SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		7 / 10 SER A 142
TYR A 155
GLY A 186
PRO A 187
TYR A 218
HIS A 221
GLU A 282
 EST  A 350 (-3.0A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
EST  A 350 (-4.1A)
None
None
EST  A 350 ( 4.6A)
 0.79A 1equA-1a27A:
44.1		 1equA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		8 / 10 SER A 142
VAL A 143
LEU A 149
TYR A 155
GLY A 186
PRO A 187
TYR A 218
HIS A 221
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
EST  A 350 (-4.1A)
None
None
 0.46A 1equA-1a27A:
44.1		 1equA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		11 / 12 SER A 142
VAL A 143
LEU A 149
TYR A 155
GLY A 186
PRO A 187
TYR A 218
HIS A 221
SER A 222
PHE A 259
MET A 279
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
EST  A 350 (-4.1A)
None
None
None
EST  A 350 (-4.0A)
EST  A 350 (-3.7A)
 0.42A 1fdsA-1a27A:
44.0		 1fdsA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		9 / 11 SER A 142
VAL A 143
LEU A 149
TYR A 155
TYR A 218
HIS A 221
SER A 222
MET A 279
GLU A 282
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
None
None
None
EST  A 350 (-3.7A)
EST  A 350 ( 4.6A)
 0.44A 1fdtA-1a27A:
44.1		 1fdtA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		11 / 12 SER A 142
VAL A 143
GLY A 144
LEU A 149
TYR A 155
GLY A 186
PRO A 187
PHE A 192
TYR A 218
SER A 222
VAL A 283
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-3.4A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
EST  A 350 (-4.1A)
NAP  A 360 (-3.9A)
None
None
None
 0.47A 1fduA-1a27A:
45.2		 1fduA-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		8 / 8 SER A 142
VAL A 143
LEU A 149
TYR A 155
PRO A 187
TYR A 218
MET A 279
VAL A 283
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
None
EST  A 350 (-3.7A)
None
 0.48A 1fduB-1a27A:
44.5		 1fduB-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		12 / 12 SER A 142
VAL A 143
GLY A 144
LEU A 149
TYR A 155
GLY A 186
PRO A 187
TYR A 218
SER A 222
PHE A 259
MET A 279
VAL A 283
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-3.4A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
EST  A 350 (-4.1A)
None
None
EST  A 350 (-4.0A)
EST  A 350 (-3.7A)
None
 0.49A 1fduC-1a27A:
45.8		 1fduC-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		6 / 6 SER A 142
VAL A 143
GLY A 144
LEU A 149
TYR A 155
GLU A 282
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-3.4A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 ( 4.6A)
 0.65A 1fduD-1a27A:
44.8		 1fduD-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		8 / 10 VAL A 143
LEU A 149
PRO A 187
TYR A 218
SER A 222
VAL A 225
PHE A 259
MET A 279
 EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.1A)
None
None
EST  A 350 (-4.7A)
EST  A 350 (-4.0A)
EST  A 350 (-3.7A)
 0.63A 1fdwA-1a27A:
42.2		 1fdwA-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		6 / 10 VAL A 143
LEU A 149
TYR A 218
PHE A 259
MET A 279
GLU A 282
 EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
None
EST  A 350 (-4.0A)
EST  A 350 (-3.7A)
EST  A 350 ( 4.6A)
 0.86A 1fdwA-1a27A:
42.2		 1fdwA-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		8 / 11 SER A 142
VAL A 143
GLY A 144
LEU A 149
MET A 193
HIS A 221
PHE A 259
GLU A 282
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-3.4A)
EST  A 350 (-4.4A)
EST  A 350 (-4.8A)
None
EST  A 350 (-4.0A)
EST  A 350 ( 4.6A)
 1.08A 1iolA-1a27A:
42.9		 1iolA-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		10 / 11 SER A 142
VAL A 143
GLY A 144
LEU A 149
TYR A 155
GLY A 186
TYR A 218
HIS A 221
PHE A 259
GLU A 282
 EST  A 350 (-3.0A)
EST  A 350 (-4.5A)
EST  A 350 (-3.4A)
EST  A 350 (-4.4A)
EST  A 350 (-4.2A)
EST  A 350 (-4.1A)
None
None
EST  A 350 (-4.0A)
EST  A 350 ( 4.6A)
 0.67A 1iolA-1a27A:
42.9		 1iolA-1a27A:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		7 / 8 LEU A 149
PRO A 187
TYR A 218
HIS A 221
SER A 222
VAL A 225
GLU A 282
 EST  A 350 (-4.4A)
EST  A 350 (-4.1A)
None
None
None
EST  A 350 (-4.7A)
EST  A 350 ( 4.6A)
 0.78A 1jtvA-1a27A:
43.6		 1jtvA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 8 VAL A 143
LEU A 149
PRO A 187
HIS A 221
VAL A 225
 EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.1A)
None
EST  A 350 (-4.7A)
 0.65A 1jtvA-1a27A:
43.6		 1jtvA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QYX_A_ASDA500_1
(ESTRADIOL 17
BETA-DEHYDROGENASE 1)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		8 / 9 LEU A 149
