SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		3 / 3 ASP A 209
ARG A 374
ILE A 352
 None
 0.81A 1a4gB-1a6dA:
undetectable		 1a4gB-1a6dA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 11 LEU B 449
ALA B 413
ILE B 503
GLY B 499
ILE B 445
 None
 0.94A 1c6yA-1a6dB:
undetectable		 1c6yA-1a6dB:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		3 / 3 GLU B 504
ALA B 506
SER B  84
 None
 0.65A 1errB-1a6dB:
0.1		 1errB-1a6dB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 10 LEU B 449
ALA B 413
ILE B 503
GLY B 499
ILE B 445
 None
 0.93A 1hsgA-1a6dB:
undetectable		 1hsgA-1a6dB:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ILE A 218
ILE A 216
ILE A 307
ALA A 285
THR A 325
 None
 1.19A 1jtxA-1a6dA:
0.8		 1jtxA-1a6dA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 10 LEU B 342
ALA B 328
LEU B 239
LEU B 240
ILE B 308
 None
 1.34A 1pcgA-1a6dB:
undetectable		 1pcgA-1a6dB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ILE A  81
ALA A 509
LYS A  32
ILE A 443
ARG A 446
 None
 1.05A 1rx8A-1a6dA:
undetectable		 1rx8A-1a6dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 7 SER B 505
ILE B 137
ILE B 503
THR B  97
 None
 0.99A 1sbrB-1a6dB:
undetectable		 1sbrB-1a6dB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 8 THR A 358
VAL A 310
VAL A 231
VAL A 347
 None
 0.94A 1t86A-1a6dA:
0.0		 1t86A-1a6dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 8 THR B  97
THR B 158
LEU B  41
VAL B 492
 None
 0.92A 1t86A-1a6dB:
0.0		 1t86A-1a6dB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 6 ILE A  55
VAL A  82
ILE A  67
ILE A  34
ASP A  72
 None
 1.24A 1uwhB-1a6dA:
0.0		 1uwhB-1a6dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ALA B 102
GLY B 104
ALA B 509
ILE B 100
SER B  34
 None
 1.00A 1ve3A-1a6dB:
undetectable		 1ve3A-1a6dB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ALA B 102
ILE B 513
ALA B 509
ILE B 100
SER B  34
 None
 1.04A 1ve3A-1a6dB:
undetectable		 1ve3A-1a6dB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 THR A 447
GLY A 104
ILE A 443
VAL A 508
GLU A 507
 None
 0.90A 1vq1B-1a6dA:
2.0		 1vq1B-1a6dA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		6 / 12 THR B  97
ILE B 477
GLY B 409
ILE B 445
GLU B 485
PRO B  43
 None
 1.44A 1vq1B-1a6dB:
undetectable		 1vq1B-1a6dB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 THR A 150
THR A 398
SER A 145
GLY A 402
ILE A 472
 None
 1.07A 2b25B-1a6dA:
undetectable		 2b25B-1a6dA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 4 VAL A 231
LEU A 336
ILE A 239
LEU A 238
 None
 0.87A 2byoA-1a6dA:
0.0		 2byoA-1a6dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.91A 2f8gA-1a6dB:
undetectable		 2f8gA-1a6dB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.80A 2f8gB-1a6dB:
undetectable		 2f8gB-1a6dB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		3 / 3 VAL B  99
VAL B  83
ASP B  71
 None
 0.77A 2fumD-1a6dB:
undetectable		 2fumD-1a6dB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 GLY B 125
HIS B 118
ALA B 129
ARG B 430
ALA B 434
 None
 1.04A 2gluB-1a6dB:
undetectable		 2gluB-1a6dB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.89A 2o4lA-1a6dB:
undetectable		 2o4lA-1a6dB:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		6 / 12 LEU B 449
ALA B 413
ILE B 503
GLY B 499
VAL B 498
ILE B 445
 None
 1.24A 2o4lB-1a6dB:
undetectable		 2o4lB-1a6dB:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU A 441
LEU A 102
ILE A 137
SER A 103
VAL A  84
 None
 1.23A 2pnjB-1a6dA:
