SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 HIS C 134
HIS C 219
HIS C 246
ASP C 360
 None
 0.37A 1e9yB-1a5lC:
61.8		 1e9yB-1a5lC:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 HIS C 134
HIS C 219
HIS C 246
HIS C 272
 None
 0.92A 1e9yB-1a5lC:
61.8		 1e9yB-1a5lC:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FWE_C_HAEC989_1
(UREASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 6 HIS C 134
HIS C 136
HIS C 219
HIS C 246
ASP C 360
 None
 0.39A 1fweC-1a5lC:
65.0		 1fweC-1a5lC:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FWE_C_HAEC989_1
(UREASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 6 HIS C 134
HIS C 136
HIS C 219
HIS C 246
HIS C 272
 None
 0.92A 1fweC-1a5lC:
65.0		 1fweC-1a5lC:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 VAL C 520
ASP C 524
ALA C 287
SER C 355
LEU C 348
 None
 1.25A 1kiaD-1a5lC:
undetectable		 1kiaD-1a5lC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 8 THR C 490
LEU C 492
VAL C 501
ASP C 185
 None
 1.14A 1o76B-1a5lC:
0.0		 1o76B-1a5lC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1a5l UREASE (ALPHA
SUBUNIT)
UREASE (BETA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 10 HIS B  39
TYR C  39
ALA C  99
GLY C  14
PHE C  13
 None
 1.35A 1uhoA-1a5lB:
undetectable		 1uhoA-1a5lB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		5 / 12 GLY C  56
HIS B  39
ALA C  99
ILE C 112
GLY C  40
 None
 1.00A 1utdL-1a5lC:
undetectable
1utdM-1a5lC:
undetectable		 1utdL-1a5lC:
9.36
1utdM-1a5lC:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		5 / 11 GLY C  40
GLY C  56
HIS B  39
ALA C  99
ILE C 112
 None
 1.01A 1utdL-1a5lC:
undetectable
1utdV-1a5lC:
undetectable		 1utdL-1a5lC:
9.36
1utdV-1a5lC:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 8 THR C 490
LEU C 492
VAL C 501
ASP C 185
 None
 1.12A 1uyuB-1a5lC:
0.0		 1uyuB-1a5lC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 THR C 169
ASP C 360
GLY C 278
HIS C 272
MET C 364
 None
 1.48A 1v8bA-1a5lC:
4.2		 1v8bA-1a5lC:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		3 / 3 THR C 301
PRO C 303
PRO C 300
 None
 0.86A 2d55C-1a5lC:
undetectable		 2d55C-1a5lC:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 11 ILE C 214
GLY C 157
THR C 171
LEU C 181
GLY C 215
 None
 1.41A 2fn1A-1a5lC:
undetectable		 2fn1A-1a5lC:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 ILE C 214
ALA C 184
VAL C 421
PHE C 491
SER C 509
 None
 1.37A 2gl0A-1a5lC:
0.0
2gl0C-1a5lC:
undetectable		 2gl0A-1a5lC:
15.58
2gl0C-1a5lC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 PHE C 491
SER C 509
ILE C 214
ALA C 184
VAL C 421
 None
 1.34A 2gl0D-1a5lC:
undetectable
2gl0E-1a5lC:
undetectable		 2gl0D-1a5lC:
15.58
2gl0E-1a5lC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 LEU C 147
ALA C 143
TRP C 137
LEU C 187
 None
 1.13A 2oaxA-1a5lC:
0.0		 2oaxA-1a5lC:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		3 / 3 ASP C 103
ASN C 101
THR C 116
 None
 0.76A 2q63B-1a5lC:
0.0		 2q63B-1a5lC:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 10 ASP C 431
LEU C 429
VAL C 421
PHE C 491
THR C 152
 None
 1.12A 2w9gA-1a5lC:
undetectable		 2w9gA-1a5lC:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 10 ASP C 431
LEU C 429
VAL C 421
PHE C 491
THR C 152
 None
 1.01A 2w9hA-1a5lC:
undetectable		 2w9hA-1a5lC:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 10 ASP C 431
LEU C 429
VAL C 421
SER C 509
PHE C 491
 None
 1.12A 2w9hA-1a5lC:
undetectable		 2w9hA-1a5lC:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 8 LEU C 193
ILE C 177
LEU C 181
THR C 490
 None
 0.74A 2xfhA-1a5lC:
0.0		 2xfhA-1a5lC:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		3 / 3 MET C 364
GLU C 220
ASN C 251
 None
 0.88A 3a27A-1a5lC:
undetectable		 3a27A-1a5lC:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		3 / 3 THR C 273
SER C 355
LYS C 406
 None
 1.00A 3aocC-1a5lC:
0.0		 3aocC-1a5lC:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1a5l UREASE (ALPHA
SUBUNIT)
UREASE (BETA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 TYR C  39
