SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 8 LEU A 104
THR A 210
VAL A 209
ALA A  97
 None
 0.76A 1fiqC-1a59A:
0.0		 1fiqC-1a59A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 7 SER A 187
ARG A 196
THR A  17
ALA A  14
 None
 1.07A 1fo4B-1a59A:
0.0		 1fo4B-1a59A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 VAL A 209
VAL A  80
LEU A 126
LEU A 104
LEU A  76
 None
 1.14A 1mx1E-1a59A:
undetectable		 1mx1E-1a59A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 PHE A 164
LEU A 160
VAL A 173
ALA A 285
ALA A 175
 None
 1.19A 1q23A-1a59A:
0.0
1q23B-1a59A:
undetectable		 1q23A-1a59A:
19.37
1q23B-1a59A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 11 ALA A 184
VAL A  48
LEU A 319
THR A 326
ALA A 323
 None
 1.11A 1rv7A-1a59A:
0.0
1rv7B-1a59A:
0.0		 1rv7A-1a59A:
13.90
1rv7B-1a59A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 10 VAL A  22
ASP A 276
LEU A 319
HIS A 269
LEU A  29
 None
None
None
CIT  A 379 ( 4.0A)
None
 1.39A 1sq5D-1a59A:
undetectable		 1sq5D-1a59A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 7 HIS A 221
ASN A 318
ASP A 276
GLY A 222
 CIT  A 379 (-3.9A)
COA  A 380 (-3.4A)
None
CIT  A 379 ( 3.7A)
 1.04A 2f6dA-1a59A:
0.0		 2f6dA-1a59A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 7 TYR A  50
ALA A  65
SER A  61
ASN A  59
 None
 1.07A 2i91A-1a59A:
undetectable		 2i91A-1a59A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 7 TYR A  50
ALA A  65
SER A  61
ASN A  59
 None
 1.07A 2i91B-1a59A:
undetectable		 2i91B-1a59A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 GLY A 266
TYR A 302
LEU A 286
TYR A 327
SER A 179
 COA  A 380 (-3.5A)
None
None
None
None
 1.35A 2vqyA-1a59A:
0.0		 2vqyA-1a59A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 8 LEU A 104
THR A 210
VAL A 209
ALA A  97
 None
 0.83A 3ax9A-1a59A:
0.0		 3ax9A-1a59A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 LEU A 126
ALA A 195
ALA A 203
GLY A 105
ILE A 346
 None
 1.07A 3c6gA-1a59A:
0.0		 3c6gA-1a59A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 9 LEU A 120
GLU A 121
HIS A 108
HIS A 206
ILE A 353
 None
 1.29A 3hy7A-1a59A:
undetectable		 3hy7A-1a59A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 9 LEU A 120
GLU A 121
HIS A 108
HIS A 206
ILE A 353
 None
 1.31A 3hy7B-1a59A:
undetectable		 3hy7B-1a59A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 8 ALA A 175
VAL A 178
LEU A 182
LEU A 286
 None
 0.72A 3roxA-1a59A:
undetectable		 3roxA-1a59A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 6 TYR A 321
PHE A 232
PRO A 325
LEU A 301
 None
 1.29A 3tgvB-1a59A:
0.0		 3tgvB-1a59A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 5 TYR A 321
PHE A 232
PRO A 325
LEU A 301
 None
 1.34A 3tgvC-1a59A:
0.0		 3tgvC-1a59A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 5 LEU A 340
ALA A 343
MET A  94
PHE A 130
 None
 1.49A 3uq6A-1a59A:
undetectable		 3uq6A-1a59A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		3 / 3 TYR A 183
ARG A 345
HIS A 186
 None
CIT  A 379 (-2.8A)
CIT  A 379 (-3.8A)
 1.15A 4fubA-1a59A:
0.0		 4fubA-1a59A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		3 / 3 MET A 124
MET A 180
TYR A  50
 None
 0.93A 4p6xI-1a59A:
0.0		 4p6xI-1a59A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 SER A 102
VAL A  80
GLY A  82
ALA A  83
LEU A  87
 None
 1.29A 5iktB-1a59A:
0.0		 5iktB-1a59A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 TRP A 349
ILE A 213
ILE A  19
ALA A 351
ALA A 123
 None
 1.29A 5oy02-1a59A:
0.0		 5oy02-1a59A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 LEU A 286
MET A 229
VAL A 228
PHE A 232
GLU A 306
 None
 1.27A 5w8aA-1a59A:
0.0		 5w8aA-1a59A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 10 TRP A 349
ILE A 213
ILE A  19
ALA A 351
ALA A 123
 None
 1.30A 5zjiB-1a59A:
0.0		 5zjiB-1a59A:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 PHE A 159
ALA A 343
PHE A 232
TYR A 302
MET A 282
 None
 1.08A 6aycA-1a59A:
undetectable		 6aycA-1a59A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 12 LEU A 153
VAL A 172
VAL A 173
MET A 330
THR A 326
 None
 1.44A 6b50A-1a59A:
0.0		 6b50A-1a59A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		3 / 3 THR A 194
ALA A 215
LYS A 217
 None
 0.73A 6fgcA-1a59A:
0.0		 6fgcA-1a59A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		3 / 3 THR A 194
ALA A 215
LYS A 217
 None
 0.68A 6fgdA-1a59A:
undetectable		 6fgdA-1a59A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		4 / 5 HIS A 186
ARG A 278
PHE A 341
ARG A 345
 CIT  A 379 (-3.8A)
CIT  A 379 (-3.0A)
CIT  A 379 (-4.8A)
CIT  A 379 (-2.8A)
 0.63A 6hxiB-1a59A:
14.8		 6hxiB-1a59A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1a59 CITRATE SYNTHASE
(Antarctic
bacterium
DS2-3R) 		5 / 5 HIS A 186
ARG A 278
ASP A 320
PHE A 341
ARG A 345
 CIT  A 379 (-3.8A)
CIT  A 379 (-3.0A)
CIT  A 379 (-2.8A)
CIT  A 379 (-4.8A)
CIT  A 379 (-2.8A)
 0.70A 6hxiD-1a59A:
16.5		 6hxiD-1a59A:
22.15