SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ALA A 188
VAL A 190
TRP A 160
 None
 0.92A 1grmA-1a99A:
undetectable		 1grmA-1a99A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 ALA A 188
VAL A 190
TRP A 160
 None
 0.92A 1grmB-1a99A:
undetectable		 1grmB-1a99A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 276
TYR A 223
PHE A 266
GLY A 141
GLY A 246
 PUT  A 371 (-4.0A)
None
None
None
None
 1.10A 1igxA-1a99A:
undetectable		 1igxA-1a99A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 9 TRP A  37
LEU A 348
SER A  87
ARG A  91
ALA A 182
 PUT  A 371 (-3.7A)
None
None
None
None
 1.46A 1pbfA-1a99A:
0.0		 1pbfA-1a99A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 8 ASP A 310
ASP A 247
ASP A 278
TYR A 336
 None
PUT  A 371 (-3.0A)
PUT  A 371 (-3.1A)
None
 0.80A 3havA-1a99A:
undetectable		 3havA-1a99A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A  68
ILE A  34
TYR A  59
ILE A  41
PHE A 280
 None
 1.30A 3kz7A-1a99A:
undetectable		 3kz7A-1a99A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 243
TRP A 160
LEU A 162
ILE A 221
PHE A 179
 None
 1.21A 3mneA-1a99A:
undetectable		 3mneA-1a99A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 12 PHE A 266
ASN A 263
ALA A 258
ALA A 234
ASN A 235
 None
 1.34A 4pclB-1a99A:
undetectable		 4pclB-1a99A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 299
THR A  53
VAL A  57
ILE A  55
 None
 0.89A 4xe3A-1a99A:
0.0		 4xe3A-1a99A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 299
THR A  53
VAL A  57
ILE A  55
 None
 0.85A 4xe3B-1a99A:
0.0		 4xe3B-1a99A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		5 / 11 PHE A 266
ASP A 247
TYR A 314
GLY A 139
GLY A 334
 None
PUT  A 371 (-3.0A)
PUT  A 371 (-4.9A)
None
None
 1.13A 4xnxA-1a99A:
0.0		 4xnxA-1a99A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		3 / 3 TYR A  40
ALA A 136
TYR A 314
 PUT  A 371 (-3.7A)
None
PUT  A 371 (-4.9A)
 0.79A 5uunB-1a99A:
0.0		 5uunB-1a99A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 5 ILE A 140
SER A 267
ALA A 155
LEU A 172
 None
 1.04A 6dwnA-1a99A:
0.0		 6dwnA-1a99A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1a99 PUTRESCINE-BINDING
PROTEIN
(Escherichia
coli) 		4 / 6 VAL A 366
ASN A 220
PRO A 219
ILE A 221
 None
 1.23A 6h7uA-1a99A:
undetectable		 6h7uA-1a99A:
20.20