SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '13pk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 5 LYS A 219
ALA A 218
ASP A 377
GLY A 339
 3PG  A 423 ( 2.6A)
ADP  A 421 (-3.4A)
MG  A 422 ( 3.4A)
ADP  A 421 ( 4.1A)
 0.97A 1e7bA-13pkA:
0.0		 1e7bA-13pkA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 130
LEU A  99
ARG A  41
VAL A  27
ALA A  43
 None
 1.20A 1n5xA-13pkA:
0.0		 1n5xA-13pkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 130
LEU A  99
ARG A  41
VAL A  27
ALA A  43
 None
 1.20A 1n5xB-13pkA:
0.0		 1n5xB-13pkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 9 LEU A 227
VAL A 282
ILE A 283
TYR A 325
ILE A 317
 None
 1.43A 1q6iA-13pkA:
undetectable		 1q6iA-13pkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 HIS A  62
ALA A 175
ILE A 180
VAL A 134
LEU A 130
 3PG  A 423 (-4.1A)
None
None
None
None
 1.04A 1udtA-13pkA:
undetectable		 1udtA-13pkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 8 GLY A 168
GLY A 397
GLY A 398
ALA A 400
ILE A 372
 3PG  A 423 (-4.7A)
None
ADP  A 421 ( 4.3A)
None
None
 1.07A 1yajC-13pkA:
undetectable		 1yajC-13pkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 8 GLY A 397
GLY A 398
GLY A 399
ALA A 400
ILE A 336
 None
ADP  A 421 ( 4.3A)
None
None
None
 0.88A 1yajC-13pkA:
undetectable		 1yajC-13pkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		3 / 3 TRP A 337
LEU A 402
LYS A 223
 None
None
ADP  A 421 (-2.7A)
 1.32A 1yajK-13pkA:
undetectable		 1yajK-13pkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 HIS A  62
ALA A 175
ILE A 180
VAL A 134
LEU A 130
 3PG  A 423 (-4.1A)
None
None
None
None
 1.11A 2h42B-13pkA:
undetectable		 2h42B-13pkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 11 GLY A 168
SER A 395
SER A 401
ASP A 377
GLY A 399
 3PG  A 423 (-4.7A)
None
None
MG  A 422 ( 3.4A)
None
 1.48A 2hmaA-13pkA:
undetectable		 2hmaA-13pkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		3 / 3 SER A  56
ASP A  13
ASP A 160
 None
 0.72A 2plwA-13pkA:
undetectable		 2plwA-13pkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PWS_A_IBPA3960_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 4 LEU A 227
ILE A 234
TRP A 337
LYS A 223
 None
None
None
ADP  A 421 (-2.7A)
 1.33A 2pwsA-13pkA:
0.0		 2pwsA-13pkA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 ILE A 180
MET A  71
ILE A 154
VAL A  58
LEU A 131
 None
 1.19A 3a51D-13pkA:
0.0		 3a51D-13pkA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 THR A 321
ASP A 316
GLY A 352
ALA A 355
ALA A 359
 None
 0.90A 3p5nA-13pkA:
0.5		 3p5nA-13pkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 THR A 321
ASP A 316
GLY A 352
ALA A 355
ALA A 359
 None
 0.91A 3p5nB-13pkA:
0.2		 3p5nB-13pkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 8 ASP A 147
GLY A 141
PRO A  70
GLN A  73
 None
 0.97A 3s3nA-13pkA:
undetectable		 3s3nA-13pkA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 9 GLY A 375
GLY A 376
ASN A  36
GLY A 397
TYR A  38
 ADP  A 421 (-3.3A)
ADP  A 421 (-4.0A)
None
None
None
 0.90A 3ztvA-13pkA:
undetectable		 3ztvA-13pkA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		3 / 3 LEU A  63
