SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 267
VAL A 262
CYH A 296
ALA A 321
 None
 1.21A 1mz9E-1a3xA:
0.0		 1mz9E-1a3xA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.71A 1p7lD-1a3xA:
undetectable		 1p7lD-1a3xA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.72A 1p7lC-1a3xA:
undetectable		 1p7lC-1a3xA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 472
ILE A 421
ILE A 399
VAL A 390
ARG A  20
 None
 0.97A 1qhyA-1a3xA:
undetectable		 1qhyA-1a3xA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.72A 1rg9A-1a3xA:
undetectable		 1rg9A-1a3xA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.72A 1rg9D-1a3xA:
undetectable		 1rg9D-1a3xA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.73A 1rg9C-1a3xA:
undetectable		 1rg9C-1a3xA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 481
VAL A 423
LEU A 401
 None
 0.74A 1yajG-1a3xA:
1.5		 1yajG-1a3xA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 199
VAL A 203
LYS A 204
ILE A 224
 None
 0.79A 2piwA-1a3xA:
0.0		 2piwA-1a3xA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  20
ARG A 415
PRO A 416
 None
 1.05A 2wljA-1a3xA:
0.0		 2wljA-1a3xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 431
ARG A 428
PRO A 427
 None
 1.01A 2wljA-1a3xA:
0.0		 2wljA-1a3xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 163
VAL A 179
LEU A 181
VAL A 145
 None
 0.87A 2zujA-1a3xA:
0.0		 2zujA-1a3xA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 179
ILE A 137
VAL A 154
VAL A 165
 None
 0.78A 3fi0B-1a3xA:
undetectable		 3fi0B-1a3xA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 179
ILE A 137
VAL A 154
VAL A 165
 None
 0.72A 3fi0G-1a3xA:
undetectable		 3fi0G-1a3xA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 179
ILE A 137
VAL A 154
VAL A 165
 None
 0.72A 3fi0I-1a3xA:
undetectable		 3fi0I-1a3xA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		8 / 10 THR A  26
PRO A  29
ARG A  49
ASN A  51
HIS A  54
GLY A  55
GLY A 333
ALA A 336
 None
None
PGA  A1005 (-3.4A)
K  A1002 (-3.6A)
None
None
None
None
 0.44A 3pp7B-1a3xA:
59.8		 3pp7B-1a3xA:
48.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		7 / 10 THR A  26
PRO A  29
HIS A  54
GLY A  55
GLY A 333
ALA A 336
LYS A 337
 None
 0.69A 3pp7B-1a3xA:
59.8		 3pp7B-1a3xA:
48.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 215
ILE A 224
VAL A 227
LEU A 228
VAL A 203
 None
 0.85A 3w67A-1a3xA:
2.3		 3w67A-1a3xA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 215
ILE A 224
VAL A 227
LEU A 228
VAL A 203
 None
 0.80A 3w68C-1a3xA:
0.1		 3w68C-1a3xA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 215
ILE A 224
VAL A 227
LEU A 228
VAL A 203
 None
 0.81A 3w68D-1a3xA:
2.3		 3w68D-1a3xA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 484
THR A 453
ILE A 460
VAL A 456
 None
 0.89A 3wriA-1a3xA:
0.0		 3wriA-1a3xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 484
THR A 453
ILE A 460
VAL A 456
 None
 0.90A 3wriB-1a3xA:
0.0		 3wriB-1a3xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 LYS A  61
ILE A  64
VAL A 207
LEU A  83
 None
 1.01A 4em2A-1a3xA:
0.0		 4em2A-1a3xA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.74A 4kttB-1a3xA:
0.0		 4kttB-1a3xA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.78A 4kttD-1a3xA:
undetectable		 4kttD-1a3xA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.70A 4ndnB-1a3xA:
undetectable		 4ndnB-1a3xA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 266
GLU A  89
ASN A  51
ARG A  49
 MN  A1001 ( 2.8A)
None
K  A1002 (-3.6A)
PGA  A1005 (-3.4A)
 1.10A 4ntxA-1a3xA:
0.0
4ntxC-1a3xA:
0.0		 4ntxA-1a3xA:
21.88
4ntxC-1a3xA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 386
ALA A 397
ALA A 395
ALA A 389
 None
 0.80A 4twdF-1a3xA:
0.0
4twdG-1a3xA:
0.0
4twdH-1a3xA:
0.0
4twdI-1a3xA:
0.0
4twdJ-1a3xA:
0.0		 4twdF-1a3xA:
20.71
4twdG-1a3xA:
20.71
4twdH-1a3xA:
20.71
4twdI-1a3xA:
20.71
4twdJ-1a3xA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 420
GLY A 438
ARG A 415
LEU A 473
ALA A 467
 None
 1.11A 5h5fA-1a3xA:
undetectable		 5h5fA-1a3xA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 297
SER A 303
THR A 311
GLU A 334
SER A 332
 None
 1.26A 5hfjE-1a3xA:
undetectable		 5hfjE-1a3xA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 318
ILE A  23
THR A 335
LEU A 301
 None
 0.78A 5og9A-1a3xA:
0.0		 5og9A-1a3xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 263
GLU A 242
ASP A 220
ILE A 237
 PGA  A1005 (-2.1A)
MN  A1001 ( 2.9A)
None
None
 0.75A 5t8sA-1a3xA:
undetectable		 5t8sA-1a3xA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LYS A   1
LEU A  10
LEU A 323
ILE A 359
ALA A 360
 None
 1.10A 5v0vA-1a3xA:
undetectable		 5v0vA-1a3xA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 413
LEU A 410
ARG A 409
 None
 0.89A 5yw0A-1a3xA:
undetectable		 5yw0A-1a3xA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A  72
ARG A  68
LYS A  69
VAL A  38
 None
 1.45A 6fgdA-1a3xA:
undetectable		 6fgdA-1a3xA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 1a3x PYRUVATE KINASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 266
ASN A 243
ASP A 220
GLY A  87
ASP A 195
 MN  A1001 ( 2.8A)
None
None
None
None
 1.28A 6mb5A-1a3xA:
0.0		 6mb5A-1a3xA:
11.07