SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a8p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 12 ILE A 141
LEU A 110
SER A 124
ILE A 126
LEU A 174
 None
 1.02A 1draA-1a8pA:
2.8		 1draA-1a8pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		3 / 3 ILE A 218
ILE A 251
THR A 115
 None
 0.60A 1rg7A-1a8pA:
2.9		 1rg7A-1a8pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 12 ILE A 141
LEU A 110
SER A 124
ILE A 126
LEU A 174
 None
 1.01A 2drcA-1a8pA:
3.0		 2drcA-1a8pA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 8 LEU A 225
PRO A 121
SER A  54
GLY A 116
 None
None
FAD  A 259 (-3.8A)
None
 1.02A 2qd5A-1a8pA:
2.4		 2qd5A-1a8pA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		3 / 3 GLY A 118
GLY A 143
GLY A 116
 None
 0.39A 3bogC-1a8pA:
0.0		 3bogC-1a8pA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_A_CHDA2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 9 LEU A 225
ARG A 190
PRO A 121
SER A  54
GLY A 116
 None
None
None
FAD  A 259 (-3.8A)
None
 1.36A 3hcpA-1a8pA:
2.4		 3hcpA-1a8pA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 6 ARG A 196
GLY A 234
GLU A 227
GLU A 230
 None
 1.15A 3k9fA-1a8pA:
0.0
3k9fB-1a8pA:
0.0
3k9fD-1a8pA:
3.3		 3k9fA-1a8pA:
19.69
3k9fB-1a8pA:
19.69
3k9fD-1a8pA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 8 GLY A 234
PHE A 235
ILE A 218
PHE A 201
 None
 0.79A 3ko0O-1a8pA:
undetectable
3ko0Q-1a8pA:
undetectable		 3ko0O-1a8pA:
16.99
3ko0Q-1a8pA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 12 GLY A 143
VAL A 138
SER A 124
MET A 123
LEU A 119
 None
 1.31A 4a83A-1a8pA:
0.0		 4a83A-1a8pA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 12 ILE A 141
LEU A 110
SER A 124
ILE A 126
LEU A 174
 None
 1.00A 4dfrA-1a8pA:
2.2		 4dfrA-1a8pA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 4 ASN A 148
VAL A 144
THR A  18
ILE A  69
 None
None
None
FAD  A 259 (-3.6A)
 1.23A 4retA-1a8pA:
3.4		 4retA-1a8pA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 4 ASN A 148
VAL A 144
THR A  18
ILE A  69
 None
None
None
FAD  A 259 (-3.6A)
 1.23A 4retC-1a8pA:
3.0		 4retC-1a8pA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 5 PHE A 185
SER A 184
ASN A  16
ASP A  17
 None
 1.43A 5kpcA-1a8pA:
3.5		 5kpcA-1a8pA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 12 GLU A  88
LEU A  83
LEU A  80
ILE A  40
GLU A   7
 None
 1.12A 5v0vA-1a8pA:
undetectable		 5v0vA-1a8pA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		6 / 9 SER A  54
THR A 117
GLY A 118
ALA A 120
CYH A 219
GLU A 252
 FAD  A 259 (-3.8A)
FAD  A 259 (-3.1A)
None
FAD  A 259 (-3.5A)
None
FAD  A 259 ( 3.9A)
 0.59A 5vw4A-1a8pA:
8.4		 5vw4A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		6 / 9 THR A 117
GLY A 118
ALA A 120
CYH A 219
GLY A 220
GLU A 252
 FAD  A 259 (-3.1A)
None
FAD  A 259 (-3.5A)
None
None
FAD  A 259 ( 3.9A)
 0.70A 5vw4A-1a8pA:
8.4		 5vw4A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 8 SER A  54
THR A 117
GLY A 118
CYH A 219
GLU A 252
 FAD  A 259 (-3.8A)
FAD  A 259 (-3.1A)
None
None
FAD  A 259 ( 3.9A)
 0.59A 5vw5A-1a8pA:
21.0		 5vw5A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		5 / 8 THR A 117
GLY A 118
CYH A 219
GLY A 220
GLU A 252
 FAD  A 259 (-3.1A)
None
None
None
FAD  A 259 ( 3.9A)
 0.72A 5vw5A-1a8pA:
21.0		 5vw5A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		6 / 8 SER A  54
THR A 117
GLY A 118
ALA A 120
CYH A 219
GLU A 252
 FAD  A 259 (-3.8A)
FAD  A 259 (-3.1A)
None
FAD  A 259 (-3.5A)
None
FAD  A 259 ( 3.9A)
 0.71A 5vw9A-1a8pA:
21.3		 5vw9A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		6 / 8 THR A 117
GLY A 118
ALA A 120
CYH A 219
GLY A 220
GLU A 252
 FAD  A 259 (-3.1A)
None
FAD  A 259 (-3.5A)
None
None
FAD  A 259 ( 3.9A)
 0.71A 5vw9A-1a8pA:
21.3		 5vw9A-1a8pA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 4 HIS A 109
LEU A 200
TYR A 177
GLY A 205
 None
 1.23A 6n91A-1a8pA:
undetectable		 6n91A-1a8pA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE
(Azotobacter
vinelandii) 		4 / 4 HIS A 109
LEU A 200
TYR A 177
GLY A 205
 None
 1.24A 6n91B-1a8pA:
undetectable		 6n91B-1a8pA:
15.56