SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 11 PHE A  99
ILE A 125
PHE A  97
TYR A   3
ALA A  80
 None
 1.39A 1ju6A-1a0cA:
0.0		 1ju6A-1a0cA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 10 HIS A 100
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.37A 1xidA-1a0cA:
39.9		 1xidA-1a0cA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		9 / 10 TRP A  48
HIS A 100
PHE A 144
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.31A 1xidA-1a0cA:
39.9		 1xidA-1a0cA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
PHE A 144
VAL A 185
TRP A 187
LYS A 233
ASP A 306
 None
None
None
None
None
None
CO  A 492 ( 1.9A)
 0.85A 1xihA-1a0cA:
39.8		 1xihA-1a0cA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 HIS A 100
THR A 140
TRP A 187
ASP A 306
ASP A 295
 None
None
None
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 1.36A 1xihA-1a0cA:
39.8		 1xihA-1a0cA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.32A 1xihA-1a0cA:
39.8		 1xihA-1a0cA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 PHE A 144
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 308
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.46A 1xihA-1a0cA:
39.8		 1xihA-1a0cA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
PHE A 144
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.42A 1xihA-1a0cA:
39.8		 1xihA-1a0cA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 7 ILE A 175
VAL A 136
GLY A 181
GLY A 139
 None
 0.72A 2wd9A-1a0cA:
undetectable		 2wd9A-1a0cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 ILE A 175
VAL A 136
GLY A 181
GLY A 139
 None
 0.73A 2wd9B-1a0cA:
undetectable		 2wd9B-1a0cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.32A 2xinA-1a0cA:
38.7		 2xinA-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		8 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.44A 2xinA-1a0cA:
38.7		 2xinA-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
GLU A 231
GLU A 267
HIS A 270
ASP A 306
ASP A 295
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 1.35A 2xinA-1a0cA:
38.7		 2xinA-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.55A 2xinA-1a0cA:
38.7		 2xinA-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
ASP A 308
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 2.4A)
 1.48A 2xinA-1a0cA:
38.7		 2xinA-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.31A 2xinB-1a0cA:
38.7		 2xinB-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
HIS A 270
ASP A 306
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 3.5A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 1.24A 2xinB-1a0cA:
38.7		 2xinB-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
VAL A 185
TRP A 187
GLU A 231
HIS A 270
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.41A 2xinB-1a0cA:
38.7		 2xinB-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.48A 2xinB-1a0cA:
38.7		 2xinB-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.67A 2xinB-1a0cA:
38.7		 2xinB-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
ASP A 308
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 2.4A)
 1.49A 2xinB-1a0cA:
38.7		 2xinB-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 HIS A 100
THR A 140
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.31A 2xinC-1a0cA:
38.9		 2xinC-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 HIS A 100
THR A 140
GLU A 231
HIS A 270
ASP A 306
ASP A 295
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 3.5A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 1.26A 2xinC-1a0cA:
38.9		 2xinC-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.39A 2xinC-1a0cA:
38.9		 2xinC-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.29A 2xinC-1a0cA:
38.9		 2xinC-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.45A 2xinC-1a0cA:
38.9		 2xinC-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.60A 2xinC-1a0cA:
38.9		 2xinC-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.27A 2xinD-1a0cA:
38.7		 2xinD-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
HIS A 270
ASP A 306
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 3.5A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 1.21A 2xinD-1a0cA:
38.7		 2xinD-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.36A 2xinD-1a0cA:
38.7		 2xinD-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.48A 2xinD-1a0cA:
38.7		 2xinD-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.66A 2xinD-1a0cA:
38.7		 2xinD-1a0cA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 5 ILE A 266
PRO A 232
PHE A 244
PRO A 234
 None
 0.91A 3bjwC-1a0cA:
0.0		 3bjwC-1a0cA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		3 / 3 GLU A 267
GLU A 231
TRP A  48
 CO  A 492 ( 2.5A)
CO  A 491 ( 2.4A)
None
 1.18A 3hrdA-1a0cA:
0.0
3hrdE-1a0cA:
0.0
3hrdF-1a0cA:
0.0		 3hrdA-1a0cA:
21.70
3hrdE-1a0cA:
21.70
3hrdF-1a0cA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 PHE A 362
ALA A 296
ALA A 268
THR A 272
 None
 0.88A 3l4dA-1a0cA:
undetectable		 3l4dA-1a0cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 PHE A 362
ALA A 296
ALA A 268
THR A 272
 None
 0.95A 3l4dD-1a0cA:
undetectable		 3l4dD-1a0cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 PHE A  97
ILE A 222
PHE A 224
ALA A 219
ALA A 141
 None
 1.19A 3nxuB-1a0cA:
0.0		 3nxuB-1a0cA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 ASP A 331
GLY A 139
GLY A 180
PHE A  99
TYR A  96
 None
 1.09A 3prsA-1a0cA:
undetectable		 3prsA-1a0cA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		3 / 3 GLU A 191
PHE A 208
GLN A 241
 None
 1.01A 3r55A-1a0cA:
0.0		 3r55A-1a0cA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 6 PHE A 211
PHE A 208
PHE A 186
THR A 140
 None
 1.05A 3t3sB-1a0cA:
0.0		 3t3sB-1a0cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 PHE A 211
PHE A 208
PHE A 186
THR A 140
 None
 1.02A 3t3sE-1a0cA:
0.0		 3t3sE-1a0cA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.35A 3ximA-1a0cA:
38.8		 3ximA-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 267
ASP A 308
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 2.4A)
 1.34A 3ximA-1a0cA:
38.8		 3ximA-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.47A 3ximA-1a0cA:
38.8		 3ximA-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 308
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.48A 3ximA-1a0cA:
38.8		 3ximA-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		8 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.30A 3ximB-1a0cA:
38.7		 3ximB-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.49A 3ximB-1a0cA:
38.7		 3ximB-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
GLU A 231
GLU A 267
HIS A 270
ASP A 308
ASP A 295
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
CO  A 491 ( 3.1A)
 1.39A 3ximC-1a0cA:
38.9		 3ximC-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
VAL A 185
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.24A 3ximC-1a0cA:
38.9		 3ximC-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.43A 3ximC-1a0cA:
38.9		 3ximC-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.23A 3ximD-1a0cA:
38.7		 3ximD-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 2.4A)
 1.29A 3ximD-1a0cA:
38.7		 3ximD-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.44A 3ximD-1a0cA:
38.7		 3ximD-1a0cA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 5 LEU A 250
HIS A 276
GLU A 281
HIS A 280
 None
 0.95A 4a7bB-1a0cA:
undetectable		 4a7bB-1a0cA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 GLU A 178
ILE A 175
ASN A 115
ASP A 119
 None
 1.09A 4d39A-1a0cA:
0.0		 4d39A-1a0cA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 HIS A 100
THR A 140
VAL A 185
ASN A 265
GLU A 267
ASP A 308
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 2.4A)
 1.36A 4dvoA-1a0cA:
39.7		 4dvoA-1a0cA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.31A 4dvoA-1a0cA:
39.7		 4dvoA-1a0cA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
ASN A 265
GLU A 267
HIS A 270
ASP A 295
ASP A 306
 None
None
None
None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
 0.39A 4dvoA-1a0cA:
39.7		 4dvoA-1a0cA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 HIS A 100
THR A 140
GLU A 267
HIS A 270
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.27A 4xiaA-1a0cA:
38.6		 4xiaA-1a0cA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
ASP A 306
 None
None
None
None
None
CO  A 492 ( 1.9A)
 0.87A 4xiaA-1a0cA:
38.6		 4xiaA-1a0cA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.36A 4xiaA-1a0cA:
38.6		 4xiaA-1a0cA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		10 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.42A 4xiaA-1a0cA:
38.6		 4xiaA-1a0cA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		8 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.29A 4xiaB-1a0cA:
38.5		 4xiaB-1a0cA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.44A 4xiaB-1a0cA:
38.5		 4xiaB-1a0cA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 308
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.45A 4xiaB-1a0cA:
38.5		 4xiaB-1a0cA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 10 PHE A 337
ALA A 361
ASP A 360
TYR A  26
GLY A 358
 None
 1.07A 4xp1A-1a0cA:
0.0		 4xp1A-1a0cA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 LEU A 335
PHE A 330
PHE A 362
GLY A 292
LEU A 282
 None
 1.11A 5fsaA-1a0cA:
0.0		 5fsaA-1a0cA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 TRP A 187
GLU A 231
ASP A 308
TRP A  48
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.4A)
None
 0.83A 5kf8A-1a0cA:
0.8		 5kf8A-1a0cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 5 TRP A 187
GLU A 231
ASP A 308
TRP A  48
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.4A)
None
 0.84A 5kgjA-1a0cA:
0.1		 5kgjA-1a0cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 TRP A 187
GLU A 231
ASP A 308
TRP A  48
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.4A)
None
 0.80A 5kgpA-1a0cA:
0.1		 5kgpA-1a0cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 8 TRP A 187
