SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 151
GLU A 152
GLU A  88
 None
MN  A 340 ( 4.3A)
None
 0.72A 1eqbB-1a76A:
0.7		 1eqbB-1a76A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 214
PHE A   5
LEU A 178
PHE A 265
 None
 0.98A 2eilP-1a76A:
undetectable
2eilW-1a76A:
0.0		 2eilP-1a76A:
19.58
2eilW-1a76A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  30
GLY A  28
TRP A  77
MET A 131
THR A 189
 None
 1.18A 2q7lA-1a76A:
undetectable		 2q7lA-1a76A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 233
ALA A 238
VAL A 250
VAL A 246
GLY A 245
 None
 0.94A 3kw4A-1a76A:
undetectable		 3kw4A-1a76A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 311
ALA A 313
LEU A 280
LEU A 278
ILE A  66
 None
 1.30A 3olsB-1a76A:
undetectable		 3olsB-1a76A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 177
ARG A 186
MET A 194
 None
 0.97A 4m11C-1a76A:
0.0		 4m11C-1a76A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 245
ALA A 247
TYR A 258
SER A 210
ILE A 209
 None
 1.34A 4pb1A-1a76A:
0.0		 4pb1A-1a76A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 6 SER A 210
LEU A 211
ASP A 212
LEU A 204
 None
 0.92A 4wozA-1a76A:
1.2
4wozB-1a76A:
1.0		 4wozA-1a76A:
21.84
4wozB-1a76A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 280
VAL A 305
ASP A 306
 None
 0.38A 4y8wC-1a76A:
0.0		 4y8wC-1a76A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 6 SER A 171
ALA A 181
ALA A 157
SER A 158
 None
 0.74A 6bocA-1a76A:
undetectable
6bocB-1a76A:
undetectable
6bocC-1a76A:
undetectable
6bocD-1a76A:
undetectable		 6bocA-1a76A:
9.30
6bocB-1a76A:
9.30
6bocC-1a76A:
9.30
6bocD-1a76A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1a76 FLAP ENDONUCLEASE-1
PROTEIN
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  26
VAL A 169
ALA A 176
TYR A 174
 None
 0.73A 6cduD-1a76A:
0.0
6cduE-1a76A:
0.0		 6cduD-1a76A:
20.45
6cduE-1a76A:
20.45