SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 10 GLY A  27
SER A  94
PHE A 181
TRP A  28
HIS A 253
 PPI  A 278 ( 3.7A)
PPI  A 278 ( 2.7A)
None
None
PPI  A 278 ( 4.0A)
 1.25A 1a8uA-1a8sA:
42.1		 1a8uA-1a8sA:
45.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 8 ALA A 101
ALA A 115
LEU A 239
VAL A 240
 None
 0.73A 2bxgA-1a8sA:
undetectable		 2bxgA-1a8sA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 6 ARG A  55
ASP A  68
THR A  71
ASP A   7
 None
 0.69A 2j2pE-1a8sA:
0.0
2j2pF-1a8sA:
undetectable		 2j2pE-1a8sA:
21.25
2j2pF-1a8sA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 7 ILE A 212
ALA A 101
VAL A 100
GLY A 116
THR A 216
 None
 1.11A 2xrzB-1a8sA:
undetectable		 2xrzB-1a8sA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 8 ALA A 193
TYR A 155
HIS A 190
ILE A 197
 None
 0.83A 2zm9A-1a8sA:
0.0		 2zm9A-1a8sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 PHE A 205
GLU A 202
SER A 201
ARG A 102
 None
 1.45A 3dqtA-1a8sA:
undetectable
3dqtB-1a8sA:
0.0		 3dqtA-1a8sA:
22.54
3dqtB-1a8sA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 GLY A 116
LEU A 117
ILE A 212
PHE A 270
ALA A 237
 None
 1.07A 3gwwA-1a8sA:
0.0		 3gwwA-1a8sA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 SER A  60
ASP A  15
ILE A  50
ASP A  75
LEU A  79
 None
 1.21A 3iv6D-1a8sA:
3.3		 3iv6D-1a8sA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 SER A 201
ARG A 102
PHE A 205
GLU A 202
 None
 1.43A 3n5tA-1a8sA:
0.0
3n5tB-1a8sA:
0.0		 3n5tA-1a8sA:
21.57
3n5tB-1a8sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 5 VAL A 240
LEU A 209
ILE A 104
ALA A 115
 None
 0.92A 3n8yB-1a8sA:
0.0		 3n8yB-1a8sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 VAL A 227
HIS A 253
ASP A 224
GLY A  27
SER A  94
 None
PPI  A 278 ( 4.0A)
None
PPI  A 278 ( 3.7A)
PPI  A 278 ( 2.7A)
 0.99A 3sufB-1a8sA:
undetectable		 3sufB-1a8sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		3 / 3 PRO A 132
THR A 128
LEU A 124
 None
 0.73A 3ttrA-1a8sA:
0.7		 3ttrA-1a8sA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 GLY A  96
GLY A  27
LEU A  30
ALA A 101
LEU A 117
 None
PPI  A 278 ( 3.7A)
None
None
None
 1.22A 3vywD-1a8sA:
undetectable		 3vywD-1a8sA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 6 HIS A 253
SER A  94
GLU A  99
ASP A  70
 PPI  A 278 ( 4.0A)
PPI  A 278 ( 2.7A)
None
None
 1.39A 4blvA-1a8sA:
2.1		 4blvA-1a8sA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 PHE A 205
GLU A 202
SER A 201
ARG A 102
 None
 1.39A 4k5jA-1a8sA:
0.0
4k5jB-1a8sA:
0.0		 4k5jA-1a8sA:
21.62
4k5jB-1a8sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 GLY A  96
GLY A  27
ILE A 118
SER A 119
ALA A 120
 None
PPI  A 278 ( 3.7A)
None
None
None
 0.94A 4qtuD-1a8sA:
2.7		 4qtuD-1a8sA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 8 ALA A  77
ILE A  80
ALA A 101
TYR A 103
LEU A  90
 None
 1.39A 4v1fA-1a8sA:
undetectable
4v1fB-1a8sA:
