SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ASN A  68
TRP A  67
GLY A  61
GLY A  52
 None
 0.76A 1rukH-1a0dA:
undetectable
1rukL-1a0dA:
undetectable		 1rukH-1a0dA:
20.05
1rukL-1a0dA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 ILE A 264
VAL A 292
VAL A  31
ILE A 371
 None
 0.86A 1uwhB-1a0dA:
0.0		 1uwhB-1a0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 10 HIS A  98
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.39A 1xidA-1a0dA:
39.8		 1xidA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		9 / 10 TRP A  47
HIS A  98
PHE A 142
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.39A 1xidA-1a0dA:
39.8		 1xidA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A  98
THR A 138
TRP A 185
ASP A 304
ASP A 293
 None
None
None
MN  A 492 ( 3.2A)
MN  A 491 ( 3.4A)
 1.35A 1xihA-1a0dA:
39.7		 1xihA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.32A 1xihA-1a0dA:
39.7		 1xihA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		9 / 12 TRP A  47
HIS A  98
THR A 138
PHE A 142
VAL A 183
TRP A 185
LYS A 231
ASP A 304
ASP A 336
 None
None
None
None
None
None
MN  A 492 ( 4.8A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.82A 1xihA-1a0dA:
39.7		 1xihA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
PHE A 142
VAL A 183
TRP A 185
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
None
None
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.45A 1xihA-1a0dA:
39.7		 1xihA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 171
GLY A 170
VAL A 183
HIS A  98
ILE A 102
 None
 1.47A 1z95A-1a0dA:
0.0		 1z95A-1a0dA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 5 TRP A  67
ALA A  83
LEU A  75
ALA A  82
 None
 1.35A 2jstA-1a0dA:
1.4
2jstB-1a0dA:
1.5		 2jstA-1a0dA:
11.96
2jstB-1a0dA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 178
GLY A 170
PHE A  97
PHE A  95
 None
 1.03A 2qx6A-1a0dA:
undetectable
2qx6B-1a0dA:
undetectable		 2qx6A-1a0dA:
18.14
2qx6B-1a0dA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
GLU A 265
HIS A 268
ASP A 304
ASP A 293
 None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.4A)
 1.29A 2xinA-1a0dA:
38.9		 2xinA-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
HIS A 268
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 492 ( 2.8A)
 1.43A 2xinA-1a0dA:
38.9		 2xinA-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.56A 2xinA-1a0dA:
38.9		 2xinA-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.35A 2xinB-1a0dA:
38.8		 2xinB-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
HIS A 268
ASP A 304
ASP A 293
 None
None
None
MN  A 492 (-4.2A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.4A)
 1.12A 2xinB-1a0dA:
38.8		 2xinB-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
HIS A 268
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 492 ( 2.8A)
 1.44A 2xinB-1a0dA:
38.8		 2xinB-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.48A 2xinB-1a0dA:
38.8		 2xinB-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.64A 2xinB-1a0dA:
38.8		 2xinB-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 304
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.4A)
 1.27A 2xinC-1a0dA:
38.7		 2xinC-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
HIS A 268
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 492 ( 2.8A)
 1.46A 2xinC-1a0dA:
38.7		 2xinC-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.62A 2xinC-1a0dA:
38.7		 2xinC-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.29A 2xinD-1a0dA:
38.8		 2xinD-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 229
HIS A 268
ASP A 304
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 (-4.2A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.4A)
 1.14A 2xinD-1a0dA:
38.8		 2xinD-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
HIS A 268
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 492 ( 2.8A)
 1.43A 2xinD-1a0dA:
38.8		 2xinD-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.48A 2xinD-1a0dA:
38.8		 2xinD-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.62A 2xinD-1a0dA:
38.8		 2xinD-1a0dA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 264
PRO A 230
PHE A 242
PRO A 232
 None
 1.00A 3bjwC-1a0dA:
0.0		 3bjwC-1a0dA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 265
GLU A 229
TRP A  47
 MN  A 492 ( 2.3A)
MN  A 491 ( 2.4A)
None
 1.22A 3hrdA-1a0dA:
0.0
3hrdE-1a0dA:
0.0
3hrdF-1a0dA:
0.0		 3hrdA-1a0dA:
21.55
3hrdE-1a0dA:
21.55
3hrdF-1a0dA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A 360
ALA A 294
ALA A 266
THR A 270
 None
 0.92A 3l4dA-1a0dA:
undetectable		 3l4dA-1a0dA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 PHE A 360
ALA A 294
ALA A 266
THR A 270
 None
