SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1a9n U2A'
(Homo
sapiens) 		5 / 12 LEU A  87
LEU A  66
ILE A  79
LEU A  26
VAL A  71
 None
 1.22A 1hrkA-1a9nA:
undetectable		 1hrkA-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1a9n U2A'
(Homo
sapiens) 		5 / 12 GLU A  10
PHE A  60
LEU A  57
PHE A  44
PHE A  49
 None
 1.29A 1nw3A-1a9nA:
undetectable		 1nw3A-1a9nA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1a9n U2A'
(Homo
sapiens) 		4 / 7 PHE A  60
LEU A  93
VAL A  71
ILE A  34
 None
 0.82A 1p2yA-1a9nA:
0.0		 1p2yA-1a9nA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1a9n U2A'
(Homo
sapiens) 		4 / 7 PHE A  60
LEU A  93
VAL A  71
ILE A  34
 None
 0.97A 1t87B-1a9nA:
0.0		 1t87B-1a9nA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1a9n U2A'
(Homo
sapiens) 		5 / 11 LEU A 118
LEU A 145
GLY A 104
TYR A 131
LYS A 128
 None
 1.28A 1y4lB-1a9nA:
undetectable		 1y4lB-1a9nA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1a9n SPLICEOSOMAL U2B''
(Homo
sapiens) 		4 / 8 LEU B  26
ILE B  21
PHE B  77
ILE B  14
 None
 0.94A 2azxA-1a9nB:
undetectable		 2azxA-1a9nB:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1a9n U2A'
(Homo
sapiens) 		5 / 12 LEU A  87
LEU A  66
ILE A  79
LEU A  26
VAL A  71
 None
 1.16A 2hrcA-1a9nA:
undetectable		 2hrcA-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a9n U2A'
(Homo
sapiens) 		5 / 12 LEU A  87
LEU A  66
ILE A  79
LEU A  26
VAL A  71
 None
 1.22A 2po7A-1a9nA:
undetectable		 2po7A-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 1a9n U2A'
(Homo
sapiens) 		5 / 11 LEU A 109
LEU A 118
LEU A 145
ILE A  79
VAL A 125
 None
 1.18A 2qd3A-1a9nA:
undetectable		 2qd3A-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 1a9n U2A'
(Homo
sapiens) 		4 / 8 LEU A  83
LEU A  66
LYS A  67
LEU A  93
 None
 1.15A 2xn3A-1a9nA:
undetectable
2xn3B-1a9nA:
0.0		 2xn3A-1a9nA:
18.95
2xn3B-1a9nA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1a9n U2A'
SPLICEOSOMAL U2B''
(Homo
sapiens;
Homo
sapiens) 		5 / 12 SER B  29
MET B  17
MET B  82
ILE B  14
LEU A 145
 None
 1.35A 3aocC-1a9nB:
3.0		 3aocC-1a9nB:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1a9n U2A'
SPLICEOSOMAL U2B''
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN A  74
ASP A  51
ARG B  28
 None
 0.91A 3k13C-1a9nA:
0.0		 3k13C-1a9nA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1a9n SPLICEOSOMAL U2B''
U2A'
(Homo
sapiens) 		5 / 12 TYR B  31
LEU A  70
VAL A  71
ARG A  27
LEU A  37
 None
 1.30A 3vt7A-1a9nB:
undetectable		 3vt7A-1a9nB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1a9n SPLICEOSOMAL U2B''
U2A'
(Homo
sapiens) 		5 / 12 TYR B  31
LEU A  70
VAL A  71
SER A  50
ARG A  27
 None
 1.47A 3vt7A-1a9nB:
undetectable		 3vt7A-1a9nB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a9n U2A'
(Homo
sapiens) 		5 / 12 LEU A 109
LEU A 118
LEU A 145
ILE A  79
VAL A 125
 None
 1.21A 4f4dA-1a9nA:
undetectable		 4f4dA-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a9n U2A'
(Homo
sapiens) 		5 / 12 LEU A 109
LEU A 118
LEU A 145
ILE A  79
VAL A 125
 None
 1.24A 4f4dB-1a9nA:
undetectable		 4f4dB-1a9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1a9n U2A'
(Homo
sapiens) 		4 / 8 ILE A   9
LEU A   8
ILE A  34
GLY A  28
 None
 0.83A 4hb6A-1a9nA:
undetectable		 4hb6A-1a9nA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1a9n U2A'
(Homo
sapiens) 		5 / 8 ALA A  39
LEU A  24
ALA A  12
LEU A  26
LEU A   4
 None
 1.04A 4z90A-1a9nA:
0.0
4z90B-1a9nA:
0.0
4z90C-1a9nA:
0.0
4z90D-1a9nA:
0.0
4z90E-1a9nA:
0.0		 4z90A-1a9nA:
20.06
4z90B-1a9nA:
20.06
4z90C-1a9nA:
20.06
4z90D-1a9nA:
20.06
4z90E-1a9nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1a9n U2A'
(Homo
sapiens) 		5 / 8 LEU A 115
VAL A 142
VAL A 139
ILE A 120
ASP A 146
 None
 1.35A 5y9mA-1a9nA:
undetectable		 5y9mA-1a9nA:
17.76