SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 PHE A 180
ASP A 159
PHE A 153
VAL A  97
 None
 1.20A 1w0fA-1a6aA:
undetectable		 1w0fA-1a6aA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 GLN A   9
PHE A  24
PHE A  32
GLY A  58
 None
 1.04A 2qmzA-1a6aA:
undetectable
2qmzB-1a6aA:
undetectable		 2qmzA-1a6aA:
24.35
2qmzB-1a6aA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 PHE A 112
VAL A 117
VAL A 119
VAL A  91
 None
 0.92A 3hs6B-1a6aA:
0.0		 3hs6B-1a6aA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 PRO A 152
SER A 133
ASN A  94
 None
 0.94A 3lslG-1a6aA:
0.0		 3lslG-1a6aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		5 / 11 LEU A 138
VAL A 136
PHE A  12
PHE A 112
PHE A 145
 None
 1.50A 4evrA-1a6aA:
undetectable		 4evrA-1a6aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens) 		4 / 7 ASN A 118
TYR A 150
LEU A 151
PHE A 153
 NAG  A 200 (-2.2A)
None
None
None
 1.24A 4yv5A-1a6aA:
0.0		 4yv5A-1a6aA:
18.09