SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 VAL A  27
GLY A  28
ASP A  53
TYR A  85
ALA A  98
 NAD  A 352 ( 4.9A)
NAD  A 352 (-3.6A)
NAD  A 352 (-2.7A)
None
NAD  A 352 (-3.7A)
 0.53A 1cetA-1a5zA:
40.9		 1cetA-1a5zA:
36.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 ASP A  62
LEU A  29
ILE A  95
THR A 246
ILE A 250
 None
None
None
OXM  A 355 (-4.6A)
None
 1.37A 1i18A-1a5zA:
0.0
1i18B-1a5zA:
0.0		 1i18A-1a5zA:
16.24
1i18B-1a5zA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 THR A 246
ILE A 250
ASP A  62
LEU A  29
ILE A  95
 OXM  A 355 (-4.6A)
None
None
None
None
 1.38A 1i18A-1a5zA:
0.0
1i18B-1a5zA:
undetectable		 1i18A-1a5zA:
16.24
1i18B-1a5zA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 LEU A  66
ASP A  62
LEU A  29
GLY A  30
 None
None
None
NAD  A 352 (-2.6A)
 0.91A 1mt1G-1a5zA:
undetectable
1mt1J-1a5zA:
0.0		 1mt1G-1a5zA:
11.49
1mt1J-1a5zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 LEU A  29
GLY A  61
ILE A  78
TYR A  79
LEU A  88
 None
None
None
FBP  A 354 (-4.0A)
None
 1.08A 1p91A-1a5zA:
2.9		 1p91A-1a5zA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLY A  99
ALA A  98
ILE A  95
ALA A 124
ILE A 123
 NAD  A 352 (-3.0A)
NAD  A 352 (-3.7A)
None
None
None
 0.89A 2nmzB-1a5zA:
undetectable		 2nmzB-1a5zA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ARG A 267
VAL A 189
THR A 169
 None
 0.68A 2nnkA-1a5zA:
0.0		 2nnkA-1a5zA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 8 LEU A  41
ALA A  46
GLY A  25
ILE A  95
LEU A  66
 None
 1.36A 2o4nB-1a5zA:
undetectable		 2o4nB-1a5zA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 LEU A 150
ILE A  95
LEU A  40
MET A  22
VAL A 298
 None
 1.10A 2ygnA-1a5zA:
undetectable		 2ygnA-1a5zA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLY A  28
PRO A 141
LEU A 113
ALA A  97
VAL A  96
 NAD  A 352 (-3.6A)
None
None
None
None
 1.09A 3av6A-1a5zA:
5.7		 3av6A-1a5zA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 THR A 146
THR A 139
ALA A  97
SER A 272
GLY A 164
 None
NAD  A 352 (-3.5A)
None
None
None
 1.20A 3mg02-1a5zA:
undetectable
3mg0V-1a5zA:
undetectable		 3mg02-1a5zA:
20.13
3mg0V-1a5zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 THR A 146
THR A 139
ALA A  97
SER A 272
GLY A 164
 None
NAD  A 352 (-3.5A)
None
None
None
 1.19A 3mg0N-1a5zA:
undetectable		 3mg0N-1a5zA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ARG A 267
VAL A 189
THR A 169
 None
 0.71A 3nduD-1a5zA:
undetectable		 3nduD-1a5zA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 ALA A  98
ASP A  53
ILE A  52
ILE A 136
VAL A 127
 NAD  A 352 (-3.7A)
NAD  A 352 (-2.7A)
None
None
None
 1.05A 3nu4A-1a5zA:
undetectable		 3nu4A-1a5zA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ARG A 267
VAL A 189
THR A 169
 None
 0.76A 3pwrA-1a5zA:
0.0		 3pwrA-1a5zA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 GLU A 241
ILE A 240
GLU A 194
HIS A 195
 CD  A   1 (-2.4A)
NAD  A 352 ( 4.6A)
None
CD  A   3 ( 3.7A)
 1.10A 4ejwB-1a5zA:
1.8		 4ejwB-1a5zA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 LEU A 307
TYR A 278
VAL A 289
ILE A 287
LEU A 322
 None
 1.40A 4lhmA-1a5zA:
undetectable		 4lhmA-1a5zA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 VAL A 289
LEU A 275
ILE A 302
LEU A 303
 None
 0.71A 4mghA-1a5zA:
0.0		 4mghA-1a5zA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 6 ILE A  52
GLY A  28
ILE A 123
LEU A  88
 None
NAD  A 352 (-3.6A)
None
None
 0.77A 4o8fB-1a5zA:
0.3		 4o8fB-1a5zA:
23.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		6 / 9 ASP A  53
VAL A  54
TYR A  85
ALA A  98
ARG A 115
ILE A 123
 NAD  A 352 (-2.7A)
NAD  A 352 (-4.4A)
None
NAD  A 352 (-3.7A)
None
None
 1.00A 4oknB-1a5zA:
41.6		 4oknB-1a5zA:
37.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 ALA A 253
ALA A 255
ALA A  39
SER A  35
ALA A 249
 None
 1.30A 4twdA-1a5zA:
0.0
4twdB-1a5zA:
0.0
4twdC-1a5zA:
0.0
4twdD-1a5zA:
0.0
4twdE-1a5zA:
undetectable		 4twdA-1a5zA:
19.77
4twdB-1a5zA:
19.77
4twdC-1a5zA:
19.77
4twdD-1a5zA:
19.77
4twdE-1a5zA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 8 VAL A  32
ILE A  95
ILE A 250
ILE A 136
PHE A 149
 NAD  A 352 (-3.3A)
None
None
None
None
 1.17A 5hi2A-1a5zA:
undetectable		 5hi2A-1a5zA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ALA A 251
GLY A  30
SER A 163
ASP A 256
ALA A 255
 None
NAD  A 352 (-2.6A)
None
None
None
 1.20A 5zvgA-1a5zA:
6.8		 5zvgA-1a5zA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ALA A 251
GLY A  30
SER A 163
ASP A 256
ALA A 255
 None
NAD  A 352 (-2.6A)
None
None
None
 1.20A 5zvgB-1a5zA:
6.9		 5zvgB-1a5zA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 PHE A 315
VAL A 289
VAL A 281
LEU A 113
ALA A 325
 None
 1.19A 6djzA-1a5zA:
undetectable		 6djzA-1a5zA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 GLY A  28
GLY A  30
VAL A  54
ASP A  55
ILE A 123
 NAD  A 352 (-3.6A)
NAD  A 352 (-2.6A)
NAD  A 352 (-4.4A)
None
None
 0.78A 6exiA-1a5zA:
5.2		 6exiA-1a5zA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 10 GLY A  28
GLY A  30
VAL A  54
ASP A  55
ILE A 123
 NAD  A 352 (-3.6A)
NAD  A 352 (-2.6A)
NAD  A 352 (-4.4A)
None
None
 0.76A 6exiB-1a5zA:
4.6		 6exiB-1a5zA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLY A  28
GLY A  30
VAL A  54
ASP A  55
ILE A 123
 NAD  A 352 (-3.6A)
NAD  A 352 (-2.6A)
NAD  A 352 (-4.4A)
None
None
 0.77A 6exiC-1a5zA:
4.3
6exiD-1a5zA:
5.0		 6exiC-1a5zA:
14.87
6exiD-1a5zA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 GLY A  28
GLY A  30
VAL A  54
ASP A  55
ILE A 123
 NAD  A 352 (-3.6A)
NAD  A 352 (-2.6A)
NAD  A 352 (-4.4A)
None
None
 0.73A 6exiC-1a5zA:
4.3
6exiD-1a5zA:
5.0		 6exiC-1a5zA:
14.87
6exiD-1a5zA:
14.87