SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 8 ILE A 166
ILE A 198
GLU A 199
VAL A 202
ILE A  66
 None
 1.47A 1linA-1a2zA:
undetectable		 1linA-1a2zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 9 ILE A  23
VAL A 168
PRO A 169
ILE A  77
VAL A  79
 None
 1.20A 2nnhB-1a2zA:
undetectable		 2nnhB-1a2zA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 8 LEU A 191
PRO A  11
VAL A  41
GLY A   8
 None
 0.81A 2qd5A-1a2zA:
3.3		 2qd5A-1a2zA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 12 LEU A  68
ALA A 201
VAL A  79
VAL A 168
ILE A 166
 None
 1.08A 3mwsB-1a2zA:
undetectable		 3mwsB-1a2zA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 12 TYR A  74
TYR A 170
GLU A  80
ALA A 201
LEU A 125
 None
 1.02A 3vywA-1a2zA:
undetectable		 3vywA-1a2zA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 12 ILE A  77
SER A 205
LEU A 206
ILE A   6
VAL A   4
 None
 1.00A 3w67B-1a2zA:
undetectable		 3w67B-1a2zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 7 ALA A 201
ALA A 120
LEU A 125
THR A 124
 None
 0.84A 4du2A-1a2zA:
0.0		 4du2A-1a2zA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 4 LEU A  68
LEU A   5
GLN A  22
GLU A  10
 None
 1.11A 4i41A-1a2zA:
undetectable		 4i41A-1a2zA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 5 LEU A  42
ALA A  24
VAL A  65
ILE A  66
 None
 0.86A 4xe3B-1a2zA:
0.0		 4xe3B-1a2zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 4 LEU A   5
ILE A  66
GLY A  39
ILE A 198
 None
 0.83A 5dzk3-1a2zA:
undetectable
5dzkm-1a2zA:
0.0		 5dzk3-1a2zA:
0.91
5dzkm-1a2zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 5 ILE A  66
GLY A  39
ILE A 198
LEU A   5
 None
 0.81A 5dzkB-1a2zA:
0.0
5dzkI-1a2zA:
0.0
5dzkW-1a2zA:
undetectable		 5dzkB-1a2zA:
22.78
5dzkI-1a2zA:
21.40
5dzkW-1a2zA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 5 ILE A  66
GLY A  39
ILE A 198
LEU A   5
 None
 0.85A 5dzki-1a2zA:
0.0
5dzkj-1a2zA:
0.0
5dzkx-1a2zA:
undetectable		 5dzki-1a2zA:
21.40
5dzkj-1a2zA:
21.40
5dzkx-1a2zA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		4 / 4 ILE A  66
GLY A  39
ILE A 198
LEU A   5
 None
 0.85A 5dzkl-1a2zA:
0.0
5dzkz-1a2zA:
undetectable		 5dzkl-1a2zA:
21.40
5dzkz-1a2zA:
0.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 12 PHE A 165
LEU A  53
ILE A  60
THR A  20
ALA A  24
 None
 1.36A 5ienA-1a2zA:
0.0		 5ienA-1a2zA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 12 ILE A  60
PRO A  62
VAL A  37
GLU A  21
GLY A  69
 None
 1.21A 5igpA-1a2zA:
0.0		 5igpA-1a2zA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 12 LEU A  68
ALA A 201
VAL A  79
VAL A 168
ILE A 166
 None
 1.05A 5kqyA-1a2zA:
undetectable		 5kqyA-1a2zA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 10 LEU A  68
ILE A 195
ALA A 197
ILE A 198
ILE A 130
 None
 1.00A 5mvmD-1a2zA:
0.0
5mvmE-1a2zA:
0.0		 5mvmD-1a2zA:
17.79
5mvmE-1a2zA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 7 GLY A   8
LEU A  68
LEU A 151
ILE A   6
GLY A  39
 None
 1.30A 5vkqA-1a2zA:
0.0
5vkqB-1a2zA:
0.0		 5vkqA-1a2zA:
8.80
5vkqB-1a2zA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 7 GLY A  39
LEU A   5
GLY A   8
LEU A  68
ILE A 121
 None
 1.11A 5vkqA-1a2zA:
0.0
5vkqB-1a2zA:
0.0		 5vkqA-1a2zA:
8.80
5vkqB-1a2zA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1a2z PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermococcus
litoralis) 		5 / 8 GLY A  39
LEU A   5
GLY A   8
LEU A  68
ILE A 121
 None
 1.10A 5vkqB-1a2zA:
0.0
5vkqC-1a2zA:
0.0		 5vkqB-1a2zA:
8.80
5vkqC-1a2zA:
8.80