SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		3 / 3 SER A  36
GLU A  37
GLU A  33
 None
 0.68A 1eqbD-1a6jA:
0.0		 1eqbD-1a6jA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		3 / 3 SER A  36
GLU A  37
GLU A  33
 None
 0.69A 1eqbB-1a6jA:
undetectable		 1eqbB-1a6jA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		4 / 4 THR A 154
LEU A  10
VAL A 127
LEU A 124
 None
 0.90A 1mz9D-1a6jA:
undetectable		 1mz9D-1a6jA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		4 / 7 ILE A  65
PHE A  96
ASP A  97
GLU A  58
 None
 1.14A 2qebA-1a6jA:
0.0		 2qebA-1a6jA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		4 / 7 ILE A  65
PHE A  96
ASP A  97
GLU A  58
 None
 1.11A 2qebB-1a6jA:
0.0		 2qebB-1a6jA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		5 / 12 THR A  80
LEU A  10
VAL A 127
ILE A 153
THR A  19
 None
 1.32A 3frqA-1a6jA:
0.0		 3frqA-1a6jA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		4 / 8 ALA A  70
GLY A  64
THR A  63
GLU A  58
 None
 0.89A 3rglA-1a6jA:
0.2		 3rglA-1a6jA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 151
THR A 156
THR A 154
 None
 0.82A 4fu9A-1a6jA:
0.0		 4fu9A-1a6jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 151
THR A 156
THR A 154
 None
 0.80A 4fufA-1a6jA:
0.0		 4fufA-1a6jA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		4 / 5 ASN A  15
LEU A  14
SER A  12
LEU A 110
 None
 1.26A 4n09C-1a6jA:
undetectable		 4n09C-1a6jA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		4 / 8 LEU A 106
THR A  19
TYR A 150
GLN A  42
 None
 1.20A 5hbsA-1a6jA:
undetectable		 5hbsA-1a6jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		4 / 4 ASN A  15
LEU A  14
SER A  12
LEU A 110
 None
 1.25A 5kb5A-1a6jA:
undetectable		 5kb5A-1a6jA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		5 / 10 ILE A  94
LEU A  90
GLY A  64
ALA A  98
PHE A  96
 None
 1.15A 5mxbA-1a6jA:
0.0		 5mxbA-1a6jA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1a6j NITROGEN REGULATORY
IIA PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  65
LEU A 124
VAL A 127
GLU A  58
ALA A  31
 None
 1.12A 5uxdB-1a6jA:
undetectable		 5uxdB-1a6jA:
19.80