SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1a21 TISSUE FACTOR
(Oryctolagus
cuniculus) 		4 / 8 LEU A 121
ALA A 166
VAL A 177
ILE A 175
 None
 0.65A 1d4yB-1a21A:
undetectable		 1d4yB-1a21A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1a21 TISSUE FACTOR
(Oryctolagus
cuniculus) 		3 / 3 ARG A  72
GLU A  88
SER A  45
 None
 0.88A 2xkkA-1a21A:
undetectable
2xkkC-1a21A:
undetectable		 2xkkA-1a21A:
14.36
2xkkC-1a21A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1a21 TISSUE FACTOR
(Oryctolagus
cuniculus) 		5 / 12 ALA A 143
PHE A  17
LEU A 141
LEU A 106
LEU A 149
 None
 1.15A 3k2hA-1a21A:
undetectable		 3k2hA-1a21A:
19.56