SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 114
GLU A 116
SER A 126
 None
None
SO4  A   1 (-2.4A)
 0.59A 4ccqA-1a79A:
undetectable		 4ccqA-1a79A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A 127
TYR A 128
LEU A 159
VAL A  91
 None
 0.95A 4e1gB-1a79A:
0.0		 4e1gB-1a79A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  10
ALA A  32
LEU A  30
LEU A  53
TYR A  52
 None
 1.15A 4g1bB-1a79A:
0.0		 4g1bB-1a79A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ASP A 111
VAL A 163
ILE A 169
TYR A 171
LEU A  95
 None
 1.30A 5hw8C-1a79A:
undetectable
5hw8H-1a79A:
undetectable		 5hw8C-1a79A:
19.55
5hw8H-1a79A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 125
SER A 126
LYS A 156
 SO4  A   1 (-3.9A)
SO4  A   1 (-2.4A)
SO4  A   1 (-3.1A)
 0.81A 5os7A-1a79A:
undetectable		 5os7A-1a79A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  26
SER A  31
LEU A  30
VAL A  21
LEU A  45
 None
 1.09A 5ubbA-1a79A:
undetectable		 5ubbA-1a79A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A  51
TYR A  77
LEU A  85
GLU A  82
 None
 1.33A 5weaA-1a79A:
undetectable		 5weaA-1a79A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1a79 TRNA ENDONUCLEASE
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 125
SER A 126
LYS A 156
 SO4  A   1 (-3.9A)
SO4  A   1 (-2.4A)
SO4  A   1 (-3.1A)
 0.81A 6gmdB-1a79A:
undetectable		 6gmdB-1a79A:
19.49