SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ad3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 6 PHE A 117
LEU A  32
VAL A 125
MET A 124
 None
 0.96A 1hk1A-1ad3A:
0.0		 1hk1A-1ad3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 7 PHE A 117
LEU A  32
VAL A 125
MET A 124
 None
 0.95A 1hk3A-1ad3A:
0.0		 1hk3A-1ad3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 8 GLU A 140
GLY A 167
ILE A   3
LEU A 175
 NAD  A 600 (-2.5A)
None
None
None
 0.91A 1jg4A-1ad3A:
5.2		 1jg4A-1ad3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 11 GLY A 282
GLY A 336
GLN A 241
LEU A 296
ILE A 297
 None
 0.88A 1jzsA-1ad3A:
undetectable		 1jzsA-1ad3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 LEU A  29
LEU A  67
VAL A  66
LEU A 136
LEU A 149
 None
 1.14A 1s19A-1ad3A:
0.0		 1s19A-1ad3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 6 SER A 367
ILE A 373
THR A 380
ALA A 350
 None
 0.94A 1w0gA-1ad3A:
0.0		 1w0gA-1ad3A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 10 ILE A 351
ALA A 350
ILE A 373
GLU A 379
ILE A 377
 None
 1.33A 2dm6A-1ad3A:
5.1
2dm6B-1ad3A:
5.1		 2dm6A-1ad3A:
23.06
2dm6B-1ad3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 7 TRP A  80
GLU A 419
ALA A 129
ALA A 130
 None
 1.00A 2ejfA-1ad3A:
0.3		 2ejfA-1ad3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 VAL A 218
ILE A 249
ILE A 341
ILE A 319
ALA A 303
 None
 0.82A 2gj5A-1ad3A:
undetectable		 2gj5A-1ad3A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 9 ALA A 411
TYR A 412
GLY A 126
GLY A 414
HIS A 413
 None
 1.36A 2v7bA-1ad3A:
2.2		 2v7bA-1ad3A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 9 ALA A 411
TYR A 412
GLY A 126
GLY A 414
HIS A 413
 None
 1.34A 2v7bB-1ad3A:
2.4		 2v7bB-1ad3A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_B_CSCB1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 LEU A 119
THR A 186
TYR A 412
LYS A 416
HIS A 413
 None
 1.43A 2vaxB-1ad3A:
2.6		 2vaxB-1ad3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_F_CSCF1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 LEU A 119
THR A 186
TYR A 412
LYS A 416
HIS A 413
 None
 1.44A 2vaxF-1ad3A:
0.8		 2vaxF-1ad3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_G_CSCG1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 LEU A 119
THR A 186
TYR A 412
LYS A 416
HIS A 413
 None
 1.45A 2vaxG-1ad3A:
1.9		 2vaxG-1ad3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 LEU A 119
THR A 186
TYR A 412
LYS A 416
HIS A 413
 None
 1.45A 2vaxH-1ad3A:
2.8		 2vaxH-1ad3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 LEU A 119
THR A 186
TYR A 412
LYS A 416
HIS A 413
 None
 1.45A 2vaxK-1ad3A:
2.5		 2vaxK-1ad3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 11 ALA A  46
ALA A  48
GLY A  45
SER A  44
ARG A 279
 None
 1.27A 2xfsB-1ad3A:
0.0		 2xfsB-1ad3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 6 TRP A  80
GLU A 419
ALA A 129
ALA A 130
 None
 1.02A 2zgwB-1ad3A:
0.0		 2zgwB-1ad3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 6 ARG A 313
PRO A 138
GLY A 143
MET A 145
 None
 1.48A 3aqiA-1ad3A:
2.8		 3aqiA-1ad3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 8 PHE A 335
GLY A 336
VAL A 338
LEU A 296
 NAD  A 600 (-3.8A)
None
None
None
 1.13A 3bgdB-1ad3A:
4.2		 3bgdB-1ad3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 ASN A 286
THR A 186
TYR A 115
LEU A  51
ARG A 283
 NAD  A 600 ( 4.4A)
None
None
None
None
 1.43A 3fsuA-1ad3A:
1.0		 3fsuA-1ad3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 8 ARG A 292
PRO A 340
GLY A 336
PRO A 337
 NAD  A 600 (-3.1A)
None
None
None
 0.82A 3hcrA-1ad3A:
2.2		 3hcrA-1ad3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 5 LEU A 148
ILE A  36
MET A  35
PHE A 117
 None
 1.04A 4dc3B-1ad3A:
3.9		 4dc3B-1ad3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 8 GLY A 295
LEU A 296
ILE A 297
ILE A 315
 None
 0.67A 4em2A-1ad3A:
0.0		 4em2A-1ad3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 8 LEU A 152
ILE A 153
ILE A 121
THR A 120
 None
 0.77A 4em2A-1ad3A:
0.0		 4em2A-1ad3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 6 PHE A 236
TYR A 271
LEU A 267
HIS A 304
 None
 1.23A 4paeA-1ad3A:
undetectable		 4paeA-1ad3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 ALA A  46
LEU A 149
ASN A 118
GLU A  62
ILE A  36
 None
 1.20A 4pb1A-1ad3A:
0.0		 4pb1A-1ad3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 ALA A  46
LEU A 149
ASN A 118
GLU A  62
ILE A  36
 None
 1.18A 4pd5A-1ad3A:
0.0		 4pd5A-1ad3A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		3 / 3 VAL A  66
LEU A  70
VAL A 125
 None
 0.59A 4wq4A-1ad3A:
0.8		 4wq4A-1ad3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		3 / 3 VAL A 342
LEU A 250
VAL A 344
 None
 0.57A 4wq4A-1ad3A:
0.8		 4wq4A-1ad3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		3 / 3 ASP A 147
GLY A 143
ASP A  50
 None
 0.64A 4xdtA-1ad3A:
0.0		 4xdtA-1ad3A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 9 ALA A  46
LEU A 149
LEU A 152
ILE A  36
 None
 0.70A 4xtaA-1ad3A:
0.0		 4xtaA-1ad3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 5 PRO A 138
LEU A  70
TYR A 412
PHE A 401
 None
 1.43A 5igjA-1ad3A:
0.0		 5igjA-1ad3A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		5 / 12 ILE A 121
LEU A  67
LEU A 136
PHE A 117
MET A 157
 None
 1.22A 6b54A-1ad3A:
1.0		 6b54A-1ad3A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)
(Rattus
norvegicus) 		4 / 6 LEU A  77
VAL A  63
PHE A 418
GLY A 131
 None
 0.98A 6hd4B-1ad3A:
undetectable		 6hd4B-1ad3A:
12.23