PRO A 187
TYR A 218
HIS A 221
SER A 222
PHE A 259
GLU A 282
VAL A 283
 EST  A 350 (-4.4A)
EST  A 350 (-4.1A)
None
None
None
EST  A 350 (-4.0A)
EST  A 350 ( 4.6A)
None
 0.56A 1qyxA-1a27A:
43.4		 1qyxA-1a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QYX_A_ASDA500_1
(ESTRADIOL 17
BETA-DEHYDROGENASE 1)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		8 / 9 VAL A 143
LEU A 149
PRO A 187
TYR A 218
HIS A 221
PHE A 259
GLU A 282
VAL A 283
 EST  A 350 (-4.5A)
EST  A 350 (-4.4A)
EST  A 350 (-4.1A)
None
None
EST  A 350 (-4.0A)
EST  A 350 ( 4.6A)
None
 0.59A 1qyxA-1a27A:
43.4		 1qyxA-1a27A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A 141
PHE A 259
GLY A 144
GLY A 145
PRO A 187
 None
EST  A 350 (-4.0A)
EST  A 350 (-3.4A)
None
EST  A 350 (-4.1A)
 1.11A 2dpmA-1a27A:
5.3		 2dpmA-1a27A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		4 / 5 LEU A  87
LEU A   6
LEU A  36
MET A 121
 None
 1.08A 2oaxF-1a27A:
0.0		 2oaxF-1a27A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A 145
TYR A 275
VAL A 283
TYR A 218
SER A 222
 None
 1.35A 2vqyA-1a27A:
undetectable		 2vqyA-1a27A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LEU A 126
VAL A 178
GLY A 135
GLY A 133
 None
 0.66A 2wd9A-1a27A:
2.3		 2wd9A-1a27A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		4 / 8 LEU A 126
VAL A 178
GLY A 135
GLY A 133
 None
 0.65A 2wd9B-1a27A:
4.1		 2wd9B-1a27A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ASP A 112
ASP A 105
ASP A  68
 None
 0.79A 3douA-1a27A:
2.7		 3douA-1a27A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		6 / 12 LEU A  22
PHE A  30
VAL A  86
THR A   3
ALA A 243
THR A 242
 None
 1.48A 3mdvB-1a27A:
0.0		 3mdvB-1a27A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		4 / 8 THR A 118
LEU A 122
VAL A 137
VAL A 139
 None
 0.88A 4em2A-1a27A:
0.0		 4em2A-1a27A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 138
VAL A  86
ALA A 243
PHE A 240
LEU A  18
 None
 1.08A 4i1rA-1a27A:
5.2		 4i1rA-1a27A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.89A 4k8cA-1a27A:
6.3		 4k8cA-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.88A 4kahA-1a27A:
6.8		 4kahA-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.87A 4kahB-1a27A:
5.8		 4kahB-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.91A 4kanA-1a27A:
6.8		 4kanA-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.89A 4kanB-1a27A:
6.3		 4kanB-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.88A 4kbeA-1a27A:
6.7		 4kbeA-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.83A 4kbeB-1a27A:
6.7		 4kbeB-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.91A 4lbgA-1a27A:
6.3		 4lbgA-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 SER A 222
TYR A 218
PRO A 187
 None
None
EST  A 350 (-4.1A)
 0.91A 4lbgB-1a27A:
5.8		 4lbgB-1a27A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 11 CYH A 166
LEU A 165
ALA A 161
VAL A 139
LEU A 182
 None
 0.97A 4p65C-1a27A:
undetectable
4p65D-1a27A:
undetectable
4p65J-1a27A:
undetectable
4p65L-1a27A:
undetectable		 4p65C-1a27A:
5.42
4p65D-1a27A:
7.17
4p65J-1a27A:
7.17
4p65L-1a27A:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 VAL A 139
LEU A 182
CYH A 166
LEU A 165
ALA A 161
 None
 0.98A 4p65B-1a27A:
undetectable
4p65D-1a27A:
undetectable
4p65I-1a27A:
undetectable
4p65J-1a27A:
undetectable		 4p65B-1a27A:
7.17
4p65D-1a27A:
7.17
4p65I-1a27A:
5.42
4p65J-1a27A:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 VAL A 139
LEU A 182
CYH A 166
LEU A 165
ALA A 161
 None
 1.01A 4p65F-1a27A:
undetectable
4p65H-1a27A:
undetectable
4p65K-1a27A:
undetectable
4p65L-1a27A:
undetectable		 4p65F-1a27A:
7.17
4p65H-1a27A:
7.17
4p65K-1a27A:
5.42
4p65L-1a27A:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		4 / 8 PRO A 187
VAL A 225
SER A 222
HIS A 221
 EST  A 350 (-4.1A)
EST  A 350 (-4.7A)
None
None
 1.05A 4qknA-1a27A:
0.0		 4qknA-1a27A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		3 / 3 VAL A 154
LEU A  95
VAL A 110
 None
 0.61A 4wq4A-1a27A:
2.5		 4wq4A-1a27A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A  15
GLY A  13
VAL A  88
VAL A  20
LEU A  18
 None
NAP  A 360 (-3.3A)
None
None
None
 1.10A 5kocB-1a27A:
5.3		 5kocB-1a27A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens) 		6 / 12 GLY A  15
GLY A  13
LEU A  45
VAL A  88
VAL A  20
LEU A  18
 None
NAP  A 360 (-3.3A)
None
None
None
None
 1.31A 5kpcA-1a27A:
5.6		 5kpcA-1a27A:
22.17