SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1aec ACTINIDIN
(Actinidia
chinensis) 		5 / 10 PRO A 132
VAL A 128
VAL A  13
ILE A 196
GLY A 168
 None
 1.49A 13gsA-1aecA:
undetectable		 13gsA-1aecA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1aec ACTINIDIN
(Actinidia
chinensis) 		5 / 9 PRO A 132
VAL A 128
VAL A  13
ILE A 196
GLY A 168
 None
 1.49A 13gsB-1aecA:
undetectable		 13gsB-1aecA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1aec ACTINIDIN
(Actinidia
chinensis) 		5 / 8 ALA A  30
GLY A  36
ILE A  37
ILE A  83
ILE A  31
 None
 1.43A 1hshD-1aecA:
0.6		 1hshD-1aecA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1aec ACTINIDIN
(Actinidia
chinensis) 		7 / 10 GLN A  19
GLY A  23
TRP A  26
PHE A  28
SER A  29
HIS A 162
ALA A 163
 E64  A 219 (-3.2A)
E64  A 219 (-3.2A)
None
None
None
E64  A 219 (-3.8A)
E64  A 219 ( 4.3A)
 0.30A 1stfE-1aecA:
36.9
1stfI-1aecA:
0.0		 1stfE-1aecA:
47.49
1stfI-1aecA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1aec ACTINIDIN
(Actinidia
chinensis) 		5 / 12 ILE A 208
GLY A 157
ALA A 159
ILE A 160
THR A 205
 None
 1.44A 1vq1A-1aecA:
undetectable		 1vq1A-1aecA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1aec ACTINIDIN
(Actinidia
chinensis) 		4 / 8 THR A  33
GLN A 131
SER A  29
SER A 213
 None
 1.03A 2xz5C-1aecA:
undetectable
2xz5D-1aecA:
undetectable		 2xz5C-1aecA:
21.43
2xz5D-1aecA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1aec ACTINIDIN
(Actinidia
chinensis) 		4 / 7 GLN A  19
GLY A  23
HIS A 162
TRP A 184
 E64  A 219 (-3.2A)
E64  A 219 (-3.2A)
E64  A 219 (-3.8A)
None
 0.48A 3ai8A-1aecA:
27.6		 3ai8A-1aecA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1aec ACTINIDIN
(Actinidia
chinensis) 		4 / 7 GLN A  19
GLY A  24
HIS A 162
TRP A 184
 E64  A 219 (-3.2A)
E64  A 219 (-4.1A)
E64  A 219 (-3.8A)
None
 0.88A 3ai8A-1aecA:
27.6		 3ai8A-1aecA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1aec ACTINIDIN
(Actinidia
chinensis) 		5 / 9 ALA A 127
ILE A 166
GLY A 168
THR A  33
ILE A  37
 None
 1.09A 4nptA-1aecA:
0.7		 4nptA-1aecA:
19.81