SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 8 TYR A  95
ARG A  97
GLY A 256
THR A 257
ALA A 258
 None
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
 0.46A 2a1hA-1a3gA:
29.5
2a1hB-1a3gA:
29.5		 2a1hA-1a3gA:
27.34
2a1hB-1a3gA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 8 TYR A  95
ARG A  97
GLY A 256
THR A 257
ALA A 258
 None
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
 0.41A 2a1hA-1a3gA:
29.5
2a1hB-1a3gA:
29.5		 2a1hA-1a3gA:
27.34
2a1hB-1a3gA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 TYR A  95
ARG A  97
GLY A 256
THR A 257
ALA A 258
 None
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
 0.34A 2coiA-1a3gA:
29.9
2coiB-1a3gA:
30.1		 2coiA-1a3gA:
29.31
2coiB-1a3gA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 TYR A  95
ARG A  97
GLY A 256
THR A 257
ALA A 258
 None
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
 0.31A 2coiA-1a3gA:
29.9
2coiB-1a3gA:
30.1		 2coiA-1a3gA:
29.31
2coiB-1a3gA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		6 / 11 PHE A  36
TYR A  95
ARG A  97
GLY A 256
THR A 257
ALA A 258
 None
None
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
 0.41A 2cojA-1a3gA:
29.6
2cojB-1a3gA:
29.7		 2cojA-1a3gA:
29.31
2cojB-1a3gA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 TYR A  95
ARG A  97
GLY A 256
THR A 257
ALA A 258
 None
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
 0.33A 2cojA-1a3gA:
29.6
2cojB-1a3gA:
29.7		 2cojA-1a3gA:
29.31
2cojB-1a3gA:
29.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		8 / 8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 256
THR A 257
ALA A 258
ALA A 259
 None
None
PLP  A 413 (-3.9A)
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
None
 0.50A 2ej3A-1a3gA:
40.0		 2ej3A-1a3gA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		10 / 10 PHE A  36
TYR A  95
ARG A  97
TYR A 164
GLY A 196
GLU A 197
GLY A 256
THR A 257
ALA A 258
ALA A 259
 None
None
None
PLP  A 413 (-4.3A)
PLP  A 413 (-3.9A)
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
None
 0.59A 2ej3B-1a3gA:
39.4		 2ej3B-1a3gA:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		8 / 8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 256
THR A 257
ALA A 258
ALA A 259
 None
None
PLP  A 413 (-3.9A)
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
None
 0.49A 2ej3C-1a3gA:
40.0		 2ej3C-1a3gA:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 ILE A  39
ILE A 121
LEU A 217
 None
None
PLP  A 413 ( 4.1A)
 0.44A 2prgA-1a3gA:
0.0		 2prgA-1a3gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 7 VAL A 280
THR A 281
ILE A 284
ILE A 225
SER A 255
 None
 1.05A 3deuA-1a3gA:
undetectable		 3deuA-1a3gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 ASP A 204
GLY A 205
LYS A 203
GLU A 251
 None
 1.18A 3hznD-1a3gA:
0.0		 3hznD-1a3gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		4 / 4 ILE A 225
PHE A 200
ILE A 226
THR A 281
 None
 1.12A 3ia4A-1a3gA:
undetectable		 3ia4A-1a3gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 10 GLY A 162
VAL A 170
TRP A 146
ILE A 154
ASN A 163
 None
 1.16A 3km6A-1a3gA:
undetectable		 3km6A-1a3gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A  60
HIS A  61
MET A  57
 None
 0.89A 3thrD-1a3gA:
undetectable		 3thrD-1a3gA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 117
SER A 116
TYR A 115
 None
 0.63A 5jsdA-1a3gA:
0.0		 5jsdA-1a3gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 117
SER A 116
TYR A 115
 None
 0.63A 5jsdB-1a3gA:
0.0		 5jsdB-1a3gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 117
SER A 116
TYR A 115
 None
 0.62A 5jsdC-1a3gA:
0.0		 5jsdC-1a3gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 117
SER A 116
TYR A 115
 None
 0.65A 5jseA-1a3gA:
0.0		 5jseA-1a3gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 117
SER A 116
TYR A 115
 None
 0.64A 5jseB-1a3gA:
0.0		 5jseB-1a3gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A 117
SER A 116
TYR A 115
 None
 0.63A 5jseC-1a3gA:
0.0		 5jseC-1a3gA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 PRO A 112
VAL A 102
GLY A 103
ASP A 104
GLY A 106
 None
 1.24A 5nnaA-1a3gA:
undetectable		 5nnaA-1a3gA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 123
PRO A  98
GLY A  38
ASP A   6
ALA A   5
 None
 0.97A 5zvgA-1a3gA:
undetectable		 5zvgA-1a3gA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A 123
PRO A  98
GLY A  38
ASP A   6
ALA A   5
 None
 0.95A 5zvgB-1a3gA:
undetectable		 5zvgB-1a3gA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
(Escherichia
coli) 		5 / 9 ALA A 184
ALA A 195
GLY A 182
SER A 167
GLY A 171
 None
None
None
PLP  A 413 ( 4.2A)
None
 1.16A 6bklE-1a3gA:
undetectable
6bklF-1a3gA:
undetectable
6bklG-1a3gA:
undetectable
6bklH-1a3gA:
undetectable		 6bklE-1a3gA:
6.88
6bklF-1a3gA:
6.88
6bklG-1a3gA:
6.88
6bklH-1a3gA:
6.88