SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		3 / 3 THR A 114
LEU A 118
VAL A 121
 None
 0.36A 1mz9E-1a0eA:
undetectable		 1mz9E-1a0eA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 10 HIS A 100
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.37A 1xidA-1a0eA:
41.4		 1xidA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		9 / 10 TRP A  48
HIS A 100
PHE A 144
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 491 ( 3.0A)
 0.36A 1xidA-1a0eA:
41.4		 1xidA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 306
ASP A 295
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.2A)
 1.24A 1xihA-1a0eA:
41.1		 1xihA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
PHE A 144
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
None
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.46A 1xihA-1a0eA:
41.1		 1xihA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
GLU A 267
HIS A 270
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.44A 2xinA-1a0eA:
40.3		 2xinA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
 1.31A 2xinA-1a0eA:
40.3		 2xinA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		8 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
 1.36A 2xinA-1a0eA:
40.3		 2xinA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.53A 2xinA-1a0eA:
40.3		 2xinA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 HIS A 100
THR A 140
HIS A 270
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.34A 2xinB-1a0eA:
40.1		 2xinB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.28A 2xinB-1a0eA:
40.1		 2xinB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 231
HIS A 270
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
 1.18A 2xinB-1a0eA:
40.1		 2xinB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
 1.28A 2xinB-1a0eA:
40.1		 2xinB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.54A 2xinB-1a0eA:
40.1		 2xinB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
GLU A 267
HIS A 270
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.42A 2xinC-1a0eA:
40.2		 2xinC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		8 / 12 HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
 1.38A 2xinC-1a0eA:
40.2		 2xinC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
 1.27A 2xinC-1a0eA:
40.2		 2xinC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.55A 2xinC-1a0eA:
40.2		 2xinC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
GLU A 231
GLU A 267
HIS A 270
ASP A 308
ASP A 295
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.46A 2xinD-1a0eA:
40.2		 2xinD-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.24A 2xinD-1a0eA:
40.2		 2xinD-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
 1.32A 2xinD-1a0eA:
40.2		 2xinD-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.52A 2xinD-1a0eA:
40.2		 2xinD-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 5 PHE A 228
PHE A 262
LEU A 253
PHE A 252
 None
 1.26A 2y69P-1a0eA:
undetectable
2y69W-1a0eA:
0.0		 2y69P-1a0eA:
18.69
2y69W-1a0eA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 5 ILE A 266
PRO A 232
PHE A 244
PRO A 234
 None
 0.94A 3bjwC-1a0eA:
0.0		 3bjwC-1a0eA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		3 / 3 GLU A 267
GLU A 231
TRP A  48
 CO  A 492 ( 2.5A)
CO  A 491 ( 2.4A)
None
 1.29A 3hrdA-1a0eA:
0.0
3hrdE-1a0eA:
0.0
3hrdF-1a0eA:
0.0		 3hrdA-1a0eA:
21.05
3hrdE-1a0eA:
21.05
3hrdF-1a0eA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 8 PHE A 362
ALA A 296
ALA A 268
THR A 272
 None
 0.96A 3khmA-1a0eA:
undetectable		 3khmA-1a0eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 8 PHE A 362
ALA A 296
ALA A 268
THR A 272
 None
 0.88A 3l4dA-1a0eA:
undetectable		 3l4dA-1a0eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 8 PHE A 362
ALA A 296
ALA A 268
THR A 272
 None
 0.94A 3l4dD-1a0eA:
undetectable		 3l4dD-1a0eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 HIS A 100
THR A 140
GLU A 267
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.42A 3ximA-1a0eA:
40.4		 3ximA-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 338
ASP A 306
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
CO  A 492 (-4.3A)
 1.46A 3ximA-1a0eA:
40.4		 3ximA-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 267
ASP A 295
ASP A 308
 None
None
None
CO  A 492 ( 2.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-3.3A)
 1.18A 3ximA-1a0eA:
40.4		 3ximA-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.57A 3ximA-1a0eA:
40.4		 3ximA-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 HIS A 100
THR A 140
GLU A 267
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.43A 3ximB-1a0eA:
40.2		 3ximB-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.26A 3ximB-1a0eA:
40.2		 3ximB-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 231
GLU A 267
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.21A 3ximB-1a0eA:
40.2		 3ximB-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
ASP A 306
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
CO  A 492 (-4.3A)
 1.39A 3ximB-1a0eA:
40.2		 3ximB-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.58A 3ximB-1a0eA:
40.2		 3ximB-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 THR A 140
GLU A 231
GLU A 267
ASP A 308
ASP A 295
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.36A 3ximC-1a0eA:
40.3		 3ximC-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
ASP A 306
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
CO  A 492 (-4.3A)
 1.42A 3ximC-1a0eA:
40.3		 3ximC-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 THR A 140
VAL A 185
GLU A 231
GLU A 267
ASP A 308
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.13A 3ximC-1a0eA:
40.3		 3ximC-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		11 / 12 TRP A  48
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.65A 3ximC-1a0eA:
40.3		 3ximC-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
GLU A 231
GLU A 267
ASP A 308
ASP A 295
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.49A 3ximD-1a0eA:
40.2		 3ximD-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.21A 3ximD-1a0eA:
40.2		 3ximD-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 231
GLU A 267
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.16A 3ximD-1a0eA:
40.2		 3ximD-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
ASP A 306
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
CO  A 492 (-4.3A)
 1.40A 3ximD-1a0eA:
40.2		 3ximD-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.58A 3ximD-1a0eA:
40.2		 3ximD-1a0eA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
VAL A 185
ASN A 265
GLU A 267
ASP A 308
 None
None
None
None
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.31A 4dvoA-1a0eA:
41.5		 4dvoA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 338
ASP A 306
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
CO  A 492 (-4.3A)
 1.49A 4dvoA-1a0eA:
41.5		 4dvoA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
ASN A 265
GLU A 267
HIS A 270
ASP A 295
ASP A 306
 None
None
None
None
None
CO  A 492 ( 4.4A)
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
 0.61A 4dvoA-1a0eA:
41.5		 4dvoA-1a0eA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		3 / 3 ARG A 148
HIS A 146
TYR A 164
 None
 0.67A 4fu8A-1a0eA:
undetectable		 4fu8A-1a0eA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		3 / 3 ARG A 148
HIS A 146
TYR A 164
 None
 0.63A 4fu9A-1a0eA:
0.0		 4fu9A-1a0eA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		3 / 3 ASN A 142
ASP A 103
ASP A 338
 None
None
CO  A 491 ( 3.0A)
 0.88A 4obwD-1a0eA:
1.4		 4obwD-1a0eA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 HIS A 100
THR A 140
GLU A 267
HIS A 270
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.26A 4xiaA-1a0eA:
40.2		 4xiaA-1a0eA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.43A 4xiaA-1a0eA:
40.2		 4xiaA-1a0eA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 491 ( 3.0A)
 0.37A 4xiaB-1a0eA:
40.1		 4xiaB-1a0eA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 5 VAL A  45
ILE A 431
PRO A 311
THR A 277
 None
 1.16A 4ze1A-1a0eA:
0.0		 4ze1A-1a0eA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 LEU A 335
PHE A 330
PHE A 362
GLY A 292
LEU A 282
 None
 1.07A 5fsaA-1a0eA:
0.0		 5fsaA-1a0eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 5 GLY A 226
THR A 225
GLY A 152
LEU A 212
 None
 0.71A 5jlcA-1a0eA:
0.0		 5jlcA-1a0eA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 8 TRP A 187
GLU A 231
ASP A 308
TRP A  48
 None
CO  A 491 ( 2.4A)
CO  A 492 (-3.3A)
None
 1.01A 5kf8A-1a0eA:
0.0		 5kf8A-1a0eA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 8 TRP A 187
GLU A 231
ASP A 308
TRP A  48
 None
CO  A 491 ( 2.4A)
CO  A 492 (-3.3A)
None
 0.98A 5kgpA-1a0eA:
0.1		 5kgpA-1a0eA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 8 TRP A 187
GLU A 231
ASP A 308
TRP A  48
 None
CO  A 491 ( 2.4A)
CO  A 492 (-3.3A)
None
 0.99A 5kgpB-1a0eA:
0.2		 5kgpB-1a0eA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 9 HIS A 100