 0.97A 3l4dD-1a0dA:
undetectable		 3l4dD-1a0dA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 141
ASP A  99
THR A 138
ALA A 139
 None
 1.33A 3mbgA-1a0dA:
undetectable
3mbgB-1a0dA:
undetectable		 3mbgA-1a0dA:
14.11
3mbgB-1a0dA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A 173
ARG A 176
LEU A 177
MET A  73
 None
 0.81A 3w1wA-1a0dA:
undetectable		 3w1wA-1a0dA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.29A 3ximA-1a0dA:
38.9		 3ximA-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 265
ASP A 306
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.35A 3ximA-1a0dA:
38.9		 3ximA-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.54A 3ximA-1a0dA:
38.9		 3ximA-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.33A 3ximB-1a0dA:
38.9		 3ximB-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.34A 3ximB-1a0dA:
38.9		 3ximB-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.55A 3ximB-1a0dA:
38.9		 3ximB-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 138
GLU A 229
GLU A 265
ASP A 306
ASP A 293
 None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
MN  A 491 ( 3.4A)
 1.46A 3ximC-1a0dA:
38.8		 3ximC-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 138
VAL A 183
GLU A 229
GLU A 265
ASP A 306
 None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.28A 3ximC-1a0dA:
38.8		 3ximC-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.47A 3ximC-1a0dA:
38.8		 3ximC-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.25A 3ximD-1a0dA:
38.8		 3ximD-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.30A 3ximD-1a0dA:
38.8		 3ximD-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.51A 3ximD-1a0dA:
38.8		 3ximD-1a0dA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 10 HIS A  48
ASP A 306
ASP A 304
PRO A 232
HIS A 268
 None
MN  A 492 ( 2.8A)
MN  A 492 ( 3.2A)
None
MN  A 492 (-4.2A)
 1.48A 4bz6A-1a0dA:
undetectable		 4bz6A-1a0dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
VAL A 183
ASN A 263
GLU A 265
ASP A 306
 None
None
None
None
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.42A 4dvoA-1a0dA:
39.8		 4dvoA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 336
 None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.1A)
 1.29A 4dvoA-1a0dA:
39.8		 4dvoA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
LYS A 231
ASN A 263
GLU A 265
HIS A 268
ASP A 293
ASP A 304
 None
None
None
None
None
MN  A 492 ( 4.8A)
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
 0.44A 4dvoA-1a0dA:
39.8		 4dvoA-1a0dA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 146
HIS A 144
TYR A 162
 None
 0.61A 4fu8A-1a0dA:
undetectable		 4fu8A-1a0dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 146
HIS A 144
TYR A 162
 None
 0.61A 4fu9A-1a0dA:
undetectable		 4fu9A-1a0dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A 140
ASP A 101
ASP A 336
 None
None
MN  A 491 ( 3.1A)
 0.86A 4obwD-1a0dA:
1.4		 4obwD-1a0dA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.29A 4xiaA-1a0dA:
38.7		 4xiaA-1a0dA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
HIS A 268
ASP A 304
ASP A 293
 None
None
None
MN  A 492 (-4.2A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.4A)
 1.30A 4xiaA-1a0dA:
38.7		 4xiaA-1a0dA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		10 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
None
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.43A 4xiaA-1a0dA:
38.7		 4xiaA-1a0dA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		9 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
LYS A 231
HIS A 268
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 492 ( 4.8A)
MN  A 492 (-4.2A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.78A 4xiaA-1a0dA:
38.7		 4xiaA-1a0dA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.28A 4xiaB-1a0dA:
38.6		 4xiaB-1a0dA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.44A 4xiaB-1a0dA:
38.6		 4xiaB-1a0dA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 322
GLY A 326
ASN A 325
SER A  43
PHE A  42
 None
 1.17A 5igyA-1a0dA:
0.0		 5igyA-1a0dA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 TRP A 185
GLU A 229
ASP A 306
TRP A  47
 None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.8A)
None
 1.00A 5kf8A-1a0dA:
0.1		 5kf8A-1a0dA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 5 TRP A 185
GLU A 229
ASP A 306
TRP A  47
 None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.8A)
None
 1.03A 5kgjA-1a0dA:
0.0		 5kgjA-1a0dA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 TRP A 185
GLU A 229
ASP A 306
TRP A  47
 None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.8A)
None
 1.03A 5kgpB-1a0dA:
0.1		 5kgpB-1a0dA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 9 HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.38A 5nhaA-1a0dA:
57.7		 5nhaA-1a0dA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		9 / 9 TRP A  47
HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.24A 5nhaA-1a0dA:
57.7		 5nhaA-1a0dA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 9 HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.38A 5nhaB-1a0dA:
57.7		 5nhaB-1a0dA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		9 / 9 TRP A  47
HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.23A 5nhaB-1a0dA:
57.7		 5nhaB-1a0dA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 9 HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.38A 5nhaC-1a0dA:
57.6		 5nhaC-1a0dA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		9 / 9 TRP A  47
HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.24A 5nhaC-1a0dA:
57.6		 5nhaC-1a0dA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 9 HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.38A 5nhaD-1a0dA:
57.6		 5nhaD-1a0dA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		9 / 9 TRP A  47
HIS A  98
TRP A 136
TRP A 185
GLU A 229
GLU A 265
HIS A 268
ASP A 293
ASP A 336
 None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 491 ( 3.1A)
 0.23A 5nhaD-1a0dA:
57.6		 5nhaD-1a0dA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 MET A 357
ALA A 352
LEU A  90
ILE A  92
PHE A  50
 None
 1.45A 5vlmA-1a0dA:
undetectable		 5vlmA-1a0dA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A  98
THR A 138
GLU A 265
ASP A 306
ASP A 293
 None
None
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
MN  A 491 ( 3.4A)
 1.49A 5ximA-1a0dA:
39.0		 5ximA-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.27A 5ximA-1a0dA:
39.0		 5ximA-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.31A 5ximA-1a0dA:
39.0		 5ximA-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.48A 5ximA-1a0dA:
39.0		 5ximA-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
TRP A 185
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.32A 5ximB-1a0dA:
38.8		 5ximB-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 265
ASP A 306
 None
None
None
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.46A 5ximB-1a0dA:
38.8		 5ximB-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.57A 5ximB-1a0dA:
38.8		 5ximB-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A  98
THR A 138
GLU A 265
ASP A 306
ASP A 293
 None
None
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
MN  A 491 ( 3.4A)
 1.42A 5ximC-1a0dA:
38.7		 5ximC-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		7 / 12 HIS A  98
THR A 138
TRP A 185
LYS A 231
GLU A 265
HIS A 268
ASP A 293
 None
None
None
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
 1.18A 5ximC-1a0dA:
38.7		 5ximC-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		6 / 12 HIS A  98
THR A 138
VAL A 183
GLU A 229
GLU A 265
ASP A 306
 None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.33A 5ximC-1a0dA:
38.7		 5ximC-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		12 / 12 TRP A  47
HIS A  98
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.50A 5ximC-1a0dA:
38.7		 5ximC-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 138
GLU A 229
GLU A 265
ASP A 306
ASP A 293
 None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
MN  A 491 ( 3.4A)
 1.45A 5ximD-1a0dA:
38.8		 5ximD-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 THR A 138
VAL A 183
GLU A 229
GLU A 265
ASP A 306
 None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 2.3A)
MN  A 492 ( 2.8A)
 1.26A 5ximD-1a0dA:
38.8		 5ximD-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		11 / 12 TRP A  47
THR A 138
VAL A 183
TRP A 185
GLU A 229
LYS A 231
GLU A 265
HIS A 268
ASP A 293
ASP A 304
ASP A 336
 None
None
None
None
MN  A 491 ( 2.4A)
MN  A 492 ( 4.8A)
MN  A 492 ( 2.3A)
MN  A 492 (-4.2A)
MN  A 491 ( 3.4A)
MN  A 492 ( 3.2A)
MN  A 491 ( 3.1A)
 0.50A 5ximD-1a0dA:
38.8		 5ximD-1a0dA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A  13
ASN A  26
ALA A 361
PHE A  24
 None
 0.81A 5xu8A-1a0dA:
undetectable		 5xu8A-1a0dA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 332
VAL A 292
PHE A 276
THR A 315
GLY A 363
 None
 0.79A 6brdC-1a0dA:
undetectable		 6brdC-1a0dA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A  98
ASN A 140
LEU A 141
 None
 0.81A 6f7lB-1a0dA:
0.0		 6f7lB-1a0dA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1a0d XYLOSE ISOMERASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A 304
GLU A 229
ASP A 293
CYH A  96
 MN  A 492 ( 3.2A)
MN  A 491 ( 2.4A)
MN  A 491 ( 3.4A)
None
 1.48A 6mn5C-1a0dA:
0.0		 6mn5C-1a0dA:
11.74