SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1a25 PROTEIN KINASE C
(BETA)
(Rattus
norvegicus) 		3 / 3 PHE A 255
SER A 241
LEU A 259
 None
 0.83A 2w1bA-1a25A:
0.0		 2w1bA-1a25A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 1a25 PROTEIN KINASE C
(BETA)
(Rattus
norvegicus) 		4 / 5 ASP A 187
LEU A 191
ILE A 215
PRO A 194
 CA  A 290 (-2.2A)
None
None
None
 1.23A 3s3vA-1a25A:
undetectable		 3s3vA-1a25A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1a25 PROTEIN KINASE C
(BETA)
(Rattus
norvegicus) 		4 / 8 LYS A 211
SER A 241
SER A 258
SER A 260
 None
 0.94A 4ikkA-1a25A:
0.3
4ikkB-1a25A:
1.1		 4ikkA-1a25A:
23.27
4ikkB-1a25A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1a25 PROTEIN KINASE C
(BETA)
(Rattus
norvegicus) 		4 / 6 ASP A 248
ASP A 187
ASN A 189
ASP A 254
 CA  A 291 ( 2.3A)
CA  A 290 (-2.2A)
None
CA  A 292 (-2.8A)
 1.20A 4mdbA-1a25A:
0.0		 4mdbA-1a25A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 1a25 PROTEIN KINASE C
(BETA)
(Rattus
norvegicus) 		3 / 3 ILE A 215
THR A 214
PRO A 221
 None
 0.62A 6ncsA-1a25A:
undetectable		 6ncsA-1a25A:
21.25