SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1a81 SYK KINASE
(Homo
sapiens) 		3 / 3 THR A 256
LEU A 255
LEU A 237
 None
 0.59A 1mz9C-1a81A:
undetectable		 1mz9C-1a81A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1a81 SYK KINASE
(Homo
sapiens) 		3 / 3 LEU A 214
HIS A 209
LYS A 212
 None
 0.83A 1y7iA-1a81A:
undetectable		 1y7iA-1a81A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 1a81 SYK KINASE
(Homo
sapiens) 		3 / 3 SER A  84
TYR A  74
HIS A  82
 None
 0.79A 2r2vD-1a81A:
0.0		 2r2vD-1a81A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1a81 SYK KINASE
(Homo
sapiens) 		3 / 3 ASN A 108
LEU A  29
PHE A  16
 None
 0.77A 5dsgA-1a81A:
0.0		 5dsgA-1a81A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1a81 SYK KINASE
(Homo
sapiens) 		3 / 3 ASN A 189
LEU A 183
PHE A 192
 None
 0.73A 5dsgA-1a81A:
0.0		 5dsgA-1a81A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1a81 SYK KINASE
(Homo
sapiens) 		4 / 5 PRO A 119
GLY A 118
THR A 117
ASN A  19
 None
 1.21A 5x23A-1a81A:
0.0		 5x23A-1a81A:
19.18