SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ad1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ARG A  87
THR A  13
VAL A  49
 None
 0.92A 1hxbA-1ad1A:
0.0		 1hxbA-1ad1A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASN A 177
ILE A 170
ALA A 199
VAL A 235
LEU A 186
 None
 1.13A 3a51E-1ad1A:
0.0		 3a51E-1ad1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASN A 246
ASP A 220
ARG A  52
 None
 0.77A 3k13A-1ad1A:
19.1		 3k13A-1ad1A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A  42
VAL A 238
ILE A 231
VAL A 243
ILE A   6
 None
 1.06A 3mwsB-1ad1A:
undetectable		 3mwsB-1ad1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 11 TYR A 110
ALA A 107
ILE A 102
PHE A  86
ALA A  91
 None
 1.20A 3nmuB-1ad1A:
undetectable
3nmuJ-1ad1A:
undetectable		 3nmuB-1ad1A:
22.45
3nmuJ-1ad1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		4 / 8 ASP A 104
VAL A 126
ILE A 170
VAL A 196
 None
 0.57A 3nu9A-1ad1A:
undetectable		 3nu9A-1ad1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		5 / 12 ASP A  45
ASP A  84
ASN A 103
ASP A 167
SER A 201
 None
 1.04A 4djeB-1ad1A:
22.4		 4djeB-1ad1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 VAL A  12
ALA A  29
PHE A  17
 None
 0.89A 4olbA-1ad1A:
undetectable		 4olbA-1ad1A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 THR A   4
HIS A 129
LEU A 189
 None
 0.82A 5axdC-1ad1A:
0.4		 5axdC-1ad1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASP A  84
ASN A 103
ASP A 167
 None
 0.83A 5vopA-1ad1A:
8.7		 5vopA-1ad1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 ASP A  84
ASN A 103
ASP A 167
 None
 0.84A 5vopB-1ad1A:
8.7		 5vopB-1ad1A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1ad1 DIHYDROPTEROATE
SYNTHETASE
(Staphylococcus
aureus) 		3 / 3 GLY A  47
ASP A  45
ILE A  81
 None
 0.58A 6dgxB-1ad1A:
0.0		 6dgxB-1ad1A:
14.29