SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a0r PHOSDUCIN
(Bos
taurus) 		5 / 12 VAL P 137
VAL P 217
LEU P 208
LEU P 221
SER P 154
 None
 1.10A 3rr3C-1a0rP:
undetectable		 3rr3C-1a0rP:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a0r PHOSDUCIN
(Bos
taurus) 		5 / 12 VAL P 137
VAL P 217
LEU P 208
LEU P 221
SER P 154
 None
 1.09A 3rr3D-1a0rP:
undetectable		 3rr3D-1a0rP:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1a0r PHOSDUCIN
(Bos
taurus) 		4 / 8 LEU P 158
VAL P 137
VAL P 114
LEU P 227
 None
 1.04A 4pwdC-1a0rP:
undetectable		 4pwdC-1a0rP:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a0r PHOSDUCIN
(Bos
taurus) 		5 / 12 VAL P 217
LEU P 208
LEU P 221
SER P 154
LEU P 155
 None
 1.13A 5jvzB-1a0rP:
0.0		 5jvzB-1a0rP:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a0r PHOSDUCIN
(Bos
taurus) 		3 / 3 ARG P 110
ILE P 133
PHE P 107
 None
 0.69A 5kirA-1a0rP:
0.0		 5kirA-1a0rP:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1a0r TRANSDUCIN (GAMMA
SUBUNIT)
(Bos
taurus) 		3 / 3 GLU G  39
TYR G  43
ARG G  47
 None
 0.82A 5uunB-1a0rG:
undetectable		 5uunB-1a0rG:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1a0r PHOSDUCIN
(Bos
taurus) 		4 / 6 ILE P 136
GLY P 194
TYR P 192
GLU P 130
 None
 1.10A 6gqiA-1a0rP:
1.2		 6gqiA-1a0rP:
17.16