ASP C  19
SER C   5
TYR C   9
ILE B  13
 None
 1.00A 3b7pC-1a5lC:
undetectable		 3b7pC-1a5lC:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 7 ASP C 132
SER C 297
GLU C 345
ASP C 346
 None
 0.99A 3bc9A-1a5lC:
5.2		 3bc9A-1a5lC:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 ILE C 112
GLY C 113
ASP C  64
GLY C 100
THR C 116
 None
 1.06A 3bwcA-1a5lC:
undetectable		 3bwcA-1a5lC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 PRO C 188
VAL C 189
THR C 171
GLY C 157
 None
 1.16A 3elzB-1a5lC:
0.0		 3elzB-1a5lC:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 7 GLY C 100
VAL C  43
ILE C 104
GLN C  57
 None
 0.92A 3fi0P-1a5lC:
undetectable		 3fi0P-1a5lC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 11 ASP C 431
LEU C 429
VAL C 421
PHE C 491
THR C 152
 None
 1.09A 3frbX-1a5lC:
undetectable		 3frbX-1a5lC:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 9 ASP C 431
LEU C 429
VAL C 421
PHE C 491
THR C 152
 None
 1.05A 3freX-1a5lC:
undetectable		 3freX-1a5lC:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 9 ASP C 431
LEU C 429
VAL C 421
SER C 509
PHE C 491
 None
 1.15A 3freX-1a5lC:
undetectable		 3freX-1a5lC:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 10 PHE C 491
ILE C 214
ALA C 418
ILE C 131
VAL C 155
 None
 1.02A 3me6A-1a5lC:
0.0		 3me6A-1a5lC:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 THR C 169
ASP C 360
GLY C 278
HIS C 272
MET C 364
 None
 1.45A 3n58C-1a5lC:
2.6		 3n58C-1a5lC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		5 / 12 ALA B  65
GLY C 100
GLY C  56
ILE C  51
GLU C  41
 None
 1.10A 3o7wA-1a5lB:
undetectable		 3o7wA-1a5lB:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 10 GLY C 223
ALA C 224
ASP C 248
LEU C 216
ILE C 218
 None
 0.85A 3ttpA-1a5lC:
undetectable		 3ttpA-1a5lC:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 10 GLY C 223
ALA C 224
ASP C 248
LEU C 216
ILE C 218
 None
 0.83A 3ttpB-1a5lC:
0.0		 3ttpB-1a5lC:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		4 / 8 GLN C 105
ARG B  60
HIS B  39
ARG B  19
 None
 1.14A 3uy4A-1a5lC:
undetectable		 3uy4A-1a5lC:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 8 GLY C  91
GLY C 451
GLY C  87
LEU C  70
VAL C  66
 None
 1.36A 3v1nA-1a5lC:
undetectable		 3v1nA-1a5lC:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 11 ILE C 241
ASP C 240
GLY C 516
VAL C 155
SER C 296
 None
 0.97A 4ac9B-1a5lC:
undetectable
4ac9C-1a5lC:
3.0		 4ac9B-1a5lC:
21.29
4ac9C-1a5lC:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H9M_A_HAEA929_1
(UREASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 HIS C 134
HIS C 219
HIS C 246
ASP C 360
 None
 0.43A 4h9mA-1a5lC:
58.6		 4h9mA-1a5lC:
41.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 VAL C 421
ALA C 418
PHE C 491
GLY C 416
ASP C 431
 None
 1.18A 4mm4A-1a5lC:
undetectable		 4mm4A-1a5lC:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 9 VAL C 421
ALA C 418
GLY C 192
PHE C 491
GLY C 416
 None
 1.16A 4mm5A-1a5lC:
0.0		 4mm5A-1a5lC:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 VAL C 421
ALA C 418
GLY C 192
GLY C 416
ASP C 431
 None
 1.09A 4mm8A-1a5lC:
undetectable		 4mm8A-1a5lC:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 9 VAL C 421
ALA C 418
GLY C 192
PHE C 491
GLY C 416
 None
 1.01A 4mmeB-1a5lC:
0.0		 4mmeB-1a5lC:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 ALA C  10
GLY C  14
ASP C 396
ASP C  19
 None
 0.84A 4n48A-1a5lC:
undetectable		 4n48A-1a5lC:
20.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 6 HIS C 134
HIS C 136
HIS C 219
HIS C 246
ASP C 360
 None
 0.42A 4ubpC-1a5lC:
69.5		 4ubpC-1a5lC:
64.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 6 HIS C 134
HIS C 136
HIS C 219
HIS C 246
HIS C 272
 None
 0.89A 4ubpC-1a5lC:
69.5		 4ubpC-1a5lC:
64.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 11 ASP C 360
ARG C 366
ILE C 342
ARG C 373
THR C 298
 None
 1.37A 4urnB-1a5lC:
undetectable		 4urnB-1a5lC:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 6 ALA C 405
THR C 408
TYR C 407
VAL C  76
HIS C  78
