SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1adq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 ASP H  61
VAL H  63
GLY H  50
ILE H  51
 None
 0.81A 1t7iB-1adqH:
undetectable		 1t7iB-1adqH:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 6 ASP H 197
VAL H 198
PRO H 194
THR H 137
 None
 1.31A 2q6oB-1adqH:
undetectable		 2q6oB-1adqH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 5 VAL H  37
VAL H  48
THR H  95
ARG H  38
 None
 1.19A 3bjwA-1adqH:
0.0		 3bjwA-1adqH:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 5 VAL H  37
VAL H  48
THR H  95
ARG H  38
 None
 1.20A 3bjwC-1adqH:
0.0		 3bjwC-1adqH:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 ASP H 197
GLY H 201
THR H 202
SER H 195
 None
 0.91A 4ac9C-1adqH:
undetectable		 4ac9C-1adqH:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 8 LEU H  80
TYR H  90
ILE H 107
VAL H  12
 None
 0.74A 4ma7A-1adqH:
undetectable		 4ma7A-1adqH:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		5 / 8 LEU H 108
GLY H  10
VAL H 109
ALA H  88
GLY H 106
 None
 1.13A 4zauA-1adqH:
undetectable		 4zauA-1adqH:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		3 / 3 TYR H  90
TYR H 185
SER H 112
 None
 1.00A 5iktB-1adqH:
0.0		 5iktB-1adqH:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1adq IGM-LAMBDA RF-AN FAB
(HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 PHE H 100
ILE H  51
SER H  97
THR H  95
 None
 1.00A 5vkqA-1adqH:
undetectable
5vkqD-1adqH:
undetectable		 5vkqA-1adqH:
9.05
5vkqD-1adqH:
9.05