SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a0j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1a0j TRYPSIN
(Salmo
salar) 		7 / 8 ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
None
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.80A 1aq7A-1a0jA:
41.1		 1aq7A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1a0j TRYPSIN
(Salmo
salar) 		7 / 8 HIS A  57
ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.48A 1aq7A-1a0jA:
41.1		 1aq7A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.34A 1bcuH-1a0jA:
18.8		 1bcuH-1a0jA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1a0j TRYPSIN
(Salmo
salar) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 (-3.3A)
 0.46A 1dwcH-1a0jA:
33.7		 1dwcH-1a0jA:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 9 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.98A 1e7aB-1a0jA:
undetectable		 1e7aB-1a0jA:
15.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		8 / 12 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.56A 1etrH-1a0jA:
33.8		 1etrH-1a0jA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.27A 1f5lA-1a0jA:
15.7		 1f5lA-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.22A 1tnlA-1a0jA:
41.5		 1tnlA-1a0jA:
73.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 11 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.98A 2bxeA-1a0jA:
undetectable		 2bxeA-1a0jA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 12 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.97A 2bxeB-1a0jA:
undetectable		 2bxeB-1a0jA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 7 SER A 145
SER A 147
SER A 148
ASN A 150
 None
 1.10A 2cmlA-1a0jA:
undetectable		 2cmlA-1a0jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 8 SER A 145
SER A 147
SER A 148
ASN A 150
 None
 1.07A 2cmlB-1a0jA:
undetectable		 2cmlB-1a0jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 8 SER A 145
SER A 147
SER A 148
ASN A 150
 None
 1.10A 2cmlC-1a0jA:
undetectable		 2cmlC-1a0jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 8 SER A 145
SER A 147
SER A 148
ASN A 150
 None
 1.13A 2cmlD-1a0jA:
undetectable		 2cmlD-1a0jA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.15A 2otvA-1a0jA:
41.6		 2otvA-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1a0j TRYPSIN
(Salmo
salar) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
None
 0.26A 2p16A-1a0jA:
35.4		 2p16A-1a0jA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.25A 2vinA-1a0jA:
16.6		 2vinA-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1a0j TRYPSIN
(Salmo
salar) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
None
BEN  A 246 (-3.3A)
None
 0.35A 2w26A-1a0jA:
14.0		 2w26A-1a0jA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		8 / 11 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
None
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.61A 3gy3A-1a0jA:
40.0		 3gy3A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		9 / 11 HIS A  57
LEU A  99
GLN A 175
ASP A 189
SER A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
None
BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.45A 3gy3A-1a0jA:
40.0		 3gy3A-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.32A 3rxfA-1a0jA:
41.6		 3rxfA-1a0jA:
73.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 (-3.3A)
 0.31A 3rxhA-1a0jA:
41.5		 3rxhA-1a0jA:
73.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 6 PHE A 181
ALA A 183
PRO A 198
VAL A 138
 None
 0.99A 4dubA-1a0jA:
undetectable		 4dubA-1a0jA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 6 PHE A 181
ALA A 183
PRO A 198
VAL A 138
 None
 0.95A 4dubB-1a0jA:
undetectable		 4dubB-1a0jA:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 SO4  A 248 (-3.9A)
None
SO4  A 248 (-3.8A)
SO4  A 248 ( 2.5A)
 0.83A 4fu8A-1a0jA:
33.9		 4fu8A-1a0jA:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 5 TYR A 151
GLN A 192
GLY A 193
SER A 195
 None
None
SO4  A 248 (-3.8A)
SO4  A 248 ( 2.5A)
 0.91A 4fu8A-1a0jA:
33.9		 4fu8A-1a0jA:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_B_15UB402_1
(PROTHROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 12 HIS A  57
LEU A  99
ASP A 189
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
BEN  A 246 (-3.0A)
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.33A 4hfpB-1a0jA:
34.4		 4hfpB-1a0jA:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 12 HIS A  57
LEU A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 SO4  A 248 (-3.9A)
None
BEN  A 246 (-3.0A)
None
None
BEN  A 246 (-3.3A)
 0.38A 4hfpD-1a0jA:
33.7		 4hfpD-1a0jA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 8 ALA A  27
SER A  26
LEU A 137
TYR A  20
 None
 1.20A 4ijiF-1a0jA:
undetectable		 4ijiF-1a0jA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 0.96A 4qdjA-1a0jA:
undetectable		 4qdjA-1a0jA:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 1a0j TRYPSIN
(Salmo
salar) 		6 / 12 HIS A  57
LEU A  99
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 SO4  A 248 (-3.9A)
None
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
 0.33A 4rn6B-1a0jA:
28.3		 4rn6B-1a0jA:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1a0j TRYPSIN
(Salmo
salar) 		4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
 BEN  A 246 ( 3.9A)
SO4  A 248 (-3.8A)
SO4  A 248 ( 2.5A)
None
 0.79A 6hu9H-1a0jA:
0.0
6hu9e-1a0jA:
undetectable		 6hu9H-1a0jA:
17.33
6hu9e-1a0jA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1a0j TRYPSIN
(Salmo
salar) 		5 / 11 SER A  37
GLY A 197
GLY A  44
LEU A 209
ASP A 102
 None
 1.18A 6i5zD-1a0jA:
undetectable		 6i5zD-1a0jA:
20.00