SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 8 ASP A 223
HIS A 252
HIS A 219
ILE A 121
 None
 0.84A 1ei6C-1a8qA:
undetectable		 1ei6C-1a8qA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		3 / 3 ARG A   6
THR A  61
VAL A   9
 None
 1.00A 2qakA-1a8qA:
0.0		 2qakA-1a8qA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 11 HIS A  26
ALA A  92
GLY A  98
ILE A 121
VAL A 225
 None
 1.17A 2uxpB-1a8qA:
undetectable		 2uxpB-1a8qA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		3 / 3 LEU A  80
LEU A  85
ARG A  20
 None
 0.75A 3hcnB-1a8qA:
3.4		 3hcnB-1a8qA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.09A 3keeA-1a8qA:
undetectable		 3keeA-1a8qA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.04A 3keeB-1a8qA:
undetectable		 3keeB-1a8qA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.05A 3keeC-1a8qA:
undetectable		 3keeC-1a8qA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.04A 3keeD-1a8qA:
undetectable		 3keeD-1a8qA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 0.95A 3sueA-1a8qA:
undetectable		 3sueA-1a8qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 0.92A 3sueB-1a8qA:
undetectable		 3sueB-1a8qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 0.95A 3sufA-1a8qA:
undetectable		 3sufA-1a8qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		6 / 12 VAL A 226
HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.12A 3sufB-1a8qA:
undetectable		 3sufB-1a8qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 11 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.05A 3sufC-1a8qA:
undetectable		 3sufC-1a8qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 4 ASN A 166
GLY A 161
ASP A 133
ASP A 222
 None
 1.26A 4n49A-1a8qA:
1.7		 4n49A-1a8qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		3 / 3 GLN A 187
HIS A  57
ARG A  54
 None
 1.26A 4qyqA-1a8qA:
0.0		 4qyqA-1a8qA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		3 / 3 GLN A 187
HIS A  57
ARG A  54
 None
 1.22A 4qyqB-1a8qA:
undetectable		 4qyqB-1a8qA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 5 PHE A 211
PRO A 214
ALA A 242
PHE A 271
 None
 1.27A 4w5oA-1a8qA:
undetectable		 4w5oA-1a8qA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 8 ARG A   6
ASP A  75
PHE A  72
ASP A  68
 None
 1.17A 4xqgA-1a8qA:
3.4		 4xqgA-1a8qA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 8 ARG A   6
ASP A  75
PHE A  72
ASP A  68
 None
 1.16A 4xqgB-1a8qA:
2.2		 4xqgB-1a8qA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 5 PHE A 211
PRO A 214
ALA A 242
PHE A 271
 None
 1.26A 4z4dA-1a8qA:
undetectable		 4z4dA-1a8qA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 5 PHE A 211
PRO A 214
ALA A 242
PHE A 271
 None
 1.25A 4z4eA-1a8qA:
undetectable		 4z4eA-1a8qA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 6 SER A  94
HIS A 252
MET A 125
LEU A 143
 None
 1.08A 5dzke-1a8qA:
0.6
5dzks-1a8qA:
undetectable		 5dzke-1a8qA:
20.62
5dzks-1a8qA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 GLY A 253
GLY A 161
SER A 164
GLY A  27
LEU A 143
 None
 1.05A 5gwxA-1a8qA:
2.5		 5gwxA-1a8qA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		4 / 7 ASP A 212
PHE A 211
GLY A 105
GLY A 108
 None
 0.93A 5n9xA-1a8qA:
2.8		 5n9xA-1a8qA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1a8q BROMOPEROXIDASE A1
(Kitasatospora
aureofaciens) 		5 / 12 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 0.98A 6c2mC-1a8qA:
undetectable		 6c2mC-1a8qA:
17.17