SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1abr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 7 LEU A 232
SER A 233
THR B 138
VAL B  16
 None
None
None
NDG  B 273 ( 4.9A)
 0.88A 1dvxB-1abrA:
0.0		 1dvxB-1abrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 1abr ABRIN-A
(Abrus
precatorius) 		3 / 3 ALA B 109
VAL B 111
TRP B  98
 None
None
NDG  B 268 (-4.0A)
 0.83A 1grmA-1abrB:
undetectable		 1grmA-1abrB:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 1abr ABRIN-A
(Abrus
precatorius) 		3 / 3 ALA B 109
VAL B 111
TRP B  98
 None
None
NDG  B 268 (-4.0A)
 0.83A 1grmB-1abrB:
undetectable		 1grmB-1abrB:
4.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1abr ABRIN-A
(Abrus
precatorius) 		6 / 9 GLY A 111
TYR A 113
ILE A 159
ALA A 163
GLU A 164
ARG A 167
 None
 0.49A 1mrgA-1abrA:
33.6		 1mrgA-1abrA:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 8 GLY A 111
TYR A 113
ILE A 159
GLU A 164
ARG A 167
 None
 0.39A 1mrjA-1abrA:
34.1		 1mrjA-1abrA:
36.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 12 THR A  53
GLY A  67
VAL A  70
ASP A  69
VAL A  76
 None
 1.21A 1n2xA-1abrA:
undetectable		 1n2xA-1abrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 TYR A 170
ILE A 192
GLU A 195
PHE A 185
 None
 1.16A 1oniA-1abrA:
undetectable
1oniC-1abrA:
undetectable		 1oniA-1abrA:
21.03
1oniC-1abrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 TYR A 170
ILE A 192
PRO A 187
GLU A 195
 None
 1.36A 1oniA-1abrA:
undetectable
1oniC-1abrA:
undetectable		 1oniA-1abrA:
21.03
1oniC-1abrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 5 PHE A 185
ILE A 192
PRO A 187
GLU A 195
 None
 1.35A 1oniG-1abrA:
0.0
1oniH-1abrA:
0.0		 1oniG-1abrA:
21.03
1oniH-1abrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 4 GLY A 204
SER A 208
ILE A  33
HIS A  34
 None
 1.14A 1yajJ-1abrA:
undetectable		 1yajJ-1abrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 12 PRO B  14
ALA B  90
ALA B  92
THR B  71
ILE B  62
 NDG  B 273 (-3.7A)
None
None
None
None
 1.29A 2jjpA-1abrB:
0.0		 2jjpA-1abrB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 9 GLY A 204
SER A 208
ILE A  36
VAL A 237
VAL B 222
 None
 1.22A 2nnhB-1abrA:
undetectable		 2nnhB-1abrA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 12 LEU B 196
ALA B 159
THR B 147
PHE B 223
MET B 238
 None
 1.16A 2qo6A-1abrB:
0.0		 2qo6A-1abrB:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 5 TYR A  17
ILE A  64
LEU A  56
PHE A   7
 None
 1.27A 3ls4L-1abrA:
undetectable		 3ls4L-1abrA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 10 TYR A  74
ILE A  68
ALA A 163
GLU A 164
ARG A 167
 None
 1.39A 3u6tA-1abrA:
33.7		 3u6tA-1abrA:
34.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		6 / 10 TYR A  74
TYR A 113
ILE A 159
ALA A 163
GLU A 164
ARG A 167
 None
 0.58A 3u6tA-1abrA:
33.7		 3u6tA-1abrA:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 12 VAL A  75
ILE A 179
LEU A  56
PHE A 141
VAL A  66
 None
 0.95A 3w68D-1abrA:
undetectable		 3w68D-1abrA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 ARG A 174
LEU A 194
MET A 191
ASP A 188
 None
 1.25A 4cevA-1abrA:
undetectable
4cevB-1abrA:
undetectable		 4cevA-1abrA:
24.13
4cevB-1abrA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 MET A 191
ASP A 188
ARG A 174
LEU A 194
 None
 1.26A 4cevA-1abrA:
undetectable
4cevC-1abrA:
undetectable		 4cevA-1abrA:
24.13
4cevC-1abrA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 ARG A 174
LEU A 194
MET A 191
ASP A 188
 None
 1.30A 4cevD-1abrA:
undetectable
4cevE-1abrA:
undetectable		 4cevD-1abrA:
24.13
4cevE-1abrA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 ARG A 174
LEU A 194
MET A 191
ASP A 188
 None
 1.27A 4cevE-1abrA:
0.0
4cevF-1abrA:
undetectable		 4cevE-1abrA:
24.13
4cevF-1abrA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 11 LEU A  39
SER A 202
LEU A 201
PHE A 168
ALA A  73
 None
 1.28A 4hwkB-1abrA:
undetectable		 4hwkB-1abrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 12 LEU A  39
SER A 202
LEU A 201
PHE A 168
ALA A  73
 None
