SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 213
ALA A 184
VAL A 160
VAL A 158
 None
 0.77A 1epbA-1a1sA:
undetectable		 1epbA-1a1sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		3 / 4 LYS A  28
ALA A  27
MET A 143
 None
 1.04A 1hk3A-1a1sA:
undetectable		 1hk3A-1a1sA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 139
ALA A 303
LEU A  24
THR A  26
 None
 1.05A 1ictB-1a1sA:
undetectable		 1ictB-1a1sA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 173
TYR A 142
SER A 209
ALA A 199
 None
 0.88A 1k5qA-1a1sA:
0.0
1k5qB-1a1sA:
0.0		 1k5qA-1a1sA:
24.34
1k5qB-1a1sA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 141
LEU A  24
ALA A 173
LEU A 170
 None
 1.03A 1nh8A-1a1sA:
0.6		 1nh8A-1a1sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 139
ALA A 303
LEU A  24
THR A  26
 None
 1.05A 2roxB-1a1sA:
undetectable		 2roxB-1a1sA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  72
GLY A  45
LEU A  70
ASP A 102
LEU A  75
 None
 1.01A 2yqzA-1a1sA:
4.2		 2yqzA-1a1sA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 11 GLN A 301
THR A  59
PHE A  63
ILE A 126
HIS A 134
 None
 1.50A 4bb2A-1a1sA:
undetectable
4bb2B-1a1sA:
undetectable		 4bb2A-1a1sA:
21.43
4bb2B-1a1sA:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 264
MET A 265
ILE A 152
 None
 0.81A 4c8bB-1a1sA:
undetectable		 4c8bB-1a1sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 139
ALA A 303
LEU A  24
THR A  26
 None
 1.07A 4i89A-1a1sA:
undetectable		 4i89A-1a1sA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 182
ALA A 232
PHE A 247
LEU A 256
VAL A 252
 None
 1.15A 4ib4A-1a1sA:
undetectable		 4ib4A-1a1sA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 8 MET A  29
LEU A  70
THR A  26
ALA A 303
LEU A 305
 None
 1.43A 4iizB-1a1sA:
undetectable		 4iizB-1a1sA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  23
ALA A 300
ALA A  27
LEU A 139
ALA A 140
 None
 1.09A 4k6iA-1a1sA:
undetectable		 4k6iA-1a1sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  23
ALA A 300
ALA A  27
LEU A 139
ALA A 140
 None
 1.10A 4nqaH-1a1sA:
0.0		 4nqaH-1a1sA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 260
ILE A 145
SER A 285
VAL A 289
 None
 0.70A 4r21A-1a1sA:
0.3		 4r21A-1a1sA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		4 / 4 LEU A 270
ILE A 283
HIS A 268
VAL A 290
 None
 0.99A 4xyzA-1a1sA:
undetectable		 4xyzA-1a1sA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ARG A   7
GLN A  13
LEU A  12
VAL A 125
SER A 133
 None
 1.45A 5uahC-1a1sA:
0.0		 5uahC-1a1sA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  23
ALA A 300
ALA A  27
LEU A 139
ALA A 140
 None
 1.04A 5z12C-1a1sA:
undetectable		 5z12C-1a1sA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1a1s ORNITHINE
CARBAMOYLTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  23
ALA A 300
ALA A  27
LEU A 139
ALA A 140
 None
 1.06A 6a5zD-1a1sA:
undetectable		 6a5zD-1a1sA:
14.29