SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		5 / 10 PRO A  63
GLY A  64
LEU A  58
THR A  70
GLY A  41
 None
 0.94A 1h4oA-1a04A:
0.9
1h4oB-1a04A:
2.1		 1h4oA-1a04A:
20.18
1h4oB-1a04A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		5 / 9 ALA A   7
ILE A 176
ARG A 203
ASP A  54
GLU A 127
 None
 1.44A 3rukC-1a04A:
0.0		 3rukC-1a04A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		3 / 3 LEU A 116
MET A 111
ASP A  14
 None
 0.71A 4j7xB-1a04A:
2.7		 4j7xB-1a04A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		3 / 3 ARG A  75
ASP A  72
ARG A 101
 None
 0.57A 4wq4B-1a04A:
1.3		 4wq4B-1a04A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		5 / 12 LEU A  11
VAL A  34
ILE A  26
LEU A 107
LEU A 116
 None
 1.35A 4yvpB-1a04A:
2.2		 4yvpB-1a04A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		3 / 3 ARG A 151
LYS A 201
GLU A 205
 None
 0.77A 5d0yA-1a04A:
0.0		 5d0yA-1a04A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		5 / 12 GLY A  21
GLN A  24
LEU A  55
GLY A 126
PHE A  86
 None
 1.23A 5fsaB-1a04A:
undetectable		 5fsaB-1a04A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		5 / 12 LEU A  68
GLY A  67
LEU A  55
ILE A  12
ASP A  59
 None
 1.10A 6bxmA-1a04A:
4.9		 6bxmA-1a04A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL
(Escherichia
coli) 		3 / 3 LEU A 180
LEU A 166
ARG A 179
 None
 0.68A 6fgdA-1a04A:
3.8		 6fgdA-1a04A:
19.76