iauA:
2.9		 4bvaA-3iauA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 VAL A 273
GLY A 217
VAL A 216
SER A 252
ARG A 258
 None
LLP  A  91 ( 3.4A)
LLP  A  91 ( 4.3A)
None
None
 1.36A 4bvaB-3iauA:
4.5		 4bvaB-3iauA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		5 / 12 LEU A  72
GLY A  76
ALA A  79
SER A  78
LEU A  82
 None
LLP  A 198 ( 3.2A)
None
None
None
 1.16A 4coxC-1cs1A:
0.0		 4coxC-1cs1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE
(Psychrobacter
arcticus) 		5 / 12 SER A 201
GLY A 199
GLY A 354
GLU A 266
ILE A 274
 LLP  A 198 ( 4.3A)
LLP  A 198 ( 2.4A)
LLP  A 198 ( 4.8A)
None
None
 0.85A 4ctkC-3ke3A:
2.4		 4ctkC-3ke3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 186
ASN A 299
GLN A 182
THR A   9
 None
None
LLP  A 205 ( 3.9A)
None
 0.95A 4d1yA-4isyA:
2.4
4d1yB-4isyA:
2.4		 4d1yA-4isyA:
21.14
4d1yB-4isyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3oks 4-AMINOBUTYRATE
TRANSAMINASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 127
VAL A 131
GLU A 132
SER A 126
VAL A 265
 LLP  A 292 ( 3.2A)
None
None
LLP  A 292 ( 3.8A)
LLP  A 292 ( 4.2A)
 1.26A 4danA-3oksA:
undetectable		 4danA-3oksA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 11 GLY A 126
VAL A 130
GLU A 131
SER A 125
VAL A 264
 LLP  A 291 ( 3.5A)
None
None
LLP  A 291 ( 4.0A)
LLP  A 291 ( 4.3A)
 1.27A 4danA-3r4tA:
undetectable		 4danA-3r4tA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)
(Mycobacteroides
abscessus) 		5 / 11 GLY A 130
VAL A 134
GLU A 135
SER A 129
VAL A 263
 LLP  A 290 ( 3.4A)
None
None
LLP  A 290 ( 3.9A)
LLP  A 290 ( 4.2A)
 1.27A 4danA-4ffcA:
undetectable		 4danA-4ffcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ARG A  86
VAL A 167
GLU A 168
ASP A 247
VAL A 214
 LLP  A 285 ( 3.1A)
None
None
LLP  A 285 ( 3.3A)
LLP  A 285 ( 4.7A)
 1.28A 4danA-3w1hA:
undetectable
4danB-3w1hA:
undetectable		 4danA-3w1hA:
21.10
4danB-3w1hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		4 / 4 LEU A  79
ILE A  39
GLY A  80
PHE A  35
 None
None
LLP  A  77 ( 3.7A)
None
 1.07A 4dc3A-4d9iA:
3.1		 4dc3A-4d9iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		5 / 11 ALA A 221
ASP A 218
GLY A 217
GLY A 215
ILE A 219
 None
None
None
LLP  A 211 ( 3.6A)
None
 1.13A 4dcmA-5x2vA:
undetectable		 4dcmA-5x2vA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 11 LEU A 336
ILE A 361
SER A  35
LEU A 301
ILE A  30
 None
None
LLP  A 230 ( 4.9A)
None
None
 1.03A 4dm8A-4j5uA:
undetectable		 4dm8A-4j5uA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 10 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.38A 4dqbB-2gn1A:
undetectable		 4dqbB-2gn1A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 10 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.36A 4dqeB-2gn1A:
undetectable		 4dqeB-2gn1A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 10 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.38A 4dqhB-2gn1A:
undetectable		 4dqhB-2gn1A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		4 / 6 PHE A  86
ALA A 210
LEU A 232
THR A 231
 None
None
None
LLP  A 230 ( 4.0A)
 1.13A 4dtzB-4j5uA:
undetectable		 4dtzB-4j5uA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 6 ALA A 226
GLY A 248
PRO A 247
VAL A 253
 None
LLP  A 311 ( 4.7A)
None
None
 0.92A 4dubA-5eueA:
undetectable		 4dubA-5eueA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		4 / 8 GLY A  50
LEU A  53
ILE A  54
ILE A  69
 LLP  A  46 ( 3.9A)
None
None
None
 0.78A 4em2A-4r2vA:
0.4		 4em2A-4r2vA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 LEU X 104
ILE X  75
ALA X  76
ALA X  81
GLY X  85
 None
None
LLP  X  42 ( 3.2A)
None
None
 1.14A 4enhA-4li3X:
undetectable		 4enhA-4li3X:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		4 / 8 PHE A 355
VAL A 356
LEU A 105
TYR A 299
 LLP  A  61 ( 4.0A)
None
LLP  A  61 ( 3.8A)
SO4  A 401 (-4.7A)
 1.19A 4f5zA-4kbxA:
undetectable		 4f5zA-4kbxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3g0t PUTATIVE
AMINOTRANSFERASE
(Porphyromonas
gingivalis) 		5 / 12 GLY A 112
GLY A 116
VAL A 111
THR A 110
SER A 256
 LLP  A 259 ( 3.5A)
None
None
None
LLP  A 259 ( 2.5A)
 1.16A 4f84A-3g0tA:
3.4		 4f84A-3g0tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 9 TRP A  52
ILE A  42
ALA A  75
LEU A  79
ALA A  53
 None
LLP  A  41 ( 4.0A)
None
None
None
 1.35A 4fe1B-4h27A:
undetectable		 4fe1B-4h27A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 238
GLY A 239
ILE A 201
PHE A  49
PHE A  45
 LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
None
None
 1.25A 4fglA-3vabA:
undetectable
4fglB-3vabA:
undetectable		 4fglA-3vabA:
20.70
4fglB-3vabA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 239
GLY A 240
ILE A 201
VAL A 235
PHE A  45
 LLP  A  61 ( 3.6A)
LLP  A  61 ( 3.3A)
None
None
None
 1.26A 4fglA-3vabA:
undetectable
4fglB-3vabA:
undetectable		 4fglA-3vabA:
20.70
4fglB-3vabA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 8 SER A   8
SER A   9
THR A 153
MET A 334
 None
None
LLP  A 198 ( 3.5A)
None
 1.01A 4fo4A-1bjnA:
undetectable		 4fo4A-1bjnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 8 SER A 319
ASN A 116
GLY A 322
CYH A 367
 FMT  A 613 (-4.5A)
LLP  A 318 ( 3.9A)
None
None
 0.83A 4fo4B-6cczA:
undetectable		 4fo4B-6cczA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ASP A 208
LEU A 214
PHE A 217
VAL A 182
ALA A 181
 None
None
None
LLP  A  42 ( 4.0A)
None
 1.11A 4foxD-5jjcA:
undetectable		 4foxD-5jjcA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 12 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
 LLP  A 270 ( 4.0A)
None
None
None
None
 0.96A 4fp9A-3l44A:
undetectable		 4fp9A-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 12 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
 LLP  A 270 ( 4.0A)
None
None
None
None
 0.94A 4fp9C-3l44A:
undetectable		 4fp9C-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 12 GLY A 273
GLY A 274
ASN A 118
PRO A 307
LEU A  89
 LLP  A 270 ( 4.0A)
None
None
None
None
 0.96A 4fp9D-3l44A:
undetectable		 4fp9D-3l44A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 5 HIS A 484
TYR A 150
GLY A 147
SER A 146
 None
LLP  A 353 (-3.8A)
SIN  A 901 ( 4.0A)
None
 1.16A 4fu8A-4q6rA:
undetectable		 4fu8A-4q6rA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 5 HIS A 441
TYR A 105
GLY A 102
SER A 101
 None
LLP  A 311 (-3.9A)
PO4  A 602 ( 3.8A)
None
 1.20A 4fu8A-5eueA:
undetectable		 4fu8A-5eueA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		3 / 3 GLN A  42
THR A  41
THR A  40
 None
LLP  A 234 ( 3.4A)
None
 0.76A 4fu9A-6c9eA:
undetectable		 4fu9A-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		3 / 3 GLN A  42
THR A  41
THR A  40
 None
LLP  A 234 ( 3.4A)
None
 0.78A 4fufA-6c9eA:
undetectable		 4fufA-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 7 ILE A 133
PRO A 134
GLY A 171
ALA A  68
GLN A 178
 None
SO4  A 403 (-4.7A)
LLP  A  41 ( 3.2A)
SO4  A 402 (-3.3A)
None
 1.47A 4g0uB-4h27A:
undetectable		 4g0uB-4h27A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 PHE A  40
PHE A 309
ALA A 251
THR A 252
VAL A 402
 None
None
None
LLP  A 247 ( 4.4A)
None
 1.14A 4g1bA-4wlhA:
undetectable		 4g1bA-4wlhA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 5 HIS A 400
ALA A 397
HIS A 248
TYR A 281
 None
None
None
LLP  A 312 ( 4.0A)
 1.41A 4gboA-4tv7A:
undetectable		 4gboA-4tv7A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 LEU A 262
GLY A 116
GLY A 113
LEU A 265
VAL A 246
 None
None
LLP  A 253 ( 3.6A)
None
None
 1.02A 4gc9A-1bw0A:
undetectable		 4gc9A-1bw0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 0.95A 4hbfA-3w1hA:
undetectable		 4hbfA-3w1hA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 2.9A)
None
 1.05A 4hbfA-3w1jA:
undetectable		 4hbfA-3w1jA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 1.01A 4hc3A-3w1hA:
undetectable		 4hc3A-3w1hA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE
(environmental
samples) 		4 / 8 ILE A 209
ILE A 247
MET A 220
GLY A 218
 None
LLP  A 274 ( 3.8A)
None
None
 0.93A 4hdlA-5uc7A:
undetectable		 4hdlA-5uc7A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 288
GLY A 289
GLY A 283
LEU A 286
VAL A  79
 LLP  A 285 ( 3.4A)
None
LLP  A 285 ( 4.4A)
LLP  A 285 ( 4.3A)
None
 1.01A 4htfB-3w1jA:
undetectable		 4htfB-3w1jA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_2
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		4 / 5 TRP A 283
SER A 317
MET A  34
ASN A 233
 None
None
LLP  A 230 ( 4.2A)
None
 1.19A 4j03A-3t32A:
1.4		 4j03A-3t32A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		4 / 8 GLY A  90
ASN A  91
PRO A 112
ILE A 247
 None
LLP  A  63 ( 3.7A)
None
None
 0.95A 4j4vC-5ybwA:
undetectable		 4j4vC-5ybwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 10 ALA A 191
ILE A  73
VAL A 226
GLY A 214
VAL A 200
 None
None
None
LLP  A 216 ( 4.4A)
None
 0.81A 4j5jB-5b7sA:
undetectable		 4j5jB-5b7sA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
innocua) 		3 / 3 ASP A 200
LEU A  93
VAL A 246
 LLP  A 226 ( 2.8A)
None
None
 0.68A 4jecB-3fd0A:
undetectable		 4jecB-3fd0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 198
LEU A 103
VAL A 251
 LLP  A 227 ( 2.9A)
None
None
 0.57A 4jecB-3h7fA:
undetectable		 4jecB-3h7fA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		3 / 3 ASP A 217
LEU A 108
VAL A 270
 LLP  A 243 ( 2.9A)
None
None
 0.71A 4jecB-3hvyA:
undetectable		 4jecB-3hvyA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE
(Listeria
monocytogenes) 		3 / 3 ASP A 200
LEU A  93
VAL A 246
 LLP  A 226 ( 2.8A)
None
None
 0.71A 4jecB-3jzlA:
undetectable		 4jecB-3jzlA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 GLN A 362
GLY A 361
THR A 365
ARG A 368
 None
LLP  A 206 ( 4.8A)
None
None
 0.97A 4k87A-2hufA:
undetectable		 4k87A-2hufA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME
(Histophilus
somni) 		4 / 8 ARG A 106
PHE A   7
THR A   9
ARG A  64
 LLP  A 102 (-3.1A)
LLP  A 102 ( 4.0A)
None
None
 0.83A 4k87A-3cebA:
undetectable		 4k87A-3cebA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		4 / 8 LEU A 114
SER A 311
VAL A 251
GLY A 250
 None
None
None
LLP  A 247 ( 4.8A)
 1.00A 4klrB-4k2bA:
undetectable		 4klrB-4k2bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		5 / 10 TRP A 392
ALA A 366
ASP A 364
THR A 502
THR A 391
 None
LLP  A 396 ( 3.5A)
LLP  A 396 ( 2.6A)
None
None
 1.24A 4km0A-2okkA:
undetectable		 4km0A-2okkA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 339
ALA A  87
ILE A  80
LEU A 256
ILE A 342
 None
LLP  A 285 ( 4.1A)
LLP  A 285 (-4.6A)
None
None
 0.99A 4km0B-3w1jA:
2.3		 4km0B-3w1jA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 198
SER A 262
GLY A 238
SER A 121
TYR A 122
 LLP  A 232 ( 2.8A)
None
None
None
None
 1.36A 4kn2A-2o0rA:
undetectable		 4kn2A-2o0rA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 198
SER A 262
GLY A 238
SER A 121
TYR A 122
 LLP  A 232 ( 2.8A)
None
None
None
None
 1.40A 4kn2C-2o0rA:
0.0		 4kn2C-2o0rA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  83
GLY A 235
GLY A  95
SER A 222
ARG A 233
 None
None
LLP  A 227 ( 3.2A)
None
None
 1.08A 4krhA-3h7fA:
2.8		 4krhA-3h7fA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  83
GLY A 235
GLY A  95
SER A 222
ARG A 233
 None
None
LLP  A 227 ( 3.2A)
None
None
 1.09A 4krhB-3h7fA:
4.3		 4krhB-3h7fA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 224
GLY A 168
ALA A 198
LEU A 223
HIS A 199
 None
LLP  A  41 ( 3.5A)
None
None
None
 1.14A 4l8fB-4h27A:
undetectable		 4l8fB-4h27A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 224
GLY A 169
ALA A 198
GLU A 194
HIS A 199
 None
LLP  A  41 ( 3.7A)
None
None
None
 1.18A 4l8fB-4h27A:
undetectable		 4l8fB-4h27A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 11 GLY A 224
GLY A 168
ALA A 198
LEU A 223
HIS A 199
 None
LLP  A  41 ( 3.5A)
None
None
None
 1.18A 4l8fD-4h27A:
undetectable		 4l8fD-4h27A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		4 / 6 GLY A  49
ASP A 284
PRO A 319
ARG A  82
 LLP  A  51 ( 4.2A)
LLP  A  51 ( 4.7A)
None
None
 1.25A 4lajA-4d8uA:
undetectable
4lajB-4d8uA:
undetectable		 4lajA-4d8uA:
20.30
4lajB-4d8uA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 12 GLY A 131
GLY A 129
LEU A 192
ALA A  76
TYR A 211
 LLP  A  78 ( 4.9A)
None
None
LLP  A  78 ( 4.3A)
LLP  A  78 ( 4.9A)
 1.08A 4lg1A-5ygrA:
undetectable		 4lg1A-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 GLY A  98
GLY A 254
LEU A 242
ALA A 102
GLU A  38
 LLP  A 244 ( 3.8A)
None
None
None
MES  A 400 (-4.1A)
 1.08A 4lg1B-3jtxA:
undetectable		 4lg1B-3jtxA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 12 GLY A 131
GLY A 129
LEU A 192
ALA A  76
TYR A 211
 LLP  A  78 ( 4.9A)
None
None
LLP  A  78 ( 4.3A)
LLP  A  78 ( 4.9A)
 1.09A 4lg1B-5ygrA:
undetectable		 4lg1B-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4zwv PUTATIVE
AMINOTRANSFERASE
(Actinomadura
melliaura) 		6 / 12 ALA A  87
GLY A  54
GLY A  57
LEU A 196
LEU A 197
ALA A  83
 None
LLP  A 187 ( 3.4A)
None
None
None
LLP  A 187 ( 3.9A)
 1.43A 4lg1C-4zwvA:
undetectable		 4lg1C-4zwvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 12 GLY A 131
GLY A 129
LEU A 192
ALA A  76
TYR A 211
 LLP  A  78 ( 4.9A)
None
None
LLP  A  78 ( 4.3A)
LLP  A  78 ( 4.9A)
 1.15A 4lg1C-5ygrA:
undetectable		 4lg1C-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 VAL A 214
ILE A 161
SER A 162
MET A 179
LEU A 186
 LLP  A 285 ( 4.7A)
None
None
None
None
 1.26A 4lhmA-3w1hA:
undetectable		 4lhmA-3w1hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 9 ALA A 243
ASP A 244
GLY A 322
VAL A 189
ILE A 246
 None
None
LLP  A  63 ( 3.8A)
LLP  A  63 ( 4.1A)
LLP  A  63 ( 4.5A)
 1.13A 4ll3B-5ybwA:
undetectable		 4ll3B-5ybwA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		3 / 3 ASP A 132
VAL A 138
ASN A 154
 None
None
LLP  A  56 ( 4.7A)
 0.81A 4lmnA-3l6rA:
undetectable		 4lmnA-3l6rA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 339
ALA A  87
ILE A  80
LEU A 256
ILE A 342
 None
LLP  A 285 ( 3.9A)
LLP  A 285 ( 4.8A)
None
None
 1.03A 4m2xE-3w1hA:
2.6		 4m2xE-3w1hA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 11 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.44A 4m83A-4xg1A:
undetectable		 4m83A-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		5 / 11 HIS A  41
VAL A  68
TYR A  58
ASN A 282
ALA A  62
 None
None
None
None
LLP  A 508 ( 4.8A)
 1.49A 4m83B-4xg1A:
undetectable		 4m83B-4xg1A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)
(Mycobacteroides
abscessus) 		4 / 5 TYR A 157
THR A 326
LEU A 298
THR A 287
 LLP  A 290 ( 4.8A)
None
None
None
 1.43A 4mbsB-4ffcA:
undetectable		 4mbsB-4ffcA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 8 MET A 261
SER A 398
VAL A 418
GLY A 252
 None
None
None
LLP  A 405 ( 3.4A)
 0.93A 4mk4A-2okjA:
4.6		 4mk4A-2okjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 8 MET A 252
SER A 389
VAL A 409
GLY A 243
 None
None
None
LLP  A 396 ( 3.6A)
 1.01A 4mk4A-2okkA:
4.1		 4mk4A-2okkA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		5 / 12 TYR A 278
SER A 247
GLY A 275
ASP A 424
THR A  66
 LLP  A 277 ( 4.7A)
LLP  A 277 ( 4.6A)
LLP  A 277 ( 4.2A)
None
None
 1.36A 4mm4A-3hbxA:
undetectable		 4mm4A-3hbxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 VAL A 239
ALA A 238
GLY A 185
ASP A 270
THR A 152
 None
None
None
LLP  A 302 ( 2.7A)
None
 1.14A 4mm4A-3k40A:
undetectable		 4mm4A-3k40A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		5 / 12 VAL A 239
ALA A 238
SER A 208
ASP A 270
THR A 152
 None
None
None
LLP  A 302 ( 2.7A)
None
 1.30A 4mm4A-3k40A:
undetectable		 4mm4A-3k40A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 12 ASP A  91
ALA A 122
TYR A 121
PHE A 115
VAL A 188
 LLP  A 226 ( 3.4A)
None
None
LLP  A 226 ( 3.7A)
None
 1.16A 4mm6A-3getA:
undetectable		 4mm6A-3getA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 164
SER A 226
LEU A 166
LEU A 197
 None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
 1.15A 4n09B-5v7iA:
4.6		 4n09B-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		4 / 5 ASN A 208
SER A 202
LEU A 333
ASN A 155
 None
LLP  A 205 ( 2.8A)
LLP  A 205 ( 4.3A)
SO4  A2001 (-3.3A)
 1.09A 4n09C-3aczA:
undetectable		 4n09C-3aczA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 5 ASN B 213
SER B 207
LEU B 340
ASN B 160
 None
LLP  B 210 ( 2.6A)
LLP  B 210 (-4.3A)
NAK  B 402 (-3.3A)
 1.12A 4n09C-4iyoB:
undetectable		 4n09C-4iyoB:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 5 ASN A 202
SER A 196
LEU A 329
ASN A 149
 None
LLP  A 199 ( 2.7A)
LLP  A 199 (-4.3A)
FMT  A 401 (-3.2A)
 1.12A 4n09C-6cjbA:
undetectable		 4n09C-6cjbA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		5 / 12 GLY A 273
GLY A 313
ALA A  79
ASN A 306
GLY A 305
 LLP  A 270 ( 4.0A)
None
None
None
None
 0.81A 4n09D-3l44A:
undetectable		 4n09D-3l44A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 164
SER A 226
LEU A 166
LEU A 197
 None
LLP  A 280 (-3.4A)
8Z1  A 601 (-4.7A)
None
 1.14A 4n09D-5v7iA:
4.7		 4n09D-5v7iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 6 ASP A 315
ASP A 350
ALA A 244
PHE A 245
 LLP  A 353 ( 2.9A)
LLP  A 353 ( 3.8A)
None
None
 1.12A 4nedA-4q6rA:
undetectable		 4nedA-4q6rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ALA A 191
ILE A 284
ILE A 281
GLY A 214
VAL A  69
 None
None
None
LLP  A 216 ( 4.4A)
None
 0.94A 4nkvC-5b7sA:
undetectable		 4nkvC-5b7sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)
(Mycobacteroides
abscessus) 		4 / 6 TYR A  45
LEU A 407
VAL A  71
ALA A  70
 None
None
LLP  A 290 ( 3.7A)
LLP  A 290 ( 3.9A)
 0.87A 4nkvC-4ffcA:
undetectable		 4nkvC-4ffcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 ALA A 191
ILE A 284
ILE A 281
GLY A 214
VAL A  69
 None
None
None
LLP  A 216 ( 4.4A)
None
 0.93A 4nkvD-5b7sA:
undetectable		 4nkvD-5b7sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 9 ILE A 197
GLY A 198
ILE A  12
ILE A 237
VAL A  47
 LLP  A 196 ( 4.0A)
None
None
None
None
 1.07A 4nptA-4ixoA:
undetectable		 4nptA-4ixoA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5ygr DIAMINOPROPIONATE
AMMONIA LYASE
(Salmonella
enterica) 		5 / 12 GLY A  79
GLY A  81
THR A 195
GLY A 131
VAL A 132
 LLP  A  78 ( 2.4A)
LLP  A  78 ( 3.4A)
None
LLP  A  78 ( 4.9A)
None
 0.89A 4o33A-5ygrA:
undetectable		 4o33A-5ygrA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE
(Campylobacter
jejuni) 		5 / 12 ALA A 217
GLY A 216
SER A  82
ILE A  78
GLY A  65
 None
None
LLP  A 205 ( 3.7A)
None
None
 1.18A 4obwA-4oc9A:
3.0		 4obwA-4oc9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		5 / 12 ASN A 432
GLY A 248
GLY A 252
ILE A 281
GLY A 279
 None
LLP  A 311 ( 4.7A)
None
None
None
 0.99A 4obwB-5eueA:
2.8		 4obwB-5eueA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		3 / 3 ALA A 321
GLN A 195
GLY A 194
 None
LLP  A  91 ( 4.4A)
None
 0.64A 4odoC-3iauA:
undetectable		 4odoC-3iauA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME
(Histophilus
somni) 		5 / 12 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.16A 4ok1A-3cebA:
undetectable		 4ok1A-3cebA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME
(Histophilus
somni) 		5 / 12 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.25A 4okbA-3cebA:
undetectable		 4okbA-3cebA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME
(Histophilus
somni) 		5 / 12 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.23A 4oktA-3cebA:
undetectable		 4oktA-3cebA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ceb D-AMINOACID
AMINOTRANSFERASE-LIK
E PLP-DEPENDENT
ENZYME
(Histophilus
somni) 		5 / 12 LEU A 154
GLY A 156
ARG A 106
THR A 148
ILE A 168
 LLP  A 102 ( 4.2A)
LLP  A 102 ( 3.3A)
LLP  A 102 (-3.1A)
None
None
 1.22A 4okwA-3cebA:
undetectable		 4okwA-3cebA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 200
PRO A 201
GLN A 196
 None
None
LLP  A 197 ( 3.1A)
 0.57A 4oltB-4xk1A:
undetectable		 4oltB-4xk1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 6a2f -
(-) 		5 / 11 SER A 194
SER A 217
LEU A 230
ASP A 331
LEU A 340
 LLP  A  34 ( 2.5A)
None
None
None
None
 1.41A 4or0A-6a2fA:
undetectable		 4or0A-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.30A 4p6xA-5kinB:
undetectable		 4p6xA-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.30A 4p6xE-5kinB:
undetectable		 4p6xE-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.33A 4p6xI-5kinB:
undetectable		 4p6xI-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 MET A 222
MET A 323
TYR A 345
 LLP  A 253 ( 3.7A)
None
None
 1.34A 4p6xI-1bw0A:
0.0		 4p6xI-1bw0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.24A 4p6xK-5kinB:
undetectable		 4p6xK-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 206
LEU A 211
GLY A 220
GLU A 304
ALA A 170
 None
None
None
LLP  A  83 ( 3.6A)
None
 1.07A 4pclA-1tufA:
undetectable		 4pclA-1tufA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  91
LEU A 260
GLY A 235
ALA A 200
ASN A  99
 None
None
None
LLP  A 227 ( 3.6A)
LLP  A 227 ( 4.7A)
 1.38A 4pclB-3h7fA:
5.2		 4pclB-3h7fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 12 GLN A  94
LEU A 264
GLY A 238
ALA A 203
ASN A 102
 None
None
None
LLP  A 230 ( 3.4A)
LLP  A 230 ( 4.5A)
 1.27A 4pclB-4j5uA:
4.3		 4pclB-4j5uA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 SER A 282
GLY A 262
GLY A 109
LEU A 256
ILE A 106
 None
None
LLP  A 252 ( 3.5A)
None
None
 1.06A 4pghA-3nraA:
3.0		 4pghA-3nraA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 SER A 282
GLY A 262
GLY A 109
LEU A 256
ILE A 106
 None
None
LLP  A 252 ( 3.5A)
None
None
 1.08A 4pghD-3nraA:
undetectable		 4pghD-3nraA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 10 VAL A  64
LEU A  50
GLY A 340
ALA A 341
LEU A 344
 None
None
LLP  A  77 ( 4.7A)
None
None
 1.02A 4ph9A-4d9iA:
0.4		 4ph9A-4d9iA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 10 VAL A  64
LEU A  50
GLY A 340
ALA A 341
LEU A 344
 None
None
LLP  A  77 ( 4.7A)
None
None
 1.01A 4ph9B-4d9iA:
0.1		 4ph9B-4d9iA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
 None
None
None
None
LLP  B  86 ( 3.1A)
 1.29A 4q15A-5kzmB:
2.3		 4q15A-5kzmB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
 None
None
None
None
LLP  B  86 ( 3.1A)
 1.28A 4q15B-5kzmB:
2.2		 4q15B-5kzmB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 9 ALA A 243
ASP A 244
GLY A 322
ILE A 290
VAL A 214
 None
None
LLP  A  63 ( 3.8A)
None
None
 1.01A 4q1wA-5ybwA:
undetectable		 4q1wA-5ybwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 11 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.44A 4q1xA-2gn1A:
undetectable		 4q1xA-2gn1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		6 / 11 GLY A 203
ALA A 236
ILE A  20
ILE A  12
GLY A 198
ILE A 197
 None
None
None
None
None
LLP  A 196 ( 4.0A)
 1.41A 4q1xA-4ixoA:
undetectable		 4q1xA-4ixoA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 11 GLY B 245
ALA B 244
ASP B 272
ILE B 292
ILE B 298
 None
None
LLP  B 304 ( 2.7A)
None
None
 0.79A 4q1xA-4ritB:
undetectable		 4q1xA-4ritB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 10 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.44A 4q1yA-2gn1A:
undetectable		 4q1yA-2gn1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		3 / 3 PRO A 159
MET A 164
TYR A 189
 None
None
LLP  A 211 ( 4.6A)
 1.09A 4qa0B-5x2vA:
3.6		 4qa0B-5x2vA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		3 / 3 PRO A 159
MET A 164
TYR A 189
 None
None
LLP  A 211 ( 4.6A)
 1.06A 4qa0A-5x2vA:
undetectable		 4qa0A-5x2vA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 315
SER B 319
SER B 194
LEU B 288
HIS B 285
 None
None
LLP  B  91 ( 3.0A)
None
None
 1.05A 4qdjA-5kinB:
undetectable		 4qdjA-5kinB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		6 / 11 ASP A 199
GLY A 200
ALA A 201
THR A 232
GLY A 233
ILE A 234
 LLP  A 225 ( 2.7A)
None
LLP  A 225 ( 3.6A)
None
None
None
 1.34A 4qgiA-5vprA:
undetectable		 4qgiA-5vprA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3pj0 LMO0305 PROTEIN
(Listeria
monocytogenes) 		4 / 8 PHE A 205
TYR A 206
GLY A 177
ILE A 183
 None
LLP  A 207 ( 3.6A)
None
None
 0.93A 4qoiA-3pj0A:
undetectable
4qoiB-3pj0A:
undetectable		 4qoiA-3pj0A:
19.56
4qoiB-3pj0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 4qvlV-6cczA:
undetectable
4qvlb-6cczA:
undetectable		 4qvlV-6cczA:
16.59
4qvlb-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 4qvlH-6cczA:
undetectable
4qvlN-6cczA:
undetectable		 4qvlH-6cczA:
16.59
4qvlN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 9 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.90A 4qvmK-3iauA:
undetectable
4qvmL-3iauA:
undetectable		 4qvmK-3iauA:
20.44
4qvmL-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 10 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.90A 4qvmY-3iauA:
undetectable
4qvmZ-3iauA:
undetectable		 4qvmY-3iauA:
20.44
4qvmZ-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.41A 4qvwV-6cczA:
undetectable
4qvwb-6cczA:
undetectable		 4qvwV-6cczA:
16.59
4qvwb-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.41A 4qvwH-6cczA:
undetectable
4qvwN-6cczA:
undetectable		 4qvwH-6cczA:
16.59
4qvwN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		5 / 10 ALA A  89
ALA A  93
GLY A 113
THR A 114
ASP A 183
 None
None
SO4  A 390 ( 4.4A)
None
LLP  A 208 ( 3.1A)
 1.04A 4qvyK-3qi6A:
undetectable
4qvyL-3qi6A:
undetectable		 4qvyK-3qi6A:
20.20
4qvyL-3qi6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.42A 4qvyH-6cczA:
undetectable
4qvyN-6cczA:
undetectable		 4qvyH-6cczA:
16.59
4qvyN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		5 / 10 ALA A  89
ALA A  93
GLY A 113
THR A 114
ASP A 183
 None
None
SO4  A 390 ( 4.4A)
None
LLP  A 208 ( 3.1A)
 1.04A 4qvyY-3qi6A:
undetectable
4qvyZ-3qi6A:
undetectable		 4qvyY-3qi6A:
20.20
4qvyZ-3qi6A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.40A 4qw1V-6cczA:
undetectable
4qw1b-6cczA:
undetectable		 4qw1V-6cczA:
16.59
4qw1b-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.40A 4qw1H-6cczA:
undetectable
4qw1N-6cczA:
undetectable		 4qw1H-6cczA:
16.59
4qw1N-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 10 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.90A 4qw3K-3iauA:
undetectable
4qw3L-3iauA:
undetectable		 4qw3K-3iauA:
20.44
4qw3L-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 10 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.90A 4qw3Y-3iauA:
undetectable
4qw3Z-3iauA:
undetectable		 4qw3Y-3iauA:
20.44
4qw3Z-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 ILE X 229
VAL X 219
SER X 207
LEU X 240
LEU X 238
 LLP  X  42 ( 4.7A)
None
None
None
None
 1.48A 4qztA-4li3X:
undetectable		 4qztA-4li3X:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2odo ALANINE RACEMASE
(Pseudomonas
fluorescens) 		4 / 6 ALA A  20
ILE A  32
GLY A 210
SER A 189
 None
LLP  A  33 ( 4.3A)
LLP  A  33 ( 3.2A)
None
 0.81A 4r21A-2odoA:
undetectable		 4r21A-2odoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 10 THR A 256
GLU A 222
LEU A  86
VAL A  94
LEU A  93
 LLP  A 255 ( 4.4A)
None
None
None
None
 1.08A 4r3aB-5vehA:
undetectable		 4r3aB-5vehA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 7 GLU A 226
ARG A 377
GLY A 233
GLY A 230
 LLP  A 288 (-4.0A)
None
None
None
 0.83A 4rdxA-3fcrA:
undetectable		 4rdxA-3fcrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3gju PUTATIVE
AMINOTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 7 GLU A 227
ARG A 378
GLY A 234
GLY A 231
 LLP  A 289 (-3.7A)
None
None
None
 0.79A 4rdxA-3gjuA:
undetectable		 4rdxA-3gjuA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3oks 4-AMINOBUTYRATE
TRANSAMINASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLU A 230
ARG A 373
GLY A 237
GLY A 234
 LLP  A 292 ( 3.8A)
None
None
None
 0.85A 4rdxA-3oksA:
undetectable		 4rdxA-3oksA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		4 / 7 GLU A 229
ARG A 372
GLY A 236
GLY A 233
 LLP  A 291 ( 3.8A)
None
None
None
 0.88A 4rdxA-3r4tA:
undetectable		 4rdxA-3r4tA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)
(Mycobacteroides
abscessus) 		4 / 7 GLU A 228
ARG A 371
GLY A 235
GLY A 232
 LLP  A 290 ( 3.7A)
None
None
None
 0.87A 4rdxA-4ffcA:
undetectable		 4rdxA-4ffcA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 GLU A 223
ARG A 373
GLY A 230
GLY A 227
 LLP  A 285 ( 3.8A)
None
None
None
 0.83A 4rdxA-4grxA:
undetectable		 4rdxA-4grxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 LEU A  55
ILE A  51
ALA A 205
ILE A 197
PHE A 240
 None
None
None
LLP  A 196 ( 4.0A)
None
 1.25A 4rp8C-4ixoA:
undetectable		 4rp8C-4ixoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 9 VAL A  64
LEU A  50
GLY A 340
ALA A 341
LEU A 344
 None
None
LLP  A  77 ( 4.7A)
None
None
 0.95A 4rs0A-4d9iA:
undetectable		 4rs0A-4d9iA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 106
ALA A 107
ILE A 264
ASN A 104
SER A 296
 LLP  A 255 ( 3.5A)
LLP  A 255 ( 3.4A)
None
None
None
 1.23A 4rtpA-3ruyA:
undetectable		 4rtpA-3ruyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		5 / 7 GLY A 256
GLN A 353
ARG A 351
ALA A 258
ILE A 263
 LLP  A  61 ( 3.4A)
LLP  A  61 (-3.7A)
LLP  A  61 (-3.3A)
None
None
 1.49A 4txnA-4kbxA:
undetectable		 4txnA-4kbxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 3b46 AMINOTRANSFERASE
BNA3
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 205
LEU A 361
PHE A 148
TYR A 407
 LLP  A 271 ( 3.2A)
None
None
None
 1.20A 4u14A-3b46A:
0.0		 4u14A-3b46A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 5 GLY A 112
ALA A 113
GLY A 109
PRO A 108
 None
None
LLP  A 252 ( 3.5A)
None
 0.95A 4u9uA-3nraA:
undetectable		 4u9uA-3nraA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3gju PUTATIVE
AMINOTRANSFERASE
(Mesorhizobium
japonicum) 		6 / 12 GLY A 120
GLY A 157
SER A 119
LEU A 118
ALA A 288
ALA A 123
 PLP  A 460 (-3.2A)
None
PLP  A 460 (-3.6A)
None
LLP  A 289 ( 2.8A)
None
 1.34A 4uckA-3gjuA:
undetectable		 4uckA-3gjuA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 ALA A 125
SER A 129
GLY A  71
GLN A 236
GLY A 183
 None
None
None
None
LLP  A  42 ( 3.7A)
 1.16A 4uilH-5jjcA:
undetectable
4uilL-5jjcA:
undetectable		 4uilH-5jjcA:
21.76
4uilL-5jjcA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ASN A 299
ARG A 129
ASP A  98
ALA A 103
SER A 177
 None
None
None
None
LLP  A 198 ( 3.7A)
 0.98A 4uroC-1bjnA:
undetectable		 4uroC-1bjnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 259
ALA A  51
ILE A  61
VAL A 261
ILE A  62
 LLP  A 255 ( 4.9A)
LLP  A 255 ( 3.9A)
None
None
None
 1.08A 4uw0A-3ruyA:
undetectable		 4uw0A-3ruyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ALA A 400
ALA A  84
ALA A  79
TYR A  80
LEU A  94
 None
LLP  A  83 ( 3.6A)
None
None
None
 1.38A 4v1fA-1tufA:
undetectable
4v1fB-1tufA:
undetectable		 4v1fA-1tufA:
12.21
4v1fB-1tufA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2odo ALANINE RACEMASE
(Pseudomonas
fluorescens) 		5 / 8 ALA A  41
ALA A  36
ILE A  32
TYR A 214
LEU A 213
 None
None
LLP  A  33 ( 4.3A)
None
None
 1.39A 4v1fA-2odoA:
undetectable
4v1fB-2odoA:
undetectable		 4v1fA-2odoA:
13.12
4v1fB-2odoA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 7 ASN A 189
PRO A 190
PHE A 340
PHE A 383
 LLP  A 252 (-4.0A)
None
None
None
 1.32A 4v32A-3nraA:
undetectable		 4v32A-3nraA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3op7 AMINOTRANSFERASE
CLASS I AND II
(Streptococcus
suis) 		4 / 7 ASN A 164
PRO A 165
PHE A 309
PHE A 349
 LLP  A 221 ( 3.9A)
None
None
None
 1.46A 4v32C-3op7A:
undetectable		 4v32C-3op7A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		5 / 12 GLY A 175
ASP A 174
PHE A 221
ILE A 199
ALA A 216
 None
LLP  A 205 ( 2.9A)
None
None
None
 1.23A 4wh5A-3lwsA:
undetectable		 4wh5A-3lwsA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 PHE A  80
LEU A  84
GLU A 214
THR A 248
 None
None
None
LLP  A 247 ( 4.3A)
 1.02A 4wnvD-4wlhA:
undetectable		 4wnvD-4wlhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 PHE A  80
LEU A  84
GLU A 214
THR A 248
 None
None
None
LLP  A 247 ( 4.3A)
 0.98A 4wnvD-4wp0A:
undetectable		 4wnvD-4wp0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		5 / 12 ALA A  48
LEU A  17
ASN A  16
VAL A  33
ALA A  37
 None
None
None
LLP  A  34 ( 3.3A)
None
 0.99A 4x20B-4qhrA:
undetectable		 4x20B-4qhrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT
(Mycobacterium
marinum) 		5 / 9 GLY A 296
ILE A 338
MET A 343
VAL A  77
THR A 334
 LLP  A 291 ( 4.9A)
None
None
None
None
 1.29A 4x3mA-3r4tA:
undetectable		 4x3mA-3r4tA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3bn1 PEROSAMINE
SYNTHETASE
(Caulobacter
vibrioides) 		3 / 3 LYS A 187
ARG A 256
VAL A 257
 LLP  A 186 ( 2.9A)
None
None
 1.00A 4x3uA-3bn1A:
undetectable
4x3uB-3bn1A:
undetectable		 4x3uA-3bn1A:
9.56
4x3uB-3bn1A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		3 / 3 LYS A 181
ARG A 209
VAL A 208
 None
LLP  A  34 ( 3.9A)
None
 1.05A 4x3uA-4qhrA:
0.3
4x3uB-4qhrA:
0.6		 4x3uA-4qhrA:
10.67
4x3uB-4qhrA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		5 / 12 GLU A 283
GLU A  47
GLY A 289
ALA A 292
GLU A 266
 LLP  A  56 ( 3.6A)
None
None
None
None
 1.28A 4xe5A-3l6rA:
3.0		 4xe5A-3l6rA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		5 / 12 ALA A 250
GLU A 222
SER A 240
TYR A  82
LEU A 289
 None
None
LLP  A 243 ( 3.8A)
None
None
 1.47A 4xqeA-3hvyA:
2.8		 4xqeA-3hvyA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE
(Bacillus
cereus) 		5 / 12 MET A 234
GLY A 195
TYR A 237
GLN A 288
HIS A 187
 None
None
None
PEG  A 384 (-3.5A)
LLP  A 190 (-4.2A)
 1.35A 4xucA-3ju7A:
undetectable		 4xucA-3ju7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE
(Bacillus
cereus) 		5 / 12 MET A 234
GLY A 195
TYR A 237
GLN A 288
HIS A 187
 None
None
None
PEG  A 384 (-3.5A)
LLP  A 190 (-4.2A)
 1.38A 4xudA-3ju7A:
2.8		 4xudA-3ju7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.13A 4xudA-6cczA:
4.3		 4xudA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.18A 4xueB-6cczA:
4.2		 4xueB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4xg1 DIAMINOPIMELATE
DECARBOXYLASE
(Psychromonas
ingrahamii) 		3 / 3 SER A 378
GLU A  86
GLU A 274
 None
None
LLP  A 508 (-3.8A)
 0.88A 4ymgB-4xg1A:
undetectable		 4ymgB-4xg1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 THR A 306
MET A 300
THR A 182
GLY A 302
ALA A 296
 None
None
LLP  A 205 ( 3.6A)
None
None
 1.22A 4ypmA-3aczA:
undetectable		 4ypmA-3aczA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 12 ALA A 119
LEU A 110
THR A 156
PRO A 344
ALA A 342
 None
None
LLP  A 221 ( 3.5A)
None
None
 1.10A 4ypmA-6c9bA:
undetectable		 4ypmA-6c9bA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 6a2f -
(-) 		5 / 10 ALA A  64
LEU A  79
LEU A  96
LEU A  90
ALA A  91
 None
LLP  A  34 ( 3.9A)
None
None
None
 1.20A 4zbrA-6a2fA:
undetectable		 4zbrA-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
TYR A 265
LEU A 264
PHE A 341
THR A   6
 LLP  A 185 ( 3.5A)
None
None
None
None
 1.16A 4ze2A-1iugA:
0.0		 4ze2A-1iugA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3nu8 AMINOTRANSFERASE
WBPE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  87
GLN A 159
GLU A 155
ASN A 110
TYR A 309
 LLP  A 185 ( 3.6A)
LLP  A 185 ( 3.6A)
None
None
None
 1.33A 4zj8A-3nu8A:
undetectable		 4zj8A-3nu8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 238
GLY A 239
ILE A 201
PHE A  49
PHE A  45
 LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
None
None
 1.19A 4zvmA-3vabA:
undetectable
4zvmB-3vabA:
undetectable		 4zvmA-3vabA:
20.75
4zvmB-3vabA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 221
PHE A  65
GLY A 262
GLY A 263
ILE A 225
 None
None
LLP  A  83 ( 4.6A)
LLP  A  83 ( 3.9A)
None
 1.40A 4zvmA-1tufA:
undetectable
4zvmB-1tufA:
undetectable		 4zvmA-1tufA:
19.47
4zvmB-1tufA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 221
PHE A  76
GLY A 262
GLY A 263
ILE A 225
 None
None
LLP  A  83 ( 4.6A)
LLP  A  83 ( 3.9A)
None
 1.27A 4zvmA-1tufA:
undetectable
4zvmB-1tufA:
undetectable		 4zvmA-1tufA:
19.47
4zvmB-1tufA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 11 VAL A 259
PHE A  65
GLY A 263
GLY A 264
ILE A 225
 None
None
LLP  A  83 ( 3.9A)
LLP  A  83 ( 3.4A)
None
 1.16A 4zvmA-1tufA:
undetectable
4zvmB-1tufA:
undetectable		 4zvmA-1tufA:
19.47
4zvmB-1tufA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 11 PHE A  49
PHE A  45
GLY A 238
GLY A 239
ILE A 201
 None
None
LLP  A  61 ( 4.8A)
LLP  A  61 ( 3.6A)
None
 1.19A 4zvmA-3vabA:
undetectable
4zvmB-3vabA:
undetectable		 4zvmA-3vabA:
20.75
4zvmB-3vabA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		4 / 7 ILE A 245
GLU A 403
GLY A 216
GLY A 213
 LLP  A 270 ( 4.2A)
None
None
None
 0.87A 5a06A-3l44A:
undetectable		 5a06A-3l44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		4 / 7 ILE A 245
GLU A 403
GLY A 216
GLY A 213
 LLP  A 270 ( 4.2A)
None
None
None
 0.86A 5a06E-3l44A:
undetectable		 5a06E-3l44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		4 / 7 ILE A 245
GLU A 403
GLY A 216
GLY A 213
 LLP  A 270 ( 4.2A)
None
None
None
 0.86A 5a06F-3l44A:
3.0		 5a06F-3l44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A 401
GLY A 306
ILE A 302
GLY A 263
 AZ1  A 502 ( 4.1A)
LLP  A  83 ( 3.0A)
None
LLP  A  83 ( 3.9A)
 0.86A 5alcL-1tufA:
undetectable		 5alcL-1tufA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 165
PRO A 166
PHE A 310
TYR A 350
 LLP  A 222 ( 3.8A)
None
None
None
 1.40A 5amhA-2z61A:
undetectable		 5amhA-2z61A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 10 GLY A 231
GLU A 217
SER A 266
GLY A 220
ILE A 262
 None
None
None
LLP  A 221 ( 2.4A)
None
 1.03A 5aqfA-6c9bA:
undetectable		 5aqfA-6c9bA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP
(Streptomyces
wadayamensis) 		5 / 10 GLY A 231
GLU A 217
SER A 266
GLY A 220
ILE A 262
 None
None
None
LLP  A 221 ( 2.4A)
None
 0.97A 5aqyA-6c9bA:
undetectable		 5aqyA-6c9bA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Mus
musculus) 		4 / 5 TYR A 246
GLY A  65
TYR A 284
GLY A 285
 LLP  A 279 ( 4.4A)
GOL  A   1 ( 4.6A)
LLP  A 279 ( 4.6A)
None
 0.92A 5ayfA-3hlmA:
undetectable		 5ayfA-3hlmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 7 ASP A 180
TRP A 105
THR A 151
SER A 184
 LLP  A 206 ( 2.9A)
LLP  A 206 ( 3.5A)
LLP  A 206 ( 4.6A)
None
 1.13A 5b6iA-2hufA:
undetectable		 5b6iA-2hufA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 6 ASP A 180
TRP A 105
THR A 151
SER A 184
 LLP  A 206 ( 2.9A)
LLP  A 206 ( 3.5A)
LLP  A 206 ( 4.6A)
None
 1.12A 5b6iB-2hufA:
undetectable		 5b6iB-2hufA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 11 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.89A 5bxnK-3iauA:
undetectable
5bxnL-3iauA:
undetectable		 5bxnK-3iauA:
20.44
5bxnL-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 11 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.90A 5bxnY-3iauA:
undetectable
5bxnZ-3iauA:
undetectable		 5bxnY-3iauA:
20.44
5bxnZ-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 GLY A 184
GLY A 186
GLY A 187
LEU A 188
ALA A 210
 LLP  A  58 ( 3.5A)
LLP  A  58 ( 3.4A)
LLP  A  58 ( 3.2A)
LLP  A  58 ( 4.5A)
None
 0.65A 5c0oF-2gn1A:
undetectable		 5c0oF-2gn1A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 GLY A 168
GLY A 170
GLY A 171
LEU A 172
GLU A 194
 LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.3A)
LLP  A  41 ( 3.2A)
LLP  A  41 ( 4.9A)
None
 0.99A 5c0oF-4h27A:
3.0		 5c0oF-4h27A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 258
GLY A 260
GLY A  55
ALA A 292
LEU A 257
 LLP  A 255 ( 4.1A)
LLP  A 255 ( 4.8A)
None
None
None
 1.00A 5c0oG-3ruyA:
undetectable		 5c0oG-3ruyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE
(Burkholderia
pseudomallei) 		3 / 3 GLU A  39
HIS A  59
ASP A 219
 LLP  A 161 ( 3.9A)
LLP  A 161 ( 4.9A)
None
 0.67A 5c0oG-4whxA:
undetectable		 5c0oG-4whxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 12 ALA A 196
GLY A 201
GLY A 197
SER A 161
GLU A 207
 None
None
LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.4A)
None
 1.06A 5c0oH-4d8uA:
undetectable		 5c0oH-4d8uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A  48
ARG A 107
GLY A 249
GLU A 111
 LLP  A 241 ( 3.2A)
None
None
None
 1.08A 5cdqA-4q76A:
undetectable
5cdqB-4q76A:
undetectable
5cdqC-4q76A:
undetectable		 5cdqA-4q76A:
20.52
5cdqB-4q76A:
17.76
5cdqC-4q76A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		3 / 3 HIS A 100
SER A 148
ASN A  73
 LLP  A 205 ( 3.6A)
None
None
 0.81A 5cprB-4isyA:
undetectable		 5cprB-4isyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE
(Klebsiella
pneumoniae) 		3 / 3 THR A 173
THR A 144
PHE A  99
 None
None
LLP  A 200 ( 3.7A)
 0.82A 5cxvA-3nnkA:
undetectable		 5cxvA-3nnkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 5d0xV-6cczA:
undetectable
5d0xb-6cczA:
undetectable		 5d0xV-6cczA:
16.59
5d0xb-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 9 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.90A 5d0xK-3iauA:
undetectable
5d0xL-3iauA:
undetectable		 5d0xK-3iauA:
20.77
5d0xL-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 11 HIS A 209
SER A 211
THR A 313
THR A 314
THR A 315
 LLP  A 318 (-3.5A)
LLP  A 318 ( 3.8A)
None
FMT  A 613 ( 4.6A)
FMT  A 613 (-3.6A)
 1.43A 5d0xH-6cczA:
undetectable
5d0xN-6cczA:
undetectable		 5d0xH-6cczA:
16.59
5d0xN-6cczA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 9 ALA A 126
ALA A  95
GLY A 154
GLY A 155
ALA A 134
 None
LLP  A  91 ( 3.6A)
None
None
None
 0.90A 5d0xY-3iauA:
undetectable
5d0xZ-3iauA:
undetectable		 5d0xY-3iauA:
20.77
5d0xZ-3iauA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A   8
HIS A 100
ASN A 154
ARG A 355
 None
LLP  A 205 ( 3.6A)
LLP  A 205 ( 4.3A)
None
 0.51A 5db5A-4isyA:
41.9
5db5B-4isyA:
41.7		 5db5A-4isyA:
27.54
5db5B-4isyA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		4 / 8 ALA A   8
HIS A  95
ASN A 145
ARG A 344
 None
LLP  A 196 ( 3.6A)
LLP  A 196 ( 4.2A)
None
 0.39A 5db5A-4ixoA:
40.4
5db5B-4ixoA:
40.1		 5db5A-4ixoA:
25.84
5db5B-4ixoA:
25.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 8 ALA A  46
HIS A 138
ASN A 190
ARG A 379
ARG A 399
 None
LLP  A 241 ( 3.6A)
LLP  A 241 ( 3.9A)
None
None
 0.66A 5db5A-4q76A:
58.3
5db5B-4q76A:
58.7		 5db5A-4q76A:
46.56
5db5B-4q76A:
46.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		5 / 8 ALA A  39
HIS A 131
ASN A 183
ARG A 367
ARG A 387
 None
LLP  A 234 ( 3.5A)
LLP  A 234 ( 4.5A)
None
None
 0.38A 5db5A-4w91A:
58.8
5db5B-4w91A:
60.0		 5db5A-4w91A:
44.92
5db5B-4w91A:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4w91 AMINOTRANSFERASE
(Brucella
suis) 		4 / 8 HIS A 131
ASN A 183
ARG A 387
THR A 231
 LLP  A 234 ( 3.5A)
LLP  A 234 ( 4.5A)
None
LLP  A 234 ( 2.7A)
 1.26A 5db5A-4w91A:
58.8
5db5B-4w91A:
60.0		 5db5A-4w91A:
44.92
5db5B-4w91A:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 8 ALA A  24
HIS A 114
ASN A 165
ARG A 351
ARG A 371
 None
LLP  A 216 ( 3.4A)
LLP  A 216 ( 3.8A)
None
None
 0.58A 5db5A-5b7sA:
53.0
5db5B-5b7sA:
55.2		 5db5A-5b7sA:
40.81
5db5B-5b7sA:
40.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 6c9e CYSTEINE DESULFURASE
(Legionella
pneumophila) 		5 / 8 ALA A  39
HIS A 131
ASN A 183
ARG A 367
ARG A 387
 EDO  A 503 (-3.5A)
LLP  A 234 ( 3.5A)
EDO  A 503 (-3.8A)
EDO  A 503 (-4.4A)
EDO  A 503 (-2.9A)
 0.58A 5db5A-6c9eA:
32.7
5db5B-6c9eA:
61.1		 5db5A-6c9eA:
undetectable
5db5B-6c9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 6 PHE A  63
SER A 274
ALA A 246
HIS A 276
 None
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 3.8A)
 1.15A 5dzkB-3hbxA:
undetectable
5dzkP-3hbxA:
undetectable		 5dzkB-3hbxA:
16.44
5dzkP-3hbxA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 7 PHE A  63
SER A 274
ALA A 246
HIS A 276
 None
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 3.8A)
 1.15A 5dzkD-3hbxA:
undetectable
5dzkR-3hbxA:
undetectable		 5dzkD-3hbxA:
16.44
5dzkR-3hbxA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 6 PHE A  63
SER A 274
ALA A 246
HIS A 276
 None
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 3.8A)
 1.15A 5dzkg-3hbxA:
undetectable
5dzku-3hbxA:
undetectable		 5dzkg-3hbxA:
16.44
5dzku-3hbxA:
0.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eeuO-2gn1A:
undetectable
5eeuP-2gn1A:
undetectable		 5eeuO-2gn1A:
11.99
5eeuP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eeuO-2gn1A:
undetectable
5eeuP-2gn1A:
undetectable		 5eeuO-2gn1A:
11.99
5eeuP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eeuQ-2gn1A:
undetectable
5eeuR-2gn1A:
undetectable		 5eeuQ-2gn1A:
11.99
5eeuR-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.15A 5eeuQ-2gn1A:
undetectable
5eeuR-2gn1A:
undetectable		 5eeuQ-2gn1A:
11.99
5eeuR-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eevA-4h27A:
undetectable
5eevB-4h27A:
undetectable		 5eevA-4h27A:
13.46
5eevB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eevO-2gn1A:
undetectable
5eevP-2gn1A:
undetectable		 5eevO-2gn1A:
11.99
5eevP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eevO-2gn1A:
undetectable
5eevP-2gn1A:
undetectable		 5eevO-2gn1A:
11.99
5eevP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eevQ-2gn1A:
undetectable
5eevR-2gn1A:
undetectable		 5eevQ-2gn1A:
11.99
5eevR-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eevQ-2gn1A:
undetectable
5eevR-2gn1A:
undetectable		 5eevQ-2gn1A:
11.99
5eevR-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eewA-4h27A:
undetectable
5eewB-4h27A:
undetectable		 5eewA-4h27A:
13.46
5eewB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eewO-2gn1A:
undetectable
5eewP-2gn1A:
undetectable		 5eewO-2gn1A:
11.99
5eewP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eewO-2gn1A:
undetectable
5eewP-2gn1A:
undetectable		 5eewO-2gn1A:
11.99
5eewP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eewQ-2gn1A:
undetectable
5eewR-2gn1A:
undetectable		 5eewQ-2gn1A:
11.99
5eewR-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eewQ-2gn1A:
undetectable
5eewR-2gn1A:
undetectable		 5eewQ-2gn1A:
11.99
5eewR-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eexA-4h27A:
undetectable
5eexB-4h27A:
undetectable		 5eexA-4h27A:
13.46
5eexB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eexO-2gn1A:
undetectable
5eexP-2gn1A:
undetectable		 5eexO-2gn1A:
11.99
5eexP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eexO-2gn1A:
undetectable
5eexP-2gn1A:
undetectable		 5eexO-2gn1A:
11.99
5eexP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eeyA-4h27A:
undetectable
5eeyB-4h27A:
undetectable		 5eeyA-4h27A:
13.46
5eeyB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eeyO-2gn1A:
undetectable
5eeyP-2gn1A:
undetectable		 5eeyO-2gn1A:
11.99
5eeyP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eeyO-2gn1A:
undetectable
5eeyP-2gn1A:
undetectable		 5eeyO-2gn1A:
11.99
5eeyP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5eezA-4h27A:
undetectable
5eezB-4h27A:
undetectable		 5eezA-4h27A:
13.46
5eezB-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5eezO-2gn1A:
undetectable
5eezP-2gn1A:
undetectable		 5eezO-2gn1A:
11.99
5eezP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5eezO-2gn1A:
undetectable
5eezP-2gn1A:
undetectable		 5eezO-2gn1A:
11.99
5eezP-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5ef0A-4h27A:
undetectable
5ef0B-4h27A:
undetectable		 5ef0A-4h27A:
13.46
5ef0B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5ef0O-2gn1A:
undetectable
5ef0P-2gn1A:
undetectable		 5ef0O-2gn1A:
11.99
5ef0P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5ef0O-2gn1A:
undetectable
5ef0P-2gn1A:
undetectable		 5ef0O-2gn1A:
11.99
5ef0P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5ef1A-4h27A:
undetectable
5ef1B-4h27A:
undetectable		 5ef1A-4h27A:
13.46
5ef1B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5ef1O-2gn1A:
undetectable
5ef1P-2gn1A:
undetectable		 5ef1O-2gn1A:
11.99
5ef1P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5ef1O-2gn1A:
undetectable
5ef1P-2gn1A:
undetectable		 5ef1O-2gn1A:
11.99
5ef1P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.14A 5ef2A-4h27A:
undetectable
5ef2B-4h27A:
undetectable		 5ef2A-4h27A:
13.46
5ef2B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5ef2O-2gn1A:
undetectable
5ef2P-2gn1A:
undetectable		 5ef2O-2gn1A:
11.99
5ef2P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5ef2O-2gn1A:
undetectable
5ef2P-2gn1A:
undetectable		 5ef2O-2gn1A:
11.99
5ef2P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 GLY A 197
GLY A 168
ALA A 269
THR A 195
HIS A 199
 None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
None
 1.15A 5ef3A-4h27A:
undetectable
5ef3B-4h27A:
undetectable		 5ef3A-4h27A:
13.46
5ef3B-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 184
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.5A)
None
None
None
None
 1.14A 5ef3O-2gn1A:
undetectable
5ef3P-2gn1A:
undetectable		 5ef3O-2gn1A:
11.99
5ef3P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 GLY A 185
ALA A 217
ILE A 183
SER A 219
ALA A 218
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.14A 5ef3O-2gn1A:
undetectable
5ef3P-2gn1A:
undetectable		 5ef3O-2gn1A:
11.99
5ef3P-2gn1A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
TYR A 265
LEU A 264
PHE A 341
THR A   6
 LLP  A 185 ( 3.5A)
None
None
None
None
 1.12A 5eskA-1iugA:
undetectable		 5eskA-1iugA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2gb3 ASPARTATE
AMINOTRANSFERASE
(Thermotoga
maritima) 		4 / 8 GLY A  98
GLY A  99
VAL A  95
ASP A 228
 LLP  A 232 ( 3.4A)
LLP  A 232 ( 3.8A)
None
None
 0.78A 5f8yA-2gb3A:
undetectable		 5f8yA-2gb3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 4dza LYSINE RACEMASE
(Proteus
mirabilis) 		3 / 3 ASN A 244
ASP A 216
GLY A 169
 LLP  A  74 ( 4.5A)
None
None
 0.55A 5fctB-4dzaA:
undetectable		 5fctB-4dzaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3jtx AMINOTRANSFERASE
(Neisseria
meningitidis) 		5 / 12 ILE A  93
GLU A  92
GLY A 258
ARG A 233
CYH A 208
 None
None
None
GOL  A 398 (-3.3A)
LLP  A 244 ( 3.5A)
 1.36A 5fhzD-3jtxA:
undetectable		 5fhzD-3jtxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 12 ALA A 269
GLY A 305
SER A 306
GLY A 224
LEU A 172
 LLP  A  41 ( 3.6A)
LLP  A  41 ( 3.9A)
None
None
LLP  A  41 ( 4.9A)
 1.12A 5gwxA-4h27A:
2.9		 5gwxA-4h27A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3bc8 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Mus
musculus) 		5 / 12 ASP A 283
PRO A 289
GLY A 292
THR A 144
SER A 317
 LLP  A 284 ( 3.2A)
None
None
LLP  A 284 ( 4.4A)
EDO  A 502 (-3.1A)
 1.23A 5hfjA-3bc8A:
2.2		 5hfjA-3bc8A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 ALA X  76
THR X 156
ILE X  45
SER X 181
ASN X  36
 LLP  X  42 ( 3.2A)
None
LLP  X  42 ( 4.0A)
LLP  X  42 ( 2.4A)
None
 1.33A 5hgcA-4li3X:
undetectable		 5hgcA-4li3X:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 GLY A 242
ALA A  62
PHE A  45
ILE A 281
GLY A 239
 None
LLP  A  61 ( 3.7A)
None
None
LLP  A  61 ( 3.6A)
 0.83A 5hieB-3vabA:
undetectable		 5hieB-3vabA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		5 / 12 VAL A 200
ALA A 191
SER A 194
THR A  83
PRO A 218
 None
None
None
None
LLP  A 216 ( 4.0A)
 1.38A 5hnzB-5b7sA:
2.1		 5hnzB-5b7sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 ASP B 382
LEU B 120
ALA B  84
SER B 376
THR B 118
 None
None
LLP  B  86 ( 4.0A)
LLP  B  86 ( 2.8A)
None
 1.29A 5hnzB-5kzmB:
undetectable		 5hnzB-5kzmB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		4 / 5 CYH A 270
ILE A 301
CYH A 303
LEU A 274
 None
None
LLP  A  41 ( 3.2A)
None
 1.44A 5hrqC-4h27A:
undetectable
5hrqD-4h27A:
undetectable
5hrqL-4h27A:
undetectable		 5hrqC-4h27A:
4.63
5hrqD-4h27A:
7.98
5hrqL-4h27A:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 8 ILE A 247
GLY A 109
LEU A 293
LEU A  86
 None
LLP  A 252 ( 3.5A)
None
None
 0.85A 5hs1A-3nraA:
undetectable		 5hs1A-3nraA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ASP A 282
ILE A 446
PHE A 449
LEU A 399
PHE A 250
 None
None
None
None
LLP  A 312 ( 3.7A)
 1.29A 5huaA-4tv7A:
undetectable		 5huaA-4tv7A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ASP A 282
VAL A 402
ILE A 446
PHE A 449
PHE A 250
 None
None
None
None
LLP  A 312 ( 3.7A)
 1.39A 5huaA-4tv7A:
undetectable		 5huaA-4tv7A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 ILE A 197
GLY A 176
THR A 248
ALA A 243
VAL A  16
 LLP  A 196 ( 4.0A)
None
None
None
None
 1.13A 5hw4A-4ixoA:
1.5		 5hw4A-4ixoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4ixo NIFS-LIKE PROTEIN
(Rickettsia
africae) 		5 / 12 ILE A 197
GLY A 176
THR A 248
ALA A 243
VAL A  16
 LLP  A 196 ( 4.0A)
None
None
None
None
 1.07A 5hw4C-4ixoA:
1.1		 5hw4C-4ixoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 8 ASP A 241
GLY A 235
THR A  47
ASN A  26
 None
LLP  A  46 ( 3.5A)
LLP  A  46 ( 4.3A)
EDO  A 384 (-4.3A)
 1.04A 5hwaA-3llxA:
undetectable		 5hwaA-3llxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 342
ALA A 343
GLY A 220
GLY A 199
VAL A 225
 None
None
LLP  A  91 ( 3.4A)
None
None
 1.23A 5i71A-3iauA:
undetectable		 5i71A-3iauA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA
(Bacillus
subtilis) 		5 / 12 ASP A 296
GLY A 253
GLY A 303
LEU A 304
GLY A 125
 None
None
None
None
LLP  A 247 ( 3.2A)
 1.05A 5i71A-4k2bA:
undetectable		 5i71A-4k2bA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 342
ALA A 343
GLY A 220
GLY A 199
VAL A 225
 None
None
LLP  A  91 ( 3.4A)
None
None
 1.20A 5i75A-3iauA:
undetectable		 5i75A-3iauA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		3 / 3 ARG A 177
HIS A  97
ARG A 145
 LLP  A 205 ( 2.9A)
LLP  A 205 ( 3.3A)
LLP  A 205 ( 4.4A)
 1.12A 5iaoC-3lwsA:
2.7		 5iaoC-3lwsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		3 / 3 ARG A 177
HIS A  97
ARG A 145
 LLP  A 205 ( 2.9A)
LLP  A 205 ( 3.3A)
LLP  A 205 ( 4.4A)
 1.13A 5iaoF-3lwsA:
2.9		 5iaoF-3lwsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 LEU A 188
ILE A 165
GLY A 166
ILE A 169
MET A 170
 LLP  A  58 ( 4.5A)
None
None
None
None
 1.13A 5ifuA-2gn1A:
undetectable		 5ifuA-2gn1A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens) 		5 / 12 GLY A 246
ASP A 373
HIS A 371
ALA A 263
ILE A 254
 None
LLP  A 405 ( 2.7A)
None
None
None
 1.23A 5igvA-2okjA:
undetectable		 5igvA-2okjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 223
GLU A 235
ALA A 242
ILE A 265
TYR A 292
 LLP  A 165 ( 3.4A)
None
None
None
None
 1.26A 5igvA-4tm5A:
undetectable		 5igvA-4tm5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3b46 AMINOTRANSFERASE
BNA3
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 209
ILE A 334
TYR A 333
PHE A 326
 LLP  A 271 ( 4.1A)
None
None
None
 1.50A 5igvA-3b46A:
undetectable		 5igvA-3b46A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 12 ILE X 229
GLY X 175
HIS X 224
ILE X 234
PHE X 233
 LLP  X  42 ( 4.7A)
None
None
None
None
 1.18A 5igwA-4li3X:
undetectable		 5igwA-4li3X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		3 / 3 LEU A 327
TYR A 101
SER A 195
 LLP  A 198 ( 4.6A)
LLP  A 198 ( 3.6A)
LLP  A 198 ( 2.8A)
 0.74A 5iktA-1cs1A:
0.0		 5iktA-1cs1A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)
(Mycobacterium
ulcerans) 		3 / 3 LEU A 337
TYR A 111
SER A 205
 LLP  A 208 (-4.2A)
LLP  A 208 (-3.7A)
LLP  A 208 ( 2.7A)
 0.88A 5iktA-3qi6A:
undetectable		 5iktA-3qi6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		3 / 3 LEU A 321
TYR A  49
SER A 258
 None
None
LLP  A 255 ( 4.3A)
 0.76A 5iktA-5vehA:
undetectable		 5iktA-5vehA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		3 / 3 LEU A 341
TYR A 114
SER A 208
 LLP  A 211 ( 4.6A)
LLP  A 211 ( 3.5A)
LLP  A 211 ( 2.7A)
 0.84A 5iktA-5x2vA:
undetectable		 5iktA-5x2vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4kbx UNCHARACTERIZED
PROTEIN YHFX
(Escherichia
coli) 		4 / 5 ILE A 317
LEU A 336
HIS A 306
VAL A   3
 LLP  A   7 (-3.5A)
None
ACE  A   0 ( 4.0A)
ACE  A   0 ( 3.9A)
 1.15A 5jmnB-4kbxA:
undetectable		 5jmnB-4kbxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4d9i DIAMINOPROPIONATE
AMMONIA-LYASE
(Escherichia
coli) 		5 / 12 VAL A  64
LEU A  50
GLY A 340
ALA A 341
LEU A 344
 None
None
LLP  A  77 ( 4.7A)
None
None
 1.04A 5jw1A-4d9iA:
undetectable		 5jw1A-4d9iA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vab DIAMINOPIMELATE
DECARBOXYLASE 1
(Brucella
melitensis) 		5 / 12 VAL A 379
SER A  64
ALA A  67
GLY A 374
ALA A 375
 LLP  A  61 (-4.3A)
None
None
None
None
 1.07A 5kirB-3vabA:
undetectable		 5kirB-3vabA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		6 / 9 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
VAL A 261
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
None
 1.31A 5kr0B-2gn1A:
undetectable		 5kr0B-2gn1A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3bn1 PEROSAMINE
SYNTHETASE
(Caulobacter
vibrioides) 		5 / 12 THR A  61
GLU A 160
ALA A 164
ASP A 157
ALA A 158
 LLP  A 186 ( 3.6A)
LLP  A 186 ( 3.4A)
None
LLP  A 186 ( 2.7A)
None
 1.23A 5kvaA-3bn1A:
2.4		 5kvaA-3bn1A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 TYR A  54
THR A 256
TYR A 313
LEU A 259
 None
LLP  A 255 ( 4.4A)
None
None
 1.33A 5kxiD-5vehA:
undetectable
5kxiE-5vehA:
undetectable		 5kxiD-5vehA:
20.13
5kxiE-5vehA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1bjn PHOSPHOSERINE
AMINOTRANSFERASE
(Escherichia
coli) 		6 / 12 GLY A  74
GLY A  78
ILE A 207
ASP A 174
SER A 176
ALA A 196
 None
None
None
LLP  A 198 ( 3.0A)
LLP  A 198 ( 3.9A)
None
 1.39A 5l0zA-1bjnA:
undetectable		 5l0zA-1bjnA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3nra ASPARTATE
AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 10 GLY A 112
GLY A 109
ILE A 215
LEU A 116
ALA A 117
 None
LLP  A 252 ( 3.5A)
None
None
None
 1.03A 5l0zB-3nraA:
undetectable		 5l0zB-3nraA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 8 SER A 258
PRO A  52
TYR A  54
SER A 318
 LLP  A 255 ( 4.3A)
None
None
BR  A 501 ( 4.9A)
 1.12A 5l1fA-5vehA:
undetectable
5l1fB-5vehA:
4.0		 5l1fA-5vehA:
19.16
5l1fB-5vehA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A 224
LYS A 205
GLU A 202
GLY A 199
GLY A 195
 None
None
None
None
LLP  A  58 ( 3.8A)
 1.15A 5l6eA-4il5A:
undetectable		 5l6eA-4il5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.32A 5lg3B-1tufA:
0.0		 5lg3B-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.30A 5lg3C-1tufA:
0.0		 5lg3C-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.28A 5lg3D-1tufA:
undetectable		 5lg3D-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 225
PHE A 235
VAL A 242
ASN A 260
GLU A 304
 None
None
None
None
LLP  A  83 ( 3.6A)
 1.28A 5lg3G-1tufA:
undetectable		 5lg3G-1tufA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 12 ILE A 203
ILE A 223
VAL A 183
GLU A 156
ILE A  92
 None
None
None
LLP  A 210 ( 3.7A)
None
 1.12A 5lg3J-4p7yA:
undetectable		 5lg3J-4p7yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_B_ACRB1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5veh KYNURENINE
AMINOTRANSFERASE
(Aedes
aegypti) 		5 / 9 GLU A 320
PHE A 257
THR A 256
TYR A 313
GLY A 319
 None
None
LLP  A 255 ( 4.4A)
None
BR  A 501 ( 4.2A)
 1.49A 5lrbB-5vehA:
0.0		 5lrbB-5vehA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		5 / 12 GLY A 208
TYR A 266
ILE A 260
SER A 211
HIS A 209
 None
None
None
LLP  A 318 ( 3.8A)
LLP  A 318 (-3.5A)
 1.17A 5lsaA-6cczA:
4.2		 5lsaA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.91A 5m45A-3fcrA:
undetectable		 5m45A-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3gju PUTATIVE
AMINOTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 4 GLU A 227
PRO A 228
ILE A 229
LEU A 230
 LLP  A 289 (-3.7A)
None
None
None
 0.95A 5m45A-3gjuA:
undetectable		 5m45A-3gjuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.84A 5m45D-3fcrA:
undetectable		 5m45D-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3gju PUTATIVE
AMINOTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 4 GLU A 227
PRO A 228
ILE A 229
LEU A 230
 LLP  A 289 (-3.7A)
None
None
None
 0.88A 5m45D-3gjuA:
undetectable		 5m45D-3gjuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.89A 5m45G-3fcrA:
undetectable		 5m45G-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3gju PUTATIVE
AMINOTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 4 GLU A 227
PRO A 228
ILE A 229
LEU A 230
 LLP  A 289 (-3.7A)
None
None
None
 0.93A 5m45G-3gjuA:
undetectable		 5m45G-3gjuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		4 / 4 GLU A 226
PRO A 227
ILE A 228
LEU A 229
 LLP  A 288 (-4.0A)
None
None
None
 0.85A 5m45J-3fcrA:
undetectable		 5m45J-3fcrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3gju PUTATIVE
AMINOTRANSFERASE
(Mesorhizobium
japonicum) 		4 / 4 GLU A 227
PRO A 228
ILE A 229
LEU A 230
 LLP  A 289 (-3.7A)
None
None
None
 0.88A 5m45J-3gjuA:
undetectable		 5m45J-3gjuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4dza LYSINE RACEMASE
(Proteus
mirabilis) 		4 / 6 TYR A  78
PHE A 265
ASP A  76
GLY A  79
 LLP  A  74 ( 4.4A)
None
None
None
 1.13A 5mraA-4dzaA:
undetectable
5mraB-4dzaA:
undetectable		 5mraA-4dzaA:
18.67
5mraB-4dzaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 9 ILE A 223
ALA A 194
ILE A  91
ALA A  94
LEU A  95
 None
None
LLP  A 230 ( 4.2A)
None
None
 1.01A 5mvmA-3t32A:
undetectable
5mvmE-3t32A:
undetectable		 5mvmA-3t32A:
12.37
5mvmE-3t32A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3t32 AMINOTRANSFERASE,
CLASS I/II
(Bacillus
anthracis) 		5 / 10 ILE A  91
ALA A  94
LEU A  95
ILE A 223
ALA A 194
 LLP  A 230 ( 4.2A)
None
None
None
None
 1.04A 5mvmD-3t32A:
undetectable
5mvmE-3t32A:
undetectable		 5mvmD-3t32A:
12.37
5mvmE-3t32A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.87A 5n0oA-3iauA:
2.2		 5n0oA-3iauA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.87A 5n0rA-3iauA:
undetectable		 5n0rA-3iauA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
ILE A 239
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.86A 5n0sA-3iauA:
undetectable		 5n0sA-3iauA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.85A 5n0sA-3iauA:
undetectable		 5n0sA-3iauA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		6 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
ILE A 239
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
None
 1.03A 5n0tA-3iauA:
2.3		 5n0tA-3iauA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.86A 5n0wA-3iauA:
undetectable		 5n0wA-3iauA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED
(Xanthomonas
oryzae) 		4 / 4 SER B  87
ALA B  90
GLN B 239
THR B  94
 LLP  B 210 ( 3.7A)
None
None
None
 1.46A 5n0wA-4iyoB:
1.4		 5n0wA-4iyoB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		4 / 4 SER A  76
ALA A  79
GLN A 228
THR A  83
 LLP  A 199 ( 3.5A)
None
None
None
 1.44A 5n0wA-6cjbA:
2.3		 5n0wA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
ILE A 239
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.89A 5n0wB-3iauA:
2.3		 5n0wB-3iauA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.84A 5n0wB-3iauA:
2.3		 5n0wB-3iauA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 273
ILE A 239
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 1.00A 5n0xA-3iauA:
undetectable		 5n0xA-3iauA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
ILE A 239
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.87A 5n4iA-3iauA:
undetectable		 5n4iA-3iauA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3iau THREONINE DEAMINASE
(Solanum
lycopersicum) 		5 / 12 ILE A 222
GLY A 219
VAL A 276
VAL A 273
VAL A 241
 None
LLP  A  91 ( 3.5A)
None
None
None
 0.85A 5n4iA-3iauA:
undetectable		 5n4iA-3iauA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 7 PHE A 214
ASP A 216
GLY A 116
GLY A 113
 None
LLP  A 253 ( 2.8A)
None
LLP  A 253 ( 3.6A)
 0.88A 5n9xA-1bw0A:
3.4		 5n9xA-1bw0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3nu8 AMINOTRANSFERASE
WBPE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 156
GLU A 155
LEU A 238
LEU A 187
SER A 170
 LLP  A 185 ( 2.9A)
None
None
None
None
 1.10A 5nd7B-3nu8A:
undetectable		 5nd7B-3nu8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 THR A 239
PRO A  43
ARG A 233
 None
None
LLP  A  46 ( 3.6A)
 0.86A 5nd7B-3llxA:
undetectable		 5nd7B-3llxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 179
GLY A 226
GLY A 224
GLY A 177
GLU A 203
 LLP  A  44 ( 3.1A)
None
None
LLP  A  44 ( 3.5A)
None
 0.94A 5njvC-5xa2A:
undetectable		 5njvC-5xa2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4qhr ALANINE RACEMASE
(Acinetobacter
baumannii) 		5 / 12 LEU A  49
PRO A 210
SER A 194
GLY A 211
HIS A  40
 None
None
LLP  A  34 ( 2.4A)
LLP  A  34 ( 3.4A)
None
 1.15A 5nnaB-4qhrA:
undetectable		 5nnaB-4qhrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 7 ASP A 350
GLY A 209
HIS A 352
HIS A 242
 LLP  A 353 ( 3.8A)
LLP  A 353 ( 4.2A)
LLP  A 353 ( 4.0A)
LLP  A 353 (-3.6A)
 1.04A 5nnwD-4q6rA:
undetectable		 5nnwD-4q6rA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens) 		4 / 7 ASP A 350
GLY A 209
HIS A 352
HIS A 242
 LLP  A 353 ( 3.8A)
LLP  A 353 ( 4.2A)
LLP  A 353 ( 4.0A)
LLP  A 353 (-3.6A)
 1.00A 5no9D-4q6rA:
undetectable		 5no9D-4q6rA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 6 ARG A 145
GLY A 148
GLU A 329
SER A 331
 LLP  A 205 ( 4.4A)
None
None
None
 1.05A 5ny7A-3lwsA:
undetectable		 5ny7A-3lwsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE
(Exiguobacterium
sibiricum) 		4 / 6 ARG A 145
GLY A 149
GLU A 329
SER A 331
 LLP  A 205 ( 4.4A)
None
None
None
 0.82A 5ny7A-3lwsA:
undetectable		 5ny7A-3lwsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		5 / 10 GLY A 244
GLY A 202
LEU A  64
THR A 247
ALA A   9
 None
LLP  A 198 ( 3.3A)
None
None
None
 1.05A 5o96G-1cs1A:
undetectable
5o96H-1cs1A:
2.2		 5o96G-1cs1A:
23.14
5o96H-1cs1A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5b7s CYSTEINE DESULFURASE
(Thermococcus
onnurineus) 		3 / 3 LYS A 217
HIS A 197
HIS A 375
 LLP  A 216 ( 2.8A)
None
None
 1.42A 5oexD-5b7sA:
undetectable		 5oexD-5b7sA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 165
PRO A 166
PHE A 310
TYR A 350
 LLP  A 222 ( 3.8A)
None
None
None
 1.26A 5oh3A-2z61A:
undetectable		 5oh3A-2z61A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A  50
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 4.9A)
 1.08A 5os7A-4q76A:
undetectable		 5os7A-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A 242
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 3.5A)
 1.06A 5os7A-4q76A:
undetectable		 5os7A-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A  34
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 4.9A)
 1.01A 5os7A-5vprA:
undetectable		 5os7A-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A 226
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 3.5A)
 1.05A 5os7A-5vprA:
undetectable		 5os7A-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Legionella
pneumophila) 		5 / 12 ILE A  22
PHE A  60
ARG A  48
ILE A  32
LEU A  49
 None
None
LLP  A 140 ( 2.5A)
None
None
 1.27A 5oy02-3lulA:
undetectable		 5oy02-3lulA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLU A  33
VAL A 301
LEU A 243
ALA A 180
GLY A 233
 None
None
None
None
LLP  A  42 ( 4.0A)
 1.17A 5syeB-5jjcA:
undetectable		 5syeB-5jjcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 5 ARG A 261
TRP A 260
ALA A 252
PRO A  43
 LLP  A 253 ( 2.9A)
None
LLP  A 253 ( 3.1A)
None
 1.35A 5syiA-1bw0A:
undetectable		 5syiA-1bw0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE
(Campylobacter
jejuni) 		4 / 6 ARG A 291
HIS A 295
LEU A 368
SER A 208
 None
None
LLP  A 205 ( 4.2A)
LLP  A 205 ( 4.6A)
 1.17A 5syjA-4oc9A:
undetectable		 5syjA-4oc9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 6 ARG A 265
HIS A 269
LEU A 341
SER A 214
 None
None
LLP  A 211 ( 4.6A)
LLP  A 211 ( 4.7A)
 1.09A 5syjA-5x2vA:
undetectable		 5syjA-5x2vA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE
(Campylobacter
jejuni) 		4 / 6 ARG A 291
HIS A 295
LEU A 368
SER A 208
 None
None
LLP  A 205 ( 4.2A)
LLP  A 205 ( 4.6A)
 1.22A 5syjB-4oc9A:
undetectable		 5syjB-4oc9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 6 ARG A 265
HIS A 269
LEU A 341
SER A 214
 None
None
LLP  A 211 ( 4.6A)
LLP  A 211 ( 4.7A)
 1.13A 5syjB-5x2vA:
undetectable		 5syjB-5x2vA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 10 ILE A 117
LEU A 281
LEU A 266
ASP A 216
PHE A 214
 None
None
None
LLP  A 253 ( 2.8A)
None
 1.33A 5tixB-1bw0A:
1.2		 5tixB-1bw0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 10 PRO A 191
ILE A 295
LEU A 189
SER A 152
GLU A 151
 None
None
None
None
LLP  A 205 ( 3.8A)
 1.40A 5tixB-3aczA:
undetectable		 5tixB-3aczA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 105
VAL A 101
ALA A 231
ALA A 100
GLY A  97
 None
None
None
None
LLP  A 219 ( 3.2A)
 1.17A 5tzoB-3ndnA:
undetectable		 5tzoB-3ndnA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 12 LEU A 191
GLY A 188
GLY A 189
VAL A 239
LEU A 218
 None
LLP  A  51 ( 3.4A)
LLP  A  51 ( 3.8A)
None
None
 1.19A 5uc1A-3tbhA:
undetectable		 5uc1A-3tbhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 5 HIS A 400
ALA A 397
HIS A 248
TYR A 281
 None
None
None
LLP  A 312 ( 4.0A)
 1.38A 5uizA-4tv7A:
undetectable		 5uizA-4tv7A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3b46 AMINOTRANSFERASE
BNA3
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 240
ALA A 422
TYR A 358
 LLP  A 271 ( 4.2A)
None
None
 0.83A 5uunB-3b46A:
undetectable		 5uunB-3b46A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4isy CYSTEINE DESULFURASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 216
VAL A  62
PHE A 206
ALA A 256
GLY A 259
 None
None
LLP  A 205 ( 4.8A)
None
None
 1.09A 5uxdB-4isyA:
undetectable		 5uxdB-4isyA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4p7y METHIONINE
GAMMA-LYASE
(Citrobacter
freundii) 		5 / 12 ILE A  89
LEU A  96
GLU A 156
TYR A 154
PHE A 133
 LLP  A 210 ( 4.3A)
None
LLP  A 210 ( 3.7A)
None
None
 1.13A 5uxdB-4p7yA:
undetectable		 5uxdB-4p7yA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 194
LEU A  66
GLU A 151
ALA A 154
GLY A 156
 None
SO4  A 407 (-4.8A)
None
LLP  A 181 ( 3.3A)
None
 1.01A 5uxdB-6blgA:
undetectable		 5uxdB-6blgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A  84
ALA A  92
THR A  95
ALA A 267
GLY A 254
 None
None
None
None
LLP  A 255 ( 2.4A)
 1.13A 5veuA-3ruyA:
undetectable		 5veuA-3ruyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		6 / 12 LEU A  84
ALA A  92
THR A  95
ALA A 267
ILE A 252
GLY A 254
 None
None
None
None
None
LLP  A 255 ( 2.4A)
 1.35A 5veuB-3ruyA:
undetectable		 5veuB-3ruyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 12 GLY A 179
GLY A 226
GLY A 224
GLY A 177
GLU A 203
 LLP  A  44 ( 3.1A)
None
None
LLP  A  44 ( 3.5A)
None
 0.97A 5vimA-5xa2A:
undetectable		 5vimA-5xa2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 154
GLU A  60
ILE A 172
VAL A 124
PHE A  88
 LLP  A 181 ( 3.3A)
None
None
None
None
 1.26A 5vlmG-6blgA:
undetectable		 5vlmG-6blgA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 12 GLY A 233
LEU A 111
GLY A  74
PHE A 150
ILE A  75
 LLP  A  42 ( 4.0A)
None
None
None
None
 1.05A 5vooD-5jjcA:
2.4		 5vooD-5jjcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 THR A  73
GLY A  76
GLY A  46
LEU A  49
 SO4  A 404 (-3.7A)
LLP  A  42 ( 3.5A)
LLP  A  42 ( 3.8A)
None
 0.68A 5vw5A-5b1hA:
undetectable		 5vw5A-5b1hA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		3 / 3 GLY A 186
ASN A 154
ARG A 135
 LLP  A  56 ( 3.7A)
LLP  A  56 ( 4.7A)
MLI  A 347 (-3.0A)
 0.79A 5w7bD-3l6rA:
undetectable		 5w7bD-3l6rA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
ASP A 190
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
None
LLP  A 226 ( 2.9A)
None
 1.21A 5weoA-3getA:
4.1
5weoD-3getA:
4.2		 5weoA-3getA:
15.74
5weoD-3getA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 SER A 225
ASP A 190
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
None
LLP  A 226 ( 2.9A)
None
 1.21A 5weoB-3getA:
3.9
5weoC-3getA:
4.2		 5weoB-3getA:
15.74
5weoC-3getA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 9 ILE A  86
SER A  90
GLY A  87
SER A 225
ASP A 190
 None
LLP  A 226 ( 2.9A)
None
LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
 1.22A 5weoA-3getA:
0.9
5weoD-3getA:
4.0		 5weoA-3getA:
15.74
5weoD-3getA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE
(Medicago
truncatula) 		4 / 8 SER A 211
TYR A 189
HIS A 209
MET A 287
 LLP  A 318 ( 3.8A)
None
LLP  A 318 (-3.5A)
None
 1.24A 5wqpA-6cczA:
undetectable		 5wqpA-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 12 ALA A 160
LYS A  65
ILE A 194
GLY A 186
ASP A 155
 None
None
None
LLP  A  58 ( 3.4A)
None
 1.09A 5wwsB-2gn1A:
2.5		 5wwsB-2gn1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4r2v CYSTEINE SYNTHETASE
(Helicobacter
pylori) 		5 / 12 LEU A  83
ILE A  11
VAL A  45
GLY A  43
GLY A  42
 None
None
LLP  A  46 ( 2.7A)
None
None
 1.09A 5wyqA-4r2vA:
undetectable		 5wyqA-4r2vA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC
(Cytophaga
hutchinsonii) 		5 / 12 GLY A 193
GLY A  10
GLU A  13
ASP A 257
VAL A 254
 LLP  A 190 ( 3.6A)
LLP  A 190 ( 3.9A)
None
None
None
 0.97A 5wz1A-3ffrA:
3.3		 5wz1A-3ffrA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3tbh O-ACETYL SERINE
SULFHYDRYLASE
(Leishmania
donovani) 		5 / 11 VAL A 185
GLY A 186
SER A 274
ALA A 209
LEU A 191
 LLP  A  51 ( 4.2A)
LLP  A  51 ( 3.5A)
LLP  A  51 ( 2.6A)
None
None
 1.21A 5x6yC-3tbhA:
3.0		 5x6yC-3tbhA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
 None
None
None
None
LLP  B  86 ( 3.1A)
 1.27A 5xipA-5kzmB:
undetectable		 5xipA-5kzmB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
 None
None
None
None
LLP  B  86 ( 3.1A)
 1.25A 5xipC-5kzmB:
undetectable		 5xipC-5kzmB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
 None
None
None
None
LLP  B  86 ( 3.1A)
 1.27A 5xiqD-5kzmB:
undetectable		 5xiqD-5kzmB:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3pj0 LMO0305 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 153
GLY A 177
GLN A  75
ILE A 194
LEU A  79
 None
None
LLP  A 207 ( 4.7A)
None
None
 1.23A 5y2tA-3pj0A:
undetectable		 5y2tA-3pj0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 232
GLY A 244
THR A  97
GLY A 100
ASN A 230
 None
LLP  A 234 ( 4.9A)
None
LLP  A 234 ( 3.6A)
None
 1.10A 5ybbA-1bjwA:
undetectable		 5ybbA-1bjwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5xa2 CYSTEINE SYNTHASE
(Planctopirus
limnophila) 		5 / 11 GLU A   9
GLY A  48
ALA A  50
ILE A 152
ARG A  46
 None
LLP  A  44 ( 3.7A)
None
None
None
 0.90A 5yk2A-5xa2A:
undetectable		 5yk2A-5xa2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 5 HIS A 301
ALA A 148
SER A 311
GLY A 146
 LLP  A 302 ( 4.3A)
LLP  A 302 ( 3.3A)
None
None
 1.10A 5yodB-3k40A:
undetectable		 5yodB-3k40A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A 233
ALA A 210
SER A 231
GLY A 100
 LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.4A)
LLP  A 234 ( 2.9A)
LLP  A 234 ( 3.1A)
 1.21A 5yodB-3wksA:
undetectable		 5yodB-3wksA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens) 		4 / 5 HIS A 404
ALA A 375
SER A 414
GLY A 251
 LLP  A 405 ( 4.2A)
LLP  A 405 ( 3.6A)
None
LLP  A 405 ( 3.3A)
 1.22A 5yodD-2okjA:
undetectable		 5yodD-2okjA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens) 		4 / 5 HIS A 395
ALA A 366
SER A 405
GLY A 242
 LLP  A 396 ( 4.1A)
LLP  A 396 ( 3.5A)
LLP  A 396 ( 4.9A)
LLP  A 396 ( 3.4A)
 1.19A 5yodD-2okkA:
undetectable		 5yodD-2okkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3hbx GLUTAMATE
DECARBOXYLASE 1
(Arabidopsis
thaliana) 		4 / 5 HIS A 276
ALA A 246
SER A 274
GLY A 125
 LLP  A 277 ( 3.8A)
LLP  A 277 ( 3.3A)
LLP  A 277 ( 2.8A)
LLP  A 277 ( 3.2A)
 1.27A 5yodD-3hbxA:
undetectable		 5yodD-3hbxA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE
(Drosophila
melanogaster) 		4 / 5 HIS A 301
ALA A 148
SER A 311
GLY A 146
 LLP  A 302 ( 4.3A)
LLP  A 302 ( 3.3A)
None
None
 1.11A 5yodD-3k40A:
undetectable		 5yodD-3k40A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE
(Symbiobacterium
thermophilum) 		4 / 5 HIS A 441
SER A 101
GLY A 102
TYR A 105
 None
None
PO4  A 602 ( 3.8A)
LLP  A 311 (-3.9A)
 1.44A 5yodH-5eueA:
undetectable		 5yodH-5eueA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE
(Aedes
aegypti) 		4 / 6 ARG A 356
GLY A  24
SER A 155
THR A 316
 1BO  A 602 (-3.0A)
None
LLP  A 206 (-2.8A)
None
 1.13A 5ysiA-2hufA:
undetectable		 5ysiA-2hufA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE
(Campylobacter
jejuni) 		5 / 11 ILE A 163
ASN A 181
VAL A 200
SER A 177
ASP A 180
 None
None
None
None
LLP  A 205 ( 3.2A)
 1.50A 5z0hA-4oc9A:
undetectable
5z0hB-4oc9A:
undetectable		 5z0hA-4oc9A:
11.82
5z0hB-4oc9A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
LEU A 206
TYR A 218
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 0.99A 5zbdA-5jjcA:
undetectable		 5zbdA-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
TYR A 218
ASP A 208
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 1.38A 5zbdA-5jjcA:
undetectable		 5zbdA-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
LEU A 206
TYR A 218
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 0.96A 5zbdB-5jjcA:
undetectable		 5zbdB-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		5 / 10 ALA A 212
TYR A 218
ASP A 208
VAL A 182
GLY A 185
 None
None
None
LLP  A  42 ( 4.0A)
LLP  A  42 ( 3.4A)
 1.37A 5zbdB-5jjcA:
undetectable		 5zbdB-5jjcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 9 VAL A 179
GLY A 243
VAL A 215
GLU A 214
GLY A 257
 None
None
LLP  A 247 ( 3.7A)
None
None
 1.33A 5zniA-4wlhA:
undetectable		 5zniA-4wlhA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 9 VAL A 179
GLY A 243
VAL A 215
GLU A 214
GLY A 257
 None
None
LLP  A 247 ( 4.7A)
None
None
 1.35A 5zniA-4wp0A:
undetectable		 5zniA-4wp0A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 ALA A 181
GLY A 304
SER A 202
ALA A 199
TYR A 149
 None
None
LLP  A 205 ( 2.8A)
None
None
 1.12A 5zvgA-3aczA:
4.0		 5zvgA-3aczA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3acz METHIONINE
GAMMA-LYASE
(Entamoeba
histolytica) 		5 / 12 ALA A 181
GLY A 304
SER A 202
ALA A 199
TYR A 149
 None
None
LLP  A 205 ( 2.8A)
None
None
 1.10A 5zvgB-3aczA:
3.9		 5zvgB-3aczA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 3kw3 ALANINE RACEMASE
(Bartonella
henselae) 		5 / 12 LEU A 173
LEU A  85
CYH A 204
LEU A 224
ARG A 226
 None
None
None
None
LLP  A  47 ( 3.9A)
 1.16A 6a7pA-3kw3A:
undetectable		 6a7pA-3kw3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 ILE A 397
VAL A 179
LEU A 104
GLY A  34
PHE A 124
 None
None
LLP  A 247 ( 4.5A)
None
None
 1.17A 6a7pA-4wlhA:
undetectable		 6a7pA-4wlhA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 9 ILE A 238
SER A 193
SER A 161
SER A 162
GLY A 165
 None
None
LLP  A  51 ( 3.4A)
None
None
 1.35A 6awpA-4d8uA:
undetectable		 6awpA-4d8uA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1m6s L-ALLO-THREONINE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 VAL A 145
LEU A 201
ASP A   7
LEU A 251
SER A 179
 None
None
LLP  A 199 ( 3.7A)
None
None
 0.94A 6b0lB-1m6sA:
undetectable		 6b0lB-1m6sA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1
(Bacillus
anthracis) 		4 / 5 GLU A 209
HIS A 148
LEU A 155
VAL A 154
 LLP  A 270 ( 3.9A)
None
None
None
 0.99A 6bc9A-3l44A:
undetectable		 6bc9A-3l44A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3oks 4-AMINOBUTYRATE
TRANSAMINASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 265
GLY A 268
ALA A 277
GLU A 132
VAL A 228
 LLP  A 292 ( 4.2A)
None
None
None
None
 1.13A 6bqgA-3oksA:
undetectable		 6bqgA-3oksA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3f0h AMINOTRANSFERASE
([Eubacterium]
rectale) 		5 / 12 VAL A 291
VAL A   6
MET A  65
ARG A  90
GLY A 320
 None
None
LLP  A 187 ( 3.8A)
LLP  A 187 ( 4.7A)
UNL  A 358 (-3.8A)
 1.09A 6brdC-3f0hA:
undetectable		 6brdC-3f0hA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)
(Escherichia
coli) 		4 / 9 LEU A 185
VAL A 171
SER A 170
ASP A 173
 None
None
None
LLP  A 198 ( 3.0A)
 0.91A 6c2mD-1cs1A:
0.0		 6c2mD-1cs1A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 LEU A 385
VAL A 341
LEU A 345
ILE A 342
 None
LLP  A 285 ( 4.9A)
None
None
 0.90A 6cb4A-3w1jA:
undetectable		 6cb4A-3w1jA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3l6r SERINE RACEMASE
(Homo
sapiens) 		4 / 7 ILE A 252
VAL A 184
ILE A 259
THR A 261
 None
LLP  A  56 ( 4.4A)
None
None
 1.01A 6cduF-3l6rA:
undetectable
6cduG-3l6rA:
undetectable		 6cduF-3l6rA:
21.94
6cduG-3l6rA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3b46 AMINOTRANSFERASE
BNA3
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 101
LEU A 104
GLY A 270
LYS A 272
 None
None
LLP  A 271 ( 2.4A)
LLP  A 271 ( 3.1A)
 0.89A 6ce2A-3b46A:
undetectable		 6ce2A-3b46A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4j8l UNCHARACTERIZED
PROTEIN YHFS
(Escherichia
coli) 		4 / 5 TYR A 101
GLN A 277
GLY A 204
ILE A  79
 LLP  A 196 ( 3.4A)
LLP  A 196 ( 4.6A)
None
None
 1.47A 6debB-4j8lA:
2.4		 6debB-4j8lA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 12 ASP A 244
GLY A 245
GLY A 295
ILE A 290
PRO A 331
 None
LLP  A  63 ( 4.2A)
None
None
None
 1.01A 6dh0B-5ybwA:
undetectable		 6dh0B-5ybwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 12 ALA A 173
ASP A 201
VAL A 224
ILE A 202
PRO A 219
 None
LLP  A 230 ( 2.9A)
None
None
None
 0.93A 6dj1B-4j5uA:
undetectable		 6dj1B-4j5uA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 2gn1 THREONINE
DEHYDRATASE
CATABOLIC
(Salmonella
enterica) 		5 / 10 ALA A 235
ASP A 236
GLY A 312
ILE A 310
