SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '12as'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 0.99A 1dfoA-12asA:
0.4		 1dfoA-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 0.99A 1dfoB-12asA:
undetectable		 1dfoB-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 0.99A 1dfoC-12asA:
0.5		 1dfoC-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 1.00A 1dfoD-12asA:
0.4		 1dfoD-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 1.02A 1eqbA-12asA:
undetectable		 1eqbA-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 1.01A 1eqbB-12asA:
0.4		 1eqbB-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 1.02A 1eqbC-12asA:
undetectable		 1eqbC-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 203
HIS A 211
ASN A 233
PHE A 167
ARG A 214
 None
 1.02A 1eqbD-12asA:
undetectable		 1eqbD-12asA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		4 / 6 ASP A 220
GLY A 231
THR A 223
PRO A 224
 None
 0.87A 1n4fA-12asA:
undetectable		 1n4fA-12asA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		3 / 3 LEU A 330
LEU A 307
MET A 302
 None
 0.87A 2itzA-12asA:
undetectable		 2itzA-12asA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		3 / 3 LEU A 133
LEU A  27
PHE A 197
 None
 0.72A 2pgrA-12asA:
undetectable		 2pgrA-12asA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 VAL A 199
GLY A 200
GLY A 202
ALA A 230
LEU A 133
 None
 1.02A 3dh0A-12asA:
undetectable		 3dh0A-12asA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		3 / 3 TYR A 218
ASP A 118
HIS A  71
 ASN  A 331 (-4.3A)
ASN  A 331 (-3.3A)
None
 0.73A 3e23A-12asA:
undetectable		 3e23A-12asA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		3 / 3 PRO A 159
LEU A 157
GLN A 306
 None
 0.69A 3hznG-12asA:
0.5
3hznH-12asA:
1.8		 3hznG-12asA:
20.77
3hznH-12asA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		6 / 12 LEU A 237
ASP A 235
ASP A 219
VAL A 199
ILE A 140
VAL A 196
 None
None
ASN  A 331 ( 3.9A)
None
None
None
 1.49A 3jw2A-12asA:
undetectable		 3jw2A-12asA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A  48
SER A  72
SER A 251
LEU A 265
HIS A 279
 None
ASN  A 331 (-2.9A)
AMP  A 332 ( 3.0A)
None
None
 1.49A 3vt3A-12asA:
0.0		 3vt3A-12asA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		4 / 5 ASP A 118
GLU A 120
GLY A 293
GLN A 116
 ASN  A 331 (-3.3A)
None
ASN  A 331 (-4.0A)
ASN  A 331 ( 3.5A)
 1.38A 3w9tB-12asA:
0.0		 3w9tB-12asA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 9 ALA A 182
GLY A 184
LEU A 237
LEU A 173
ILE A 189
 None
 1.15A 3wdmC-12asA:
undetectable		 3wdmC-12asA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLU A  31
TYR A  93
SER A  20
 None
 0.99A 4at0A-12asA:
undetectable		 4at0A-12asA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 9 ILE A 140
ARG A  26
LEU A  27
ILE A 236
GLY A 292
 None
 1.06A 4kukA-12asA:
undetectable		 4kukA-12asA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		4 / 8 SER A  72
ASP A  46
GLN A 116
ARG A 100
 ASN  A 331 (-2.9A)
ASN  A 331 (-3.4A)
ASN  A 331 ( 3.5A)
AMP  A 332 (-2.9A)
 1.10A 4lnwA-12asA:
0.0		 4lnwA-12asA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		3 / 3 LEU A 133
ILE A 291
ARG A 255
 None
None
ASN  A 331 (-3.2A)
 0.59A 4mk4B-12asA:
undetectable		 4mk4B-12asA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		4 / 6 TYR A 218
GLY A  50
SER A  49
LEU A  48
 ASN  A 331 (-4.3A)
None
None
None
 1.19A 5bphA-12asA:
undetectable		 5bphA-12asA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		4 / 4 TYR A 218
GLY A  50
SER A  49
LEU A  48
 ASN  A 331 (-4.3A)
None
None
None
 1.20A 5bphC-12asA:
undetectable		 5bphC-12asA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		4 / 8 LEU A 261
THR A  44
GLN A  83
MET A 287
 None
 1.13A 5hbsA-12asA:
0.2		 5hbsA-12asA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		4 / 8 GLY A 234
ARG A 255
GLN A 289
TYR A 218
 None
ASN  A 331 (-3.2A)
None
ASN  A 331 (-4.3A)
 1.01A 5vlmA-12asA:
undetectable		 5vlmA-12asA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 100
GLU A 103
GLY A 296
ARG A 299
ILE A 310
 AMP  A 332 (-2.9A)
AMP  A 332 (-3.7A)
AMP  A 332 (-3.1A)
AMP  A 332 (-3.8A)
None
 0.89A 6bniA-12asA:
23.7		 6bniA-12asA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		6 / 10 GLU A 103
HIS A 110
GLU A 248
GLY A 296
ARG A 299
ILE A 310
 AMP  A 332 (-3.7A)
AMP  A 332 (-4.9A)
AMP  A 332 (-4.0A)
AMP  A 332 (-3.1A)
AMP  A 332 (-3.8A)
None
 0.73A 6bniA-12asA:
23.7		 6bniA-12asA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 100
GLU A 103
GLY A 296
ARG A 299
ILE A 310
 AMP  A 332 (-2.9A)
AMP  A 332 (-3.7A)
AMP  A 332 (-3.1A)
AMP  A 332 (-3.8A)
None
 0.90A 6bniB-12asA:
23.8		 6bniB-12asA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 12as ASPARAGINE
SYNTHETASE
(Escherichia
coli) 		6 / 10 GLU A 103
HIS A 110
GLU A 248
GLY A 296
ARG A 299
ILE A 310
 AMP  A 332 (-3.7A)
AMP  A 332 (-4.9A)
AMP  A 332 (-4.0A)
AMP  A 332 (-3.1A)
AMP  A 332 (-3.8A)
None
 0.74A 6bniB-12asA:
23.8		 6bniB-12asA:
13.58