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
 1.33A 5nhaA-1a0eA:
58.6		 5nhaA-1a0eA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 491 ( 3.0A)
 0.22A 5nhaA-1a0eA:
58.6		 5nhaA-1a0eA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 491 ( 3.0A)
 0.23A 5nhaB-1a0eA:
58.6		 5nhaB-1a0eA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 9 HIS A 100
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
 1.34A 5nhaC-1a0eA:
58.6		 5nhaC-1a0eA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 491 ( 3.0A)
 0.22A 5nhaC-1a0eA:
58.6		 5nhaC-1a0eA:
51.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		9 / 9 TRP A  48
HIS A 100
TRP A 138
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 295
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 491 ( 3.0A)
 0.22A 5nhaD-1a0eA:
58.6		 5nhaD-1a0eA:
51.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 7 TYR A 370
ILE A 325
GLY A 365
PHE A 366
 None
 0.88A 5nooB-1a0eA:
0.0		 5nooB-1a0eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 6 ASN A 115
THR A 114
ARG A 102
ILE A 175
 None
 1.22A 5uigA-1a0eA:
undetectable		 5uigA-1a0eA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 5 PHE A 228
PHE A 262
LEU A 253
PHE A 252
 None
 1.24A 5xdqC-1a0eA:
0.0
5xdqJ-1a0eA:
0.0		 5xdqC-1a0eA:
18.69
5xdqJ-1a0eA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 HIS A 100
THR A 140
GLU A 267
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.39A 5ximA-1a0eA:
40.4		 5ximA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
 1.36A 5ximA-1a0eA:
40.4		 5ximA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 231
GLU A 267
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.16A 5ximA-1a0eA:
40.4		 5ximA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.59A 5ximA-1a0eA:
40.4		 5ximA-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 HIS A 100
THR A 140
GLU A 267
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.42A 5ximB-1a0eA:
40.2		 5ximB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.25A 5ximB-1a0eA:
40.2		 5ximB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 267
ASP A 308
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.31A 5ximB-1a0eA:
40.2		 5ximB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		11 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.59A 5ximB-1a0eA:
40.2		 5ximB-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
GLU A 267
HIS A 270
ASP A 308
ASP A 295
 None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.38A 5ximC-1a0eA:
40.2		 5ximC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 HIS A 100
THR A 140
TRP A 187
GLU A 267
HIS A 270
ASP A 295
 None
None
None
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
 1.19A 5ximC-1a0eA:
40.2		 5ximC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		7 / 12 HIS A 100
THR A 140
VAL A 185
GLU A 231
GLU A 267
HIS A 270
ASP A 308
 None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 492 (-3.3A)
 1.25A 5ximC-1a0eA:
40.2		 5ximC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		6 / 12 THR A 140
TRP A 187
GLU A 231
GLU A 267
HIS A 270
ASP A 338
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.0A)
 1.33A 5ximC-1a0eA:
40.2		 5ximC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		12 / 12 TRP A  48
HIS A 100
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.54A 5ximC-1a0eA:
40.2		 5ximC-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 THR A 140
GLU A 231
GLU A 267
ASP A 308
ASP A 295
 None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
CO  A 491 ( 3.2A)
 1.35A 5ximD-1a0eA:
40.3		 5ximD-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		5 / 12 THR A 140
VAL A 185
GLU A 231
GLU A 267
ASP A 308
 None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 2.5A)
CO  A 492 (-3.3A)
 1.11A 5ximD-1a0eA:
40.3		 5ximD-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		11 / 12 TRP A  48
THR A 140
VAL A 185
TRP A 187
GLU A 231
LYS A 233
GLU A 267
HIS A 270
ASP A 295
ASP A 306
ASP A 338
 None
None
None
None
CO  A 491 ( 2.4A)
CO  A 492 ( 4.4A)
CO  A 492 ( 2.5A)
CO  A 492 ( 3.5A)
CO  A 491 ( 3.2A)
CO  A 492 (-4.3A)
CO  A 491 ( 3.0A)
 0.60A 5ximD-1a0eA:
40.3		 5ximD-1a0eA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		3 / 3 HIS A 100
ASN A 142
LEU A 143
 None
 0.88A 6f7lB-1a0eA:
undetectable		 6f7lB-1a0eA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1a0e XYLOSE ISOMERASE
(Thermotoga
neapolitana) 		4 / 6 ALA A 141
GLY A 189
ILE A 230
PHE A 262
 None
 0.89A 6f8cA-1a0eA:
1.5		 6f8cA-1a0eA:
14.24