 1.26A 4hwkC-1abrA:
undetectable		 4hwkC-1abrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 11 LEU A  39
SER A 202
LEU A 201
PHE A 168
ALA A  73
 None
 1.28A 4hwkD-1abrA:
undetectable		 4hwkD-1abrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 7 GLU B 175
ASP B 170
GLN B 176
ASN B 172
 None
 1.23A 4ii8A-1abrB:
undetectable		 4ii8A-1abrB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 10 ALA A 165
ALA A 166
ALA A 163
VAL A  66
LEU A  56
 None
 1.19A 4j6cB-1abrA:
0.0		 4j6cB-1abrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 12 PHE A  86
GLN A  83
ALA A  80
VAL A  75
LEU A 155
 None
 1.12A 4jbtA-1abrA:
0.6		 4jbtA-1abrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 11 ALA A 165
ALA A 166
ALA A 163
VAL A  66
LEU A  56
 None
 1.15A 4jbtB-1abrA:
0.2		 4jbtB-1abrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 12 GLY B 135
GLY B 101
ARG B 137
ALA B 114
ARG B 133
 None
 1.23A 4kicA-1abrB:
undetectable		 4kicA-1abrB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 8 ASP B 234
SER B 231
ALA B 217
TYR B 233
 None
 1.06A 4lv9A-1abrB:
undetectable
4lv9B-1abrB:
undetectable		 4lv9A-1abrB:
20.61
4lv9B-1abrB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 7 TYR B 233
ASP B 234
SER B 231
ALA B 217
 None
 1.06A 4lv9A-1abrB:
undetectable
4lv9B-1abrB:
undetectable		 4lv9A-1abrB:
20.61
4lv9B-1abrB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 5 THR B 127
LEU B 110
THR B  70
MET B  81
 None
 1.47A 4mbsB-1abrB:
0.0		 4mbsB-1abrB:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 5 TYR A  74
TYR A 113
ILE A 159
ARG A 167
 None
 0.34A 4o0oA-1abrA:
33.7		 4o0oA-1abrA:
34.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 ASN A 148
TYR A  78
LEU A 155
PHE A 141
 None
 1.29A 4twdI-1abrA:
0.0
4twdJ-1abrA:
undetectable		 4twdI-1abrA:
23.58
4twdJ-1abrA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1abr ABRIN-A
(Abrus
precatorius) 		7 / 9 TYR A  74
GLY A 111
TYR A 113
ILE A 159
ALA A 163
GLU A 164
ARG A 167
 None
 0.57A 4yp2B-1abrA:
33.6		 4yp2B-1abrA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 9 TYR A  74
ILE A  68
ALA A 163
GLU A 164
ARG A 167
 None
 1.38A 4yp2B-1abrA:
33.6		 4yp2B-1abrA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1abr ABRIN-A
(Abrus
precatorius) 		7 / 9 TYR A  74
GLY A 111
TYR A 113
ILE A 159
ALA A 163
GLU A 164
ARG A 167
 None
 0.54A 5cf9B-1abrA:
33.8		 5cf9B-1abrA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1abr ABRIN-A
(Abrus
precatorius) 		5 / 9 TYR A  74
ILE A  68
ALA A 163
GLU A 164
ARG A 167
 None
 1.41A 5cf9B-1abrA:
33.8		 5cf9B-1abrA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1abr ABRIN-A
ABRIN-A
(Abrus
precatorius;
Abrus
precatorius) 		5 / 12 PRO A 214
GLY B 139
ILE B  18
PHE A 213
LEU A 232
 None
 1.16A 5fa8A-1abrA:
undetectable		 5fa8A-1abrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 5 SER B 116
SER B 117
SER B 118
SER B 213
 None
 1.35A 5hswA-1abrB:
0.0		 5hswA-1abrB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 SER B  64
GLY B  32
ASN B  31
ILE B  39
 None
 1.01A 5j4nA-1abrB:
undetectable		 5j4nA-1abrB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 ARG A  27
LEU A  28
ARG A  29
ARG A  25
 None
 1.27A 5l6eA-1abrA:
undetectable
5l6eB-1abrA:
undetectable		 5l6eA-1abrA:
22.48
5l6eB-1abrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 ARG A 223
PHE B 145
ILE B 149
THR B 265
 None
 1.13A 5vceA-1abrA:
0.0		 5vceA-1abrA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1abr ABRIN-A
(Abrus
precatorius) 		6 / 6 TYR A  74
VAL A  75
TYR A 113
ILE A 159
GLU A 164
ARG A 167
 None
 0.36A 5z3jA-1abrA:
41.1		 5z3jA-1abrA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1abr ABRIN-A
(Abrus
precatorius) 		3 / 3 TYR A  74
ALA A 166
LEU A 242
 None
 0.70A 6ag0C-1abrA:
undetectable		 6ag0C-1abrA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1abr ABRIN-A
(Abrus
precatorius) 		4 / 6 ILE A 138
LEU A 134
ARG A  79
THR A  53
 None
 1.08A 6nmfN-1abrA:
0.0
6nmfW-1abrA:
0.0		 6nmfN-1abrA:
18.68
6nmfW-1abrA:
11.11