GLU A 231
ASP A 308
TRP A  48
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.4A)
None
 0.83A 5kgpB-1a0cA:
0.3		 5kgpB-1a0cA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 9 HIS A 100
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.35A 5nhaA-1a0cA:
59.0		 5nhaA-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 9 HIS A 100
TRP A 187
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.38A 5nhaA-1a0cA:
59.0		 5nhaA-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.20A 5nhaA-1a0cA:
59.0		 5nhaA-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 9 HIS A 100
TRP A 187
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.39A 5nhaB-1a0cA:
58.9		 5nhaB-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.20A 5nhaB-1a0cA:
58.9		 5nhaB-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 9 TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.23A 5nhaB-1a0cA:
58.9		 5nhaB-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 9 HIS A 100
TRP A 187
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.39A 5nhaC-1a0cA:
58.9		 5nhaC-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.20A 5nhaC-1a0cA:
58.9		 5nhaC-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 9 HIS A 100
TRP A 187
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.38A 5nhaD-1a0cA:
59.0		 5nhaD-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 491 ( 3.1A)
 0.20A 5nhaD-1a0cA:
59.0		 5nhaD-1a0cA:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 9 TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.23A 5nhaD-1a0cA:
59.0		 5nhaD-1a0cA:
49.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 6 ASN A 115
THR A 114
ARG A 102
ILE A 175
 None
 1.19A 5uigA-1a0cA:
undetectable		 5uigA-1a0cA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 10 PHE A  99
ILE A 125
PHE A  97
TYR A   3
ALA A  80
 None
 1.40A 5x66D-1a0cA:
0.0		 5x66D-1a0cA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 338
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
 1.37A 5ximA-1a0cA:
38.8		 5ximA-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		8 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.29A 5ximA-1a0cA:
38.8		 5ximA-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.45A 5ximA-1a0cA:
38.8		 5ximA-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 308
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.48A 5ximA-1a0cA:
38.8		 5ximA-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 306
ASP A 295
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 1.24A 5ximB-1a0cA:
38.7		 5ximB-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		6 / 12 THR A 140
VAL A 185
TRP A 187
GLU A 267
HIS A 270
ASP A 308
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.48A 5ximB-1a0cA:
38.7		 5ximB-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.52A 5ximB-1a0cA:
38.7		 5ximB-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 308
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.46A 5ximB-1a0cA:
38.7		 5ximB-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		8 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 306
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 1.19A 5ximC-1a0cA:
38.9		 5ximC-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		8 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.33A 5ximC-1a0cA:
38.9		 5ximC-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.47A 5ximC-1a0cA:
38.9		 5ximC-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		7 / 12 THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.34A 5ximD-1a0cA:
38.8		 5ximD-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		11 / 12 TRP A  48
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.1A)
CO  A 492 ( 1.9A)
CO  A 491 ( 3.1A)
 0.48A 5ximD-1a0cA:
38.8		 5ximD-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 308
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 ( 2.4A)
 1.49A 5ximD-1a0cA:
38.8		 5ximD-1a0cA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		3 / 3 TYR A 261
LEU A 253
ASP A 243
 None
 0.88A 5zv2B-1a0cA:
undetectable		 5zv2B-1a0cA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 ILE A  92
PHE A  23
PHE A  43
GLY A 358
ALA A 357
 None
 1.00A 6dwnD-1a0cA:
undetectable		 6dwnD-1a0cA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		5 / 12 ILE A  92
PHE A  43
GLY A 358
ALA A 357
ASP A 360
 None
 0.89A 6dwnD-1a0cA:
undetectable		 6dwnD-1a0cA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		3 / 3 HIS A 100
ASN A 142
LEU A 143
 None
 0.86A 6f7lB-1a0cA:
undetectable		 6f7lB-1a0cA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 6 ALA A 141
GLY A 189
ILE A 230
PHE A 262
 None
 0.84A 6f8cA-1a0cA:
0.0		 6f8cA-1a0cA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1a0c XYLOSE ISOMERASE
(Thermoanaerobact
erium
thermosulfurigen
es) 		4 / 6 ASP A 306
GLU A 231
ASP A 295
CYH A  98
 CO  A 492 ( 1.9A)
CO  A 491 ( 2.4A)
CO  A 491 ( 3.1A)
None
 1.40A 6mn5C-1a0cA:
0.0		 6mn5C-1a0cA:
12.37