SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 LEU A 175
LEU A 178
HIS A 138
LEU A 280
ILE A 161
 None
 1.35A 1fmlA-1a2oA:
0.7		 1fmlA-1a2oA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		3 / 3 LEU A 117
HIS A  26
ILE A  22
 None
 0.67A 1s9pB-1a2oA:
0.0		 1s9pB-1a2oA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 4 LEU A 158
PRO A 258
ILE A 245
LEU A 236
 None
 1.14A 1ya4B-1a2oA:
3.2		 1ya4B-1a2oA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 6 LEU A 175
PHE A 199
ILE A 227
ALA A 225
 None
 1.08A 2j5mA-1a2oA:
0.0		 2j5mA-1a2oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 PRO A  36
VAL A   9
ILE A  45
ASP A  43
PHE A  67
 None
 1.15A 2v95A-1a2oA:
undetectable		 2v95A-1a2oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 LEU A 280
VAL A 185
ILE A 227
PHE A 199
 None
 0.92A 2weyB-1a2oA:
undetectable		 2weyB-1a2oA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 LEU A 203
ASN A 204
LEU A 206
GLN A 176
VAL A 174
 None
 1.45A 2yloA-1a2oA:
undetectable		 2yloA-1a2oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 5 ASP A 216
ILE A 186
ILE A 247
GLY A 217
 None
 0.93A 3bufA-1a2oA:
undetectable		 3bufA-1a2oA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 8 ASP A  37
ASP A  11
GLY A  64
LEU A  68
VAL A  82
 None
 1.26A 3em6A-1a2oA:
0.0		 3em6A-1a2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 ARG A 134
VAL A 278
LEU A 292
ILE A 302
 None
 0.80A 3gp0A-1a2oA:
undetectable		 3gp0A-1a2oA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		3 / 3 PRO A 179
LEU A 180
GLN A 208
 None
 0.67A 3hznG-1a2oA:
0.0
3hznH-1a2oA:
0.0		 3hznG-1a2oA:
22.54
3hznH-1a2oA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 5 LEU A 338
SER A 334
LEU A 178
PRO A 179
 None
 0.96A 3onnA-1a2oA:
5.4		 3onnA-1a2oA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 THR A 301
GLY A 290
GLY A 323
ALA A 318
GLY A 287
 None
 1.05A 3tegA-1a2oA:
undetectable		 3tegA-1a2oA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 6 GLY A 167
VAL A 310
HIS A 138
THR A 281
 None
 1.15A 3tj7A-1a2oA:
0.0
3tj7B-1a2oA:
0.0		 3tj7A-1a2oA:
20.12
3tj7B-1a2oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 6 GLY A 167
VAL A 310
HIS A 138
THR A 281
 None
 1.12A 3tj7C-1a2oA:
0.0
3tj7D-1a2oA:
0.0		 3tj7C-1a2oA:
20.12
3tj7D-1a2oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 6 VAL A 310
HIS A 138
THR A 281
GLY A 167
 None
 1.11A 3tj7C-1a2oA:
0.0
3tj7D-1a2oA:
0.0		 3tj7C-1a2oA:
20.12
3tj7D-1a2oA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 ASP A 286
GLY A 282
THR A 165
SER A 259
 None
 1.05A 4ac9C-1a2oA:
8.2		 4ac9C-1a2oA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 GLY A 166
ALA A 170
ILE A 102
VAL A 310
ILE A 135
 None
 1.11A 4aztA-1a2oA:
3.6		 4aztA-1a2oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 LEU A 178
ILE A 159
VAL A 276
ALA A 339
LEU A 338
 None
 1.41A 4m11A-1a2oA:
0.0		 4m11A-1a2oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 5 TYR A 119
THR A 168
LEU A  94
THR A  86
 None
 1.48A 4mbsB-1a2oA:
0.0		 4mbsB-1a2oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 9 VAL A 324
ILE A 187
ALA A 163
THR A 281
ALA A 303
 None
 1.15A 4oqrA-1a2oA:
0.0		 4oqrA-1a2oA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 ALA A 228
GLY A 162
VAL A 267
SER A 266
 None
 0.74A 4r20A-1a2oA:
0.0		 4r20A-1a2oA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 GLY A 166
ALA A 170
ILE A 102
VAL A 310
ILE A 135
 None
 1.01A 4uw0A-1a2oA:
undetectable		 4uw0A-1a2oA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.82A 4zdzA-1a2oA:
undetectable		 4zdzA-1a2oA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.84A 4ze3A-1a2oA:
0.0		 4ze3A-1a2oA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.85A 5eseA-1a2oA:
0.0		 5eseA-1a2oA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.85A 5esfA-1a2oA:
0.0		 5esfA-1a2oA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.83A 5esjA-1a2oA:
0.0		 5esjA-1a2oA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.84A 5esmA-1a2oA:
0.0		 5esmA-1a2oA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 ILE A 135
VAL A  52
MET A  81
VAL A  80
GLY A  64
 None
 1.09A 5igjA-1a2oA:
0.0		 5igjA-1a2oA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 ILE A 341
ILE A 227
VAL A 260
LEU A 263
ILE A 186
 None
 1.01A 5mugA-1a2oA:
undetectable		 5mugA-1a2oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		3 / 3 GLY A 194
THR A 196
GLU A 213
 None
 0.51A 6b58A-1a2oA:
undetectable		 6b58A-1a2oA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 GLY A 230
PHE A 104
THR A 168
GLY A 167
GLY A 166
 None
 1.12A 6brdB-1a2oA:
undetectable		 6brdB-1a2oA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 1a2o CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 10 GLY A 111
TYR A 119
ASP A  56
ASP A  10
VAL A  79
 None
 1.27A 6cgdA-1a2oA:
0.0		 6cgdA-1a2oA:
10.94