SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 4 THR A 212
LEU A 216
VAL A 219
LEU A 223
 None
 0.63A 1fbmB-1a5cA:
undetectable		 1fbmB-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 4 THR A 212
LEU A 216
VAL A 219
LEU A 223
 None
 0.73A 1fbmD-1a5cA:
0.0		 1fbmD-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 4 THR A 262
LEU A 263
VAL A 267
LEU A 271
 None
 0.98A 1fbmD-1a5cA:
0.0		 1fbmD-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 5 THR A 212
LEU A 216
VAL A 219
LEU A 223
 None
 0.64A 1fbmE-1a5cA:
undetectable		 1fbmE-1a5cA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		3 / 3 THR A 212
LEU A 216
VAL A 219
 None
 0.65A 1mz9E-1a5cA:
undetectable		 1mz9E-1a5cA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 7 PHE A  69
ALA A  38
ILE A  45
GLU A  40
 None
 0.93A 1oniA-1a5cA:
undetectable
1oniB-1a5cA:
undetectable		 1oniA-1a5cA:
16.90
1oniB-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 7 PHE A  69
ALA A  38
ILE A  45
GLU A  40
 None
 0.88A 1oniD-1a5cA:
0.0
1oniF-1a5cA:
0.0		 1oniD-1a5cA:
16.90
1oniF-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 7 ILE A  45
GLU A  40
PHE A  69
ALA A  38
 None
 1.14A 1oniD-1a5cA:
0.0
1oniE-1a5cA:
0.6		 1oniD-1a5cA:
16.90
1oniE-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 7 ILE A  45
GLU A  40
PHE A  69
ALA A  38
 None
 1.02A 1oniG-1a5cA:
undetectable
1oniI-1a5cA:
undetectable		 1oniG-1a5cA:
16.90
1oniI-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 5 TRP A 301
PRO A 268
LEU A 230
GLY A 232
 None
 1.46A 1ya4C-1a5cA:
1.4		 1ya4C-1a5cA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 12 THR A 212
ALA A 242
THR A 250
VAL A 255
GLY A 256
 None
 1.25A 2ve3B-1a5cA:
0.7		 2ve3B-1a5cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 12 GLY A 280
LEU A 277
GLU A 283
ALA A 286
ASN A 289
 None
 1.10A 3kkzA-1a5cA:
undetectable		 3kkzA-1a5cA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		3 / 3 GLU A 194
LEU A 277
LEU A  36
 None
 0.72A 3ohtA-1a5cA:
undetectable		 3ohtA-1a5cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		3 / 3 GLU A 194
LEU A 277
LEU A  36
 None
 0.68A 3ohtB-1a5cA:
undetectable		 3ohtB-1a5cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 4 GLY A  75
GLY A  73
THR A  71
LEU A 333
 None
 0.93A 3si7C-1a5cA:
0.0
3si7D-1a5cA:
0.4		 3si7C-1a5cA:
23.45
3si7D-1a5cA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 4 PHE A 305
TYR A 345
ARG A 264
LEU A 235
 None
 1.25A 3sueA-1a5cA:
0.0		 3sueA-1a5cA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 12 LEU A  68
GLY A 308
GLU A  40
GLN A 312
ALA A  81
 None
 1.04A 3tbgB-1a5cA:
undetectable		 3tbgB-1a5cA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 12 LEU A  68
GLY A 308
GLU A  40
GLN A 312
ALA A  81
 None
 1.06A 3tbgD-1a5cA:
undetectable		 3tbgD-1a5cA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 5 HIS A 203
GLY A 243
TYR A 244
GLU A 196
 None
 1.27A 4ae1B-1a5cA:
0.0		 4ae1B-1a5cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 12 PHE A  69
VAL A  99
PRO A 109
SER A 306
GLY A  34
 None
 1.47A 4hvcA-1a5cA:
undetectable		 4hvcA-1a5cA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 6 LEU A 290
LEU A 277
THR A 241
VAL A 255
 None
 1.02A 4udaA-1a5cA:
undetectable		 4udaA-1a5cA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 11 LEU A  68
GLY A 308
GLU A  40
GLN A 312
ALA A  81
 None
 1.09A 4wnuA-1a5cA:
0.0		 4wnuA-1a5cA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 11 LEU A  68
GLY A 308
GLU A  40
GLN A 312
ALA A  81
 None
 1.06A 4wnuC-1a5cA:
0.0		 4wnuC-1a5cA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		4 / 8 ASN A 238
PRO A 237
PHE A 276
SER A 278
 None
 1.46A 5amiB-1a5cA:
0.0		 5amiB-1a5cA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE
(Plasmodium
falciparum) 		5 / 12 PHE A 220
VAL A 219
PRO A 195
PHE A 276
GLY A 279
 None
 1.29A 5f9zB-1a5cA:
undetectable		 5f9zB-1a5cA:
22.98