GLU A 132
SER A  61
 None
 0.61A 4ccqA-13pkA:
1.7		 4ccqA-13pkA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 7 PHE A 167
GLY A 375
ILE A 372
PHE A 200
 None
ADP  A 421 (-3.3A)
None
None
 0.80A 4ejjA-13pkA:
0.0		 4ejjA-13pkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 7 PHE A 167
GLY A 375
ILE A 372
PHE A 200
 None
ADP  A 421 (-3.3A)
None
None
 0.73A 4ejjD-13pkA:
0.0		 4ejjD-13pkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 GLY A 352
GLY A 342
THR A 353
TYR A 325
VAL A 326
 None
ADP  A 421 (-3.1A)
None
None
None
 0.78A 4f84A-13pkA:
2.0		 4f84A-13pkA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 7 ARG A 148
GLY A 179
ILE A 183
GLU A 149
 None
 0.91A 4g0vA-13pkA:
undetectable		 4g0vA-13pkA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 7 ILE A 239
LEU A 227
LYS A 219
GLY A 399
 None
None
3PG  A 423 ( 2.6A)
None
 0.82A 4hajA-13pkA:
undetectable		 4hajA-13pkA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 8 ILE A 239
LEU A 227
LYS A 219
GLY A 399
 None
None
3PG  A 423 ( 2.6A)
None
 0.89A 4hb6A-13pkA:
undetectable		 4hb6A-13pkA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 8 ILE A 239
LEU A 227
LYS A 219
GLY A 399
 None
None
3PG  A 423 ( 2.6A)
None
 0.80A 4hb8A-13pkA:
undetectable		 4hb8A-13pkA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 MET A  60
LEU A 131
LEU A 114
ILE A 183
LEU A  20
 None
 1.25A 4j26B-13pkA:
undetectable		 4j26B-13pkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 8 GLY A 374
ASN A 338
PHE A 200
ILE A 372
 None
ADP  A 421 (-3.3A)
None
None
 1.00A 4j4vC-13pkA:
0.0		 4j4vC-13pkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 8 GLY A 376
ARG A  41
PRO A 340
PHE A 344
 ADP  A 421 (-4.0A)
None
ADP  A 421 (-4.3A)
None
 0.87A 4j4vC-13pkA:
0.0		 4j4vC-13pkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		3 / 3 LEU A 410
PRO A 411
ARG A  39
 None
None
3PG  A 423 (-2.7A)
 0.59A 4klrB-13pkA:
1.5		 4klrB-13pkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 10 GLU A 387
ILE A 356
VAL A 326
ALA A 335
ILE A 329
 None
 0.99A 4lbgA-13pkA:
3.1		 4lbgA-13pkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 8 VAL A 128
LEU A  99
ASP A 165
ILE A  21
 None
 0.82A 4lzrA-13pkA:
undetectable		 4lzrA-13pkA:
15.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		8 / 12 GLY A 217
ALA A 218
GLY A 241
PHE A 294
MET A 313
LEU A 315
GLY A 342
VAL A 343
 ADP  A 421 (-2.9A)
ADP  A 421 (-3.4A)
ADP  A 421 (-3.4A)
None
None
None
ADP  A 421 (-3.1A)
ADP  A 421 (-3.4A)
 0.58A 4o33A-13pkA:
48.4		 4o33A-13pkA:
44.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		6 / 12 GLY A 217
GLY A 241
PHE A 294
MET A 313
LEU A 315
VAL A 343
 ADP  A 421 (-2.9A)
ADP  A 421 (-3.4A)
None
None
None
ADP  A 421 (-3.4A)
 1.02A 4o33A-13pkA:
48.4		 4o33A-13pkA:
44.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		8 / 12 GLY A 217
ALA A 218
GLY A 241
PHE A 294
MET A 313
LEU A 315
GLY A 342
VAL A 343
 ADP  A 421 (-2.9A)
ADP  A 421 (-3.4A)
ADP  A 421 (-3.4A)
None
None
None
ADP  A 421 (-3.1A)
ADP  A 421 (-3.4A)
 0.55A 4o3fA-13pkA:
45.9		 4o3fA-13pkA:
44.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 ASP A 316
