SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.16A 1dfoA-1a4sA:
undetectable		 1dfoA-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.15A 1dfoB-1a4sA:
0.0		 1dfoB-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.15A 1dfoC-1a4sA:
undetectable		 1dfoC-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.15A 1dfoD-1a4sA:
0.0		 1dfoD-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 6 LEU A 228
VAL A  60
VAL A 217
GLN A 219
 None
 1.11A 1e7aB-1a4sA:
1.1		 1e7aB-1a4sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.15A 1eqbA-1a4sA:
0.0		 1eqbA-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.14A 1eqbB-1a4sA:
undetectable		 1eqbB-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.15A 1eqbC-1a4sA:
undetectable		 1eqbC-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A  56
LEU A 228
VAL A 234
ASN A  22
SER A  66
 None
 1.15A 1eqbD-1a4sA:
undetectable		 1eqbD-1a4sA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 7 ALA A 164
TYR A 167
ILE A 171
ASP A 118
PHE A 169
 None
 1.42A 1upfB-1a4sA:
undetectable		 1upfB-1a4sA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 8 VAL A 296
TYR A 453
GLY A 450
THR A 451
ALA A 429
 None
 1.31A 2a1hA-1a4sA:
0.0
2a1hB-1a4sA:
0.0		 2a1hA-1a4sA:
21.92
2a1hB-1a4sA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 10 TYR A 453
GLY A 450
THR A 451
ALA A 429
VAL A 296
 None
 1.35A 2coiA-1a4sA:
undetectable
2coiB-1a4sA:
undetectable		 2coiA-1a4sA:
21.36
2coiB-1a4sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 10 VAL A 296
TYR A 453
GLY A 450
THR A 451
ALA A 429
 None
 1.36A 2coiA-1a4sA:
undetectable
2coiB-1a4sA:
undetectable		 2coiA-1a4sA:
21.36
2coiB-1a4sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 11 TYR A 453
GLY A 450
THR A 451
ALA A 429
VAL A 296
 None
 1.38A 2cojA-1a4sA:
undetectable
2cojB-1a4sA:
undetectable		 2cojA-1a4sA:
21.36
2cojB-1a4sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 9 VAL A 296
TYR A 453
GLY A 450
THR A 451
ALA A 429
 None
 1.45A 2cojA-1a4sA:
undetectable
2cojB-1a4sA:
undetectable		 2cojA-1a4sA:
21.36
2cojB-1a4sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 5 TRP A 165
GLY A 220
LYS A 189
LEU A 163
 None
 1.21A 2dqyA-1a4sA:
1.8		 2dqyA-1a4sA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 9 GLN A 295
GLY A 109
GLU A 104
ASN A 107
ALA A  44
 None
 1.19A 2drdA-1a4sA:
0.0		 2drdA-1a4sA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 8 TYR A 453
GLY A 450
THR A 451
ALA A 429
ALA A 449
 None
 1.39A 2ej3A-1a4sA:
undetectable		 2ej3A-1a4sA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 8 TYR A 453
GLY A 450
THR A 451
ALA A 429
ALA A 449
 None
 1.39A 2ej3C-1a4sA:
undetectable		 2ej3C-1a4sA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 5 LEU A 278
ASP A 275
MET A 310
LEU A 314
 None
 1.28A 2jfaA-1a4sA:
2.3		 2jfaA-1a4sA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 8 ILE A 401
GLY A 403
LEU A 339
LEU A 345
 None
 0.73A 2vctA-1a4sA:
0.0		 2vctA-1a4sA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 8 ILE A 401
GLY A 403
LEU A 339
LEU A 345
 None
 0.73A 2vctB-1a4sA:
0.0		 2vctB-1a4sA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 8 LEU A 270
PRO A 269
ALA A 449
LEU A 447
ALA A 444
 None
 1.22A 2vcvF-1a4sA:
0.0		 2vcvF-1a4sA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 7 LEU A 369
VAL A 326
GLY A 327
GLY A 338
 None
 0.81A 2wd9A-1a4sA:
3.7		 2wd9A-1a4sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 5 ILE A 459
SER A 460
PRO A 461
PHE A 466
 None
 1.35A 3bjwC-1a4sA:
0.0		 3bjwC-1a4sA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 8 PHE A 188
GLY A 198
LEU A 201
ILE A 200
 None
 0.81A 4em2A-1a4sA:
0.0		 4em2A-1a4sA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 7 VAL A  85
MET A  86
ALA A  89
TYR A 129
 None
 1.10A 4lb2A-1a4sA:
0.0		 4lb2A-1a4sA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 9 ARG A 476
TYR A 485
GLY A 468
LEU A 264
VAL A 243
 None
 1.42A 4mjrA-1a4sA:
undetectable		 4mjrA-1a4sA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		4 / 6 VAL A  17
LEU A  49
LEU A 103
PHE A 188
 None
 1.05A 4o1zA-1a4sA:
0.0		 4o1zA-1a4sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 8 ALA A   1
ILE A 200
GLU A 207
ALA A 208
PHE A 205
 None
 1.34A 4v1fA-1a4sA:
0.9
4v1fB-1a4sA:
0.0		 4v1fA-1a4sA:
10.93
4v1fB-1a4sA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A 225
ALA A  57
ASP A  61
VAL A 218
VAL A 158
 None
 1.13A 4wnwB-1a4sA:
undetectable		 4wnwB-1a4sA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 11 VAL A 325
PHE A 381
LEU A 376
GLY A 337
LEU A 331
 None
 1.31A 4zbqA-1a4sA:
undetectable		 4zbqA-1a4sA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 VAL A 386
VAL A 305
VAL A 282
GLY A 284
ALA A 285
 None
 1.12A 5iktA-1a4sA:
0.0		 5iktA-1a4sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 GLY A 265
ALA A 164
ASN A 166
VAL A 296
LYS A 175
 None
 1.37A 5kbwB-1a4sA:
undetectable		 5kbwB-1a4sA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 LEU A 214
GLY A 213
GLY A 209
VAL A  85
LEU A 180
 None
 0.98A 5xv7A-1a4sA:
undetectable		 5xv7A-1a4sA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 9 GLY A 109
VAL A 105
GLU A 104
GLY A 338
PRO A 329
 None
 1.07A 5zniA-1a4sA:
undetectable		 5zniA-1a4sA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1a4s BETAINE ALDEHYDE
DEHYDROGENASE
(Gadus
morhua) 		5 / 12 ALA A 115
GLY A 337
GLY A 109
PHE A 381
ASP A 328
 None
 1.02A 6clxA-1a4sA:
4.0		 6clxA-1a4sA:
21.44