SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1a9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		4 / 7 PHE E  42
PHE E  45
VAL E  67
HIS E  92
 HEM  E 147 (-4.3A)
None
HEM  E 147 (-4.2A)
HEM  E 147 (-3.3A)
 0.81A 1lh6A-1a9wE:
14.0		 1lh6A-1a9wE:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		4 / 7 MET E  18
ILE E 113
ARG E  30
GLY E 119
 None
 1.01A 2pnjB-1a9wE:
undetectable		 2pnjB-1a9wE:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		5 / 10 LEU E 114
VAL E 134
ALA E  23
LEU E 106
PHE E  71
 None
None
None
HEM  E 147 (-4.3A)
HEM  E 147 ( 4.7A)
 1.14A 3fl9A-1a9wE:
undetectable		 3fl9A-1a9wE:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		5 / 10 LEU E 114
VAL E 134
ALA E  23
LEU E 106
PHE E  71
 None
None
None
HEM  E 147 (-4.3A)
HEM  E 147 ( 4.7A)
 1.17A 3fl9F-1a9wE:
undetectable		 3fl9F-1a9wE:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		4 / 5 LEU E 106
LEU E  28
GLY E  25
GLY E  29
 HEM  E 147 (-4.3A)
None
None
None
 0.82A 3si7C-1a9wE:
0.0
3si7D-1a9wE:
undetectable		 3si7C-1a9wE:
19.24
3si7D-1a9wE:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		4 / 5 GLN E 127
VAL E 126
TRP E 130
THR E  12
 None
 1.36A 6cduI-1a9wE:
2.5
6cduJ-1a9wE:
2.5		 6cduI-1a9wE:
18.53
6cduJ-1a9wE:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		5 / 12 LEU E  32
LEU E  48
HIS E  63
SER E  70
LEU E  31
 None
None
HEM  E 147 ( 4.5A)
HEM  E 147 (-3.3A)
None
 1.10A 6ew0B-1a9wE:
undetectable		 6ew0B-1a9wE:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		5 / 12 LEU E  32
LEU E  48
HIS E  63
SER E  70
LEU E  31
 None
None
HEM  E 147 ( 4.5A)
HEM  E 147 (-3.3A)
None
 1.10A 6ew0D-1a9wE:
undetectable		 6ew0D-1a9wE:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		5 / 12 LEU E  32
LEU E  48
HIS E  63
SER E  70
LEU E  31
 None
None
HEM  E 147 ( 4.5A)
HEM  E 147 (-3.3A)
None
 1.10A 6ew0H-1a9wE:
undetectable		 6ew0H-1a9wE:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1a9w HEMOGLOBIN (BETA
CHAIN)
(Homo
sapiens) 		5 / 12 LEU E  32
LEU E  48
HIS E  63
SER E  70
LEU E  31
 None
None
HEM  E 147 ( 4.5A)
HEM  E 147 (-3.3A)
None
 1.10A 6ew0I-1a9wE:
undetectable		 6ew0I-1a9wE:
18.40