SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ae9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1ae9 LAMBDA INTEGRASE
(Escherichia
virus
Lambda) 		4 / 7 LEU A 180
LEU A 313
SER A 314
VAL A 213
 None
 0.97A 1dvxB-1ae9A:
undetectable		 1dvxB-1ae9A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1ae9 LAMBDA INTEGRASE
(Escherichia
virus
Lambda) 		5 / 12 LEU A 331
GLY A 332
LEU A 330
LEU A 216
ASP A 215
 None
 1.03A 3gwvA-1ae9A:
undetectable		 3gwvA-1ae9A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1ae9 LAMBDA INTEGRASE
(Escherichia
virus
Lambda) 		5 / 12 GLY A 210
LEU A 331
LEU A 317
SER A 312
ALA A 206
 None
 1.16A 3kkzA-1ae9A:
undetectable		 3kkzA-1ae9A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ae9 LAMBDA INTEGRASE
(Escherichia
virus
Lambda) 		4 / 5 SER A 281
THR A 284
GLU A 218
ASP A 223
 None
 1.40A 3tm4A-1ae9A:
undetectable		 3tm4A-1ae9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1ae9 LAMBDA INTEGRASE
(Escherichia
virus
Lambda) 		5 / 12 LEU A 266
CYH A 217
ALA A 206
PHE A 307
THR A 284
 None
 1.41A 4iaqA-1ae9A:
undetectable		 4iaqA-1ae9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1ae9 LAMBDA INTEGRASE
(Escherichia
virus
Lambda) 		5 / 12 LEU A 246
PHE A 326
ALA A 315
GLY A 332
LEU A 331
 None
 1.13A 4j7xB-1ae9A:
undetectable		 4j7xB-1ae9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1ae9 LAMBDA INTEGRASE
(Escherichia
virus
Lambda) 		4 / 5 TYR A 318
GLN A 321
GLY A 227
ILE A 242
 None
 1.42A 6debB-1ae9A:
undetectable		 6debB-1ae9A:
18.39