SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		4 / 6 ALA A  68
LEU A  62
GLU A  65
LEU A   3
 None
None
GTS  A 203 (-3.1A)
None
 1.00A 1mt1D-1a0fA:
0.0
1mt1E-1a0fA:
undetectable		 1mt1D-1a0fA:
19.21
1mt1E-1a0fA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 133
VAL A 136
LEU A 140
 None
 0.49A 1mz9B-1a0fA:
undetectable		 1mz9B-1a0fA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		5 / 12 HIS A 106
TYR A 157
SER A  14
ALA A  13
ALA A  74
 GTS  A 203 (-3.9A)
None
None
None
None
 1.19A 2igtC-1a0fA:
undetectable		 2igtC-1a0fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 194
GLU A 198
LEU A 195
LEU A  12
ILE A 153
 None
 1.11A 2jfaA-1a0fA:
undetectable		 2jfaA-1a0fA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 194
GLU A 198
LEU A 195
LEU A  12
ILE A 153
 None
 1.14A 2qxsA-1a0fA:
undetectable		 2qxsA-1a0fA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 194
GLU A 198
LEU A 195
LEU A  12
ILE A 153
 None
 1.16A 2qxsB-1a0fA:
undetectable		 2qxsB-1a0fA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		5 / 12 PRO A 111
THR A 124
VAL A 125
GLN A 128
LEU A 129
 None
 0.85A 2xrlA-1a0fA:
undetectable		 2xrlA-1a0fA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A  12
SER A  14
THR A 152
TYR A 157
 None
 1.01A 4drjB-1a0fA:
2.4		 4drjB-1a0fA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1a0f GLUTATHIONE
S-TRANSFERASE
(Escherichia
coli) 		4 / 7 ILE A  69
LEU A  55
MET A   1
LEU A  57
 None
 0.90A 5u4sA-1a0fA:
undetectable		 5u4sA-1a0fA:
22.14