undetectable		 2pnjB-1a6dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 7 GLU B 270
GLN B 300
ALA B 306
ILE B 308
 None
 0.80A 2xkwA-1a6dB:
0.2		 2xkwA-1a6dB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ALA B 173
LEU B 153
LEU B 152
ILE B 493
GLY B 491
 None
 1.06A 2yjaB-1a6dB:
undetectable		 2yjaB-1a6dB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ILE B 122
GLY B 125
SER B 130
ALA B 133
ILE B 503
 None
 0.70A 3adsB-1a6dB:
0.2		 3adsB-1a6dB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 6 ILE B 442
ALA B 441
ALA B 510
THR B 507
 None
 1.06A 3mdrB-1a6dB:
0.3		 3mdrB-1a6dB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.87A 3nu5B-1a6dB:
undetectable		 3nu5B-1a6dB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 9 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.95A 3oxvA-1a6dB:
undetectable		 3oxvA-1a6dB:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 9 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.89A 3oxvC-1a6dB:
undetectable		 3oxvC-1a6dB:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 10 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.96A 3oxwB-1a6dB:
undetectable		 3oxwB-1a6dB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 10 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.87A 3oxwD-1a6dB:
undetectable		 3oxwD-1a6dB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 0.97A 3oxxA-1a6dB:
undetectable		 3oxxA-1a6dB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 11 LEU B 449
ALA B 413
GLY B 499
VAL B 498
ILE B 445
 None
 1.12A 3oxxB-1a6dB:
undetectable		 3oxxB-1a6dB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		6 / 11 LEU B 449
ALA B 413
ILE B 503
GLY B 499
VAL B 498
ILE B 445
 None
 1.25A 3oxxD-1a6dB:
undetectable		 3oxxD-1a6dB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ALA B 173
LEU B 153
LEU B 152
ILE B 493
GLY B 491
 None
 0.99A 3q95A-1a6dB:
undetectable		 3q95A-1a6dB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ILE A  81
ALA A 509
LYS A  32
ILE A 443
ARG A 446
 None
 1.10A 3ql3A-1a6dA:
undetectable		 3ql3A-1a6dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		3 / 3 ASN A 286
ALA A 285
LYS A 235
 None
 0.90A 3runA-1a6dA:
0.0		 3runA-1a6dA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU B 105
GLY B 125
ILE B 511
ARG B 430
ALA B 434
 None
 1.12A 3uj7A-1a6dB:
0.0		 3uj7A-1a6dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU B 105
GLY B 125
ILE B 511
ARG B 430
ALA B 434
 None
 1.11A 3uj7B-1a6dB:
undetectable		 3uj7B-1a6dB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 8 GLY B  45
GLY B  42
SER B  40
ILE B 100
VAL B  37
 None
 1.33A 3v1nA-1a6dB:
undetectable		 3v1nA-1a6dB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		3 / 3 ARG B 305
ASP B 230
GLN B 350
 None
 0.92A 4azsA-1a6dB:
undetectable		 4azsA-1a6dB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 8 ARG A 386
GLU A 383
GLU A 385
LYS A 201
 None
 0.99A 4bqfB-1a6dA:
undetectable		 4bqfB-1a6dA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 8 GLY A  93
GLY A  64
LEU A  68
VAL A  84
 None
 0.91A 4fgzA-1a6dA:
undetectable		 4fgzA-1a6dA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 9 VAL A 360
GLU A 349
VAL A 310
ILE A 218
SER A 370
 None
 1.12A 4fwdA-1a6dA:
undetectable		 4fwdA-1a6dA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU A 171
VAL A 175
VAL A 384
ALA A 396
VAL A 199
 None
 1.27A 4ib4A-1a6dA:
2.3		 4ib4A-1a6dA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 GLN B 115