 None
 1.32A 5eckA-1a5lC:
0.0		 5eckA-1a5lC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 6 ALA C 405
THR C 408
TYR C 407
VAL C  76
HIS C  78
 None
 1.31A 5eckD-1a5lC:
0.0		 5eckD-1a5lC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 ALA C 405
THR C 408
TYR C 407
HIS C  78
 None
 1.13A 5ecmA-1a5lC:
undetectable		 5ecmA-1a5lC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 8 ILE C  81
VAL C  82
VAL C  43
ILE C  51
ILE C 119
 None
 1.44A 5hi2A-1a5lC:
undetectable		 5hi2A-1a5lC:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 8 ILE C 424
ASP C  77
GLY C 129
THR C 408
 None
 0.83A 5hwaA-1a5lC:
0.4		 5hwaA-1a5lC:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 7 GLY C  56
VAL C  69
ASP C  85
ILE C 110
 None
 0.78A 5ik1A-1a5lC:
0.0		 5ik1A-1a5lC:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		3 / 3 VAL C 377
SER C 297
MET C 364
 None
 0.91A 5ikqA-1a5lC:
0.0		 5ikqA-1a5lC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		6 / 12 GLY C 129
THR C 153
ILE C 424
ALA C 430
GLY C 450
ILE C  93
 None
 1.28A 5kb6A-1a5lC:
3.5		 5kb6A-1a5lC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		6 / 12 THR C 152
GLY C 129
THR C 153
ALA C 430
GLY C 450
ILE C  93
 None
 1.32A 5kb6A-1a5lC:
3.5		 5kb6A-1a5lC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 4 GLN C 208
THR C 171
THR C 490
LEU C 505
 None
 1.46A 5m5kA-1a5lC:
undetectable		 5m5kA-1a5lC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 4 GLN C 208
THR C 171
THR C 490
LEU C 505
 None
 1.46A 5m5kC-1a5lC:
3.5		 5m5kC-1a5lC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 4 GLN C 208
THR C 171
THR C 490
LEU C 505
 None
 1.48A 5m66B-1a5lC:
undetectable		 5m66B-1a5lC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 6 ASP C 360
HIS C 272
HIS C 136
HIS C 219
 None
 0.85A 5ncdA-1a5lC:
3.1
5ncdD-1a5lC:
undetectable		 5ncdA-1a5lC:
17.05
5ncdD-1a5lC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 6 HIS C 219
ASP C 360
HIS C 272
HIS C 136
 None
 0.89A 5ncdB-1a5lC:
2.9
5ncdC-1a5lC:
3.2		 5ncdB-1a5lC:
17.05
5ncdC-1a5lC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 4 ASP C 360
HIS C 272
HIS C 246
HIS C 136
 None
 1.28A 5ncdD-1a5lC:
undetectable		 5ncdD-1a5lC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 6 ASP C 360
HIS C 272
HIS C 136
HIS C 219
 None
 0.90A 5nelA-1a5lC:
undetectable
5nelD-1a5lC:
3.3		 5nelA-1a5lC:
17.05
5nelD-1a5lC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 7 GLY C 212
LEU C 187
ILE C 214
GLY C 215
LEU C 194
 None
 1.34A 5vkqA-1a5lC:
2.2
5vkqB-1a5lC:
2.1		 5vkqA-1a5lC:
16.37
5vkqB-1a5lC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 8 GLY C 212
VAL C 514
GLY C 195
LEU C 194
ILE C 131
 None
 1.24A 5vkqB-1a5lC:
2.2
5vkqC-1a5lC:
2.2		 5vkqB-1a5lC:
16.37
5vkqC-1a5lC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 ALA C 236
VAL C 520
GLY C 416
LEU C 356
LEU C 294
 None
 0.88A 5x23A-1a5lC:
0.0		 5x23A-1a5lC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 ALA C 236
VAL C 520
GLY C 416
LEU C 356
LEU C 294
 None
 0.84A 5xxiA-1a5lC:
0.0		 5xxiA-1a5lC:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		3 / 3 VAL B  82
TYR B  59
GLU C  41
 None
 0.85A 5zmqD-1a5lB:
0.0
5zmqE-1a5lB:
undetectable		 5zmqD-1a5lB:
19.66
5zmqE-1a5lB:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 ILE C 284
THR C 341
VAL C 543
THR C 270
LEU C 294
 None
 1.34A 6djzB-1a5lC:
0.0		 6djzB-1a5lC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		5 / 12 LEU C 260
ILE C 284
THR C 341
VAL C 543
THR C 270
 None
 1.16A 6djzB-1a5lC:
0.0		 6djzB-1a5lC:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 THR C 267
ARG C 518
THR C 133
ASP C 360
 None
 1.31A 6ectA-1a5lC:
0.0		 6ectA-1a5lC:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 THR C 267
ARG C 518
THR C 133
ASP C 360
 None
 1.34A 6ecxA-1a5lC:
undetectable		 6ecxA-1a5lC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 1a5l UREASE (ALPHA
SUBUNIT)
(Klebsiella
aerogenes) 		4 / 5 LEU C 193
THR C 171
THR C 169
GLY C 158
 None
 1.13A 6gtqA-1a5lC:
0.7		 6gtqA-1a5lC:
16.34