SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ad6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		5 / 11 LEU A 461
ALA A 490
GLY A 449
TYR A 453
PHE A 404
 None
 1.41A 1l5rA-1ad6A:
undetectable		 1l5rA-1ad6A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		4 / 5 VAL A 434
SER A 508
GLY A 442
ARG A 445
 None
 0.90A 3v4tA-1ad6A:
0.3
3v4tD-1ad6A:
0.4		 3v4tA-1ad6A:
18.45
3v4tD-1ad6A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		4 / 7 ASP A 511
SER A 513
GLU A 545
HIS A 549
 None
 1.33A 4aq7A-1ad6A:
0.1		 4aq7A-1ad6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		4 / 8 LEU A 486
TYR A 453
VAL A 531
LEU A 461
 None
 1.00A 4l1xA-1ad6A:
undetectable		 4l1xA-1ad6A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		4 / 5 LEU A 487
VAL A 494
TYR A 446
ARG A 544
 None
 1.12A 4r7iA-1ad6A:
undetectable		 4r7iA-1ad6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		3 / 3 ASN A 505
SER A 503
ARG A 500
 None
 0.60A 5b2qA-1ad6A:
undetectable		 5b2qA-1ad6A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		4 / 7 ALA A 496
THR A 497
GLU A 545
HIS A 549
 None
 1.22A 5ecnA-1ad6A:
undetectable		 5ecnA-1ad6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		4 / 7 ILE A 401
LEU A 400
MET A 457
LEU A 461
 None
 1.00A 5u4sA-1ad6A:
undetectable		 5u4sA-1ad6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		5 / 8 LEU A 521
LEU A 487
LEU A 512
ARG A 445
TYR A 446
 None
 1.43A 6ce2A-1ad6A:
0.0		 6ce2A-1ad6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR
(Homo
sapiens) 		3 / 3 LEU A 476
SER A 474
PHE A 473
 None
 0.66A 6fgcA-1ad6A:
undetectable		 6fgcA-1ad6A:
18.78