ARG B 430
LEU B 112
VAL B 121
ILE B 122
 None
 1.48A 4k38A-1a6dB:
undetectable
4k38D-1a6dB:
undetectable		 4k38A-1a6dB:
21.15
4k38D-1a6dB:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 5 VAL A 199
LEU A 388
ILE A 373
LEU A 372
 None
 0.86A 4mghA-1a6dA:
0.0		 4mghA-1a6dA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 11 LEU B 449
ALA B 413
ILE B 503
GLY B 499
ILE B 445
 None
 0.94A 4qgiB-1a6dB:
undetectable		 4qgiB-1a6dB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 6 TYR A 127
THR A 112
LEU A 113
GLN A 109
 None
 1.34A 4qztA-1a6dA:
undetectable		 4qztA-1a6dA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 8 GLU A 450
LEU A 102
LEU A  42
GLY A 409
 None
 0.79A 4r3aA-1a6dA:
0.7		 4r3aA-1a6dA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ALA B 173
LEU B 153
LEU B 152
ILE B 493
GLY B 491
 None
 0.99A 4xi3B-1a6dB:
2.1		 4xi3B-1a6dB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		3 / 3 LEU B 244
ASP B 297
ILE B 290
 None
 0.60A 4xi3D-1a6dB:
0.0		 4xi3D-1a6dB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 11 ALA B 173
LEU B 153
LEU B 152
ILE B 493
GLY B 491
 None
 1.02A 5dxbB-1a6dB:
undetectable		 5dxbB-1a6dB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ALA B 173
LEU B 153
LEU B 152
ILE B 493
GLY B 491
 None
 0.99A 5gtrA-1a6dB:
undetectable		 5gtrA-1a6dB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 8 ILE A  55
VAL A  82
ILE A  34
ILE B 520
ASP A  72
 None
 1.17A 5hi2A-1a6dA:
2.6		 5hi2A-1a6dA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ILE A 154
VAL A 179
GLU A 385
ALA A 195
VAL A 192
 None
 1.01A 5igjA-1a6dA:
0.0		 5igjA-1a6dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ILE A 154
VAL A 179
GLU A 385
ALA A 195
VAL A 192
 None
 1.00A 5igtA-1a6dA:
0.0		 5igtA-1a6dA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 THR B 412
GLY B 409
GLY B 476
ILE B 442
LEU B 449
 None
 0.95A 5l0zA-1a6dB:
3.1		 5l0zA-1a6dB:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 11 ALA B  98
THR B  97
GLY B 104
GLY B 103
ALA B 102
 None
 1.03A 5lf3K-1a6dB:
undetectable
5lf3L-1a6dB:
undetectable		 5lf3K-1a6dB:
16.35
5lf3L-1a6dB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 11 ALA B  98
THR B  97
GLY B 104
GLY B 103
ALA B 102
 None
 1.03A 5lf3Y-1a6dB:
undetectable
5lf3Z-1a6dB:
undetectable		 5lf3Y-1a6dB:
16.35
5lf3Z-1a6dB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SVL_A_ACTA411_0
(P2X PURINOCEPTOR 3)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 5 LYS B 223
GLN B 350
VAL B 232
ASP B 230
 None
 1.25A 5svlA-1a6dB:
0.1		 5svlA-1a6dB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 6 LEU A 502
VAL A 506
THR A 510
GLU A 442
 None
 0.90A 5tudD-1a6dA:
0.0		 5tudD-1a6dA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 ARG B  44
ASN B 452
GLY B  45
GLY B 409
ILE B 477
 None
 1.10A 5vooB-1a6dB:
undetectable		 5vooB-1a6dB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1a6d THERMOSOME (BETA
SUBUNIT)
(Thermoplasma
acidophilum) 		4 / 6 GLN B 110
MET B  80
ARG B 515
PRO B 119
 None
 1.24A 6brdB-1a6dB:
0.7		 6brdB-1a6dB:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 12 LEU A 107
GLY A 104
SER A  85
VAL A  38
ASP A  36
 None
 1.24A 6bxlA-1a6dA:
0.0		 6bxlA-1a6dA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1a6d THERMOSOME (ALPHA
SUBUNIT)
(Thermoplasma
acidophilum) 		5 / 10 VAL A 288
ALA A 237
LEU A 302
LEU A 333
LEU A 243
 None
 0.96A 6f5uA-1a6dA:
undetectable
6f5uB-1a6dA:
0.5		 6f5uA-1a6dA:
9.01
6f5uB-1a6dA:
10.43