VAL A 208
 None
None
LLP  A  58 ( 3.5A)
None
None
 0.98A 6dj2A-2gn1A:
undetectable		 6dj2A-2gn1A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 5ybw ASPARTATE RACEMASE
(Scapharca
broughtonii) 		5 / 10 ALA A 243
ASP A 244
GLY A 322
ILE A 290
VAL A 214
 None
None
LLP  A  63 ( 3.8A)
None
None
 0.91A 6dj2A-5ybwA:
undetectable		 6dj2A-5ybwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE
(Rickettsia
rickettsii) 		5 / 12 ALA A 173
ASP A 201
VAL A 224
ILE A 202
PRO A 219
 None
LLP  A 230 ( 2.9A)
None
None
None
 0.92A 6dj2B-4j5uA:
undetectable		 6dj2B-4j5uA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 235
PHE A 354
VAL A 126
VAL A 349
ALA A 365
 LLP  A 234 ( 3.7A)
None
None
None
None
 1.05A 6djzC-1bjwA:
0.0		 6djzC-1bjwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
ASP A 190
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
None
LLP  A 226 ( 2.9A)
None
 1.23A 6dlzA-3getA:
4.3
6dlzD-3getA:
3.4		 6dlzA-3getA:
13.92
6dlzD-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
LEU A  73
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
None
None
LLP  A 226 ( 2.9A)
None
 1.17A 6dlzA-3getA:
4.3
6dlzD-3getA:
3.4		 6dlzA-3getA:
13.92
6dlzD-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.50A 6dlzA-3w1jA:
3.0
6dlzD-3w1jA:
3.1		 6dlzA-3w1jA:
11.58
6dlzD-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
 None
LLP  A  41 ( 2.9A)
None
LLP  A  41 ( 3.7A)
None
 1.01A 6dlzA-4h27A:
undetectable
6dlzD-4h27A:
undetectable		 6dlzA-4h27A:
13.57
6dlzD-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 ILE A  86
SER A  90
GLY A  87
SER A 225
ASP A 190
 None
LLP  A 226 ( 2.9A)
None
LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
 1.23A 6dlzB-3getA:
3.6
6dlzC-3getA:
4.1		 6dlzB-3getA:
13.92
6dlzC-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 ILE A  86
SER A  90
GLY A  87
SER A 225
LEU A  73
 None
LLP  A 226 ( 2.9A)
None
LLP  A 226 ( 2.4A)
None
 1.18A 6dlzB-3getA:
3.6
6dlzC-3getA:
4.1		 6dlzB-3getA:
13.92
6dlzC-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.49A 6dlzB-3w1jA:
4.3
6dlzC-3w1jA:
3.1		 6dlzB-3w1jA:
11.58
6dlzC-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
 LLP  A  41 ( 3.7A)
None
None
LLP  A  41 ( 2.9A)
None
 1.01A 6dlzB-4h27A:
undetectable
6dlzC-4h27A:
undetectable		 6dlzB-4h27A:
13.57
6dlzC-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.48A 6dm0A-3w1jA:
3.1
6dm0D-3w1jA:
3.0		 6dm0A-3w1jA:
11.58
6dm0D-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
ASP A 190
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
None
LLP  A 226 ( 2.9A)
None
 1.13A 6dm0B-3getA:
4.1
6dm0C-3getA:
4.6		 6dm0B-3getA:
13.92
6dm0C-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
LEU A  73
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
None
None
LLP  A 226 ( 2.9A)
None
 1.10A 6dm0B-3getA:
4.1
6dm0C-3getA:
4.6		 6dm0B-3getA:
13.92
6dm0C-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.48A 6dm0B-3w1jA:
3.0
6dm0C-3w1jA:
2.9		 6dm0B-3w1jA:
11.58
6dm0C-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
ASP A 190
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
None
LLP  A 226 ( 2.9A)
None
 1.24A 6dm1A-3getA:
4.1
6dm1D-3getA:
2.7		 6dm1A-3getA:
13.92
6dm1D-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 SER A 225
LEU A  73
ILE A  86
SER A  90
GLY A  87
 LLP  A 226 ( 2.4A)
None
None
LLP  A 226 ( 2.9A)
None
 1.19A 6dm1A-3getA:
4.1
6dm1D-3getA:
2.7		 6dm1A-3getA:
13.92
6dm1D-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.49A 6dm1A-3w1jA:
3.0
6dm1D-3w1jA:
3.0		 6dm1A-3w1jA:
11.58
6dm1D-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
 None
LLP  A  41 ( 2.9A)
None
LLP  A  41 ( 3.7A)
None
 1.00A 6dm1A-4h27A:
undetectable
6dm1D-4h27A:
undetectable		 6dm1A-4h27A:
13.57
6dm1D-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 ILE A  86
SER A  90
GLY A  87
SER A 225
ASP A 190
 None
LLP  A 226 ( 2.9A)
None
LLP  A 226 ( 2.4A)
LLP  A 226 ( 2.6A)
 1.24A 6dm1B-3getA:
3.6
6dm1C-3getA:
4.1		 6dm1B-3getA:
13.92
6dm1C-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE
(Campylobacter
jejuni) 		5 / 10 ILE A  86
SER A  90
GLY A  87
SER A 225
LEU A  73
 None
LLP  A 226 ( 2.9A)
None
LLP  A 226 ( 2.4A)
None
 1.19A 6dm1B-3getA:
3.6
6dm1C-3getA:
4.1		 6dm1B-3getA:
13.92
6dm1C-3getA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.50A 6dm1B-3w1jA:
4.3
6dm1C-3w1jA:
3.1		 6dm1B-3w1jA:
11.58
6dm1C-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens) 		5 / 10 ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
 LLP  A  41 ( 3.7A)
None
None
LLP  A  41 ( 2.9A)
None
 1.01A 6dm1B-4h27A:
undetectable
6dm1C-4h27A:
undetectable		 6dm1B-4h27A:
13.57
6dm1C-4h27A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.49A 6dm2A-3w1jA:
2.7
6dm2D-3w1jA:
3.2		 6dm2A-3w1jA:
11.58
6dm2D-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.49A 6dm2B-3w1jA:
2.4
6dm2C-3w1jA:
1.8		 6dm2B-3w1jA:
11.58
6dm2C-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 231
ASP A 242
ILE A 228
SER A  50
LEU A 257
 None
None
LLP  A 255 ( 3.9A)
None
None
 1.05A 6ectA-3ruyA:
undetectable		 6ectA-3ruyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 6c3b UNCHARACTERIZED
PROTEIN
(Streptomyces
cattleya) 		4 / 5 THR A 296
THR A  35
GLN A  37
ASP A  32
 None
LLP  A 235 ( 4.4A)
None
None
 1.37A 6ectA-6c3bA:
3.5		 6ectA-6c3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMM_A_SALA303_0
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4d8u D-CYSTEINE
DESULFHYDRASE
(Salmonella
enterica) 		5 / 9 HIS A  80
SER A 195
ASN A  50
LEU A  58
LEU A  55
 LLP  A  51 (-4.8A)
LLP  A  51 ( 2.4A)
LLP  A  51 ( 3.1A)
None
LLP  A  51 ( 3.7A)
 1.45A 6emmA-4d8uA:
2.7		 6emmA-4d8uA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 8 GLY A 315
THR A 317
PHE A 289
TYR A 286
 LLP  A 312 ( 4.6A)
None
LLP  A 312 ( 4.9A)
LLP  A 312 ( 4.6A)
 0.92A 6eqpA-3f6tA:
undetectable		 6eqpA-3f6tA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5jjc CYSTEINE SYNTHASE
(Brucella
abortus) 		4 / 6 PHE A 246
LEU A 243
ALA A 189
SER A 184
 None
None
None
LLP  A  42 ( 2.6A)
 0.86A 6f88A-5jjcA:
undetectable		 6f88A-5jjcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		5 / 9 LEU A 198
PRO A 192
VAL A 225
SER A 208
LEU A 213
 None
None
None
LLP  A 211 ( 2.7A)
None
 1.40A 6fdyU-5x2vA:
undetectable		 6fdyU-5x2vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 9 LEU A 186
PRO A 180
VAL A 213
SER A 196
LEU A 201
 None
None
None
LLP  A 199 ( 2.7A)
None
 1.41A 6fdyU-6cjbA:
undetectable		 6fdyU-6cjbA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 6cjb CYSTATHIONINE
BETA-LYASE
(Legionella
pneumophila) 		5 / 9 LEU A 186
VAL A 213
SER A 196
LEU A 201
ILE A  62
 None
None
LLP  A 199 ( 2.7A)
None
None
 1.17A 6fdyU-6cjbA:
undetectable		 6fdyU-6cjbA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 HIS A  62
ARG A 225
ILE A 224
 LLP  A 165 ( 4.8A)
LLP  A 165 ( 4.0A)
LLP  A 165 ( 3.7A)
 0.79A 6fgdA-4tm5A:
undetectable		 6fgdA-4tm5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 5 ALA A  87
TYR A  86
GLN A 117
ILE A  90
 LLP  A  46 ( 3.7A)
None
None
None
 1.30A 6g9bA-3llxA:
undetectable
6g9bB-3llxA:
undetectable		 6g9bA-3llxA:
13.01
6g9bB-3llxA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A  50
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 4.9A)
 1.08A 6gmdB-4q76A:
undetectable		 6gmdB-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 HIS A 240
SER A  48
LYS A 242
 LLP  A 241 ( 3.7A)
LLP  A 241 ( 3.2A)
LLP  A 241 ( 3.5A)
 1.06A 6gmdB-4q76A:
undetectable		 6gmdB-4q76A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A  34
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 4.9A)
 1.01A 6gmdB-5vprA:
undetectable		 6gmdB-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5vpr CYSTEINE DESULFURASE
(Elizabethkingia
anophelis) 		3 / 3 HIS A 224
SER A  32
LYS A 226
 LLP  A 225 ( 3.7A)
LLP  A 225 ( 3.3A)
LLP  A 225 ( 3.5A)
 1.05A 6gmdB-5vprA:
undetectable		 6gmdB-5vprA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 109
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.14A 6gneA-4wd2A:
undetectable		 6gneA-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 279
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.11A 6gneA-4wd2A:
undetectable		 6gneA-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 109
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.13A 6gneB-4wd2A:
3.4		 6gneB-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB
(Burkholderia
cenocepacia) 		5 / 12 GLY A 103
GLY A 105
VAL A 279
GLN A 287
PRO A 286
 LLP  A 246 ( 3.8A)
None
None
None
None
 1.10A 6gneB-4wd2A:
3.4		 6gneB-4wd2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN
(Francisella
tularensis) 		4 / 6 LEU B  80
THR B  87
GLY B  82
ARG B 378
 None
LLP  B  86 ( 4.4A)
None
None
 1.12A 6gtqB-5kzmB:
0.0
6gtqD-5kzmB:
undetectable		 6gtqB-5kzmB:
20.88
6gtqD-5kzmB:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4li3 CYSTEINE SYNTHASE
(Haemophilus
influenzae) 		5 / 10 ALA X  76
LEU X  77
VAL X  80
ALA X  53
ALA X 148
 LLP  X  42 ( 3.2A)
None
None
None
None
 1.09A 6h1lA-4li3X:
undetectable		 6h1lA-4li3X:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3fcr PUTATIVE
AMINOTRANSFERASE
(Ruegeria
sp.
TM1040) 		5 / 11 ALA A 352
VAL A 262
THR A 263
ILE A 234
ALA A  56
 None
LLP  A 288 (-4.4A)
None
None
None
 1.10A 6h1lB-3fcrA:
undetectable		 6h1lB-3fcrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3f6t ASPARTATE
AMINOTRANSFERASE
(Lactobacillus
acidophilus) 		4 / 7 VAL A 105
ILE A 145
GLY A 315
ALA A  49
 None
None
LLP  A 312 ( 4.6A)
None
 0.83A 6hd6B-3f6tA:
undetectable		 6hd6B-3f6tA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLN A  41
GLY A  44
VAL A 289
SER A 231
 None
LLP  A 234 ( 4.3A)
None
LLP  A 234 ( 2.9A)
 1.06A 6hu9S-3wksA:
undetectable
6hu9q-3wksA:
undetectable		 6hu9S-3wksA:
12.37
6hu9q-3wksA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4xk1 PHOSPHOSERINE
AMINOTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 196
GLY A 194
VAL A 207
SER A  78
 LLP  A 197 ( 3.1A)
LLP  A 197 ( 4.5A)
None
LLP  A 197 ( 2.4A)
 1.05A 6hu9S-4xk1A:
undetectable
6hu9q-4xk1A:
undetectable		 6hu9S-4xk1A:
13.11
6hu9q-4xk1A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4grx AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 ALA A  61
GLY A 290
ALA A 336
LYS A 335
 None
LLP  A 285 ( 4.4A)
None
None
 0.76A 6mdqA-4grxA:
undetectable		 6mdqA-4grxA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG
(Clostridium
acetobutylicum) 		4 / 7 ASP A 217
TYR A 255
GLU A 222
GLU A 225
 LLP  A 243 ( 2.9A)
None
None
None
 1.32A 6mn5B-3hvyA:
undetectable		 6mn5B-3hvyA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 6a2f -
(-) 		4 / 4 HIS A  40
LEU A  49
TYR A  17
GLY A 211
 None
None
None
LLP  A  34 ( 3.4A)
 1.46A 6n91A-6a2fA:
5.3		 6n91A-6a2fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 7 ALA A 234
GLY A 235
GLY A 173
TYR A 176
 LLP  A  46 ( 3.8A)
LLP  A  46 ( 3.5A)
TRS  A 383 ( 3.9A)
TRS  A 383 ( 4.1A)
 0.85A 6nm4A-3llxA:
undetectable		 6nm4A-3llxA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4rit PYRIDOXAL-DEPENDENT
DECARBOXYLASE
(Sphaerobacter
thermophilus) 		5 / 9 GLY B 378
LEU B 454
GLY B 276
TYR B 275
ARG B 284
 GOL  B 504 (-3.1A)
GOL  B 504 (-4.8A)
None
LLP  B 304 ( 4.8A)
None
 1.31A 6nm4B-4ritB:
undetectable		 6nm4B-4ritB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5tch TRYPTOPHAN SYNTHASE
BETA CHAIN
(Mycobacterium
tuberculosis) 		5 / 9 ALA B 316
GLY B 317
LEU B 318
GLY B 393
ARG B 155
 MLI  B 501 (-3.6A)
LLP  B 101 ( 4.2A)
None
None
None
 1.07A 6nm4B-5tchB:
undetectable		 6nm4B-5tchB:
18.83