GLY A 318
ASP A 287
LYS A 351
ILE A 322
 None
 1.39A 4pghB-13pkA:
undetectable		 4pghB-13pkA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 11 GLY A 216
GLY A 240
ILE A 214
GLY A 375
PHE A 344
 None
None
None
ADP  A 421 (-3.3A)
None
 1.13A 4qoiA-13pkA:
3.3
4qoiB-13pkA:
3.3		 4qoiA-13pkA:
21.18
4qoiB-13pkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 ALA A 381
SER A 380
GLY A 376
ALA A 242
GLY A 216
 None
None
ADP  A 421 (-4.0A)
ADP  A 421 ( 4.4A)
None
 1.18A 4r29A-13pkA:
0.0		 4r29A-13pkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 ALA A 381
SER A 380
GLY A 376
ALA A 242
GLY A 216
 None
None
ADP  A 421 (-4.0A)
ADP  A 421 ( 4.4A)
None
 1.18A 4r29C-13pkA:
0.0		 4r29C-13pkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		3 / 3 SER A 380
ASP A 165
ASP A  37
 None
 0.74A 4uckA-13pkA:
2.1		 4uckA-13pkA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 7 GLU A 196
GLY A 374
SER A 401
GLY A 399
 None
 1.00A 5e26A-13pkA:
2.3
5e26B-13pkA:
0.0		 5e26A-13pkA:
22.97
5e26B-13pkA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 GLY A 187
ILE A 372
GLY A 374
GLY A 398
LEU A 410
 None
None
None
ADP  A 421 ( 4.3A)
None
 1.01A 5eqbA-13pkA:
0.0		 5eqbA-13pkA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 GLY A 368
PHE A 167
PHE A 200
GLY A 168
GLY A 398
 None
None
None
3PG  A 423 (-4.7A)
ADP  A 421 ( 4.3A)
 1.03A 5eqbA-13pkA:
0.0		 5eqbA-13pkA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 9 LEU A 238
GLY A 216
GLY A 374
ILE A 373
VAL A 212
 None
 1.01A 5kr0B-13pkA:
undetectable		 5kr0B-13pkA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 9 LEU A  51
LEU A 103
ILE A  21
LEU A  14
ALA A  43
 PO4  A 701 ( 4.9A)
PO4  A 701 (-4.9A)
None
None
None
 1.30A 5og9A-13pkA:
undetectable		 5og9A-13pkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 8 VAL A 203
HIS A 393
GLY A 368
LEU A 369
 None
 0.93A 5w3jB-13pkA:
3.1		 5w3jB-13pkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 7 ASN A  26
HIS A  62
GLY A  68
ASN A 133
 3PG  A 423 (-3.9A)
3PG  A 423 (-4.1A)
None
None
 1.11A 5x7pA-13pkA:
undetectable		 5x7pA-13pkA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		4 / 6 LEU A  20
VAL A  58
LEU A 131
VAL A 120
 None
 0.92A 5x7zA-13pkA:
0.0		 5x7zA-13pkA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		3 / 3 MET A 177
ASP A  24
ARG A  65
 None
3PG  A 423 (-2.7A)
3PG  A 423 (-4.3A)
 1.13A 5z6kA-13pkA:
1.1		 5z6kA-13pkA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		3 / 3 ARG A 172
LYS A 408
ARG A 135
 3PG  A 423 (-3.4A)
None
3PG  A 423 (-2.8A)
 1.39A 6az3C-13pkA:
0.0
6az3L-13pkA:
0.0
6az3M-13pkA:
0.0		 6az3C-13pkA:
11.90
6az3L-13pkA:
13.69
6az3M-13pkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 12 GLY A 398
GLY A 375
GLY A 412
HIS A  62
PRO A 181
 ADP  A 421 ( 4.3A)
ADP  A 421 (-3.3A)
None
3PG  A 423 (-4.1A)
None
 0.95A 6gngB-13pkA:
3.6		 6gngB-13pkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 13pk 3-PHOSPHOGLYCERATE
KINASE
(Trypanosoma
brucei) 		5 / 10 ALA A 213
VAL A 215
ILE A 224
ALA A 275
LEU A 227
 None
 1.10A 6h1lA-13pkA:
0.0		 6h1lA-13pkA:
20.80