SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 5 TYR A 248
LEU A 279
THR A 266
ARG A 269
 None
 1.19A 1i2wA-1aeiA:
undetectable		 1i2wA-1aeiA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		3 / 3 ASP A 278
LEU A 279
HIS A 255
 None
 0.78A 1qknA-1aeiA:
0.0		 1qknA-1aeiA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		5 / 11 ALA A 197
SER A 153
LEU A 150
ASN A 146
LEU A 235
 None
 1.11A 2ceoA-1aeiA:
0.0		 2ceoA-1aeiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		3 / 3 LEU A  71
TYR A  75
GLY A 304
 None
 0.39A 2ocuA-1aeiA:
undetectable		 2ocuA-1aeiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 8 SER A 263
ASP A 104
ARG A 252
ALA A 256
 None
 1.34A 2rk8A-1aeiA:
undetectable		 2rk8A-1aeiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 5 ASN A 193
ALA A 197
ALA A 194
ARG A 199
 None
 1.36A 3kp2B-1aeiA:
0.2		 3kp2B-1aeiA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 8 GLU A 163
ASN A 166
HIS A 169
ILE A 207
 None
 1.16A 3kp6A-1aeiA:
0.0
3kp6B-1aeiA:
0.0		 3kp6A-1aeiA:
22.51
3kp6B-1aeiA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		5 / 12 ILE A 214
GLY A 183
ARG A 191
ALA A 176
ALA A 175
 None
 1.01A 3sudC-1aeiA:
undetectable		 3sudC-1aeiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 5 LEU A 220
GLU A 224
LEU A 236
LYS A 240
 None
 1.19A 4k4yA-1aeiA:
0.0		 4k4yA-1aeiA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 5 LEU A 220
GLU A 224
LEU A 236
LYS A 240
 None
 1.19A 4k4yI-1aeiA:
0.0		 4k4yI-1aeiA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 6 ARG A  23
LEU A  63
LYS A  61
SER A  69
 None
 1.14A 4ot2A-1aeiA:
1.2		 4ot2A-1aeiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		5 / 11 LEU A  63
LYS A  68
LEU A  67
LEU A  80
ARG A  84
 None
 0.98A 4wg0C-1aeiA:
undetectable
4wg0D-1aeiA:
undetectable
4wg0E-1aeiA:
undetectable		 4wg0C-1aeiA:
4.26
4wg0D-1aeiA:
4.26
4wg0E-1aeiA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		5 / 11 LEU A  63
LYS A  68
LEU A  67
LEU A  80
ARG A  84
 None
 0.94A 4wg0E-1aeiA:
undetectable
4wg0F-1aeiA:
undetectable
4wg0G-1aeiA:
undetectable		 4wg0E-1aeiA:
4.26
4wg0F-1aeiA:
4.26
4wg0G-1aeiA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		5 / 11 LYS A  68
LEU A  67
LEU A  80
ARG A  84
LEU A  83
 None
 1.01A 4wg0E-1aeiA:
undetectable
4wg0F-1aeiA:
undetectable
4wg0G-1aeiA:
undetectable		 4wg0E-1aeiA:
4.26
4wg0F-1aeiA:
4.26
4wg0G-1aeiA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		4 / 7 LEU A  80
LEU A  83
LYS A  68
LEU A  67
 None
 0.81A 4wg0L-1aeiA:
undetectable
4wg0M-1aeiA:
undetectable		 4wg0L-1aeiA:
4.26
4wg0M-1aeiA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1aei ANNEXIN XII
(Hydra
vulgaris) 		5 / 12 ILE A 214
GLY A 183
ARG A 191
ALA A 176
ALA A 175
 None
 1.02A 6c2mD-1aeiA:
undetectable		 6c2mD-1aeiA:
17.91