SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 7 MET A 485
ALA A 189
PHE A 486
ARG A 122
 None
 1.34A 1t9wA-1a4eA:
0.0		 1t9wA-1a4eA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 127
PHE A 108
ILE A 313
ILE A 266
LEU A 262
 None
 1.01A 1z11A-1a4eA:
0.0		 1z11A-1a4eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 127
PHE A 108
ILE A 313
ILE A 266
LEU A 262
 None
 1.04A 1z11B-1a4eA:
0.0		 1z11B-1a4eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 8 CYH A  90
THR A 133
THR A 102
VAL A 310
 None
 1.12A 2fb2A-1a4eA:
undetectable		 2fb2A-1a4eA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 6 ASP A  88
VAL A 310
ARG A 308
ILE A 278
 None
 1.22A 2yfbB-1a4eA:
undetectable		 2yfbB-1a4eA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 121
PHE A 322
HIS A  70
ALA A  71
SER A 117
 None
None
HEM  A 503 ( 3.4A)
None
None
 1.17A 3apvB-1a4eA:
0.0		 3apvB-1a4eA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 229
THR A 280
ILE A  89
ILE A  86
 None
 0.86A 3deuA-1a4eA:
0.8		 3deuA-1a4eA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 313
PHE A 131
VAL A 231
VAL A 276
GLY A 311
 None
 0.94A 3kw4A-1a4eA:
undetectable		 3kw4A-1a4eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 137
PRO A 375
TYR A 376
ALA A 377
 None
 1.23A 3twpD-1a4eA:
0.0		 3twpD-1a4eA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 333
GLY A 214
ALA A 342
GLN A 192
 None
HEM  A 503 ( 4.8A)
None
None
 1.12A 4g0uA-1a4eA:
undetectable		 4g0uA-1a4eA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 121
ASP A 123
GLY A 113
ALA A 251
 None
 0.88A 4m48A-1a4eA:
0.0		 4m48A-1a4eA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_A_HQEA503_1
(CATALASE)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 123
PRO A 124
PHE A 149
LEU A 196
PHE A 197
 None
 0.36A 4qopA-1a4eA:
53.4		 4qopA-1a4eA:
41.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_B_HQEB503_1
(CATALASE)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 123
PRO A 124
PHE A 149
LEU A 196
PHE A 197
 None
 0.36A 4qopB-1a4eA:
53.3		 4qopB-1a4eA:
41.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_C_HQEC503_1
(CATALASE)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		5 / 8 ASP A 123
PRO A 124
PHE A 149
LEU A 196
PHE A 197
 None
 0.36A 4qopC-1a4eA:
53.3		 4qopC-1a4eA:
41.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		4 / 7 SER A  92
ALA A  93
PRO A 338
LEU A 138
 None
 1.11A 5dzkD-1a4eA:
undetectable
5dzkR-1a4eA:
undetectable		 5dzkD-1a4eA:
16.19
5dzkR-1a4eA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  72
SER A  74
ARG A 125
 None
 0.99A 5u63A-1a4eA:
undetectable		 5u63A-1a4eA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		3 / 3 THR A 202
ALA A 247
LYS A 249
 None
 0.65A 6fgcA-1a4eA:
undetectable		 6fgcA-1a4eA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1a4e CATALASE A
(Saccharomyces
cerevisiae) 		3 / 3 THR A 202
ALA A 247
LYS A 249
 None
 0.66A 6fgdA-1a4eA:
undetectable		 6fgdA-1a4eA:
23.35