0.0		 4v1fA-1a8sA:
19.70
4v1fB-1a8sA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 PHE A 205
PHE A 200
GLY A 134
LEU A 135
VAL A 139
 None
PPI  A 278 (-3.6A)
None
None
None
 1.12A 4wnwA-1a8sA:
0.0		 4wnwA-1a8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 PHE A 205
PHE A 200
GLY A 134
LEU A 135
VAL A 139
 None
PPI  A 278 (-3.6A)
None
None
None
 1.09A 4wnwB-1a8sA:
0.0		 4wnwB-1a8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 PHE A 205
GLU A 202
SER A 201
ARG A 102
 None
 1.40A 5adlA-1a8sA:
0.0
5adlB-1a8sA:
0.0		 5adlA-1a8sA:
21.62
5adlB-1a8sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 5 PHE A 200
ARG A 144
ILE A 143
ILE A 197
 PPI  A 278 (-3.6A)
None
None
None
 1.01A 5dzk4-1a8sA:
undetectable
5dzkg-1a8sA:
1.0
5dzkm-1a8sA:
0.2
5dzkn-1a8sA:
0.5		 5dzk4-1a8sA:
0.75
5dzkg-1a8sA:
24.57
5dzkm-1a8sA:
22.89
5dzkn-1a8sA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 6 GLY A  96
THR A  95
SER A  25
HIS A  57
 None
PPI  A 278 (-3.7A)
None
None
 1.07A 5ewuA-1a8sA:
1.1		 5ewuA-1a8sA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 PHE A 205
GLU A 202
SER A 201
ARG A 102
 None
 1.40A 5fj3A-1a8sA:
0.0
5fj3B-1a8sA:
0.0		 5fj3A-1a8sA:
21.62
5fj3B-1a8sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 THR A   5
ASP A  75
ASP A   7
GLY A  66
 None
 1.00A 5hwaA-1a8sA:
0.0		 5hwaA-1a8sA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 6 ASP A 195
ASN A  31
ASN A 192
GLN A  62
 None
 1.18A 5l6eA-1a8sA:
1.4		 5l6eA-1a8sA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		5 / 12 ALA A 115
LEU A 117
ILE A 118
LEU A  76
ILE A 104
 None
 1.05A 5m24A-1a8sA:
undetectable		 5m24A-1a8sA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 6 SER A 201
ARG A 102
PHE A 205
GLU A 202
 None
 1.39A 5uo8A-1a8sA:
0.0
5uo8B-1a8sA:
0.0		 5uo8A-1a8sA:
21.43
5uo8B-1a8sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 PHE A 205
GLU A 202
SER A 201
ARG A 102
 None
 1.38A 5vv7A-1a8sA:
0.0
5vv7B-1a8sA:
0.0		 5vv7A-1a8sA:
21.62
5vv7B-1a8sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 PHE A 205
GLU A 202
SER A 201
ARG A 102
 None
 1.41A 5vvnA-1a8sA:
0.0
5vvnB-1a8sA:
0.0		 5vvnA-1a8sA:
21.62
5vvnB-1a8sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		3 / 3 MET A  39
ASP A  33
ARG A  54
 None
 0.90A 5z6jA-1a8sA:
undetectable		 5z6jA-1a8sA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 SER A 201
ARG A 102
PHE A 205
GLU A 202
 None
 1.35A 6av6A-1a8sA:
0.0
6av6B-1a8sA:
0.0		 6av6A-1a8sA:
12.41
6av6B-1a8sA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 PHE A 205
GLU A 202
SER A 201
ARG A 102
 None
 1.31A 6av6C-1a8sA:
0.0
6av6D-1a8sA:
0.0		 6av6C-1a8sA:
12.41
6av6D-1a8sA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1a8s CHLOROPEROXIDASE F
(Pseudomonas
fluorescens) 		4 / 7 SER A 201
ARG A 102
PHE A 205
GLU A 202
 None
 1.37A 6av7A-1a8sA:
0.0
6av7B-1a8sA:
0.0		 6av7A-1a8sA:
12.41
6av7B-1a8sA:
12.41