SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		4 / 8 SER A  50
VAL A  44
LEU A  90
VAL A 174
 None
 0.98A 1fduB-1a0iA:
undetectable		 1fduB-1a0iA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		4 / 6 LEU A 154
MET A 177
LEU A  90
ILE A   4
 None
 0.98A 1z95A-1a0iA:
undetectable		 1z95A-1a0iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		5 / 12 GLU A 194
LEU A 207
LEU A 219
GLY A 218
HIS A 216
 None
 1.34A 2zj0B-1a0iA:
undetectable		 2zj0B-1a0iA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		5 / 12 GLU A 194
LEU A 207
LEU A 219
GLY A 218
HIS A 216
 None
 1.31A 3ce6B-1a0iA:
undetectable		 3ce6B-1a0iA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		4 / 7 TYR A 184
MET A 177
LEU A 148
LEU A  76
 None
 1.15A 3nk2X-1a0iA:
undetectable		 3nk2X-1a0iA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		6 / 12 LEU A 144
GLY A  40
ASP A  91
VAL A 174
ILE A 188
ILE A 146
 None
 1.37A 3s54B-1a0iA:
undetectable		 3s54B-1a0iA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		5 / 12 LEU A 169
MET A 170
VAL A 174
MET A 177
ILE A 227
 None
 0.95A 4okbA-1a0iA:
undetectable		 4okbA-1a0iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		4 / 7 LEU A 154
MET A 177
LEU A  90
ILE A   4
 None
 0.94A 4okwA-1a0iA:
0.0		 4okwA-1a0iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		5 / 9 LYS A  97
VAL A  96
ASP A 100
THR A 115
LEU A 139
 None
 1.38A 5j2tB-1a0iA:
undetectable		 5j2tB-1a0iA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		5 / 12 TRP A 254
GLY A 267
ILE A 266
THR A 292
VAL A 295
 None
 0.75A 5nz0A-1a0iA:
0.0		 5nz0A-1a0iA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		5 / 12 LEU A 181
VAL A 174
LEU A 148
TRP A  73
LEU A  76
 None
 1.17A 5og9B-1a0iA:
0.0		 5og9B-1a0iA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1a0i DNA LIGASE
(Escherichia
virus
T7) 		3 / 3 ASP A  86
LEU A 154
ARG A 230
 None
 0.87A 7dfrA-1a0iA:
0.0		 7dfrA-1a0iA:
20.98