SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 5 TYR A 193
SER A 139
SER A 142
ASN A 177
 None
PO4  A 322 ( 2.6A)
None
PO4  A 322 ( 4.6A)
 1.31A 1yvpA-1a40A:
undetectable		 1yvpA-1a40A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		5 / 12 ALA A  54
VAL A 273
PHE A  72
GLY A  41
ILE A  45
 None
 1.25A 2dcfA-1a40A:
0.0		 2dcfA-1a40A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		5 / 12 ALA A  54
VAL A 273
TYR A  33
PHE A  72
GLY A  41
 None
 0.98A 2dcfA-1a40A:
0.0		 2dcfA-1a40A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 6 ARG A 135
PRO A 219
GLY A  78
TRP A 250
 PO4  A 322 ( 2.7A)
None
None
None
 1.45A 3aqiA-1a40A:
undetectable		 3aqiA-1a40A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		3 / 3 ILE A  45
SER A  55
SER A  39
 None
 0.54A 3iltH-1a40A:
5.2		 3iltH-1a40A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		3 / 3 SER A 139
GLY A 140
THR A 141
 PO4  A 322 ( 2.6A)
PO4  A 322 ( 3.4A)
PO4  A 322 ( 3.5A)
 0.10A 3k9wA-1a40A:
undetectable		 3k9wA-1a40A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 8 SER A 295
ASN A 289
GLN A 287
TRP A  19
 None
 1.31A 3n62A-1a40A:
undetectable		 3n62A-1a40A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		5 / 12 ALA A  54
TYR A 281
TYR A  33
GLY A  53
ILE A 258
 None
 1.33A 3vwqA-1a40A:
0.0		 3vwqA-1a40A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		5 / 9 ILE A 180
ARG A 135
PRO A 219
GLY A  78
TRP A 250
 None
PO4  A 322 ( 2.7A)
None
None
None
 1.44A 3w1wB-1a40A:
0.8		 3w1wB-1a40A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 5 LEU A 125
ASP A 113
TRP A 111
ILE A 103
 None
 1.03A 4mwrA-1a40A:
undetectable		 4mwrA-1a40A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 7 ALA A   9
THR A  10
ALA A  13
THR A 256
 PO4  A 322 (-3.2A)
PO4  A 322 ( 2.8A)
None
None
 0.95A 4qw0K-1a40A:
undetectable		 4qw0K-1a40A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 7 ALA A   9
THR A  10
ALA A  13
THR A 256
 PO4  A 322 (-3.2A)
PO4  A 322 ( 2.8A)
None
None
 0.95A 4qw0Y-1a40A:
undetectable		 4qw0Y-1a40A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 6 PRO A  73
ILE A  76
VAL A  15
PHE A  11
 None
 0.99A 4xe5A-1a40A:
undetectable		 4xe5A-1a40A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		5 / 12 GLY A  77
TYR A 196
TYR A 198
ALA A 228
ALA A 294
 None
 1.10A 4ymgA-1a40A:
0.1		 4ymgA-1a40A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		3 / 3 THR A 256
THR A 255
PHE A 224
 None
 0.81A 5cxvA-1a40A:
undetectable		 5cxvA-1a40A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 5 ILE A 260
GLY A  68
ILE A 312
LEU A  69
 None
 0.87A 5dzki-1a40A:
undetectable
5dzkj-1a40A:
undetectable
5dzkx-1a40A:
undetectable		 5dzki-1a40A:
20.12
5dzkj-1a40A:
20.12
5dzkx-1a40A:
0.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		4 / 5 ILE A 260
GLY A  68
ILE A 312
LEU A  69
 None
 0.85A 5dzkd-1a40A:
undetectable
5dzkk-1a40A:
undetectable
5dzky-1a40A:
undetectable		 5dzkd-1a40A:
20.94
5dzkk-1a40A:
20.12
5dzky-1a40A:
0.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		5 / 12 GLY A 176
GLY A 173
TRP A 168
GLY A 140
SER A 142
 None
None
None
PO4  A 322 ( 3.4A)
None
 1.12A 5hikA-1a40A:
undetectable		 5hikA-1a40A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR
(Escherichia
coli) 		5 / 8 ASN A  48
THR A   5
GLN A  44
ILE A  45
GLY A   6
 None
 1.27A 5nzxA-1a40A:
0.0		 5nzxA-1a40A:
22.59